Location: Faber, Rudy, 2000 @ 38c7579ade65 / faber_rudy_2000.cellml

Author:
James Lawson <j.lawson@auckland.ac.nz>
Date:
2009-12-17 12:26 +1300
Desc:
added simulation metadata, added cmeta:id's to cellml file
Permanent Source URI:
http://models.cellml.org/workspace/faber_rudy_2000/rawfile/38c7579ade6597203d4c47286012aad2a9b4306f/faber_rudy_2000.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 07/12/2009 at 13:44:52 using:

COR (0.9.31.1333)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study</title>
  <author>
    <firstname>Penny</firstname>
          <surname>Noble</surname>
    <affiliation>
      <shortaffil>Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model has been curated and validated by Penny Noble of Oxford University and is known to run in PCEnv and COR to recreate the published results.  The units have been checked and they are consistent.  Note that this is the model in steady state.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>ABSTRACT:  Sodium overload of cardiac cells can accompany various pathologies and induce fatal cardiac arrhythmias. We investigate effects of elevated intracellular sodium on the cardiac action potential (AP) and on intracellular calcium using the Luo-Rudy model of a mammalian ventricular myocyte. The results are: 1) During rapid pacing, AP duration (APD) shortens in two phases, a rapid phase without Na(+) accumulation and a slower phase that depends on [Na(+)](i). 2) The rapid APD shortening is due to incomplete deactivation (accumulation) of I(Ks). 3) The slow phase is due to increased repolarizing currents I(NaK) and reverse-mode I(NaCa), secondary to elevated [Na(+)](i). 4) Na(+)-overload slows the rate of AP depolarization, allowing time for greater I(Ca(L)) activation; it also enhances reverse-mode I(NaCa). The resulting increased Ca(2+) influx triggers a greater [Ca(2+)](i) transient. 5) Reverse-mode I(NaCa) alone can trigger Ca(2+) release in a voltage and [Na(+)](i)-dependent manner. 6) During I(NaK) block, Na(+) and Ca(2+) accumulate and APD shortens due to enhanced reverse-mode I(NaCa); contribution of I(K(Na)) to APD shortening is negligible. By slowing AP depolarization (hence velocity) and shortening APD, Na(+)-overload acts to enhance inducibility of reentrant arrhythmias. Shortened APD with elevated [Ca(2+)](i) (secondary to Na(+)-overload) also predisposes the myocardium to arrhythmogenic delayed afterdepolarizations.
</para>

<para>
The original paper reference is cited below:
</para>

<para>
Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study, Gregory M. Faber and Yoram Rudy, 2000, Biophysical Journal, 78, 2392-2404.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10777735&amp;dopt=Abstract">PubMed ID: 10777735</ulink>
</para>

<informalfigure float="0" id="fig_cell_diagram_faber">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="faber_2000.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram of the Faber and Rudy 2000 cardiac myocyte model.</caption>
</informalfigure>

</sect1>
</article>
</documentation>
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                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">2.535   <sep/>
                                 -7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaCa" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaK" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaNa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
      <variable initial_value="1" name="gamma_Cai" units="dimensionless"/>
      <variable initial_value="0.341" name="gamma_Cao" units="dimensionless"/>
      <variable name="I_CaCa" units="microA_per_microF"/>
      <variable name="I_CaK" units="microA_per_microF"/>
      <variable name="I_CaNa" units="microA_per_microF"/>
      <variable initial_value="0.00054" name="P_Ca" units="litre_per_farad_millisecond"/>
      <variable initial_value="6.75e-7" name="P_Na" units="litre_per_farad_millisecond"/>
      <variable initial_value="1.93e-7" name="P_K" units="litre_per_farad_millisecond"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_CaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Cai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Na</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_K</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaCa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaNa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaK</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaCa</ci>
               <ci>i_CaK</ci>
               <ci>i_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable initial_value="5.82597094505446e-6" name="d" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d" units="per_ms"/>
      <variable name="beta_d" units="per_ms"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="E0_d" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>E0_d</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.035</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">6.24</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_d</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1   <sep/>
                     -5</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
                        <ci>d_infinity</ci>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>E0_d</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.035</cn>
                        <ci>E0_d</ci>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <divide/>
               <ci>d_infinity</ci>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>d_infinity</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_d</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>d</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_d</ci>
                  <ci>d</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable initial_value="0.997765362821995" name="f" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f" units="per_ms"/>
      <variable name="beta_f" units="per_ms"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">35.06</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <apply>
               <divide/>
               <ci>f_infinity</ci>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>f_infinity</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_f</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_f</ci>
                  <ci>f</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_Ca_gate">
      <variable name="f_Ca" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0006" name="Km_Ca" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cai</ci>
                     <ci>Km_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.05" name="g_CaT" units="milliS_per_microF"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="b" private_interface="in" units="dimensionless"/>
      <variable name="g" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_b_gate">
      <variable initial_value="0.00136737866785149" name="b" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="b_inf" units="dimensionless"/>
      <variable name="tau_b" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3.7</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">6.1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_inf</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_g_gate">
      <variable initial_value="0.98881442877378" name="g" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="g_inf" units="dimensionless"/>
      <variable name="tau_g" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_g</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms_per_millivolt">0.875</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">12</cn>
                  </apply>
                  <apply>
                     <leq/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">12</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_inf</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Kr" units="milliS_per_microF"/>
      <variable initial_value="0.02614" name="G_Kr" units="milliS_per_microF"/>
      <variable name="Rect" units="dimensionless"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="xr" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <ci>G_Kr</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Rect</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>Rect</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current_xr_gate">
      <variable initial_value="0.000204700363126417" name="xr" public_interface="out" units="dimensionless"/>
      <variable name="xr_infinity" units="dimensionless"/>
      <variable name="tau_xr" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.123</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Ks" units="milliS_per_microF"/>
      <variable initial_value="0.433" name="G_Ks" units="milliS_per_microF"/>
      <variable name="E_Ks" units="millivolt"/>
      <variable initial_value="0.01833" name="PNaK" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="xs1" private_interface="in" units="dimensionless"/>
      <variable name="xs2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <ci>G_Ks</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millimolar">3.8   <sep/>
                              -5</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs1_gate">
      <variable initial_value="0.00660746743356887" name="xs1" public_interface="out" units="dimensionless"/>
      <variable name="xs1_infinity" units="dimensionless"/>
      <variable name="tau_xs1" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19   <sep/>
                        -5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs2_gate">
      <variable initial_value="0.0303768241233812" name="xs2" public_interface="out" units="dimensionless"/>
      <variable name="xs2_infinity" units="dimensionless"/>
      <variable name="tau_xs2" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19   <sep/>
                        -5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="microA_per_microF"/>
      <variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
      <variable name="g_K1" units="milliS_per_microF"/>
      <variable initial_value="0.75" name="G_K1" units="milliS_per_microF"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="K1_infinity" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>G_K1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_K1_gate">
      <variable name="K1_infinity" public_interface="out" units="dimensionless"/>
      <variable name="alpha_K1" units="per_ms"/>
      <variable name="beta_K1" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.49124</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08032</cn>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.476</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">594.31</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="plateau_potassium_current">
      <variable name="i_Kp" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.00552" name="g_Kp" units="milliS_per_microF"/>
      <variable name="Kp" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_activated_potassium_current">
      <variable name="i_K_Na" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.12848" name="g_K_Na" units="milliS_per_microF"/>
      <variable initial_value="2.8" name="nKNa" units="dimensionless"/>
      <variable name="pona" units="dimensionless"/>
      <variable name="pov" units="dimensionless"/>
      <variable initial_value="66" name="kdKNa" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>pona</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.85</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>kdKNa</ci>
                        <ci>Nai</ci>
                     </apply>
                     <ci>nKNa</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pov</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.8</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.65</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">125</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_Na</ci>
            <apply>
               <times/>
               <ci>g_K_Na</ci>
               <ci>pona</ci>
               <ci>pov</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ATP_sensitive_potassium_current">
      <variable name="i_K_ATP" public_interface="out" units="microA_per_microF"/>
      <variable name="g_K_ATP" units="milliS_per_microF"/>
      <variable initial_value="1" name="i_K_ATP_on" units="dimensionless"/>
      <variable initial_value="0.24" name="nATP" units="dimensionless"/>
      <variable initial_value="5e-5" name="nicholsarea" units="dimensionless"/>
      <variable initial_value="3" name="ATPi" units="millimolar"/>
      <variable initial_value="2" name="hATP" units="dimensionless"/>
      <variable initial_value="0.00025" name="kATP" units="millimolar"/>
      <variable name="pATP" units="dimensionless"/>
      <variable name="GKbaraATP" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_ATP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_K_ATP_on</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.000193</cn>
               </apply>
               <ci>nicholsarea</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pATP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <ci>kATP</ci>
                     </apply>
                     <ci>hATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GKbaraATP</ci>
            <apply>
               <times/>
               <ci>g_K_ATP</ci>
               <ci>pATP</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">4</cn>
                  </apply>
                  <ci>nATP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_ATP</ci>
            <apply>
               <times/>
               <ci>GKbaraATP</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable name="i_to" public_interface="out" units="microA_per_microF"/>
      <variable name="g_to" units="milliS_per_microF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="rvdv" units="dimensionless"/>
      <variable name="zdv" private_interface="in" units="dimensionless"/>
      <variable name="ydv" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rvdv</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>zdv</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ydv</ci>
               <ci>rvdv</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_zdv_gate">
      <variable initial_value="0.0144622472219576" name="zdv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_zdv" units="per_ms"/>
      <variable name="beta_zdv" units="per_ms"/>
      <variable name="tau_zdv" units="ms"/>
      <variable name="zdv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_zdv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>zdv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_zdv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>zdv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>zdv_ss</ci>
                  <ci>zdv</ci>
               </apply>
               <ci>tau_zdv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_ydv_gate">
      <variable initial_value="0.999945568566232" name="ydv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_ydv" units="per_ms"/>
      <variable name="beta_ydv" units="per_ms"/>
      <variable name="tau_ydv" units="ms"/>
      <variable name="ydv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.015</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ydv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ydv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_ydv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ydv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ydv_ss</ci>
                  <ci>ydv</ci>
               </apply>
               <ci>tau_ydv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump">
      <variable name="i_p_Ca" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="K_mpCa" units="millimolar"/>
      <variable initial_value="1.15" name="I_pCa" units="microA_per_microF"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable name="i_Na_b" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.004" name="g_Nab" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable name="i_Ca_b" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.003016" name="g_Cab" units="milliS_per_microF"/>
      <variable name="E_Ca" public_interface="out" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable name="i_NaK" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="2.25" name="I_NaK" units="microA_per_microF"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable initial_value="10" name="K_mNai" units="millimolar"/>
      <variable initial_value="1.5" name="K_mKo" units="millimolar"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>I_NaK</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>K_mNai</ci>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ko</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>K_mKo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_specific_calcium_activated_current">
      <variable name="i_ns_Ca" public_interface="out" units="microA_per_microF"/>
      <variable name="i_ns_Na" public_interface="out" units="microA_per_microF"/>
      <variable name="i_ns_K" public_interface="out" units="microA_per_microF"/>
      <variable name="P_ns_Ca" units="litre_per_farad_millisecond"/>
      <variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="I_ns_Na" units="microA_per_microF"/>
      <variable name="I_ns_K" units="microA_per_microF"/>
      <variable initial_value="0.0012" name="K_m_ns_Ca" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>P_ns_Ca</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_millisecond">1.75   <sep/>
            -7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger">
      <variable cmeta:id="Na_Ca_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.00025" name="c1" units="microA_per_microF"/>
      <variable initial_value="0.0001" name="c2" units="dimensionless"/>
      <variable initial_value="0.15" name="gamma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>c1</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>gamma</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <power/>
                           <ci>Nao</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <ci>c2</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>gamma</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cao</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nao</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_dynamics">
      <variable name="i_rel" public_interface="out" units="millimolar_per_ms"/>
      <variable name="i_up" public_interface="out" units="millimolar_per_ms"/>
      <variable name="i_leak" public_interface="out" units="millimolar_per_ms"/>
      <variable name="i_tr" public_interface="out" units="millimolar_per_ms"/>
      <variable name="G_rel" units="per_ms"/>
      <variable name="G_rel_Viswanathan" units="per_ms"/>
      <variable initial_value="60" name="G_rel_max" units="per_ms"/>
      <variable initial_value="4" name="G_rel_overload" units="per_ms"/>
      <variable initial_value="180" name="tau_tr" units="ms"/>
      <variable initial_value="0.0008" name="K_mrel" units="millimolar"/>
      <variable initial_value="0.00018" name="delta_Ca_ith" units="millimolar"/>
      <variable initial_value="10" name="CSQN_max" units="millimolar"/>
      <variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
      <variable initial_value="0.00092" name="K_mup" units="millimolar"/>
      <variable name="K_leak" units="per_ms"/>
      <variable initial_value="0.00875" name="I_up" units="millimolar_per_ms"/>
      <variable initial_value="15" name="Ca_NSR_max" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable initial_value="0.000117482029668194" name="Cai" public_interface="out" units="millimolar"/>
      <variable initial_value="1.8" name="Cao" public_interface="out" units="millimolar"/>
      <variable initial_value="1.12791401197882" name="Ca_JSR" public_interface="out" units="millimolar"/>
      <variable initial_value="1.76731003671612" name="Ca_NSR" public_interface="out" units="millimolar"/>
      <variable name="V_myo" public_interface="in" units="micro_litre"/>
      <variable name="A_cap" public_interface="in" units="cm2"/>
      <variable name="V_JSR" public_interface="in" units="micro_litre"/>
      <variable name="V_NSR" public_interface="in" units="micro_litre"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="K_mTn" units="millimolar"/>
      <variable initial_value="0.00238" name="K_mCMDN" units="millimolar"/>
      <variable initial_value="0.07" name="Tn_max" units="millimolar"/>
      <variable initial_value="0.05" name="CMDN_max" units="millimolar"/>
      <variable name="dVdt" public_interface="in" units="microA_per_microF"/>
      <variable initial_value="9.65910542308504e-196" name="APtrack" units="dimensionless"/>
      <variable initial_value="5.33944967562997e-195" name="APtrack2" units="dimensionless"/>
      <variable initial_value="0.000129515197402902" name="APtrack3" units="dimensionless"/>
      <variable initial_value="2.69380318286645e-196" name="Cainfluxtrack" units="millimolar"/>
      <variable initial_value="0" name="OVRLDtrack" units="dimensionless"/>
      <variable initial_value="0" name="OVRLDtrack2" units="dimensionless"/>
      <variable initial_value="0" name="OVRLDtrack3" units="dimensionless"/>
      <variable initial_value="0.7" name="CSQNthresh" units="dimensionless"/>
      <variable initial_value="0.98" name="Logicthresh" units="dimensionless"/>
      <variable name="RyRopen" units="dimensionless"/>
      <variable name="RyRclose" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack</ci>
                     </apply>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>dVdt</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_per_ms">150</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>APtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack2</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack2</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack2</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.18</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>APtrack2</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack3</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack3</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack3</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.18</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.01</cn>
                     </apply>
                     <ci>APtrack3</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cainfluxtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                        </apply>
                        <ci>A_cap</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_CaCa</ci>
                                 <ci>i_Ca_T</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>i_NaCa</ci>
                              </apply>
                           </apply>
                           <ci>i_p_Ca</ci>
                           <ci>i_Ca_b</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>APtrack</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                  </apply>
               </piece>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar_per_ms">0</cn>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>APtrack2</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
                     </apply>
                     <apply>
                        <leq/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>Cainfluxtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <ci>K_mCSQN</ci>
                                 <ci>Ca_JSR</ci>
                              </apply>
                           </apply>
                        </apply>
                        <ci>CSQNthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack3</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.37</cn>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>APtrack3</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.37</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>OVRLDtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack2</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack2</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack2</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>OVRLDtrack2</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack3</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack3</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack3</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.01</cn>
                     </apply>
                     <ci>OVRLDtrack3</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>G_rel_Viswanathan</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>G_rel_max</ci>
                           <apply>
                              <minus/>
                              <ci>Cainfluxtrack</ci>
                              <ci>delta_Ca_ith</ci>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>K_mrel</ci>
                              <ci>Cainfluxtrack</ci>
                           </apply>
                           <ci>delta_Ca_ith</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>APtrack2</ci>
                     </apply>
                     <ci>APtrack2</ci>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Cainfluxtrack</ci>
                     <ci>delta_Ca_ith</ci>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <times/>
                     <ci>G_rel_overload</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack2</ci>
                     </apply>
                     <ci>OVRLDtrack2</ci>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <leq/>
                        <ci>Cainfluxtrack</ci>
                        <ci>delta_Ca_ith</ci>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack2</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>RyRopen</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>APtrack2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RyRclose</ci>
            <apply>
               <minus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <ci>RyRopen</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>G_rel</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>RyRopen</ci>
                  <ci>RyRclose</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">150</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_CaCa</ci>
                                 <ci>i_Ca_T</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>i_NaCa</ci>
                              </apply>
                           </apply>
                           <ci>i_p_Ca</ci>
                           <ci>i_Ca_b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">5</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0.9</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_rel</ci>
            <apply>
               <times/>
               <ci>G_rel</ci>
               <apply>
                  <minus/>
                  <ci>Ca_JSR</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Cai</ci>
                  <ci>K_mup</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_leak</ci>
            <apply>
               <divide/>
               <ci>I_up</ci>
               <ci>Ca_NSR_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>K_leak</ci>
               <ci>Ca_NSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_JSR</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CSQN_max</ci>
                           <ci>K_mCSQN</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mCSQN</ci>
                              <ci>Ca_JSR</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>i_tr</ci>
                  <ci>i_rel</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_NSR</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_tr</ci>
                        </apply>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>i_leak</ci>
               </apply>
               <ci>i_up</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cai</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CMDN_max</ci>
                           <ci>K_mCMDN</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mCMDN</ci>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Tn_max</ci>
                           <ci>K_mTn</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mTn</ci>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                        </apply>
                        <ci>A_cap</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_CaCa</ci>
                                 <ci>i_Ca_T</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>i_NaCa</ci>
                              </apply>
                           </apply>
                           <ci>i_p_Ca</ci>
                           <ci>i_Ca_b</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_rel</ci>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_myo</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_leak</ci>
                           <ci>i_up</ci>
                        </apply>
                        <ci>V_NSR</ci>
                     </apply>
                     <ci>V_myo</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable initial_value="13.3649235394859" name="Nai" public_interface="out" units="millimolar"/>
      <variable initial_value="140" name="Nao" public_interface="out" units="millimolar"/>
      <variable initial_value="141.056872392446" name="Ki" public_interface="out" units="millimolar"/>
      <variable initial_value="5.4" name="Ko" public_interface="out" units="millimolar"/>
      <variable name="A_cap" public_interface="in" units="cm2"/>
      <variable name="V_myo" public_interface="in" units="micro_litre"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaNa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_ns_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kp" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
      <variable name="i_ns_K" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to" public_interface="in" units="microA_per_microF"/>
      <variable name="I_st" public_interface="in" units="microA_per_microF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_Na</ci>
                     <ci>i_CaNa</ci>
                     <ci>i_Na_b</ci>
                     <ci>i_ns_Na</ci>
                     <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>I_st</ci>
                     <ci>i_CaK</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_K1</ci>
                     <ci>i_Kp</ci>
                     <ci>i_K_Na</ci>
                     <ci>i_K_ATP</ci>
                     <ci>i_to</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="geometry">
      <variable initial_value="0.1" name="preplength" units="mm"/>
      <variable initial_value="0.011" name="radius" units="mm"/>
      <variable name="volume" units="micro_litre"/>
      <variable name="V_myo" public_interface="out" units="micro_litre"/>
      <variable name="V_JSR" public_interface="out" units="micro_litre"/>
      <variable name="V_NSR" public_interface="out" units="micro_litre"/>
      <variable initial_value="0.0001534" name="A_cap" public_interface="out" units="cm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>volume</ci>
            <apply>
               <times/>
               <pi/>
               <ci>preplength</ci>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_myo</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0048</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0552</cn>
               <ci>volume</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transmembrane_currents"/>
   <component name="intracellular_currents"/>
   <component name="Ions_n_reversal_potentials"/>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="cell">
         <component_ref component="geometry"/>
         <component_ref component="transmembrane_currents">
            <component_ref component="fast_sodium_current">
               <component_ref component="fast_sodium_current_m_gate"/>
               <component_ref component="fast_sodium_current_h_gate"/>
               <component_ref component="fast_sodium_current_j_gate"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
               <component_ref component="L_type_Ca_channel_d_gate"/>
               <component_ref component="L_type_Ca_channel_f_gate"/>
               <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
               <component_ref component="T_type_Ca_channel_b_gate"/>
               <component_ref component="T_type_Ca_channel_g_gate"/>
            </component_ref>
            <component_ref component="rapid_delayed_rectifier_potassium_current">
               <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
            </component_ref>
            <component_ref component="slow_delayed_rectifier_potassium_current">
               <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
               <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
               <component_ref component="time_independent_potassium_current_K1_gate"/>
            </component_ref>
            <component_ref component="transient_outward_current">
               <component_ref component="transient_outward_current_zdv_gate"/>
               <component_ref component="transient_outward_current_ydv_gate"/>
            </component_ref>
            <component_ref component="Na_Ca_exchanger"/>
            <component_ref component="plateau_potassium_current"/>
            <component_ref component="sodium_activated_potassium_current"/>
            <component_ref component="ATP_sensitive_potassium_current"/>
            <component_ref component="sodium_background_current"/>
            <component_ref component="calcium_background_current"/>
            <component_ref component="sodium_potassium_pump"/>
            <component_ref component="non_specific_calcium_activated_current"/>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="sarcolemmal_calcium_pump"/>
         </component_ref>
         <component_ref component="Ions_n_reversal_potentials">
            <component_ref component="ionic_concentrations"/>
            <component_ref component="calcium_dynamics"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_b_gate"/>
         <component_ref component="T_type_Ca_channel_g_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_potassium_current">
         <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_potassium_current">
         <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
         <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
      <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_zdv_gate"/>
         <component_ref component="transient_outward_current_ydv_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="cell" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sodium_activated_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_Na" variable_2="i_K_Na"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="ATP_sensitive_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="transient_outward_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="Na_Ca_exchanger"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="plateau_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sarcolemmal_calcium_pump"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sodium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="calcium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="cell" component_2="non_specific_calcium_activated_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
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<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#dd1796f4-c286-4c30-9e0d-ba79d2f0e2d2"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#9b6b12f4-7c11-4a19-a5d0-b72a173411ff"/></creator><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#7bbc1652-a7fd-41eb-a3f0-7900d6d7ef93"/></Journal><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">2404</last_page><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">2392</first_page><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#6080d8cb-d870-4d50-90b8-9ae31af5b294"/></issued><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">78</volume><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study.</title></rdf:Description><rdf:Description rdf:nodeID="n1"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">3000</endingValue><pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">10000</pointDensity><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.1</maximumStepSize></rdf:Description><rdf:Description rdf:about="//home/jlaw060/cellml_repository/pmr2/faber_rudy_2000/faber_rudy_2000.cellml#faber_2000"><cmeta:comment><rdf:Description rdf:about="rdf:#a1a005fa-0d09-4031-b9f0-91e01567551e"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n2"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#4fbe3ba6-328e-4c4d-9249-8a2a965ecaea"/></reference><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></simulation></rdf:Description><rdf:Description rdf:about="rdf:#d9a861c5-da9e-48cf-bf39-fed2ac4822c1"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">University of Oxford</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en"></Orgunit></rdf:Description><rdf:Description rdf:about="rdf:#1f9ded7d-a130-4df8-afbf-2b38b71f8826"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2008-05-14T01:30:59+12:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#b2535049-2e20-4454-9c79-7b61b3fb2d79"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#250e831d-159c-4178-8bfd-ab2851fbaab4"/></N></rdf:Description><rdf:Description rdf:nodeID="n2"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n4"/></subject></rdf:Description><rdf:Description rdf:nodeID="n5"><rdf:first><rdf:Description rdf:nodeID="n1"/></rdf:first><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest></rdf:Description><rdf:Description rdf:about="rdf:#9b6b12f4-7c11-4a19-a5d0-b72a173411ff"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_2><rdf:Description rdf:about="rdf:#e7b77551-d534-4391-8f1a-73f244372afd"/></rdf:_2><rdf:_1><rdf:Description rdf:about="rdf:#dba32688-0867-4a2a-acfa-18cbf0261435"/></rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#05739223-6287-4bc4-b98b-4191b106c2ae"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Penny Noble</FN></rdf:Description><rdf:Description rdf:about="rdf:#52b20981-fb3e-431a-be2c-d0abd9b365f6"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#05739223-6287-4bc4-b98b-4191b106c2ae"/></creator><rdf:value xml:lang="en">Since the model was published in 1994, it has been updated several times, incorporating new experimental data taken from papers written by other authors.  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