- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2010-08-06 05:05:01+12:00
- Desc:
- Minor changes to metadata.
- Permanent Source URI:
- http://models.cellml.org/workspace/dougherty_wright_yew_2005/rawfile/ef3815f4d017b9666f0c9a47778c44b022de9e5a/dougherty_wright_yew_2005.cellml
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COR (0.9.31.979)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.CellML.org/
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<title>Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</title>
<author>
<firstname>Geoffrey</firstname>
<surname>Nunns</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
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<title>Model Status</title>
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This model runs in both OpenCell and COR and the units are consistent. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.
</para>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Abstract: We develop a mechanistic mathematical model of the G-protein coupled signaling pathway responsible for generating current responses in frog olfactory receptor neurons. The model incorporates descriptions of ligand-receptor interaction, intracellular transduction events involving the second messenger cAMP, effector ion-channel activity, and calcium-mediated feedback steps. We parameterized the model with respect to suction pipette current recordings from single cells stimulated with multiple odor concentrations. The proposed model accurately predicts the receptor-current response of the neuron to brief and prolonged odorant exposure and is able to produce the adaptation observed under repeated or sustained stimulation.
</para>
<para>
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<caption>Schematic diagram of the Dougherty et al model.</caption>
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<para>
The complete original paper reference is cited below:
</para>
<para>
Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons, Daniel P. Dougherty, Geraldine A. Wright, Alice C. Yew, 2005,
<emphasis>Proceeding of the National Academy of Sciences</emphasis>
, 102, 10415- 10420. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16027364 &dopt=Abstract">PubMed ID: 16027364 </ulink>
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<plus/>
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<ci>ninhcng</ci>
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<variable units="uM" public_interface="in" name="hmc_2"/>
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<variable units="millivolt" public_interface="in" name="V"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
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<times/>
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<divide/>
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<times/>
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<plus/>
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<power/>
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<apply>
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<cn cellml:units="millivolt">1000</cn>
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<minus/>
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<ci>V</ci>
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</apply>
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<times/>
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<variable units="millivolt" public_interface="in" name="V"/>
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<eq/>
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<times/>
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<divide/>
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<apply>
<minus/>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<map_variables variable_2="cc_2" variable_1="cc_2"/>
<map_variables variable_2="cc1lin" variable_1="cc1lin"/>
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<connection>
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<map_variables variable_2="Ca" variable_1="Ca"/>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
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<connection>
<map_components component_2="I_CNG" component_1="Ca"/>
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<connection>
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<connection>
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<connection>
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<map_variables variable_2="I_CNG" variable_1="I_CNG"/>
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<connection>
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<connection>
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<map_variables variable_2="V_cng" variable_1="V_cng"/>
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<connection>
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<connection>
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<connection>
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<rdf:Description rdf:about="rdf:#21c2c822-4150-45c6-968c-d7bf274505c4">
<dc:title>Proceedings of the National Academy of Sciences</dc:title>
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<vCard:Given>Geoffrey</vCard:Given>
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<dc:title>Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons</dc:title>
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<bqs:first_page>10415</bqs:first_page>
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<vCard:Given>Geoffrey</vCard:Given>
<vCard:Family>Nunns</vCard:Family>
<vCard:Other>Rogan</vCard:Other>
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<rdf:value>gnunns1@jhem.jhu.edu</rdf:value>
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<dcterms:W3CDTF>2008-07-17T15:04:20+12:00</dcterms:W3CDTF>
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<vCard:Given>Geraldine</vCard:Given>
<vCard:Family>Wright</vCard:Family>
<vCard:Other>A</vCard:Other>
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<rdf:value>This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
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<rdf:value>This model runs in both PCEnv and COR. The model recreates results from a sinlge pulse experiment suitable for adaptation and oscillatory behavior. Modification of the stimulus and addition of IX, an intermediate Ca2+ generated substance can be made to fulfill different simulations.</rdf:value>
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<dcterms:modified rdf:resource="rdf:#7ad92605-f215-4187-a122-c841bb28ffa1"/>
<rdf:value>Fixed "not exactly equivalent but dimensionally equivalent" errors.</rdf:value>
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<vCard:FN>Geoff Nunns</vCard:FN>
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<dcterms:W3CDTF>2008-06-25T00:00:00+00:00</dcterms:W3CDTF>
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<vCard:Given>Alice</vCard:Given>
<vCard:Family>Yew</vCard:Family>
<vCard:Other>C</vCard:Other>
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<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
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<vCard:FN>Geoff Nunns</vCard:FN>
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<dcterms:W3CDTF>2005-05-25 00:00</dcterms:W3CDTF>
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<vCard:Given>Daniel</vCard:Given>
<vCard:Family>Dougherty</vCard:Family>
<vCard:Other>P</vCard:Other>
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