Model Status
This model has been curated by Penny Noble of Oxford University and is known to run in OpenCell and COR and reproduce the results published in the paper it is based on.
This model is valid CellML and has fully consistent units
Model Structure
This model is based on the paper:
A model of the single atrial cell: relation between calcium current and calcium release by Earm Y, Noble D, Proceedings of the Royal Society of London. Series B, Biological Sciences, Vol. 240, No. 1297. (May 22, 1990), pp. 83-96.
ABSTRACT: The hypothesis that calcium release from the sarcoplasmic reticulum in cardiac muscle is induced by rises in free cytosolic calcium (Fabiato 1983, Am. J. Physiol 245) allows the possibility that the release could be at least partly regenerative. There would then be a non-linear relation between calcium current and calcium release. We have investigated this possibility in a single-cell version of the rabbit-atrial model developed by Hilgemann & Noble (1987, Proc. R. Soc. Lond. B 230). The model predicts different voltage ranges of activation for calcium-dependent processes (like the sodium-calcium exchange current, contraction or Fura-2 signals) and the calcium current, in agreement with the experimental results obtained by Earm et al. (1990, Proc. R. Soc. Lond. B 240) on exchange current tails, Cannell et al. (1987, Science, Wash. 238) by using Fura-2 signals, and Fedida et al. (1987, J. Physiol., Lond. 385) and Talo et al. (1988, Biology of isolated adult cardiac myocytes) by using contraction. However, when the Fura-2 concentration is sufficiently high (greater than 200 microM) the activation ranges become very similar as the buffering properties of Fura-2 are sufficient to remove the regenerative effect. It is therefore important to allow for the buffering properties of calcium indicators when investigating the correlation between calcium current and calcium release.
schematic diagram of a human atrial myocyte
A schematic representation of the Earm and Noble 1990 model.
The complete original paper reference is cited below:
A model of the single atrial cell: relation between calcium current and calcium release, Y. E. Earm and D. Noble, 1990,
Proceedings of the Royal Society of London. Series B, Biological Sciences
, 240, 83-96. PubMed ID: 1972993
A Model of the Single Atrial Cell: Relation between Calcium Current and Calcium Release
240
83
96
1990-01-01 00:00
Made 2 new variables - dCaCalmoddt and dCaTropdt in component "intracellular_calcium_concentration," equated these variables to d(CaCalmod)/d(time) and d(CaTrop)/d(time), respectively. This was done to allow PCEnv 0.2 to run the model.
2007-09-20T12:35:21+12:00
2007-12-19T14:35:31+13:00
2007-09-19T00:00:00+00:00
Y
Earm
E
D
Noble
Penny
Noble
J
James Lawson
Penny
Noble
J
James
Lawson
Richard
penny.noble@dpag.ox.ac.uk
keyword
electrophysiology
atrial myocyte
James Lawson
This model has been curated by Penny Noble of Oxford University and is known to run in PCEnv and COR and reproduce the results published in the paper it is based on.
1972993
Oxford University
Department of Physiology, Anatomy & Genetics
Units checked, curated
This file is a CellML description of the model described in the paper "A model of the single atrial cell: relation between calcium current and calcium release by Earm Y, Noble D, Proceedings of the Royal Society of London. Series B, Biological Sciences, Vol. 240, No. 1297. (May 22, 1990), pp. 83-96."
50000
0.001
Proceedings of the Royal Society of London. Series B, Biological Sciences
Department of Physiology, Anatomy & Genetics, University of Oxford