Differential Feedback Regulation of the MAPK Cascade Underlies the
Quantitative Differences in EGF and NGF Signalling in PC12 Cells
Jeelean
Lim
Bioengineering Institute, University of Auckland
Model Status
This is the initial translation of the model into CellML. Concentrations have no dimensions in order to balance units. The percentage activation variables used to produce the graphs in the paper have not yet been added to this model. The model can therefore run in Opencell and COR but does not reproduce the figures in the paper.
Model Structure
ABSTRACT: Although epidermal growth factor (EGF) induces transient activation of Ras and the mitogen-activated protein kinase (MAPK) cascade in PC12 cells, whereas nerve growth factor (NGF) stimulates sustained activation, the basis for these contrasting responses is not known. We have developed a computer simulation of EGF-induced MAPK cascade activation, which provides quantitative evidence that feedback inhibition of the MAPK cascade is the most important factor in determining the duration of cascade activation. Hence, we propose that the observed quantitative differences in EGF and NGF signalling can be accounted for by differential feedback regulation of the MAPK cascade.
The complete original paper reference is cited below:
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells, Frances A. Brightman, David A. Fell, 2000,Federation of European Biochemical Societies Letters, 482(3), 169-174. PubMed ID: 11024454
reaction diagram
Schematic representation of the computer simulation of EGF signal transduction.
Lim
Jeelean
jlim063@aucklanduni.ac.nz
The University of Auckland
The Auckland Bioengineering Institute
2001-09-10
The Brightman, Fell Model of Differential Feedback Regulation of the MAPK Cascade Underlying the Quantitative Differences in EGF and NGF Signalling in PC12 Cells
This is the CellML description of Brightman and Fell's model of differential feedback regulation of the MAPK cascade underlying the quantitative differences in EGF and NGF signalling in PC12 cells
Jeelean Lim
keyword
Epidermal Growth Factor
Mitogen-activated protein kinase
Signal Transduction
11024454
Brightman
F
A
Fell
D
A
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells.
2000-10
Federation of European Biochemical Societies Letters
482
169
174