- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-20 13:32:07+12:00
- Desc:
- init
- Permanent Source URI:
- http://models.cellml.org/workspace/bdd/rawfile/1c60b798a8557bc5178173c44c46b529d118de25/exposure/exposure_frontpage.rst
About
====================
Landing page for the proteins constituting the background calcium current (**CaB**).
This current was introduced by Luo and Rudy in order to make their model of the cardiomyocyte maintain calcium homeostasis, by counterbalancing the extrusion of calcium from the cytosol through the NCX.
In reality, little is known of such channels. They may be some variant of the transient receptor potential (TRP) channel, which exist on the plasma membrane (among other places) and show permeability to calcium.
Other name for this current: **Ca-leak**
Subfamilies
===================
The following list contains the known proteins which may form the **CaB** current.
.. csv-table:: Variants within the human species
:header: "Name", "Alias", Gene, Structure
:widths: 4,4, 7,7
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A Capacitative Calcium Current in Cultured Skeletal Muscle Cells Is Mediated by the Calcium-specific Leak Channel and Inhibited by Dihydropyridine Compounds <https://doi.org/10.1074/jbc.271.37.22358>`_", "Hopf et al."
"`A Capacitative Calcium Current in Cultured Skeletal Muscle Cells Is Mediated by the Calcium-specific Leak Channel and Inhibited by Dihydropyridine Compounds <https://doi-org.ezproxy.auckland.ac.nz/10.1016/S1050-1738(00)00075-X>`_, "Alderton and Steinhardt"
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_CaB <https://models.physiomeproject.org/workspace/82a>`_", "S Fong"
"`A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes*^ <https://models.physiomeproject.org/exposure/8f2ba36d47893780d4a1b41ae1b1a959>`_", "Luo and Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
