Location: Cooling, Hunter, Crampin, 2009 @ 00be32aed712 / NFATCycling_DualProtocol.cellml

Author:
Mike Cooling <m.cooling@auckland.ac.nz>
Date:
2010-06-02 13:32:24+12:00
Desc:
Removed the sub-folder structure and pulling all three models into one folder, to avoid UI issues with the Repository.
Permanent Source URI:
http://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/00be32aed712c03ef96e6cd04f55cc5d219406c9/NFATCycling_DualProtocol.cellml

<?xml version="1.0" encoding="iso-8859-1"?>
<model
    name="NFATCycling"
    cmeta:id="NFATCycling"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
    
<rdf:RDF
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:bqs="http://www.cellml.org/bqs/1.0#"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
    <rdf:Description rdf:about="#NFATCycling">
        <dc:creator rdf:parseType="Resource">
            <vCard:N rdf:parseType="Resource">
                <vCard:Family>Cooling</vCard:Family>
                <vCard:Given>Michael</vCard:Given>
            </vCard:N>
            <vCard:EMAIL rdf:parseType="Resource">
                <rdf:value>m.cooling@auckland.ac.nz</rdf:value>
                <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
            </vCard:EMAIL>
        </dc:creator>

        <dc:title>Cooling's NFAT Cycling module for the Dual calcium protocol</dc:title>
    </rdf:Description>
</rdf:RDF> 
<!--
*******************************************************
***         U   N   I   T   S                       ***
*******************************************************
-->
   <units name="s">
      <unit units="second"/>
   </units>
   
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
         <unit units="mole" prefix="nano"/>
         <unit units="liter" exponent="-1"/>
      </units>
      <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_s">
         <unit units="s" exponent="-1"/>
      </units>
      <units xmlns="http://www.cellml.org/cellml/1.0#" name="nM_per_s">
         <unit units="nM"/>
         <unit units="s" exponent="-1"/>
      </units>
    <units xmlns="http://www.cellml.org/cellml/1.0#" name="per_nM_s">
       <unit units="nM" exponent="-1"/>
       <unit units="s" exponent="-1"/>
    </units>
<!--
*********************************************************
***       C   O   M   P   O   N   E   N   T   S       ***
*********************************************************
-->
  <component name="NFAT_Cycling">
          <variable name="t"   units="s" public_interface="in"/>
          
          <variable name="NFATN_c" units="nM" initial_value="0.0017047398"/>
          <variable name="NFATN_n" units="nM" initial_value="0.50910553" public_interface="out"/>
          <variable name="NFATp_c" units="nM" initial_value="0.9825855442"/>
          <variable name="NFATp_n" units="nM" initial_value="0.27638027" public_interface="out"/>
           
          <variable name="Ccn" units="dimensionless" private_interface="in"/> 
          <variable name="Ntot" units="nM" public_interface="in"/>
          <variable name="act_N" units="dimensionless" private_interface="in"/>
          
          <variable name="k_f1" units="per_nM_s" initial_value="7.68934e-6"/>
          <variable name="k_r1" units="per_s" initial_value="0.019256"/>
          <variable name="k_f2" units="per_s" initial_value="0.00144192"/>
          <variable name="k_f3" units="per_s" initial_value="0.000361944"/>
          <variable name="k_r3" units="per_nM_s" initial_value="4.70813e-5"/>
          <variable name="k_f4" units="per_s" initial_value="0.000444695"/>
    
          <variable name="J1" units="nM_per_s"/>
          <variable name="J2" units="nM_per_s"/>
          <variable name="J3" units="nM_per_s"/>
          <variable name="J4" units="nM_per_s"/>
     <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
                 <eq/>
                 <ci>J1</ci>
                 <apply>
                    <minus/>
                    <apply>
                       <times/>
                       <ci>k_f1</ci>
                       <ci>NFATp_c</ci>
                       <ci>Ntot</ci>
                       <ci>act_N</ci>
                    </apply>
                    <apply>
                       <times/>
                       <ci>k_r1</ci>
                       <ci>NFATN_c</ci>
                       <apply>
                          <minus/>
                          <cn cellml:units="dimensionless">1</cn>
                          <ci>act_N</ci>
                       </apply>
                    </apply>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <ci>J2</ci>
                 <apply>
                    <times/>
                    <ci>k_f2</ci>
                    <ci>NFATN_c</ci>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <ci>J3</ci>
                 <apply>
                    <minus/>
                    <apply>
                       <times/>
                       <ci>k_f3</ci>
                       <ci>NFATN_n</ci>
                       <apply>
                          <minus/>
                          <cn cellml:units="dimensionless">1</cn>
                          <ci>act_N</ci>
                       </apply>
                    </apply>
                    <apply>
                       <times/>
                       <ci>k_r3</ci>
                       <ci>NFATp_n</ci>
                       <ci>Ntot</ci>
                       <ci>act_N</ci>
                    </apply>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <ci>J4</ci>
                 <apply>
                    <times/>
                    <ci>k_f4</ci>
                    <ci>NFATp_n</ci>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <apply>
                    <diff/>
                    <bvar>
                       <ci>t</ci>
                    </bvar>
                    <ci>NFATp_c</ci>
                 </apply>
                 <apply>
                    <minus/>
                    <apply>
                       <divide/>
                       <ci>J4</ci>
                       <ci>Ccn</ci>
                    </apply>
                    <ci>J1</ci>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <apply>
                    <diff/>
                    <bvar>
                       <ci>t</ci>
                    </bvar>
                    <ci>NFATN_c</ci>
                 </apply>
                 <apply>
                    <minus/>
                    <ci>J1</ci>
                    <ci>J2</ci>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <apply>
                    <diff/>
                    <bvar>
                       <ci>t</ci>
                    </bvar>
                    <ci>NFATN_n</ci>
                 </apply>
                 <apply>
                    <minus/>
                    <apply>
                       <times/>
                       <ci>J2</ci>
                       <ci>Ccn</ci>
                    </apply>
                    <ci>J3</ci>
                 </apply>
              </apply>
              <apply>
                 <eq/>
                 <apply>
                    <diff/>
                    <bvar>
                       <ci>t</ci>
                    </bvar>
                    <ci>NFATp_n</ci>
                 </apply>
                 <apply>
                    <minus/>
                    <ci>J3</ci>
                    <ci>J4</ci>
                 </apply>
          </apply>
     </math>
    </component>

</model>