- Author:
- mikec <devnull@localhost>
- Date:
- 2015-03-18 15:06:52+13:00
- Desc:
- 1) Fixed some minor structural issues in all 3 NFAT models (Shen, Tomida and Dual Protocol).
2) Incorporated annotation work done by Rory Lynch.
This model seems to have been adjusted since I first submitted it, so I don't know for sure
if it still behaves properly. This commit has not been 'regression tested' in any way.
- Permanent Source URI:
- http://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/6038bb1d88ec1229cc2541bd89e06608fd9259f7/calcineurin_DualProtocol.cellml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="calcineurin"
cmeta:id="calcineurin"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#calcineurin">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cooling</vCard:Family>
<vCard:Given>Michael</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
</vCard:EMAIL>
</dc:creator>
<dc:title>Cooling's calcineurin module for the Dual calcium protocol</dc:title>
</rdf:Description>
</rdf:RDF>
<!--
*******************************************************
*** U N I T S ***
*******************************************************
-->
<units name="s">
<unit units="second"/>
</units>
<units name="nM">
<unit units="mole" prefix="nano"/>
<unit units="liter" exponent="-1"/>
</units>
<!--
*********************************************************
*** C O M P O N E N T S ***
*********************************************************
-->
<component name="calcineurin">
<variable cmeta:id="v7" name="t" units="s" public_interface="in"/>
<variable cmeta:id="v4" name="Ca" units="nM" public_interface="in"/>
<variable cmeta:id="v1" name="M" units="nM" initial_value="6000"/>
<variable cmeta:id="v0" name="Ntot" units="nM" initial_value="1000" public_interface="out"/>
<variable cmeta:id="v2" name="K_mN" units="nM" initial_value="535"/>
<variable cmeta:id="v3" name="n" units="dimensionless" initial_value="2.92"/>
<variable cmeta:id="v6" name="K_dN" units="nM" initial_value="1760"/>
<variable cmeta:id="v5" name="act_N" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>act_N</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Ca</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca</ci>
<ci>n</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mN</ci>
<ci>n</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_dN</ci>
<ci>M</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<rdf:RDF
xmlns:ro="http://www.obofoundry.org/ro/ro.owl#"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
>
<rdf:Description rdf:ID="v1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:contained_in>
<rdf:Description rdf:about="#entity_3">
<ro:contained_in>
<rdf:Description rdf:about="#entity_4">
<semsim:refersTo rdf:resource="http://identifiers.org/fma/FMA:14067" />
</rdf:Description>
</ro:contained_in>
<semsim:refersTo rdf:resource="http://identifiers.org/fma/FMA:66835" />
</rdf:Description>
</ro:contained_in>
<semsim:refersTo rdf:resource="http://www.uniprot.org/uniprot/P62158" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:ID="v2">
<bqbiol:identity rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000191" />
</rdf:Description>
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<bqbiol:identity rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000190" />
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<semsim:refersTo rdf:resource="http://identifiers.org/fma/FMA:14067" />
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<semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:39123" />
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</rdf:Description>
<rdf:Description rdf:ID="v6">
<bqbiol:identity rdf:resource="http://identifiers.org/biomodels.sbo/SBO:0000191" />
</rdf:Description>
<rdf:Description rdf:ID="v7">
<bqbiol:identity rdf:resource="http://identifiers.org/opb/OPB_01361" />
</rdf:Description>
</rdf:RDF>
</model>
