Location: Cooling, Hunter, Crampin, 2009 @ e4e4bc136629 / calcineurin_ShenProtocol.cellml

Author:
mtcooling <mtcooling.development@gmail.com>
Date:
2015-08-24 10:57:56+12:00
Desc:
Split the annotation for the protocols into separate files in line with the metadata spec 2.0
Permanent Source URI:
http://models.cellml.org/workspace/cooling_hunter_crampin_2009/rawfile/e4e4bc1366292fd3387f8391e774271f5a4e9c14/calcineurin_ShenProtocol.cellml

<?xml version="1.0" encoding="iso-8859-1"?>
<model
    name="calcineurin"
    cmeta:id="calcineurin"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
	>
<!--
*******************************************************
***         U   N   I   T   S                       ***
*******************************************************
-->
   <units name="s">
      <unit units="second"/>
   </units>
   
   <units  name="nM">
         <unit units="mole" prefix="nano"/>
         <unit units="liter" exponent="-1"/>
      </units>

<!--
*********************************************************
***       C   O   M   P   O   N   E   N   T   S       ***
*********************************************************
-->
     <component name="calcineurin">
		<variable cmeta:id="v0" name="Ntot" units="nM" initial_value="1000" public_interface="out"/>
		<variable cmeta:id="v1" name="M" units="nM" initial_value="6000"/>
		<variable cmeta:id="v2" name="K_mN" units="nM" initial_value="535"/>
		<variable cmeta:id="v3" name="n" units="dimensionless" initial_value="2.92"/>
		<variable cmeta:id="v4" name="Ca" units="nM" public_interface="in"/>
		<variable cmeta:id="v5" name="act_N" units="dimensionless"/>
		<variable cmeta:id="v6" name="K_dN" units="nM" initial_value="1760"/>
		<variable cmeta:id="v7" name="t"   units="s" public_interface="in"/>
		<variable cmeta:id="v8" name="act_Napp" units="dimensionless" public_interface="out"/>
		<variable cmeta:id="v9" name="tau_actN" units="s" initial_value="0.070059"/>
		<variable cmeta:id="v10" name="tNinhib" units="s" initial_value="3600"/>
      
       <math xmlns="http://www.w3.org/1998/Math/MathML">
        <apply>
                  <eq/>
                  <ci>act_N</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <power/>
                        <ci>Ca</ci>
                        <ci>n</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>Ca</ci>
                           <ci>n</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>K_mN</ci>
                              <ci>n</ci>
                           </apply>
                           <apply>
                              <plus/>
                              <cn cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <ci>K_dN</ci>
                                 <ci>M</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <eq/>
                  <ci>act_Napp</ci>
                  <piecewise>
                     <piece>
                        <ci>act_N</ci>
                        <apply>
                           <lt/>
                           <ci>t</ci>
                           <ci>tNinhib</ci>
                        </apply>
                     </piece>
                     <piece>
                        <apply>
                           <times/>
                           <ci>act_N</ci>
                           <apply>
                              <power/>
                              <exponentiale/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <apply>
                                       <minus/>
                                       <ci>t</ci>
                                       <ci>tNinhib</ci>
                                    </apply>
                                 </apply>
                                 <ci>tau_actN</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <geq/>
                           <ci>t</ci>
                           <ci>tNinhib</ci>
                        </apply>
                     </piece>
                  </piecewise>
         </apply>
         </math>
   </component>

  
</model>