- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-16 14:14:07+12:00
- Desc:
- Init
- Permanent Source URI:
- http://models.cellml.org/workspace/bd6/rawfile/56f23193d87b51416c7c3b155bf1047a4faa93b4/exposure/exposure_frontpage.rst
About
====================
Landing page for the sodium calcium exchanger **NCX**.
NCX helps maintain resting membrane potential through helping establish the sodium and calcium concentration gradients across the membrane, through the passive extrusion of one calcium ion for the entry of three sodium ions.
Part of the solute carrier family 8 (SLC8), which itself belongs to the CaCA (Ca2+/Cation Antiporter) superfamily.
Pictures
===================
.. figure:: exposure/alphafold_NCX2.png
:width: 75%
:align: center
:alt: NCX_pic
Fig 1: NCX 2 structure predicted by Alphafold software:
*Jumper, J et al. Highly accurate protein structure prediction with AlphaFold. Nature (2021).*
*Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024).*
Subfamilies
===================
The following list contains all known member of the SLC8 family.
.. csv-table:: Variants within the human species
:header: "Name", "Alias", Gene, Structure
:widths: 7,7,7,7
SLC8A1, NCX1/NAC1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P32418/entry>`_, `PDB 1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/8JP0>`_
SLC8A2, NCX2/NAC2, `Uniprot 2 <https://www.uniprot.org/uniprotkb/Q9UPR5/entry>`_, `Alphafold 2 <https://alphafold.ebi.ac.uk/entry/Q9UPR5>`_
SLC8A3, NCX3/NAC3, `Uniprot 3 <https://www.uniprot.org/uniprotkb/P57103/entry>`_, `Alphafold 3 <https://alphafold.ebi.ac.uk/entry/P57103>`_
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
"`A thermodynamic framework for modelling membrane transporters <https://arxiv.org/abs/1806.04341>`_", "Pan et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_NCX <https://models.physiomeproject.org/workspace/828>`_", "S Fong"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`IPSC-model <https://github.com/ClancyLabUCD/IPSC-model>`_", "Kernik et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"calcium:sodium antiporter activity", "`Gene Ontology <https://amigo.geneontology.org/amigo/term/GO:0005432>`_"
