Quantitative Analysis Of Mitochondrial Ca2+ Uptake And Release Pathways In Sympathetic Neurons
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This model can not be solved as it is unsuitably constrained.
ValidateCellML verifies this model as valid CellML with consistent units.
Model Structure
One of the central goals in the study of calcium signalling is to understand the basis of [Ca2+] dynamics. This is complicated by the fact that Ca2+ is present in several membrane-bound intracellular compartments, each of which uses a distinct Ca2+ transport system and the rate of Ca2+ transport between these compartments can exhibit a complex non-linear dependence on free [Ca2+].
In their 2000 model, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel have studied how mitochondrial Ca2+ transport contributes to the redistribution of intracellular Ca2+ during and after depolarisation-evoked Ca2+ entry in sympathetic neurons. The total Ca2+ flux during the recovery phase following membrane depolarisation was divided into three components (see below): one representing net Ca2+ extrusion across the plasma membrane (Jextru), one representing mitochondrial Ca2+ uptake via the uniporter (Juni) and one representing mitochondrial Ca2+ release via the Na+/Ca2+ exchanger (JNaCa). This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in .
The complete original paper reference is cited below:
Quantitative Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations
, Stephen L. Colegrove, Meredith A. Albrecht and David D. Friel, 2000,
The Journal Of General Physiology
, 115, 371-388. PubMed ID: 10694264
cell schematic for the model
Schematic of the model indicating Ca2+ compartmentalization in the extracellular matrix, cytosol and the mitochondrial matrix and pathways for Ca2+ ion movement between the compartments.
calcium dynamics
neuron
sympathetic
electrophysiology
The University of Auckland, Bioengineering Institute
2002-03-21T00:00:00+00:00
2000-03
Added more metadata.
Journal of General Physiology
10694264
Stephen
Colegrove
L
The University of Auckland
The Bioengineering Institute
Quantitative analysis of mitochondrial Ca2+ uptake and release.
sympathetic neuron
keyword
2003-04-09
Catherine
Lloyd
May
This is the CellML description of Colegrove et al's 2000 model of
mitochondrial Ca2+ uptake and release pathways in sympathetic neurons.
2009-06-05T15:33:47+12:00
2003-03-28
Meredith
Albrecht
A
Catherine
Lloyd
May
David
Friel
D
Added publication date information.
Catherine Lloyd
Changed the name and cmeta:id of the model to reflect the proper
spelling of Colegrove.
James
Lawson
Richard
2002-07-18
Autumn
Cuellar
A
c.lloyd@auckland.ac.nz
Quantitive Analysis of Mitochondrial Ca2+ Uptake and Release Pathways in Sympathetic Neurons Reconstruction of the Recovery after Depolarisation-evoked [Ca2+] Elevations
115
371
388
updated curation status, removed reference link in documentation
Autumn
Cuellar
A