Mitochondria And Ca2+ Signalling
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
Model Structure
In 2001 Christopher Fall and Joel Keizer published a detailed mathematical model to describe mitochondrial function and mitochondrial Ca2+ handling coupled to endoplasmic reticulum (ER) based IP3-dependent Ca2+ release. Their aim was to create a biologically realistic model of the influence of mitochondria on IP3-mediated Ca2+ signaling. They aimed to integrate the separate IP3 receptor/channel (DeYoung-Keizer 1992) and mitochondrial Ca2+ handling (Magnus-Keizer 1997, 1998) models into a single, common framework (see below).
The complete original paper reference is cited below:
Mitochondrial Modulation of Intracellular Ca2+ Signaling, Christopher P. Fall and Joel E. Keizer, 2001,
J. theor. Biol.
, 210, 151-165. (A full text (html) and PDF versions of the article are available to subscribers on the Science Direct website.) PubMed ID: 11371172
The raw CellML description of the mitochondria and Ca2+ signaling model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.
diagram of the mitochondria and Ca2+ signaling model
Key components of the IP3-mediated intracellular Ca2+ signaling diagram shows endoplasmic reticulum based Ca2+ release and uptake mechanisms, mitochondrial Ca2+ release and uptake mechanisms, in addition to other components which are not included in the mathematical model.
the cellml rendering of the mitochondria and Ca2+ signaling model
The network defined in the CellML description of the mitochondria and Ca2+ signaling model.
mitochondria
IP3
signal transduction
Pancreatic Beta-Cell
calcium dynamics
ip3
electrophysiology
beta cell
2002-03-01
Joel
Keizer
E
2003-08-12
2002-02-26
The University of Auckland
The Bioengineering Research Group
Journal of theoretical Biology
c.lloyd@auckland.ac.nz
Mitochondrial modulation of intracellular Ca2+ signaling
Pancreatic Beta-cell
Corrected equations: J_uni in Ca_uniporter component, JH_F1 in
F0_F1_ATPase component.
Catherine
Lloyd
May
Mitochondrial Modulation of Intracellular Ca2+ Signalling
210
151
165
Added more metadata.
The University of Auckland, Bioengineering Research Group
2002-01-21
Autumn
Cuellar
A
2003-04-09
keyword
Corrected units.
11371172
2002-01-14
Catherine
Lloyd
May
Catherine
Lloyd
May
Added publication date information.
Catherine
Lloyd
May
This is the CellML description of Christopher Fall and Joel Keizer's
2001 model of mitochondrial modulation of Ca2+ signaling. They
combine the previously separate models of mitochondrial Ca2+ handling
and IP3-dependent Ca2+ release from the ER into a single,
comprehensive model.
Catherine Lloyd
Corrected several equations.
Catherine
Lloyd
May
2002-07-22
Autumn
Cuellar
A.
2001-05-21
Christopher
Fall
P
Updated metadata to conform to the 16/1/02 CellML Metadata 1.0
Specification.