Mathematical Model Of A Human Atrial Action Potential, 1998
Noble
Penny
Oxford University
Model Status
This model has been validated by Penny Noble of Oxford University and is known to run in COR and PCEnv.
ValidateCellML verifies this model as valid CellML, but detects unit inconsistencies.
Model Structure
The ionic mechanisms underlying many important properties of the human atrial action potential are poorly understood. Using specific formulations of the K+, Na+ and Ca2+ currents based on experimental data recorded from human atrial myocytes, along with representations of pump, exchange and background currents, Marc Courtemanche, Rafael J. Ramirez and Stanley Nattel developed a mathematical model of the action potential (see the figure below).
This mathematical model builds mostly on the classical work of Luo and Rudy (see The Luo-Rudy Ventricular Model II (dynamic), 1994). Courtemanche et al effectively develop a working model of the human atrial action potential from the Luo-Rudy model which is based on guinea pig ventricular cells. Their primary goal was to develop a useful model of the action potential from which they could gain insights into experimental observations made on human atrial cells and tissues and make predictions regarding the behaviour of these cells under previously untested conditions
The complete original paper reference is cited below:
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model, Marc Courtemanche, Rafael J. Ramirez and Stanley Nattel, 1998,
American Journal of Physiology
, 275, H301-H321. PubMed ID: 9688927
schematic diagram of a human atrial myocyte
A schematic representation of currents, pumps and exchangers included in the model. The cell includes three intracellular compartments: cytoplasm, sarcoplasmic reticulum (SR) release compartment [junctional SR (JSR)], and SR uptake compartment [network SR (NSR)].
atrial myocyte
electrophysiology
This model has been validated by Penny Noble of Oxford University.
Department of Physiology, Anatomy & Genetics, University of Oxford
9688927
Autumn
Cuellar
A
Atrial Myocyte
Courtemanche et al's 1998 Mathematical Model of the Ionic Mechanisms
Underlying Human Atrial Acton Potential Properties.
Homo sapiens
Units checked and curated.
2006-09-27T13:25:00+12:00
Oxford University
Department of Physiology, Anatomy & Genetics
Penny
Noble
J
Changed the name and cmeta:id of the model to reflect the proper
spelling of Courtemanche.
2007-06-19T13:27:57+12:00
American Journal of Physiology
2007-11-27T15:56:04+13:00
added cmeta:id's for some variables to allow referencing by a PCEnv session file
James Lawson
James
Lawson
Richard
Marc
Courtemanche
penny.noble@dpag.ox.ac.uk
2007-12-19T13:21:11+13:00
James
Lawson
Richard
Rafael
Ramirez
J
Catherine Lloyd
2006-09-27T00:00:00+00:00
1998-07
This model has been validated by Penny Noble of Oxford University (v02 created from v01,) and is known to run in COR and PCEnv. A PCEnv session is also associated with this file.
keyword
Catherine
Lloyd
May
This is the CellML description of Courtemanche et al's mathematical
model of the ionic mechanisms underlying human atrial action potential properties.
fixed e-notation errors,
updated curation status,
removed reference link in documentation
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model
275
H301
H321
James
Lawson
Richard
James
Lawson
Richard
Penny
Noble
J
2003-06-04
5000
100000
0.1
2009-06-08T13:24:53+12:00
Corrected equations: alpha_j_calculation and beta_j_calculation in
fast_sodium_current_j_gate, oa_infinity_calculation in
transient_outward_K_current_oa_gate, alpha_ui_calculation in
ultrarapid_delayed_rectifier_K_current_ui_gate, i_Ca_L_calculation in
L_type_Ca_channel, and i_rel_calculation in
Ca_release_current_from_JSR.
Stanley
Nattel
2003-03-28
Added cmeta:id's to several variables to allow creation of a PCEnv session file.