A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This model runs in both COR and PCEnv to reproduce the figures shown in the original paper. The units have been checked and they are consistent.
Model Structure
ABSTRACT: S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.
The complete paper reference is cited below:
A Role for Calcium Release-Activated Current (CRAC) in Cholinergic Modulation of Electrical Activity in Pancreatic Beta-Cells, Richard Bertram, Paul Smolen, Arthur Sherman, David Mears, Illani Atwater, Franz Martin and Bernat Soria, 1995,
Biophysical Journal, 68, 2323-2332. PubMed ID: 7647236
diagram of the cellular model
keyword
cholinergic modulation
metabolism
electrophysiology
beta cell
crac
pancreas
signal transduction
100000
60000
Added more metadata.
Bertram et al's 1995 model for a modulatory role for CRAC in islet electrical activity.
Pancreatic Beta-cell
68
2216
A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells
2217
2005-04-20
2009-05-27T14:35:15+12:00
Atwater
I
Mears
D
c.lloyd@auckland.ac.nz
2002-07-22
2002-05-06T00:00:00+00:00
Villiger
Peter
J
Biophysical Journal
Catherine Lloyd
2003-04-09
Sherman
Arthur
Made MathML id's unique
7647236
Updated curation status
Added publication date information.
Cuellar
Autumn
A
Bertram
Richard
Lawson
James
Richard
Martin
F
Smolen
P
Soria
B
The University of Auckland, Auckland Bioengineering Institute
Lloyd
Catherine
May
1995-06
The University of Auckland
Auckland Bioengineering Institute
This is the CellML description of Bertram et al's 1995 model for a modulatory role for CRAC in islet electrical activity.
Lloyd
Catherine
May