Location: Cooling, Hunter, Crampin, Cellml, 2008 @ 4067f1d906d2 / cooling_hunter_crampin_CellML_2008.cellml

Author:
pmr2.import <nobody@models.cellml.org>
Date:
2007-12-17 03:45:42+13:00
Desc:
committing version01 of cooling_hunter_crampin_CellML_2008
Permanent Source URI:
http://models.cellml.org/workspace/cooling_hunter_crampin_CellML_2008/rawfile/4067f1d906d259150ba751cdd55ce7a1b4f99600/cooling_hunter_crampin_CellML_2008.cellml
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<article>
  <articleinfo>
  <title>NFAT Cycling Calcium Sensitivity: A Quantitative Myocyte Model</title>
  <author>
    <firstname>Michael</firstname>
          <surname>Cooling</surname>
    <affiliation>
      <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
    </affiliation>
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  <section id="sec_status">
    <title>Model Status</title>
    <para>
        This CellML model is the model which was used to produce the original results in the paper, and therefore it is known to be completely accurate.
          </para>
  </section>
  <sect1 id="sec_structure">
  <title>Model Structure</title>

<para>
The model structure illustrates a modular version of the cardiac myocyte IP3 production system as developed in the paper:
</para>

<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/93/10/3421">Modeling hypertrophic IP3 transients in the cardiac myocyte</ulink>, Michael Cooling, Peter Hunter and Edmund J. Crampin, 2007, <ulink url="http://www.biophysj.org/">
            <emphasis>Biophysical Journal</emphasis>
          </ulink>, 93, 3421-3433.  (<ulink url="http://www.biophysj.org/cgi/content/full/93/10/3421">Full text</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/93/10/3421">PDF</ulink> versions of the article are available to journal subscribers on the <emphasis>Biophysical Journal</emphasis> website.)  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17693463&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 17693463</ulink>
</para>
 
<para>
The process of how this model was modularised into functional and messenger components is described in detail in the paper:
</para>

<para>
<ulink url="http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&amp;id=ISBEAT000002000002000073000001&amp;idtype=cvips&amp;gifs=Yes">Modelling biological modularity with CellML</ulink>, M.T. Cooling, P. Hunter, and E.J. Crampin, 2008, <ulink url="http://www.ietdl.org/">
            <emphasis>IET Systems Biology</emphasis>
          </ulink>, 2(2), 73-79. (Currently In Press).
</para>

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<caption>A schematic diagram of the CellML model.</caption>
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<para>
Related models: Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte (ref to: http://www.cellml.org/models/cooling_hunter_crampin_2007_version01)
</para>


<para>
This is a link to Modeling Biological Modularity with CellML.  Please get the model code <ulink url="http://www.cellml.org/models_1.1/cooling-et-al-2008-modeling-biological-modularity-with-cellml/">here</ulink>.
</para>
</sect1>


</article>
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