Location: Cooling, Hunter, Crampin, 2009 @ 36debb705900 / NFATMyocyte_DualProtocol_Submodel.cellml

Author:
Mike Cooling <m.cooling@auckland.ac.nz>
Date:
2010-06-02 13:32 +1200
Desc:
Removed the sub-folder structure and pulling all three models into one folder, to avoid UI issues with the Repository.
Permanent Source URI:
http://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/36debb7059008b6378de6f382001fa98fba20ef1/NFATMyocyte_DualProtocol_Submodel.cellml

<?xml version="1.0" encoding="utf-8"?>

<model
    name="NFATMyocyte_DualProtocol"
    cmeta:id="NFATMyocyte_DualProtocol"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:xlink="http://www.w3.org/1999/xlink">
    
    <import xlink:href="calcium_DualProtocol.cellml">
            <component name="calcium" component_ref="calcium" />
        </import>
        <import xlink:href="calcineurin_DualProtocol.cellml">
                    <component name="calcineurin" component_ref="calcineurin" />
        </import>
        <import xlink:href="NFATCycling_DualProtocol.cellml">
                    <component name="NFAT_Cycling" component_ref="NFAT_Cycling" />
        </import>
        
        <rdf:RDF
            xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
            xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
            xmlns:bqs="http://www.cellml.org/bqs/1.0#"
            xmlns:dc="http://purl.org/dc/elements/1.1/"
            xmlns:dcterms="http://purl.org/dc/terms/"
            xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
            <rdf:Description rdf:about="">
                <dc:creator rdf:parseType="Resource">
                    <vCard:N rdf:parseType="Resource">
                        <vCard:Family>Cooling</vCard:Family>
                        <vCard:Given>Michael</vCard:Given>
                    </vCard:N>
                    <vCard:ORG rdf:parseType="Resource">
                        <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
                        <vCard:Orgunit>University of Auckland</vCard:Orgunit>
                    </vCard:ORG>
                    <vCard:EMAIL rdf:parseType="Resource">
                        <rdf:value>m.cooling@auckland.ac.nz</rdf:value>
                        <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
                    </vCard:EMAIL>
                </dc:creator>
        
                <dc:title>Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Dual Calcium Protocol)</dc:title>
            </rdf:Description>
            
            <rdf:Description rdf:about="#NFATMyocyte_DualProtocol">
	                <bqs:reference rdf:parseType="Resource">
	                    <bqs:JournalArticle rdf:parseType="Resource">
	                        <dc:creator>
	                            <rdf:Seq>
	                            <rdf:li rdf:parseType="Resource">
	                                <vCard:N rdf:parseType="Resource">
	                                <vCard:Family>Cooling</vCard:Family>
	                                <vCard:Given>Mike</vCard:Given>
	                                </vCard:N>
	                                <vCard:EMAIL rdf:parseType="Resource">
	                                <rdf:value>m.cooling@auckland.ac.nz</rdf:value>
	                                <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
	                                </vCard:EMAIL>
	                                <vCard:ORG rdf:parseType="Resource">
	                                <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
	                                <vCard:Orgunit>University of Auckland</vCard:Orgunit>
	                                </vCard:ORG>
	                            </rdf:li>
	    			<rdf:li rdf:parseType="Resource">
	    			    <vCard:N rdf:parseType="Resource">
	    			    <vCard:Family>Hunter</vCard:Family>
	    			    <vCard:Given>Peter</vCard:Given>
	    			    </vCard:N>
	    			    <vCard:EMAIL rdf:parseType="Resource">
	    			    <rdf:value>p.hunter@auckland.ac.nz</rdf:value>
	    			    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
	    			    </vCard:EMAIL>
	    			    <vCard:ORG rdf:parseType="Resource">
	    			    <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
	    			    <vCard:Orgunit>University of Auckland</vCard:Orgunit>
	    			    </vCard:ORG>
	                            </rdf:li>
	    			<rdf:li rdf:parseType="Resource">
	    			    <vCard:N rdf:parseType="Resource">
	    			    <vCard:Family>Crampin</vCard:Family>
	    			    <vCard:Given>Edmund</vCard:Given>
	    			    </vCard:N>
	    			    <vCard:EMAIL rdf:parseType="Resource">
	    			    <rdf:value>e.crampin@auckland.ac.nz</rdf:value>
	    			    <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
	    			    </vCard:EMAIL>
	    			    <vCard:ORG rdf:parseType="Resource">
	    			    <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
	    			    <vCard:Orgunit>University of Auckland</vCard:Orgunit>
	    			    </vCard:ORG>
	                            </rdf:li>
	                            </rdf:Seq>
	                        </dc:creator>
	                        <dc:title>Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes</dc:title>
	                        <bqs:volume>96</bqs:volume>
	                        <bqs:first_page>2095</bqs:first_page>
	                        <bqs:last_page>2104</bqs:last_page>
	                        <bqs:Journal rdf:parseType="Resource">
	                                <dc:title>Biophysical Journal</dc:title>
	                        </bqs:Journal>
	                        <dcterms:issued rdf:parseType="Resource">
	                                <dcterms:W3CDTF>2009-00-00 00:00</dcterms:W3CDTF>
	                        </dcterms:issued>
	                    </bqs:JournalArticle>
	                </bqs:reference>
	    
	                <bqs:reference rdf:parseType="Resource">
	                        <dc:subject rdf:parseType="Resource">
	                                <bqs:subject_type>keyword</bqs:subject_type>
	                                <rdf:value>
	                                        <rdf:Bag>
	                                                <rdf:li>Signal Transduction</rdf:li>
	                                                <rdf:li>Calcium Dynamics</rdf:li>
	                                                <rdf:li>Gene Regulation</rdf:li>
	                                                <rdf:li>Excitation-Transcription Coupling</rdf:li>
	                                                <rdf:li>NFAT</rdf:li>
	                                        </rdf:Bag>
	                                </rdf:value>
	                        </dc:subject>
	                </bqs:reference>
        </rdf:Description>
            
</rdf:RDF>
        
        <!--
        *******************************************************
        ***         U   N   I   T   S                       ***
        *******************************************************
        -->
        
   <units name="s">
      <unit units="second"/>
   </units>
   
   <units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
         <unit units="mole" prefix="nano"/>
         <unit units="liter" exponent="-1"/>
      </units>
   
   <!--
     *********************************************************
     ***       C   O   M   P   O   N   E   N   T   S       ***
     *********************************************************
     -->
   
  <component name="environment">
          <variable name="t" units="s" private_interface="out"/>
     </component>
     
     
    <component name="geometry">
         <variable name="Ccn" units="dimensionless" initial_value="50" private_interface="out"/>
    </component>
   
      <component name="NFAT_Cycling_interface">
          <variable name="nuclearNFAT" units="nM"/>
          <variable name="NFATN_n" units="nM" public_interface="in"/>
          <variable name="NFATp_n" units="nM" public_interface="in"/>
   
          <math xmlns="http://www.w3.org/1998/Math/MathML">
              <apply>
                      <eq/>
                      <ci>nuclearNFAT</ci>
                      <apply>
                         <plus/>
                         <ci>NFATN_n</ci>
                         <ci>NFATp_n</ci>
                      </apply>
            </apply>
          </math>
   </component>
   
   
<group>
    <relationship_ref relationship="encapsulation" />
        <component_ref component="environment">
            <component_ref component="geometry">
                <component_ref component="calcium"/>
                <component_ref component="calcineurin"/>
                <component_ref component="NFAT_Cycling"/>
                <component_ref component="NFAT_Cycling_interface"/>
             </component_ref>
        </component_ref>
</group>   

   
<connection>
    <map_components
        component_1="environment" component_2="calcium" />
    <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="environment" component_2="calcineurin" />
        <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="environment" component_2="NFAT_Cycling" />
        <map_variables variable_1="t" variable_2="t" />
</connection>

<connection>
    <map_components component_1="geometry" component_2="NFAT_Cycling" />
        <map_variables variable_1="Ccn" variable_2="Ccn" />
</connection>

<connection>
    <map_components component_1="calcium" component_2="calcineurin" />
        <map_variables variable_1="Ca" variable_2="Ca" />
</connection>

<connection>
    <map_components component_1="calcineurin" component_2="NFAT_Cycling" />
        <map_variables variable_1="act_N" variable_2="act_N" />
        <map_variables variable_1="Ntot" variable_2="Ntot" />
</connection>

<connection>
    <map_components component_1="NFAT_Cycling_interface" component_2="NFAT_Cycling" />
        <map_variables variable_1="NFATN_n" variable_2="NFATN_n" />
        <map_variables variable_1="NFATp_n" variable_2="NFATp_n" />
</connection>
   

</model>