Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This model is consistently represented within the CellML but contains sets of algebraic equations that prevent the model from being solved in currently available software - 03/08.
ValidateCellML found unit inconsistencies in this model
Model Structure
Calcium is an important signalling ion, and changes in Ca2+ concentration ([Ca2+]) regulate diverse processes in many cellular compartments. In excitable cells, depolarisation-induced Ca2+ entry increases [Ca2+]i, leading to secondary changes in [Ca2+] within organelles such as mitochondria and ER that regulate specific Ca2+-sensitive targets within these organelles. Although mitochondria accumulate Ca2+ in response to depolarisation-evoked [Ca2+]i elevations (see The Colegrove et al Model Of Mitochondrial Ca2+ Uptake And Release, 2000), the ER is also an important component in Ca2+ signalling in virtually all non-muscle cells, and it has been described as either a Ca2+ source or sink. Different modes of net ER Ca2+ transport are expected to have very different effects on cytoplasmic and intraluminal Ca2+ signals and on the processes they regulate (see The Albrecht et al Model Of Multiple Modes of Ca2+-induced Ca2+ Release in Sympathetic Neurons, 2001).
In a follow up study to their 2001 paper, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel have examined how differential regulation of ER Ca2+ uptake and release rates accounts for multiple modes of Ca2+-induced Ca2+ release. Three different macroscopic Ca2+ fluxes were modelled: JSERCA, the rate of Ca2+ uptake via SR Ca-ATPases; JICa, the total cytoplasmic Ca2+ flux when SR Ca-ATPases are inhibited; and Jpm, the rate of Ca2+ extrusion across the plasma membrane. One additional flux Jrelease was calculated from the difference between JICa and Jpm (see below). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .
The complete original paper reference is cited below:
Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release, Meredith A. Albrecht, Stephen L. Colegrove and David D. Friel, 2002,
The Journal Of General Physiology
, 119, 211-233. (Full text and PDF versions of the article are available for Journal Members on the JGP website.) PubMed ID: 11865019
cell schematic for the model
Schematic of the model indicating Ca2+ compartmentation in the extracellular matrix, cytosol and the ER and pathways for Ca2+ ion movement between the compartments.
neuron
electrophysiology
calcium dynamics
er
Catherine
Lloyd
May
The University of Auckland, Bioengineering Institute
Differential regulation of ER Ca2+ uptake and release.
sympathetic neuron
Stephen
Colegrove
L
c.lloyd@auckland.ac.nz
2002-07-18
Journal of General Physiology
Catherine
Lloyd
May
David
Friel
D
This is the CellML description of Albrecht et al's 2002 model of
differential regulation of ER Ca2+ uptake and rates.
Catherine Lloyd
updated curation status
The University of Auckland
The Bioengineering Institute
Added more metadata.
2002-03
Added publication date information.
2003-04-09
Autumn
Cuellar
A
2002-03-21T00:00:00+00:00
keyword
Differential Regulation of ER Ca2+ Uptake and Release Rates Accounts for Multiple Modes of Ca2+-induced Ca2+ Release
119
211
233
11865019
2009-04-30T16:04:07+12:00
Meredith
Albrecht
A
James
Lawson
Richard