- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-16 09:46:30+12:00
- Desc:
- Adding annos
- Permanent Source URI:
- http://models.cellml.org/workspace/bd4/rawfile/a70c663f5b3da18261538e034231b2eb97b5ce10/exposure/exposure_frontpage.rst
About
====================
Landing page for the proteins constituting the background sodium current (**NaB**).
This current was introduced by Luo and Rudy in order to make their model of the cardiomyocyte possess electroneutrality, by counterbalancing the extrusion of sodium form the cytosol through the NaK pump. In reality, this current appears to be made of contributions from the sodium leak channel - nonselective (NALCN), the hyperpolarization-activated cation channels (h) and voltage-gated sodium (NaV) channels, found from studies of the neuron.
Other name for this current: **Na-leak**
Subfamilies
===================
The following list contains the known proteins which may form the **NaB** current.
.. csv-table:: Variants within the human species
:header: "Name", "Alias", Gene, Structure
:widths: 4,4, 7,7
NALCN, VGCNL1, "`Uniprot NALCN <https://www.uniprot.org/uniprotkb/Q8IZF0/entry>`_", "`PDF NALCN <https://www.ebi.ac.uk/pdbe-srv/view/entry/6XIW>`_"
h, HCN, "`Uniprot h <https://www.uniprot.org/uniprotkb/O60741/entry>`_", "`PDF h <https://www.ebi.ac.uk/pdbe-srv/view/entry/5U6O>`_"
To date, information on the voltage gated sodium channel involved in creating the NaV current were not found.
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm <https://doi.org/10.1016/j.cell.2007.02.041>`_", "Lu et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_Nab <https://models.physiomeproject.org/workspace/82b>`_", "S Fong"
"`A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes*^ <https://models.physiomeproject.org/exposure/8f2ba36d47893780d4a1b41ae1b1a959>`_", "Luo and Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
