- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-19 14:37:22+12:00
- Desc:
- Change Cav to Cav1
- Permanent Source URI:
- http://models.cellml.org/workspace/bd9/rawfile/1b05ba584d3611d6bea8c8151e1d2ea43224f186/exposure/exposure_frontpage.rst
About
====================
Landing page for the L-type calcium pump **CaL**.
CaL allows for calcium entry into the cell and is responsible for triggering muscle contraction predominantly within cardiac, skeletal and smooth muscle cells.
When the cell membrane is depolarised above a given potential (such as during an action potential) the gated, voltage-dependent channel opens to allow for calcium entry.
CaLs are multisubunit complexes, consisting of a combination of alpha, beta, gamma and delta subunits. The channel activity is generally directed by the pore-forming and voltage-sensitive alpha subunit.
Other names: **Cav1**, **LCC**
Pictures
===================
.. figure:: exposure/L-type_calcium_channel_3JBR.png
:width: 75%
:align: center
:alt: LCC_pic
Fig 1: Crystallographic structure of the L-type calcium channel complex.
Subfamilies
===================
The following list contains all known isoforms of the L-type voltage dependent calcium channel family. Only the pore-forming alpha subunits are included.
.. csv-table:: Variants within the human species
:header: "Name", "Alias", Gene, Structure, Modulated by
:widths: 6,6,6,6, 9
CACNA1C, Cav1.2, `Uniprot C <https://www.uniprot.org/uniprotkb/Q13936/entry>`_, `PDB C <https://www.ebi.ac.uk/pdbe-srv/view/entry/1T0J>`_, CACNB1/CACNB2/CACNB3/CACNA2D1/CACNA2D4/CACNG4/CACNG6/CACNG7/CACNG8
CACNA1D, Cav1.3, `Uniprot D <https://www.uniprot.org/uniprotkb/Q01668/entry>`_, `PDB D <https://www.ebi.ac.uk/pdbe-srv/view/entry/3LV3>`_, CABP1/CABP4
CACNA1F, Cav1.4, `Uniprot F <https://www.uniprot.org/uniprotkb/O60840/entry>`_, `Alphafold F <https://alphafold.ebi.ac.uk/entry/O60840>`_, CABP4
CACNA1S, Cav1.1, `Uniprot S <https://www.uniprot.org/uniprotkb/Q13698/entry>`_, `PDB S <https://www.ebi.ac.uk/pdbe-srv/view/entry/2VAY>`_, CACNB1/CACNB2/CACNG1/CACNA2D1
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`L-Type Calcium Channels: The Low Down <https://doi.org/10.1152/jn.00486.2004>`_", "Lipscombe et al."
"`A thermodynamic framework for modelling membrane transporters <https://arxiv.org/abs/1806.04341>`_", "Pan et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_LCC <https://models.physiomeproject.org/workspace/6d7>`_", "S Fong"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`IPSC-model <https://github.com/ClancyLabUCD/IPSC-model>`_", "Kernik et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"voltage-gated calcium channel activity involved in cardiac muscle cell action potential", "`Gene Ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0086007>`_"
