- Author:
- mcoo001 <devnull@localhost>
- Date:
- 2010-01-11 14:49:09+13:00
- Desc:
- Added a description file for the Exposure.
- Permanent Source URI:
- http://models.cellml.org/workspace/cooling_hunter_crampin_CellML_2008/rawfile/6aaf535b0ab191ef47034e0769431affd5c0aa25/cooling_hunter_crampin_CellML_2008.cellml
<?xml version='1.0' encoding='utf-8'?>
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="cooling08_d" name="cooling08_d">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>NFAT Cycling Calcium Sensitivity: A Quantitative Myocyte Model</title>
<author>
<firstname>Michael</firstname>
<surname>Cooling</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model is the model which was used to produce the original results in the paper, and therefore it is known to be completely accurate.
</para>
<para>
This is a link to Modeling Biological Modularity with CellML. Please get the model code <ulink url="http://www.cellml.org/models_1.1/cooling-et-al-2008-modeling-biological-modularity-with-cellml/">here</ulink>.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
The model structure illustrates a modular version of the cardiac myocyte IP3 production system as developed in the paper:
</para>
<para>
Modeling hypertrophic IP3 transients in the cardiac myocyte, Michael Cooling, Peter Hunter and Edmund J. Crampin, 2007,
<emphasis>Biophysical Journal</emphasis>
, 93, 3421-3433. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17693463&query_hl=1&itool=pubmed_docsum">PubMed ID: 17693463</ulink>
</para>
<para>
The process of how this model was modularised into functional and messenger components is described in detail in the paper:
</para>
<para>
<ulink url="http://scitation.aip.org/getabs/servlet/GetabsServlet?prog=normal&id=ISBEAT000002000002000073000001&idtype=cvips&gifs=Yes">Modelling biological modularity with CellML</ulink>, M.T. Cooling, P. Hunter, and E.J. Crampin, 2008, <ulink url="http://www.ietdl.org/">
<emphasis>IET Systems Biology</emphasis>
</ulink>, 2(2), 73-79. (Currently In Press).
</para>
<informalfigure float="0" id="diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="cooling_2008.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the CellML model.</caption>
</informalfigure>
<para>
Related models: Modelling Hypertrophic IP3 Transients in the Cardiac Myocyte (ref to: http://www.cellml.org/models/cooling_hunter_crampin_2007_version01)
</para>
</sect1>
</article>
</documentation>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#d4b34559-35e7-41b2-b559-5104752810e9">
<rdf:li rdf:resource="rdf:#15c9f861-d767-4fe1-a6bf-900daa4d45c0"/>
<rdf:li rdf:resource="rdf:#ee3f9566-fb5b-42ae-8b46-00e7ee6812f8"/>
<rdf:li rdf:resource="rdf:#0b20a761-3b9f-45c0-ba62-bfa7c9f91bf1"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#d01a3b7f-2d18-49ce-9e5d-db21c8ed1d82">
<vCard:N rdf:resource="rdf:#c6083d38-c941-4abf-b02d-15308fbc8d11"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#19c6e802-cdc4-44ff-88ad-079e3411ad4f">
<vCard:FN/>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher/>
<cmeta:comment rdf:resource="rdf:#5eeaad26-9ab0-4a83-9dc9-f5bb8b345f92"/>
<dcterms:created rdf:resource="rdf:#b62ffee9-94a0-474e-b177-24e9efd71da0"/>
<dc:creator rdf:resource="rdf:#f1ff7c9c-97f0-4efd-84f3-95636cfdce88"/>
<cmeta:modification rdf:resource="rdf:#eb14b1e4-027e-41c7-a8b4-9d7ba4a01687"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a7570e5b-d3ea-4191-bcdf-44d31c4b164c">
<dc:title>IET Systems Biology</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5eeaad26-9ab0-4a83-9dc9-f5bb8b345f92">
<dc:creator rdf:resource="rdf:#19c6e802-cdc4-44ff-88ad-079e3411ad4f"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b62ffee9-94a0-474e-b177-24e9efd71da0">
<dcterms:W3CDTF>2007-12-17T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#323768a4-741b-4a0f-9883-967efdcbbf4c">
<dc:creator rdf:resource="rdf:#3ad21145-1ec1-4f36-bdff-c8fe87ea6150"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0b20a761-3b9f-45c0-ba62-bfa7c9f91bf1">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#8705aeab-0910-4114-9e5f-41e20bac8a64"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#244dff71-1545-4f31-a28f-0b5ecacd38dc">
<dc:creator rdf:resource="rdf:#d4b34559-35e7-41b2-b559-5104752810e9"/>
<dc:title>Modeling Biological Modularity with CellML</dc:title>
<bqs:volume>In Press</bqs:volume>
<bqs:first_page/>
<bqs:Journal rdf:resource="rdf:#a7570e5b-d3ea-4191-bcdf-44d31c4b164c"/>
<dcterms:issued rdf:resource="rdf:#47e9ae69-7850-4733-bd01-8e1688c77729"/>
<bqs:last_page/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8478e156-80a6-4656-8590-2308367fa2c0">
<vCard:Given>Mike</vCard:Given>
<vCard:Family>Cooling</vCard:Family>
<vCard:Other/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#538161c9-79de-4be4-987e-908e722b85d7">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a13ddeb9-0773-49b8-a41e-b930b5d84675">
<vCard:Orgname/>
<vCard:Orgunit/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ecac1ac5-5c3f-4425-bc6f-5e09f6a2e43d">
<bqs:Pubmed_id/>
<bqs:JournalArticle rdf:resource="rdf:#244dff71-1545-4f31-a28f-0b5ecacd38dc"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3ad21145-1ec1-4f36-bdff-c8fe87ea6150">
<vCard:FN/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0f0cd96b-8bcd-4897-8647-1c9bd6e76ef2">
<vCard:Given>Peter</vCard:Given>
<vCard:Family>Hunter</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c6083d38-c941-4abf-b02d-15308fbc8d11">
<vCard:Given>James</vCard:Given>
<vCard:Family>Lawson</vCard:Family>
<vCard:Other>Richard</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ee3f9566-fb5b-42ae-8b46-00e7ee6812f8">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#0f0cd96b-8bcd-4897-8647-1c9bd6e76ef2"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#eb14b1e4-027e-41c7-a8b4-9d7ba4a01687">
<dcterms:modified rdf:resource="rdf:#53d241d1-c6b3-49d2-bd9d-929133f3c213"/>
<rdf:value>updated curation status,
removed reference publication link from documentation.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#d01a3b7f-2d18-49ce-9e5d-db21c8ed1d82"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#15c9f861-d767-4fe1-a6bf-900daa4d45c0">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#f4aafa8f-2359-4102-9540-e206d8b07e9b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f4aafa8f-2359-4102-9540-e206d8b07e9b">
<vCard:Given>Michael</vCard:Given>
<vCard:Family>Cooling</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f1ff7c9c-97f0-4efd-84f3-95636cfdce88">
<vCard:ORG rdf:resource="rdf:#a13ddeb9-0773-49b8-a41e-b930b5d84675"/>
<vCard:EMAIL rdf:resource="rdf:#538161c9-79de-4be4-987e-908e722b85d7"/>
<vCard:N rdf:resource="rdf:#8478e156-80a6-4656-8590-2308367fa2c0"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8705aeab-0910-4114-9e5f-41e20bac8a64">
<vCard:Given>Edmund</vCard:Given>
<vCard:Family>Crampin</vCard:Family>
<vCard:Other>J.</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="#cooling08_d">
<bqs:reference rdf:resource="rdf:#ecac1ac5-5c3f-4425-bc6f-5e09f6a2e43d"/>
<cmeta:comment rdf:resource="rdf:#323768a4-741b-4a0f-9883-967efdcbbf4c"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#47e9ae69-7850-4733-bd01-8e1688c77729">
<dcterms:W3CDTF>2008-00-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#53d241d1-c6b3-49d2-bd9d-929133f3c213">
<dcterms:W3CDTF>2009-06-05T15:57:04+12:00</dcterms:W3CDTF>
</rdf:Description>
</rdf:RDF>
</model>