Models of respiratory rhythm generation in the Pre-Botzinger complex. II. Populations Of coupled pacemaker neurons
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML model represents a single neuron in a network of cells. This cell model is based on "model 1" published in a preceding paper (Butera et al. 1999) which is also described in CellML as a stand alone CellML 1.0 model. To model inter-cellular coupling a synaptic input current Isyn_e has been added to the model.
Model Structure
model diagram
The single cell neuron model is based on a single-compartment Hodgkin-Huxley type formalism. It is composed of five ionic currents across the plasma membrane: a fast sodium current, INa; a delayed rectifier potassium current, IK; a persistent sodium current, INaP; a passive leakage current, IL; and a tonic current, Itonic_e In addition for the multicellular model a synaptic current (Isyn_e) has been added to connect the cells in the network.
The original paper reference is cited below:
Models of respiratory rhythm generation in the Pre-Botzinger complex. II. Populations Of coupled pacemaker neurons, Butera RJ Jr, Rinzel J, Smith JC, 1999, Journal of Neurophysiology, 82, 398-415. PubMed ID: 10400967
This CellML model describes the single cell (neuron) of the Butera et al. 1999 model. This model is imported by the multicellular model 10 times.
Catherine Lloyd
In order to facilitate the import of this single cell model by the multicellular model the current model is encapsulated in a top component called "single_neuron_model".
Catherine Lloyd
single_neuron_model
top component which encapsulates the single neuron cell model