Location: Iyer, Hajjar, Armoundas, 2007 @ 05d2dd284888 / iyer_2007_ss.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2009-10-09 13:46:52+13:00
Desc:
Carried out units curation and upadted documentation. Specifically, removed the equation for kryr as this is a constant and it was this equation which was causing the unit inconsistencies.
Permanent Source URI:
http://models.cellml.org/workspace/iyer_hajjar_armoundas_2007/rawfile/05d2dd2848885b6f0bdda4b5980a94767b2a2510/iyer_2007_ss.cellml

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 20/07/2009 at 14:53:30 using:

COR (0.9.31.1297)
Copyright 2002-2009 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="IyerHajjarArmoundas2007" cmeta:id="IyerHajjarArmoundas2007">

<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<section id="sec_status">
				<title>Model Status</title>
				<para>            This CellML model is known to run in both COR and OpenCell to recreate the original results.  This model is valid CellML and has consistent units</para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
<para>
ABSTRACT: Catecholaminergic polymorphic ventricular tachycardia is a heritable arrhythmia unmasked by exertion or stress
and is characterized by triggered activity and sudden cardiac death. In this study, we simulated mutations in 2 genes
linked to catecholaminergic polymorphic ventricular tachycardia, the first located in calsequestrin (CSQN2) and the
second in the ryanodine receptor (RyR2). The aim of the study was to investigate the mechanistic basis for spontaneous
Ca2 release events that lead to delayed afterdepolarizations in affected patients. Sarcoplasmic reticulum (SR) luminal
Ca2 sensing was incorporated into a model of the human ventricular myocyte, and CSQN2 mutations were modeled
by simulating disrupted RyR2 luminal Ca2 sensing. In voltage-clamp mode, the mutant CSQN2 model recapitulated
the smaller calcium transients, smaller time to peak calcium transient, and accelerated recovery from inactivation seen
in experiments. In current clamp mode, in the presence of stimulation, we observed delayed afterdepolarizations,
suggesting that accelerated recovery of RyR2 induced by impaired luminal Ca2 sensing underlies the triggered activity
observed in mutant CSQN2-expressing myocytes. In current-clamp mode, in a model of mutant RyR2 that is
characterized by reduced FKBP12.6 binding to the RyR2 on stimulation, the impaired coupled gating characteristic
of these mutations was modeled by reducing cooperativity of RyR2 activation. In current-clamp mode, the mutant RyR2
model exhibited increased diastolic RyR2 open probability that resulted in formation of delayed afterdepolarizations. In
conclusion, these minimal order models of mutant CSQN2 and RyR2 provide plausible mechanisms by which defects
in RyR2 gating may lead to the cellular triggers for arrhythmia, with implications for the development of
targeted therapy. 

</para>

<para>
   Mechanisms of Abnormal Calcium Homeostasis in Mutations Responsible for Catecholaminergic Polymorphic Ventricular Tachycardia, Vivek Iyer, Roger J. Hajjar, Antonis A. Armoundas, 2007, <emphasis>Circulation Research</emphasis>, 100, e22-31. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17234962&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 17234962</ulink>.
</para>
			
			</sect1>
		</article>
	</documentation>

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      <variable name="iso" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="CSQN2" units="dimensionless" initial_value="0" public_interface="out"/>
      <variable name="RyR2" units="dimensionless" initial_value="0" public_interface="out"/>
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      <variable name="IKr" units="uA_per_uF" public_interface="in"/>
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               <cn cellml:units="mF_per_cm2" type="e-notation">1<sep/>-3</cn>
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      <variable name="stim_duration" units="ms" initial_value="3"/>
      <variable name="stim_amplitude" units="uA_per_uF" initial_value="-15"/>
      <variable name="stim_offset" units="ms" initial_value="100"/>
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                           <ci>past</ci>
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      <variable name="Cai" units="mM" public_interface="in"/>
      <variable name="Kfb" units="mM" initial_value="0.000168"/>
      <variable name="Nfb" units="dimensionless" initial_value="1.2"/>
      <variable name="rb" units="dimensionless"/>
      <variable name="CaNSR" units="mM" public_interface="in"/>
      <variable name="Krb" units="mM" initial_value="3.29"/>
      <variable name="Nrb" units="dimensionless" initial_value="1"/>
      <variable name="Jup" units="mM_per_ms" public_interface="out"/>
      <variable name="KSR" units="mM" initial_value="1.2"/>
      <variable name="vmaxf" units="per_ms" initial_value="7.48e-5"/>
      <variable name="vmaxr" units="per_ms" initial_value="0.000318"/>
      <variable name="Jrel" units="mM_per_ms" public_interface="out"/>
      <variable name="v1" units="per_ms" initial_value="1.8"/>
      <variable name="O1_RyR" units="dimensionless" public_interface="in"/>
      <variable name="O2_RyR" units="dimensionless" public_interface="in"/>
      <variable name="CaJSR" units="mM" public_interface="in"/>
      <variable name="CaSS" units="mM" public_interface="in"/>
      <variable name="Jtr" units="mM_per_ms" public_interface="out"/>
      <variable name="tautr" units="ms" initial_value="0.5747"/>
      <variable name="Jxfer" units="mM_per_ms" public_interface="out"/>
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                              <ci>fb</ci>
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                              <ci>rb</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>fb</ci>
                        <ci>rb</ci>
                     </apply>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>iso</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">1.5</cn>
                        <ci>KSR</ci>
                        <apply>
                           <minus/>
                           <apply>
                              <times/>
                              <ci>vmaxf</ci>
                              <ci>fb</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>vmaxr</ci>
                              <ci>rb</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>fb</ci>
                        <ci>rb</ci>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>Jrel</ci>
            <apply>
               <times/>
               <ci>v1</ci>
               <apply>
                  <plus/>
                  <ci>O1_RyR</ci>
                  <ci>O2_RyR</ci>
               </apply>
               <apply>
                  <minus/>
                  <ci>CaJSR</ci>
                  <ci>CaSS</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Jtr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaNSR</ci>
                  <ci>CaJSR</ci>
               </apply>
               <ci>tautr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Jxfer</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>CaSS</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tauxfer</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
      <variable name="LTRPNtot" units="mM" initial_value="0.07"/>
      <variable name="HTRPNtot" units="mM" initial_value="0.14"/>
      <variable name="khtrpn_plus" units="per_mM_per_ms" initial_value="20"/>
      <variable name="khtrpn_minus" units="per_ms" initial_value="6.6e-5"/>
      <variable name="kltrpn_plus" units="per_mM_per_ms" initial_value="40"/>
      <variable name="kltrpn_minus" units="per_ms" initial_value="0.04"/>
      <variable name="CMDNtot" units="mM" initial_value="0.05"/>
      <variable name="CSQNtot" units="mM"/>
      <variable name="EGTAtot" units="mM" initial_value="0"/>
      <variable name="KmCMDN" units="mM" initial_value="0.00238"/>
      <variable name="KmCSQN" units="mM" initial_value="0.8"/>
      <variable name="KmEGTA" units="mM" initial_value="0.00015"/>
      <variable name="Cai" units="mM" public_interface="in"/>
      <variable name="dLTRPNCa" units="per_ms"/>
      <variable name="dHTRPNCa" units="per_ms"/>
      <variable name="Jtrpn" units="mM_per_ms" public_interface="out"/>
      <variable name="CaSS" units="mM" public_interface="in"/>
      <variable name="beta_SS" units="dimensionless" public_interface="out"/>
      <variable name="beta_JSR" units="dimensionless" public_interface="out"/>
      <variable name="beta_i" units="dimensionless" public_interface="out"/>
      <variable name="CaJSR" units="mM" public_interface="in"/>
      <variable name="LTRPNCa" units="dimensionless" initial_value="0.280466039150394" public_interface="out"/>
      <variable name="HTRPNCa" units="dimensionless" initial_value="0.99347761599363" public_interface="out"/>
      <variable name="time" units="ms" public_interface="in"/>
      <variable name="CSQN2" units="dimensionless" public_interface="in"/>
      <variable name="RyR2" units="dimensionless" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>CSQNtot</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="mM">15</cn>
                  <apply>
                     <eq/>
                     <ci>RyR2</ci>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.5</cn>
                     <cn cellml:units="mM">15</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>dLTRPNCa</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kltrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>LTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>kltrpn_minus</ci>
                  <ci>LTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dHTRPNCa</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>khtrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>HTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>khtrpn_minus</ci>
                  <ci>HTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LTRPNCa</ci>
            </apply>
            <ci>dLTRPNCa</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HTRPNCa</ci>
            </apply>
            <ci>dHTRPNCa</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Jtrpn</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>LTRPNtot</ci>
                  <ci>dLTRPNCa</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>HTRPNtot</ci>
                  <ci>dHTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_SS</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDNtot</ci>
                        <ci>KmCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaSS</ci>
                           <ci>KmCMDN</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>EGTAtot</ci>
                        <ci>KmEGTA</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaSS</ci>
                           <ci>KmEGTA</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_JSR</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CSQNtot</ci>
                        <ci>KmCSQN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>CaJSR</ci>
                           <ci>KmCSQN</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_i</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDNtot</ci>
                        <ci>KmCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Cai</ci>
                           <ci>KmCMDN</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>EGTAtot</ci>
                        <ci>KmEGTA</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>Cai</ci>
                           <ci>KmEGTA</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
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      <variable name="kaminus" units="per_ms" initial_value="0.576"/>
      <variable name="kbplus" units="per_uM3_per_ms" initial_value="0.00405"/>
      <variable name="kbminus" units="per_ms" initial_value="1.93"/>
      <variable name="kcplus" units="per_ms" initial_value="0.1"/>
      <variable name="kcminus" units="per_ms" initial_value="0.0008"/>
      <variable name="ncoop" units="dimensionless" initial_value="4"/>
      <variable name="mcoop" units="dimensionless" initial_value="3"/>
      <variable name="kryr" units="dimensionless"  initial_value="1"/>
      <variable name="klumenC1O1" units="dimensionless"/>
      <variable name="klumenO1C2" units="dimensionless"/>
      <variable name="klumenC2O1" units="dimensionless"/>
      <variable name="HmaxC1O1" units="dimensionless" initial_value="0.5"/>
      <variable name="HmaxO1C2" units="dimensionless"/>
      <variable name="HmaxC2O1" units="dimensionless" initial_value="0.5"/>
      <variable name="Hmin" units="dimensionless" initial_value="5"/>
      <variable name="H50C1O1" units="mM" initial_value="1"/>
      <variable name="H50O1C2" units="mM" initial_value="1"/>
      <variable name="H50C2O1" units="mM"/>
      <variable name="HN" units="dimensionless" initial_value="2.5"/>
      <variable name="CaSS" units="mM" public_interface="in"/>
      <variable name="CaJSR" units="mM" public_interface="in"/>
      <variable name="dC1_RyR" units="per_ms"/>
      <variable name="dO2_RyR" units="per_ms"/>
      <variable name="dC2_RyR" units="per_ms"/>
      <variable name="dO1_RyR" units="per_ms"/>
      <variable name="time" units="ms" public_interface="in"/>
      <variable name="C1_RyR" units="dimensionless" initial_value="0.132070890861418" public_interface="out"/>
      <variable name="O2_RyR" units="dimensionless" initial_value="3.11350788541838e-7" public_interface="out"/>
      <variable name="C2_RyR" units="dimensionless" initial_value="0.866791951404883" public_interface="out"/>
      <variable name="O1_RyR" units="dimensionless" initial_value="0.00113684728532807" public_interface="out"/>
      <variable name="CSQN2" units="dimensionless" public_interface="in"/>
      <variable name="RyR2" units="dimensionless" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>HmaxO1C2</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="dimensionless">0.2</cn>
                  <apply>
                     <eq/>
                     <ci>CSQN2</ci>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="dimensionless">0.5</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>H50C2O1</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="mM">0.5</cn>
                  <apply>
                     <eq/>
                     <ci>CSQN2</ci>
                     <cn cellml:units="dimensionless">1</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="mM">1</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>klumenC1O1</ci>
            <apply>
               <minus/>
               <ci>HmaxC1O1</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxC1O1</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50C1O1</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>klumenO1C2</ci>
            <apply>
               <minus/>
               <ci>HmaxO1C2</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxO1C2</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50O1C2</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>klumenC2O1</ci>
            <apply>
               <minus/>
               <ci>HmaxC2O1</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>HmaxC2O1</ci>
                     <ci>Hmin</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>H50C2O1</ci>
                           <ci>CaJSR</ci>
                        </apply>
                        <ci>HN</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dC1_RyR</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>kaplus</ci>
                  </apply>
                  <ci>klumenC1O1</ci>
                  <apply>
                     <power/>
                     <apply>
                        <times/>
                        <ci>CaSS</ci>
                        <cn cellml:units="m2u">1000</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>ncoop</ci>
                        <ci>kryr</ci>
                     </apply>
                  </apply>
                  <ci>C1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kaminus</ci>
                  <ci>O1_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dO2_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kbplus</ci>
                  <apply>
                     <power/>
                     <apply>
                        <times/>
                        <ci>CaSS</ci>
                        <cn cellml:units="m2u">1000</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>mcoop</ci>
                        <ci>kryr</ci>
                     </apply>
                  </apply>
                  <ci>O1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kbminus</ci>
                  <ci>O2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dC2_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <ci>kcplus</ci>
                     <ci>klumenO1C2</ci>
                  </apply>
                  <ci>O1_RyR</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>kcminus</ci>
                  <ci>klumenC2O1</ci>
                  <ci>C2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dO1_RyR</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>dC1_RyR</ci>
                  <ci>dO2_RyR</ci>
                  <ci>dC2_RyR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1_RyR</ci>
            </apply>
            <ci>dC1_RyR</ci>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O2_RyR</ci>
            </apply>
            <ci>dO2_RyR</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2_RyR</ci>
            </apply>
            <ci>dC2_RyR</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O1_RyR</ci>
            </apply>
            <ci>dO1_RyR</ci>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES">
      <variable name="fL" units="per_ms" initial_value="0.3"/>
      <variable name="gL" units="per_ms" initial_value="4"/>
      <variable name="bL" units="dimensionless" initial_value="2"/>
      <variable name="aL" units="dimensionless" initial_value="2"/>
      <variable name="C0_to_C1" units="per_ms"/>
      <variable name="C1_to_C2" units="per_ms"/>
      <variable name="C2_to_C3" units="per_ms"/>
      <variable name="C3_to_C4" units="per_ms"/>
      <variable name="C1_to_C0" units="per_ms"/>
      <variable name="C2_to_C1" units="per_ms"/>
      <variable name="C3_to_C2" units="per_ms"/>
      <variable name="C4_to_C3" units="per_ms"/>
      <variable name="CCa0_to_CCa1" units="per_ms"/>
      <variable name="CCa1_to_CCa2" units="per_ms"/>
      <variable name="CCa2_to_CCa3" units="per_ms"/>
      <variable name="CCa3_to_CCa4" units="per_ms"/>
      <variable name="CCa1_to_CCa0" units="per_ms"/>
      <variable name="CCa2_to_CCa1" units="per_ms"/>
      <variable name="CCa3_to_CCa2" units="per_ms"/>
      <variable name="CCa4_to_CCa3" units="per_ms"/>
      <variable name="C0_to_CCa0" units="per_ms"/>
      <variable name="C1_to_CCa1" units="per_ms"/>
      <variable name="C2_to_CCa2" units="per_ms"/>
      <variable name="C3_to_CCa3" units="per_ms"/>
      <variable name="C4_to_CCa4" units="per_ms"/>
      <variable name="CCa0_to_C0" units="per_ms"/>
      <variable name="CCa1_to_C1" units="per_ms"/>
      <variable name="CCa2_to_C2" units="per_ms"/>
      <variable name="CCa3_to_C3" units="per_ms"/>
      <variable name="CCa4_to_C4" units="per_ms"/>
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="alpha" units="per_ms"/>
      <variable name="beta" units="per_ms"/>
      <variable name="alpha_prime" units="per_ms"/>
      <variable name="beta_prime" units="per_ms"/>
      <variable name="gamma" units="per_ms"/>
      <variable name="omega" units="per_ms"/>
      <variable name="a1_Ca0" units="per_ms"/>
      <variable name="a2_Ca0" units="per_ms"/>
      <variable name="a1_Ca1" units="per_ms"/>
      <variable name="a2_Ca1" units="per_ms"/>
      <variable name="a1_Ca2" units="per_ms"/>
      <variable name="a2_Ca2" units="per_ms"/>
      <variable name="a1_Ca3" units="per_ms"/>
      <variable name="a2_Ca3" units="per_ms"/>
      <variable name="a1_Ca4" units="per_ms"/>
      <variable name="a2_Ca4" units="per_ms"/>
      <variable name="a1_C0" units="per_ms"/>
      <variable name="a2_C0" units="per_ms"/>
      <variable name="a1_C1" units="per_ms"/>
      <variable name="a2_C1" units="per_ms"/>
      <variable name="a1_C2" units="per_ms"/>
      <variable name="a2_C2" units="per_ms"/>
      <variable name="a1_C3" units="per_ms"/>
      <variable name="a2_C3" units="per_ms"/>
      <variable name="a1_C4" units="per_ms"/>
      <variable name="a2_C4" units="per_ms"/>
      <variable name="CaSS" units="mM" public_interface="in"/>
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      <variable name="C1" units="dimensionless" initial_value="0.00834457719966281"/>
      <variable name="C2" units="dimensionless" initial_value="5.60736209083906e-5"/>
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      <variable name="CCa2" units="dimensionless" initial_value="0.000943745917866092"/>
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      <variable name="CCa4" units="dimensionless" initial_value="5.05056944609524e-8"/>
      <variable name="time" units="ms" public_interface="in"/>
      <variable name="Open" units="dimensionless" initial_value="1.40806027419488e-11" public_interface="out"/>
      <variable name="yCa" units="dimensionless" initial_value="0.995434385054729" public_interface="out"/>
      <variable name="a1_Cainf" units="dimensionless"/>
      <variable name="yCa_inf" units="dimensionless"/>
      <variable name="tau_yCa" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha</ci>
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               <cn cellml:units="dimensionless">1.2</cn>
               <cn cellml:units="dimensionless">0.416</cn>
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                     <cn cellml:units="per_mV">0.012</cn>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">35</cn>
                     </apply>
                  </apply>
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            </apply>
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               <times/>
               <cn cellml:units="per_ms">4</cn>
               <cn cellml:units="dimensionless">0.45</cn>
               <cn cellml:units="dimensionless">0.049</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.065</cn>
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                     <apply>
                        <minus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">22</cn>
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                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_prime</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>alpha</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_prime</ci>
            <apply>
               <divide/>
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               <ci>bL</ci>
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            <eq/>
            <ci>gamma</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.6</cn>
               <cn cellml:units="per_mM">0.09233</cn>
               <ci>CaSS</ci>
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         <apply>
            <eq/>
            <ci>omega</ci>
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               <times/>
               <cn cellml:units="per_ms">0.25</cn>
               <cn cellml:units="dimensionless">0.01</cn>
            </apply>
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         <apply>
            <eq/>
            <ci>C0_to_C1</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">4</cn>
               <ci>alpha</ci>
            </apply>
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         <apply>
            <eq/>
            <ci>C1_to_C2</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">3</cn>
               <ci>alpha</ci>
            </apply>
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         <apply>
            <eq/>
            <ci>C2_to_C3</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>alpha</ci>
            </apply>
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         <apply>
            <eq/>
            <ci>C3_to_C4</ci>
            <ci>alpha</ci>
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         <apply>
            <eq/>
            <ci>CCa0_to_CCa1</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">4</cn>
               <ci>alpha_prime</ci>
            </apply>
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         <apply>
            <eq/>
            <ci>CCa1_to_CCa2</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">3</cn>
               <ci>alpha_prime</ci>
            </apply>
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            <eq/>
            <ci>CCa2_to_CCa3</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>alpha_prime</ci>
            </apply>
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            <eq/>
            <ci>CCa3_to_CCa4</ci>
            <ci>alpha_prime</ci>
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         <apply>
            <eq/>
            <ci>C1_to_C0</ci>
            <ci>beta</ci>
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            <eq/>
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               <times/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>beta</ci>
            </apply>
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            <ci>C3_to_C2</ci>
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               <times/>
               <cn cellml:units="dimensionless">3</cn>
               <ci>beta</ci>
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            <ci>C4_to_C3</ci>
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               <times/>
               <cn cellml:units="dimensionless">4</cn>
               <ci>beta</ci>
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         <apply>
            <eq/>
            <ci>CCa1_to_CCa0</ci>
            <ci>beta_prime</ci>
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            <eq/>
            <ci>CCa2_to_CCa1</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">2</cn>
               <ci>beta_prime</ci>
            </apply>
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            <eq/>
            <ci>CCa3_to_CCa2</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">3</cn>
               <ci>beta_prime</ci>
            </apply>
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            <eq/>
            <ci>CCa4_to_CCa3</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">4</cn>
               <ci>beta_prime</ci>
            </apply>
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            <eq/>
            <ci>C0_to_CCa0</ci>
            <ci>gamma</ci>
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            <eq/>
            <ci>C1_to_CCa1</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C0_to_CCa0</ci>
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            <eq/>
            <ci>C2_to_CCa2</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C1_to_CCa1</ci>
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            <eq/>
            <ci>C3_to_CCa3</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C2_to_CCa2</ci>
            </apply>
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            <eq/>
            <ci>C4_to_CCa4</ci>
            <apply>
               <times/>
               <ci>aL</ci>
               <ci>C3_to_CCa3</ci>
            </apply>
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            <eq/>
            <ci>CCa0_to_C0</ci>
            <ci>omega</ci>
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            <eq/>
            <ci>CCa1_to_C1</ci>
            <apply>
               <divide/>
               <ci>CCa0_to_C0</ci>
               <ci>bL</ci>
            </apply>
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            <eq/>
            <ci>CCa2_to_C2</ci>
            <apply>
               <divide/>
               <ci>CCa1_to_C1</ci>
               <ci>bL</ci>
            </apply>
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            <eq/>
            <ci>CCa3_to_C3</ci>
            <apply>
               <divide/>
               <ci>CCa2_to_C2</ci>
               <ci>bL</ci>
            </apply>
         </apply>
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            <eq/>
            <ci>CCa4_to_C4</ci>
            <apply>
               <divide/>
               <ci>CCa3_to_C3</ci>
               <ci>bL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C0</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C0_to_C1</ci>
                  <ci>C0_to_CCa0</ci>
               </apply>
               <ci>C0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1_to_C0</ci>
                  <ci>C1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa0_to_C0</ci>
                  <ci>CCa0</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_C0</ci>
               <ci>a1_C0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C1_to_C0</ci>
                  <ci>C1_to_C2</ci>
                  <ci>C1_to_CCa1</ci>
               </apply>
               <ci>C1</ci>
            </apply>
         </apply>
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            <eq/>
            <ci>a2_C1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C0_to_C1</ci>
                  <ci>C0</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2_to_C1</ci>
                  <ci>C2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa1_to_C1</ci>
                  <ci>CCa1</ci>
               </apply>
            </apply>
         </apply>
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            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>C1</ci>
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            <apply>
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               <ci>a1_C1</ci>
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         </apply>
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            <eq/>
            <ci>a1_C2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C2_to_C1</ci>
                  <ci>C2_to_C3</ci>
                  <ci>C2_to_CCa2</ci>
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               <ci>C2</ci>
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            <eq/>
            <ci>a2_C2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1_to_C2</ci>
                  <ci>C1</ci>
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               <apply>
                  <times/>
                  <ci>C3_to_C2</ci>
                  <ci>C3</ci>
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               <apply>
                  <times/>
                  <ci>CCa2_to_C2</ci>
                  <ci>CCa2</ci>
               </apply>
            </apply>
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            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>C2</ci>
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            <apply>
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               <ci>a1_C2</ci>
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            <ci>a1_C3</ci>
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               <times/>
               <apply>
                  <plus/>
                  <ci>C3_to_C2</ci>
                  <ci>C3_to_C4</ci>
                  <ci>C3_to_CCa3</ci>
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               <ci>C3</ci>
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            <eq/>
            <ci>a2_C3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C2_to_C3</ci>
                  <ci>C2</ci>
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               <apply>
                  <times/>
                  <ci>C4_to_C3</ci>
                  <ci>C4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CCa3_to_C3</ci>
                  <ci>CCa3</ci>
               </apply>
            </apply>
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            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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            <apply>
               <minus/>
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               <ci>a1_C3</ci>
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            <ci>a1_C4</ci>
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                  <plus/>
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                  <ci>fL</ci>
                  <ci>C4_to_CCa4</ci>
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               <ci>C4</ci>
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                  <times/>
                  <ci>C3_to_C4</ci>
                  <ci>C3</ci>
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               <apply>
                  <times/>
                  <ci>gL</ci>
                  <ci>Open</ci>
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               <apply>
                  <times/>
                  <ci>CCa4_to_C4</ci>
                  <ci>CCa4</ci>
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            </apply>
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            <apply>
               <diff/>
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                  <ci>time</ci>
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                  <ci>time</ci>
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                  <ci>fL</ci>
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                  <times/>
                  <ci>gL</ci>
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            <ci>a1_Ca0</ci>
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                  <ci>C0_to_CCa0</ci>
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            <ci>a1_Ca1</ci>
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                  <ci>CCa1_to_C1</ci>
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               <ci>CCa1</ci>
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            <ci>a1_Ca2</ci>
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                  <ci>CCa2_to_C2</ci>
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                  <ci>CCa1_to_CCa2</ci>
                  <ci>CCa1</ci>
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                  <ci>CCa3_to_CCa2</ci>
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                  <ci>C2_to_CCa2</ci>
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            <ci>a1_Ca3</ci>
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                  <ci>CCa3_to_C3</ci>
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               <ci>CCa3</ci>
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                  <ci>CCa2</ci>
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               <apply>
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                  <ci>CCa4_to_CCa3</ci>
                  <ci>CCa4</ci>
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               <apply>
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                  <ci>C3_to_CCa3</ci>
                  <ci>C3</ci>
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      </math>
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   <component name="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES">
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="alpha_act43" units="per_ms"/>
      <variable name="beta_act43" units="per_ms"/>
      <variable name="alpha_inact43" units="per_ms"/>
      <variable name="beta_inact43" units="per_ms"/>
      <variable name="C0Kv43_to_C1Kv43" units="per_ms"/>
      <variable name="C1Kv43_to_C2Kv43" units="per_ms"/>
      <variable name="C2Kv43_to_C3Kv43" units="per_ms"/>
      <variable name="C3Kv43_to_OKv43" units="per_ms"/>
      <variable name="CI0Kv43_to_CI1Kv43" units="per_ms"/>
      <variable name="CI1Kv43_to_CI2Kv43" units="per_ms"/>
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            <ci>a2_CI0</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C0Kv14_to_CI0Kv14</ci>
                  <ci>C0Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI1Kv14_to_CI0Kv14</ci>
                  <ci>CI1Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI0Kv14</ci>
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            <apply>
               <minus/>
               <ci>a2_CI0</ci>
               <ci>a1_CI0</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI1</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI1Kv14_to_CI2Kv14</ci>
                  <ci>CI1Kv14_to_C1Kv14</ci>
                  <ci>CI1Kv14_to_CI0Kv14</ci>
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               <ci>CI1Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_CI1</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CI2Kv14_to_CI1Kv14</ci>
                  <ci>CI2Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1Kv14_to_CI1Kv14</ci>
                  <ci>C1Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI0Kv14_to_CI1Kv14</ci>
                  <ci>CI0Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI1Kv14</ci>
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            <apply>
               <minus/>
               <ci>a2_CI1</ci>
               <ci>a1_CI1</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>a1_CI2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI2Kv14_to_CI3Kv14</ci>
                  <ci>CI2Kv14_to_C2Kv14</ci>
                  <ci>CI2Kv14_to_CI1Kv14</ci>
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               <ci>CI2Kv14</ci>
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         <apply>
            <eq/>
            <ci>a2_CI2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>CI3Kv14_to_CI2Kv14</ci>
                  <ci>CI3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C2Kv14_to_CI2Kv14</ci>
                  <ci>C2Kv14</ci>
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               <apply>
                  <times/>
                  <ci>CI1Kv14_to_CI2Kv14</ci>
                  <ci>CI1Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI2Kv14</ci>
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            <apply>
               <minus/>
               <ci>a2_CI2</ci>
               <ci>a1_CI2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_CI3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>CI3Kv14_to_OIKv14</ci>
                  <ci>CI3Kv14_to_C3Kv14</ci>
                  <ci>CI3Kv14_to_CI2Kv14</ci>
               </apply>
               <ci>CI3Kv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_CI3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>OIKv14_to_CI3Kv14</ci>
                  <ci>OIKv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3Kv14_to_CI3Kv14</ci>
                  <ci>C3Kv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI2Kv14_to_CI3Kv14</ci>
                  <ci>CI2Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CI3Kv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_CI3</ci>
               <ci>a1_CI3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_OI</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>OIKv14_to_OKv14</ci>
                  <ci>OIKv14_to_CI3Kv14</ci>
               </apply>
               <ci>OIKv14</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_OI</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>OKv14_to_OIKv14</ci>
                  <ci>OKv14</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CI3Kv14_to_OIKv14</ci>
                  <ci>CI3Kv14</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OIKv14</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a2_OI</ci>
               <ci>a1_OI</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_REVERSAL_POTENTIALS">
      <variable name="ENa" units="mV" public_interface="out"/>
      <variable name="EK" units="mV" public_interface="out"/>
      <variable name="EKs" units="mV" public_interface="out"/>
      <variable name="ECa" units="mV" public_interface="out"/>
      <variable name="RT_over_F" units="mV" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="Nai" units="mM" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="Ki" units="mM" public_interface="in"/>
      <variable name="Cao" units="mM" public_interface="in"/>
      <variable name="Cai" units="mM" public_interface="in"/>
      <variable name="a1" units="mM"/>
      <variable name="a2" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>ENa</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Nai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>EK</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1</ci>
            <apply>
               <plus/>
               <ci>Ko</ci>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.01833</cn>
                  <ci>Nao</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2</ci>
            <apply>
               <plus/>
               <ci>Ki</ci>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.01833</cn>
                  <ci>Nai</ci>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>EKs</ci>
            <apply>
               <times/>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>a1</ci>
                     <ci>a2</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ECa</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.5</cn>
               <ci>RT_over_F</ci>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
      <variable name="GKr" units="mS_per_uF" initial_value="0.0186"/>
      <variable name="GKs" units="mS_per_uF" initial_value="0.0035"/>
      <variable name="GK1" units="mS_per_uF" initial_value="0.125305126118808"/>
      <variable name="GNa" units="mS_per_uF" initial_value="56.32"/>
      <variable name="GNab" units="mS_per_uF" initial_value="0.001"/>
      <variable name="KvScale" units="dimensionless" initial_value="0.872"/>
      <variable name="Kv43Frac" units="dimensionless" initial_value="0.889"/>
      <variable name="GKv43" units="mS_per_uF"/>
      <variable name="PKv14" units="litre_per_farad_second"/>
      <variable name="OKv14" units="dimensionless" public_interface="in"/>
      <variable name="na6" units="dimensionless" public_interface="in"/>
      <variable name="na7" units="dimensionless" public_interface="in"/>
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="ENa" units="mV" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="OHerg" units="dimensionless" public_interface="in"/>
      <variable name="O1ks" units="dimensionless" public_interface="in"/>
      <variable name="O2ks" units="dimensionless" public_interface="in"/>
      <variable name="OKv43" units="dimensionless" public_interface="in"/>
      <variable name="RT_over_F" units="mV" public_interface="in"/>
      <variable name="Faraday" units="coulomb_per_millimole" public_interface="in"/>
      <variable name="Ki" units="mM" public_interface="in"/>
      <variable name="EK" units="mV" public_interface="in"/>
      <variable name="fKo" units="dimensionless"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
      <variable name="a1_K" units="mM"/>
      <variable name="a2" units="dimensionless"/>
      <variable name="a1_Na" units="mM"/>
      <variable name="K1_inf" units="dimensionless"/>
      <variable name="IKr" units="uA_per_uF" public_interface="out"/>
      <variable name="IKs" units="uA_per_uF" public_interface="out"/>
      <variable name="IKv43" units="uA_per_uF" public_interface="out"/>
      <variable name="IKv14_K" units="uA_per_uF" public_interface="out"/>
      <variable name="Nai" units="mM" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="IKv14_Na" units="uA_per_uF" public_interface="out"/>
      <variable name="IKv14" units="uA_per_uF" public_interface="out"/>
      <variable name="Ito1" units="uA_per_uF" public_interface="out"/>
      <variable name="IK1" units="uA_per_uF" public_interface="out"/>
      <variable name="INab" units="uA_per_uF" public_interface="out"/>
      <variable name="INa" units="uA_per_uF" public_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>PKv14</ci>
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               <times/>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>Kv43Frac</ci>
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               <ci>KvScale</ci>
               <cn cellml:units="litre_per_farad_second" type="e-notation" >4.2986<sep/>-7</cn>
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         </apply>
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            <eq/>
            <ci>GKv43</ci>
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               <times/>
               <ci>Kv43Frac</ci>
               <ci>KvScale</ci>
               <cn cellml:units="mS_per_uF">0.1</cn>
            </apply>
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         <apply>
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            <ci>INa</ci>
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               <times/>
               <ci>GNa</ci>
               <apply>
                  <plus/>
                  <ci>na6</ci>
                  <ci>na7</ci>
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               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>ENa</ci>
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         <apply>
            <eq/>
            <ci>fKo</ci>
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               <root/>
               <apply>
                  <divide/>
                  <ci>Ko</ci>
                  <cn cellml:units="mM">4</cn>
               </apply>
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         </apply>
         <apply>
            <eq/>
            <ci>IKr</ci>
            <apply>
               <times/>
               <ci>GKr</ci>
               <ci>fKo</ci>
               <ci>OHerg</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>IKs</ci>
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               <times/>
               <ci>GKs</ci>
               <apply>
                  <plus/>
                  <ci>O1ks</ci>
                  <ci>O2ks</ci>
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               <apply>
                  <minus/>
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                  <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>IKv43</ci>
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               <times/>
               <ci>GKv43</ci>
               <ci>OKv43</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         <apply>
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            <ci>VF_over_RT</ci>
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               <divide/>
               <ci>V</ci>
               <ci>RT_over_F</ci>
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         <apply>
            <eq/>
            <ci>VFsq_over_RT</ci>
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               <times/>
               <cn cellml:units="dimensionless">1000</cn>
               <ci>Faraday</ci>
               <ci>VF_over_RT</ci>
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         <apply>
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            <ci>a1_K</ci>
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               <minus/>
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                  <times/>
                  <ci>Ki</ci>
                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
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               <ci>Ko</ci>
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         <apply>
            <eq/>
            <ci>a2</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <ci>VF_over_RT</ci>
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               <cn cellml:units="dimensionless">1</cn>
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         <apply>
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            <ci>IKv14_K</ci>
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               <divide/>
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                  <times/>
                  <ci>PKv14</ci>
                  <ci>OKv14</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_K</ci>
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               <ci>a2</ci>
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                  <times/>
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                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
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               </apply>
               <ci>Nao</ci>
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            <ci>IKv14_Na</ci>
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                  <times/>
                  <cn cellml:units="dimensionless">0.02</cn>
                  <ci>PKv14</ci>
                  <ci>OKv14</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_Na</ci>
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               <ci>a2</ci>
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            <ci>IKv14</ci>
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               <plus/>
               <ci>IKv14_K</ci>
               <ci>IKv14_Na</ci>
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            <ci>Ito1</ci>
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               <plus/>
               <ci>IKv43</ci>
               <ci>IKv14</ci>
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            <ci>K1_inf</ci>
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                  <cn cellml:units="dimensionless">0.94</cn>
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                     <exp/>
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                        <times/>
                        <apply>
                           <divide/>
                           <cn cellml:units="dimensionless">1.26</cn>
                           <ci>RT_over_F</ci>
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                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>IK1</ci>
            <apply>
               <times/>
               <ci>GK1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
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               <ci>K1_inf</ci>
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                  <minus/>
                  <ci>V</ci>
                  <ci>EK</ci>
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         <apply>
            <eq/>
            <ci>INab</ci>
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               <times/>
               <ci>GNab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>ENa</ci>
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            </apply>
         </apply>
      </math>
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   <component name="COMPUTE_INaK_INaCa_ICab_IpCa">
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      <variable name="ECa" units="mV" public_interface="in"/>
      <variable name="RT_over_F" units="mV" public_interface="in"/>
      <variable name="Nai" units="mM" public_interface="in"/>
      <variable name="Nao" units="mM" public_interface="in"/>
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="Cai" units="mM" public_interface="in"/>
      <variable name="Cao" units="mM" public_interface="in"/>
      <variable name="kNaCa" units="uA_per_uF" initial_value="0.44"/>
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      <variable name="KmCa" units="mM" initial_value="1.38"/>
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      <variable name="KmNai" units="mM" initial_value="20"/>
      <variable name="KmKo" units="mM" initial_value="1.5"/>
      <variable name="IpCamax" units="uA_per_uF" initial_value="0.05"/>
      <variable name="KmpCa" units="mM" initial_value="0.0005"/>
      <variable name="GCab" units="mS_per_uF" initial_value="7.684e-5"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="a1_Na" units="dimensionless"/>
      <variable name="a2_Na" units="dimensionless"/>
      <variable name="fNaK" units="dimensionless"/>
      <variable name="a1_K" units="dimensionless"/>
      <variable name="a2_K" units="dimensionless"/>
      <variable name="INaK" units="uA_per_uF" public_interface="out"/>
      <variable name="a1_ncx" units="mM4"/>
      <variable name="a2_ncx" units="mM4"/>
      <variable name="a3_ncx" units="dimensionless"/>
      <variable name="a4_ncx" units="mM"/>
      <variable name="a5_ncx" units="mM3"/>
      <variable name="INaCa" units="uA_per_uF" public_interface="out"/>
      <variable name="ICab" units="uA_per_uF" public_interface="out"/>
      <variable name="IpCa" units="uA_per_uF" public_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
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            <ci>ICab</ci>
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               <times/>
               <ci>GCab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>ECa</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>IpCa</ci>
            <apply>
               <divide/>
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                  <times/>
                  <ci>IpCamax</ci>
                  <ci>Cai</ci>
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               <apply>
                  <plus/>
                  <ci>KmpCa</ci>
                  <ci>Cai</ci>
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         <apply>
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            <ci>VF_over_RT</ci>
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               <ci>V</ci>
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         <apply>
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            <ci>sigma</ci>
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               <divide/>
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                  <minus/>
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                        <divide/>
                        <ci>Nao</ci>
                        <cn cellml:units="mM">67.3</cn>
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                  <cn cellml:units="dimensionless">1</cn>
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               <cn cellml:units="dimensionless">7</cn>
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            <ci>a1_Na</ci>
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                  <cn cellml:units="dimensionless">0.1245</cn>
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                     <exp/>
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                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="dimensionless">0.1</cn>
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                        <ci>VF_over_RT</ci>
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         <apply>
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            <ci>a2_Na</ci>
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               <times/>
               <cn cellml:units="dimensionless">0.0365</cn>
               <ci>sigma</ci>
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                  <exp/>
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                        <minus/>
                        <cn cellml:units="dimensionless">1.33</cn>
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                     <ci>VF_over_RT</ci>
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         <apply>
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            <ci>fNaK</ci>
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               <divide/>
               <cn cellml:units="dimensionless">1</cn>
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                  <plus/>
                  <ci>a1_Na</ci>
                  <ci>a2_Na</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_K</ci>
            <apply>
               <divide/>
               <ci>Ko</ci>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>KmKo</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_K</ci>
            <apply>
               <plus/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>KmNai</ci>
                     <ci>Nai</ci>
                  </apply>
                  <cn cellml:units="dimensionless">1.5</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>INaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>INaKmax</ci>
                  <ci>fNaK</ci>
                  <ci>a1_K</ci>
               </apply>
               <ci>a2_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_ncx</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>eta</ci>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nai</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_ncx</ci>
            <apply>
               <times/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>eta</ci>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <apply>
                  <power/>
                  <ci>Nao</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>Cai</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a3_ncx</ci>
            <apply>
               <plus/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <times/>
                  <ci>ksat</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>eta</ci>
                           <cn cellml:units="dimensionless">1</cn>
                        </apply>
                        <ci>VF_over_RT</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a4_ncx</ci>
            <apply>
               <plus/>
               <ci>KmCa</ci>
               <ci>Cao</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a5_ncx</ci>
            <apply>
               <divide/>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>KmNa</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Nao</ci>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
               <cn cellml:units="dimensionless">5000</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>INaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>kNaCa</ci>
                  <apply>
                     <minus/>
                     <ci>a1_ncx</ci>
                     <ci>a2_ncx</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>a4_ncx</ci>
                  <ci>a3_ncx</ci>
                  <ci>a5_ncx</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="COMPUTE_ICa_ICaK">
      <variable name="Ko" units="mM" public_interface="in"/>
      <variable name="Ki" units="mM" public_interface="in"/>
      <variable name="RT_over_F" units="mV" public_interface="in"/>
      <variable name="Cai" units="mM" public_interface="in"/>
      <variable name="Cao" units="mM" public_interface="in"/>
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="yCa" units="dimensionless" public_interface="in"/>
      <variable name="Open" units="dimensionless" public_interface="in"/>
      <variable name="Faraday" units="coulomb_per_millimole" public_interface="in"/>
      <variable name="PKprime" units="litre_per_farad_second"/>
      <variable name="VF_over_RT" units="dimensionless"/>
      <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
      <variable name="a1_Ca" units="mM"/>
      <variable name="a2_Ca" units="dimensionless"/>
      <variable name="a1_K" units="mM"/>
      <variable name="a2_K" units="dimensionless"/>
      <variable name="ICa" units="uA_per_uF" public_interface="out"/>
      <variable name="ICaK" units="uA_per_uF" public_interface="out"/>
      <variable name="ICamax" units="uA_per_uF"/>
      <variable name="Icabar" units="uA_per_uF"/>
      <variable name="PCa" units="litre_per_farad_second"/>
      <variable name="PK" units="litre_per_farad_second"/>
      <variable name="ICahalf" units="uA_per_uF" initial_value="-0.265"/>
      <variable name="Pscale" units="dimensionless" initial_value="7"/>
      <variable name="iso" units="dimensionless" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>PK</ci>
            <apply>
               <times/>
               <ci>Pscale</ci>
               <cn cellml:units="litre_per_farad_second" type="e-notation" >4.574<sep/>-7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>PCa</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <ci>Pscale</ci>
                     <cn cellml:units="litre_per_farad_second" type="e-notation">2.469<sep/>-4</cn>
                  </apply>
                  <apply>
                     <eq/>
                     <ci>iso</ci>
                     <cn cellml:units="dimensionless">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">1.5</cn>
                     <ci>Pscale</ci>
                     <cn cellml:units="litre_per_farad_second" type="e-notation">2.469<sep/>-4</cn>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>VF_over_RT</ci>
            <apply>
               <divide/>
               <ci>V</ci>
               <ci>RT_over_F</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VFsq_over_RT</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">1000</cn>
               <ci>Faraday</ci>
               <ci>VF_over_RT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_Ca</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn cellml:units="mM" type="e-notation" >1<sep/>-3</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>VF_over_RT</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>Cao</ci>
                  <cn cellml:units="dimensionless">0.341</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_Ca</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICamax</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>PCa</ci>
                  <cn cellml:units="dimensionless">4</cn>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_Ca</ci>
               </apply>
               <ci>a2_Ca</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICa</ci>
            <apply>
               <times/>
               <ci>ICamax</ci>
               <ci>yCa</ci>
               <ci>Open</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Icabar</ci>
            <piecewise>
               <piece>
                  <cn cellml:units="uA_per_uF">0</cn>
                  <apply>
                     <geq/>
                     <ci>ICamax</ci>
                     <cn cellml:units="uA_per_uF">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <ci>ICamax</ci>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>PKprime</ci>
            <apply>
               <divide/>
               <ci>PK</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Icabar</ci>
                     <ci>ICahalf</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_K</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>Ki</ci>
                  <apply>
                     <exp/>
                     <ci>VF_over_RT</ci>
                  </apply>
               </apply>
               <ci>Ko</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_K</ci>
            <apply>
               <minus/>
               <apply>
                  <exp/>
                  <ci>VF_over_RT</ci>
               </apply>
               <cn cellml:units="dimensionless">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ICaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>PKprime</ci>
                  <ci>Open</ci>
                  <ci>yCa</ci>
                  <ci>VFsq_over_RT</ci>
                  <ci>a1_K</ci>
               </apply>
               <ci>a2_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="INa">
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="time" units="ms" public_interface="in"/>
      <variable name="Temp_Scale" units="dimensionless"/>
      <variable name="alpha1" units="per_ms"/>
      <variable name="beta1" units="per_ms"/>
      <variable name="gamma1" units="per_ms"/>
      <variable name="Delta1" units="per_ms"/>
      <variable name="On" units="per_ms"/>
      <variable name="Of" units="per_ms"/>
      <variable name="GammaGamma" units="per_ms"/>
      <variable name="DeltaDelta" units="per_ms"/>
      <variable name="epsilon" units="per_ms"/>
      <variable name="omega_na" units="per_ms"/>
      <variable name="rho" units="per_ms"/>
      <variable name="mu" units="per_ms"/>
      <variable name="Cn" units="per_ms"/>
      <variable name="Cf" units="per_ms"/>
      <variable name="parameter_a" units="dimensionless"/>
      <variable name="k12" units="per_ms"/>
      <variable name="k23" units="per_ms"/>
      <variable name="k34" units="per_ms"/>
      <variable name="k45" units="per_ms"/>
      <variable name="k56" units="per_ms"/>
      <variable name="k67" units="per_ms"/>
      <variable name="k89" units="per_ms"/>
      <variable name="k910" units="per_ms"/>
      <variable name="k1011" units="per_ms"/>
      <variable name="k1112" units="per_ms"/>
      <variable name="k1213" units="per_ms"/>
      <variable name="k57" units="per_ms"/>
      <variable name="k21" units="per_ms"/>
      <variable name="k32" units="per_ms"/>
      <variable name="k43" units="per_ms"/>
      <variable name="k54" units="per_ms"/>
      <variable name="k65" units="per_ms"/>
      <variable name="k76" units="per_ms"/>
      <variable name="k98" units="per_ms"/>
      <variable name="k109" units="per_ms"/>
      <variable name="k1110" units="per_ms"/>
      <variable name="k1211" units="per_ms"/>
      <variable name="k1312" units="per_ms"/>
      <variable name="k75" units="per_ms"/>
      <variable name="k81" units="per_ms"/>
      <variable name="k92" units="per_ms"/>
      <variable name="k103" units="per_ms"/>
      <variable name="k114" units="per_ms"/>
      <variable name="k125" units="per_ms"/>
      <variable name="k136" units="per_ms"/>
      <variable name="k18" units="per_ms"/>
      <variable name="k29" units="per_ms"/>
      <variable name="k310" units="per_ms"/>
      <variable name="k411" units="per_ms"/>
      <variable name="k512" units="per_ms"/>
      <variable name="k613" units="per_ms"/>
      <variable name="na1" units="dimensionless" initial_value="0.111284526171411" public_interface="out"/>
      <variable name="na2" units="dimensionless" initial_value="0.0481019786429977" public_interface="out"/>
      <variable name="na3" units="dimensionless" initial_value="0.00779692701457915" public_interface="out"/>
      <variable name="na4" units="dimensionless" initial_value="0.000561699600929369" public_interface="out"/>
      <variable name="na5" units="dimensionless" initial_value="1.51746424723121e-5" public_interface="out"/>
      <variable name="na6" units="dimensionless" initial_value="1.02118700961583e-7" public_interface="out"/>
      <variable name="na7" units="dimensionless" initial_value="1.93499158844817e-8" public_interface="out"/>
      <variable name="na8" units="dimensionless" initial_value="0.368582741846592" public_interface="out"/>
      <variable name="na9" units="dimensionless" initial_value="0.312463212648791" public_interface="out"/>
      <variable name="na10" units="dimensionless" initial_value="0.0993398770493615" public_interface="out"/>
      <variable name="na11" units="dimensionless" initial_value="0.0140431688972267" public_interface="out"/>
      <variable name="na12" units="dimensionless" initial_value="0.000750073829883749" public_interface="out"/>
      <variable name="na13" units="dimensionless" initial_value="0.0370604970714329" public_interface="out"/>
      <variable name="TNa" units="kelvin" initial_value="294.16"/>
      <variable name="KToverH" units="per_ms"/>
      <variable name="FoverRT" units="per_mV"/>
      <variable name="RToverF" units="mV" public_interface="in"/>
      <variable name="RTNa" units="joule_per_mole"/>
      <variable name="RTNaF" units="mV"/>
      <variable name="Faraday" units="coulomb_per_millimole" public_interface="in"/>
      <variable name="Rgas" units="joule_per_mole_kelvin" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>FoverRT</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <ci>RToverF</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>KToverH</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="joule_per_kelvin" type="e-notation" >1.381<sep/>-23</cn>
                  <ci>TNa</ci>
               </apply>
               <cn cellml:units="joule_ms" type="e-notation" >6.626<sep/>-31</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RTNa</ci>
            <apply>
               <times/>
               <ci>Rgas</ci>
               <ci>TNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RTNaF</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Rgas</ci>
                  <ci>TNa</ci>
               </apply>
               <ci>Faraday</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Temp_Scale</ci>
            <cn cellml:units="dimensionless">1.38862291252871</cn>
         </apply>
         <apply>
            <eq/>
            <ci>alpha1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">114007.462700232</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">224.114</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.286374268596235</cn>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">272470.273489681</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">708.146</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">2.28528417586424</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">196336.575735923</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">529.952</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2.78084918596045</cn>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Delta1</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">133689.9304091</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">229.205</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">1.55804214553883</cn>
                           </apply>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>On</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">62123.0784380481</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">39.295</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.288816042743232</cn>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Of</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole">97657.8497137015</cn>
                        </apply>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole_kelvin">1.51</cn>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.0684861993100685</cn>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GammaGamma</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <cn cellml:units="joule_per_mole">116431.142142348</cn>
                        <ci>RTNa</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="joule_per_mole_kelvin">578.317</cn>
                        </apply>
                        <ci>Rgas</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">0.764126011745707</cn>
                           <ci>V</ci>
                        </apply>
                        <ci>RTNaF</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>DeltaDelta</ci>
            <apply>
               <times/>
               <ci>Temp_Scale</ci>
               <ci>KToverH</ci>
               <apply>
                  <exp/>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
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      <variable name="B0_HERG" units="per_mV" initial_value="0.03304608038835"/>
      <variable name="A1_HERG" units="per_ms" initial_value="0.03969328381141"/>
      <variable name="B1_HERG" units="per_mV" initial_value="-0.0430605416398"/>
      <variable name="A2_HERG" units="per_ms" initial_value="0.02057448605977"/>
      <variable name="B2_HERG" units="per_mV" initial_value="0.02617412715118"/>
      <variable name="A3_HERG" units="per_ms" initial_value="0.00134366604423"/>
      <variable name="B3_HERG" units="per_mV" initial_value="-0.02691385498399"/>
      <variable name="A4_HERG" units="per_ms" initial_value="0.10666316491288"/>
      <variable name="B4_HERG" units="per_mV" initial_value="0.00568908859717"/>
      <variable name="A5_HERG" units="per_ms" initial_value="0.00646393910049"/>
      <variable name="B5_HERG" units="per_mV" initial_value="-0.04536642959543"/>
      <variable name="A6_HERG" units="per_ms" initial_value="8.039374403e-5"/>
      <variable name="B6_HERG" units="per_mV" initial_value="6.9808924e-7"/>
      <variable name="C2H_to_C3H" units="per_ms"/>
      <variable name="C3H_to_C2H" units="per_ms"/>
      <variable name="C1H_to_C2H" units="per_ms"/>
      <variable name="C2H_to_C1H" units="per_ms"/>
      <variable name="C3H_to_OH" units="per_ms"/>
      <variable name="OH_to_C3H" units="per_ms"/>
      <variable name="OH_to_IH" units="per_ms"/>
      <variable name="IH_to_OH" units="per_ms"/>
      <variable name="C3H_to_IH" units="per_ms"/>
      <variable name="IH_to_C3H" units="per_ms"/>
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="C1Herg" units="dimensionless" initial_value="0.994948338598163" public_interface="out"/>
      <variable name="a1_C2" units="per_ms"/>
      <variable name="a2_C2" units="per_ms"/>
      <variable name="C2Herg" units="dimensionless" initial_value="0.000595653663190548" public_interface="out"/>
      <variable name="a1_C3" units="per_ms"/>
      <variable name="a2_C3" units="per_ms"/>
      <variable name="C3Herg" units="dimensionless" initial_value="0.000228183228829573" public_interface="out"/>
      <variable name="a1_O" units="per_ms"/>
      <variable name="a2_O" units="per_ms"/>
      <variable name="OHerg" units="dimensionless" initial_value="0.00120284688677794" public_interface="out"/>
      <variable name="a1_I" units="per_ms"/>
      <variable name="a2_I" units="per_ms"/>
      <variable name="IHerg" units="dimensionless" initial_value="0.000243789721526602" public_interface="out"/>
      <variable name="time" units="ms" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>C2H_to_C3H</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <cn cellml:units="per_ms">0.02608362043337</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3H_to_C2H</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <cn cellml:units="per_ms">0.14832978132145</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1H_to_C2H</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A0_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B0_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C2H_to_C1H</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A1_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B1_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3H_to_OH</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A2_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B2_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>OH_to_C3H</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A3_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B3_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>OH_to_IH</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A4_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B4_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IH_to_OH</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A5_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B5_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C3H_to_IH</ci>
            <apply>
               <times/>
               <ci>T_Const_HERG</ci>
               <ci>A6_HERG</ci>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <ci>B6_HERG</ci>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>IH_to_C3H</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>OH_to_C3H</ci>
                  <ci>IH_to_OH</ci>
                  <ci>C3H_to_IH</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3H_to_OH</ci>
                  <ci>OH_to_IH</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1Herg</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>C2H_to_C1H</ci>
                  <ci>C2Herg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1H_to_C2H</ci>
                  <ci>C1Herg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C2</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C1H_to_C2H</ci>
                  <ci>C1Herg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C3H_to_C2H</ci>
                  <ci>C3Herg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C2</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C2H_to_C1H</ci>
                  <ci>C2H_to_C3H</ci>
               </apply>
               <ci>C2Herg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2Herg</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a1_C2</ci>
               <ci>a2_C2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_C3</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C2H_to_C3H</ci>
                  <ci>C2Herg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>OH_to_C3H</ci>
                  <ci>OHerg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>IH_to_C3H</ci>
                  <ci>IHerg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_C3</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>C3H_to_IH</ci>
                  <ci>C3H_to_OH</ci>
                  <ci>C3H_to_C2H</ci>
               </apply>
               <ci>C3Herg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3Herg</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a1_C3</ci>
               <ci>a2_C3</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_O</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C3H_to_OH</ci>
                  <ci>C3Herg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>IH_to_OH</ci>
                  <ci>IHerg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_O</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>OH_to_C3H</ci>
                  <ci>OH_to_IH</ci>
               </apply>
               <ci>OHerg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OHerg</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a1_O</ci>
               <ci>a2_O</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a1_I</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>C3H_to_IH</ci>
                  <ci>C3Herg</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>OH_to_IH</ci>
                  <ci>OHerg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>a2_I</ci>
            <apply>
               <times/>
               <apply>
                  <plus/>
                  <ci>IH_to_C3H</ci>
                  <ci>IH_to_OH</ci>
               </apply>
               <ci>IHerg</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>IHerg</ci>
            </apply>
            <apply>
               <minus/>
               <ci>a1_I</ci>
               <ci>a2_I</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="IKs">
      <variable name="C0ks_C1ks" units="per_ms"/>
      <variable name="C1ks_O1ks" units="per_ms"/>
      <variable name="O1ks_O2ks" units="per_ms"/>
      <variable name="O1ks_C1ks" units="per_ms"/>
      <variable name="O2ks_O1ks" units="per_ms"/>
      <variable name="C1ks_C0ks" units="per_ms"/>
      <variable name="C0ks" units="dimensionless" initial_value="0.938064990549233" public_interface="out"/>
      <variable name="C1ks" units="dimensionless" initial_value="0.0360525668093578" public_interface="out"/>
      <variable name="O1ks" units="dimensionless" initial_value="5.65460174551007e-7" public_interface="out"/>
      <variable name="O2ks" units="dimensionless" initial_value="0.0258818770122187" public_interface="out"/>
      <variable name="V" units="mV" public_interface="in"/>
      <variable name="time" units="ms" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>C0ks_C1ks</ci>
            <cn cellml:units="per_ms">0.00795600798004</cn>
         </apply>
         <apply>
            <eq/>
            <ci>C1ks_O1ks</ci>
            <cn cellml:units="per_ms">0.03966720676071</cn>
         </apply>
         <apply>
            <eq/>
            <ci>O1ks_O2ks</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.00767254363063</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <cn cellml:units="per_mV">0.08662945914655</cn>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>O1ks_C1ks</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.00700806628929</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.14999754700285</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>O2ks_O1ks</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.00379737998368</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.01425668126881</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>C1ks_C0ks</ci>
            <apply>
               <times/>
               <cn cellml:units="per_ms">0.2162557589585</cn>
               <apply>
                  <exp/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.00001889123021</cn>
                     </apply>
                     <ci>V</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0ks</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>C0ks_C1ks</ci>
                  </apply>
                  <ci>C0ks</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>C1ks_C0ks</ci>
                  <ci>C1ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1ks</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>C0ks_C1ks</ci>
                     <ci>C0ks</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <ci>C1ks_C0ks</ci>
                        <ci>C1ks_O1ks</ci>
                     </apply>
                     <ci>C1ks</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>O1ks_C1ks</ci>
                  <ci>O1ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O1ks</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>C1ks_O1ks</ci>
                     <ci>C1ks</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <plus/>
                        <ci>O1ks_C1ks</ci>
                        <ci>O1ks_O2ks</ci>
                     </apply>
                     <ci>O1ks</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>O2ks_O1ks</ci>
                  <ci>O2ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O2ks</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>O1ks_O2ks</ci>
                  <ci>O1ks</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>O2ks_O1ks</ci>
                  <ci>O2ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <connection>
      <map_components component_1="environment" component_2="IKs"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="IKr"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="INa"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
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   <connection>
      <map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="CSQN2" variable_2="CSQN2"/>
      <map_variables variable_1="RyR2" variable_2="RyR2"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="CSQN2" variable_2="CSQN2"/>
      <map_variables variable_1="RyR2" variable_2="RyR2"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="I_stimulus"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="COMPUTE_ICa_ICaK"/>
      <map_variables variable_1="iso" variable_2="iso"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES"/>
      <map_variables variable_1="iso" variable_2="iso"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKs"/>
      <map_variables variable_1="V" variable_2="V"/>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKr"/>
      <map_variables variable_1="V" variable_2="V"/>
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   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="INa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="RT_over_F" variable_2="RToverF"/>
      <map_variables variable_1="Faraday" variable_2="Faraday"/>
      <map_variables variable_1="Rgas" variable_2="Rgas"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="CaSS" variable_2="CaSS"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INaK_INaCa_ICab_IpCa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="INaCa" variable_2="INaCa"/>
      <map_variables variable_1="INaK" variable_2="INaK"/>
      <map_variables variable_1="ICab" variable_2="ICab"/>
      <map_variables variable_1="IpCa" variable_2="IpCa"/>
      <map_variables variable_1="RT_over_F" variable_2="RT_over_F"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_REVERSAL_POTENTIALS" component_2="COMPUTE_INaK_INaCa_ICab_IpCa"/>
      <map_variables variable_1="ECa" variable_2="ECa"/>
   </connection>
   <connection>
      <map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="INa" variable_2="INa"/>
      <map_variables variable_1="INab" variable_2="INab"/>
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