Location: Jafri, Rice, Winslow, 1998 @ 54567f5be960 / jafri_rice_winslow_1998_a.cellml

Author:
Dougal Cowan
Date:
2010-10-11 09:53 +1300
Desc:
fixed the URLs by removing file:// references
Permanent Source URI:
http://models.cellml.org/workspace/jafri_rice_winslow_1998/rawfile/54567f5be960aa8658e32476454eebba041c4543/jafri_rice_winslow_1998_a.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 22/05/2007 at 15:02:58 using:

COR (0.9.31.587)
Copyright 2002-2007 Oxford Cardiac Electrophysiology Group
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="jafri_1998" name="jafri_1998">
  
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Jafri-Rice-Winslow Ventricular Model 1998</title>
  <author>
    <firstname>Noble</firstname>
          <surname>Penny</surname>
    <affiliation>
      <shortaffil>Cardiac Electrophysiology Group, Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model is known to run in both OpenCell and COR, and has been curated by Penny Noble of Oxford University. The units have been checked and they are consistent.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para> 
ABSTRACT: We construct a detailed mathematical model for Ca2+ regulation in the ventricular myocyte that includes novel descriptions of subcellular mechanisms based on recent experimental findings: 1) the Keizer-Levine model for the ryanodine receptor (RyR), which displays adaptation at elevated Ca2+; 2) a model for the L-type Ca2+ channel that inactivates by mode switching; and 3) a restricted subspace into which the RyRs and L-type Ca2+ channels empty and interact via Ca2+. We add membrane currents from the Luo-Rudy Phase II ventricular cell model to our description of Ca2+ handling to formulate a new model for ventricular action potentials and Ca2+ regulation. The model can simulate Ca2+ transients during an action potential similar to those seen experimentally. The subspace [Ca2+] rises more rapidly and reaches a higher level (10-30 microM) than the bulk myoplasmic Ca2+ (peak [Ca2+]i approximately 1 microM). Termination of sarcoplasmic reticulum (SR) Ca2+ release is predominately due to emptying of the SR, but is influenced by RyR adaptation. Because force generation is roughly proportional to peak myoplasmic Ca2+, we use [Ca2+]i in the model to explore the effects of pacing rate on force generation. The model reproduces transitions seen in force generation due to changes in pacing that cannot be simulated by previous models. Simulation of such complex phenomena requires an interplay of both RyR adaptation and the degree of SR Ca2+ loading. This model, therefore, shows improved behavior over existing models that lack detailed descriptions of subcellular Ca2+ regulatory mechanisms.
</para>
				<para>
The original paper reference is cited below:
</para>
				<para>
					Cardiac Calcium Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load, M. Saleet Jafri, J. Jeremy Rice and Raimond L. Winslow, 1998, 
						<emphasis>Biophysical Journal</emphasis>, 74, 1149-1168.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=9512016&amp;dopt=Abstract">PubMed ID: 9512016</ulink>
				</para>


<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the Jafri-Rice-Winslow model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="jafri_rice_winslow_1998.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram describing the current flows across the cell membrane that are captured in the Jafri-Rice-Winslow model.</caption>
</informalfigure>

</sect1>
</article>
</documentation>


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                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.0000002535</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L_Ca" name="i_Ca_L_Ca" public_interface="out" units="uA_per_mm2"/>
      <variable name="i_Ca_L_K" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="33.75e-6" name="P_Ca" units="mm_per_ms"/>
      <variable initial_value="1e-9" name="P_K" units="mm_per_ms"/>
      <variable name="p_k" units="mm_per_ms"/>
      <variable initial_value="-4.58e-3" name="i_Ca_L_Ca_half" units="uA_per_mm2"/>
      <variable name="i_Ca_L_Ca_max" units="uA_per_mm2"/>
      <variable initial_value="9.84546e-21" name="O" units="dimensionless"/>
      <variable initial_value="0" name="O_Ca" units="dimensionless"/>
      <variable name="alpha" units="per_ms"/>
      <variable name="beta" units="per_ms"/>
      <variable name="gamma" units="per_ms"/>
      <variable name="alpha_a" units="per_ms"/>
      <variable name="beta_b" units="per_ms"/>
      <variable initial_value="2" name="a" units="dimensionless"/>
      <variable initial_value="2" name="b" units="dimensionless"/>
      <variable initial_value="2" name="g" units="per_ms"/>
      <variable initial_value="0.3" name="f" units="per_ms"/>
      <variable initial_value="0" name="g_" units="per_ms"/>
      <variable initial_value="0" name="f_" units="per_ms"/>
      <variable initial_value="0.01" name="omega" units="per_ms"/>
      <variable initial_value="0.997208" name="C0" units="dimensionless"/>
      <variable initial_value="6.38897e-5" name="C1" units="dimensionless"/>
      <variable initial_value="1.535e-9" name="C2" units="dimensionless"/>
      <variable initial_value="1.63909e-14" name="C3" units="dimensionless"/>
      <variable initial_value="6.56337e-20" name="C4" units="dimensionless"/>
      <variable initial_value="2.72826e-3" name="C_Ca0" units="dimensionless"/>
      <variable initial_value="6.99215e-7" name="C_Ca1" units="dimensionless"/>
      <variable initial_value="6.71989e-11" name="C_Ca2" units="dimensionless"/>
      <variable initial_value="2.87031e-15" name="C_Ca3" units="dimensionless"/>
      <variable initial_value="4.59752e-20" name="C_Ca4" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="mV"/>
      <variable name="Ca_SS" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="y" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_L_Ca</ci>
            <apply>
               <times/>
               <ci>i_Ca_L_Ca_max</ci>
               <ci>y</ci>
               <apply>
                  <plus/>
                  <ci>O</ci>
                  <ci>O_Ca</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
						<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="balancing">1</cn>
                        <ci>p_k</ci>
                        <ci>y</ci>
                        <apply>
                           <plus/>
                           <ci>O</ci>
                           <ci>O_Ca</ci>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <ci>Ko</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>p_k</ci>
            <apply>
               <divide/>
               <ci>P_K</ci>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>i_Ca_L_Ca_max</ci>
                     <ci>i_Ca_L_Ca_half</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L_Ca_max</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="balancing">1</cn>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>P_Ca</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                           <ci>V</ci>
                           <apply>
                              <power/>
                              <ci>F</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">0.001</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.341</cn>
                           <ci>Cao</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.4</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">12</cn>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">10</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.05</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">12</cn>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">13</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_a</ci>
            <apply>
               <times/>
               <ci>alpha</ci>
               <ci>a</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_b</ci>
            <apply>
               <divide/>
               <ci>beta</ci>
               <ci>b</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>gamma</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1875</cn>
                  <ci>Ca_SS</ci>
               </apply>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C0</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta</ci>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>omega</ci>
                     <ci>C_Ca0</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <ci>alpha</ci>
                     </apply>
                     <ci>gamma</ci>
                  </apply>
                  <ci>C0</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>alpha</ci>
                     <ci>C0</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <ci>b</ci>
                     </apply>
                     <ci>C_Ca1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>beta</ci>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>alpha</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma</ci>
                        <ci>a</ci>
                     </apply>
                  </apply>
                  <ci>C1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha</ci>
                     <ci>C1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <ci>C_Ca2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>alpha</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma</ci>
                        <apply>
                           <power/>
                           <ci>a</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha</ci>
                     <ci>C2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta</ci>
                     <ci>C4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                     <ci>C_Ca3</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>alpha</ci>
                     <apply>
                        <times/>
                        <ci>gamma</ci>
                        <apply>
                           <power/>
                           <ci>a</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C4</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha</ci>
                     <ci>C3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>g</ci>
                     <ci>O</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        </apply>
                     </apply>
                     <ci>C_Ca4</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     </apply>
                     <ci>f</ci>
                     <apply>
                        <times/>
                        <ci>gamma</ci>
                        <apply>
                           <power/>
                           <ci>a</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C4</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>f</ci>
                  <ci>C4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>g</ci>
                  <ci>O</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Ca0</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>beta_b</ci>
                     <ci>C_Ca1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>C_Ca0</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        <ci>alpha_a</ci>
                     </apply>
                     <ci>omega</ci>
                  </apply>
                  <ci>C_Ca0</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Ca1</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>alpha_a</ci>
                     <ci>C_Ca0</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>beta_b</ci>
                     <ci>C_Ca2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <ci>a</ci>
                     <ci>C1</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>beta_b</ci>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        <ci>alpha_a</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <ci>b</ci>
                     </apply>
                  </apply>
                  <ci>C_Ca1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Ca2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>alpha_a</ci>
                     <ci>C_Ca1</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     <ci>beta_b</ci>
                     <ci>C_Ca3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <apply>
                        <power/>
                        <ci>a</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <ci>C2</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta_b</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>alpha_a</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C_Ca2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Ca3</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>alpha_a</ci>
                     <ci>C_Ca2</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     <ci>beta_b</ci>
                     <ci>C_Ca4</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <apply>
                        <power/>
                        <ci>a</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>C3</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta_b</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>alpha_a</ci>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C_Ca3</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C_Ca4</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>alpha_a</ci>
                     <ci>C_Ca3</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>g_</ci>
                     <ci>O_Ca</ci>
                  </apply>
                  <apply>
                     <times/>
                     <ci>gamma</ci>
                     <apply>
                        <power/>
                        <ci>a</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     </apply>
                     <ci>C4</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>beta_b</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                     </apply>
                     <ci>f_</ci>
                     <apply>
                        <divide/>
                        <ci>omega</ci>
                        <apply>
                           <power/>
                           <ci>b</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">4</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>C_Ca4</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>O_Ca</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>f_</ci>
                  <ci>C_Ca4</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>g_</ci>
                  <ci>O_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_y_gate">
      <variable initial_value="0.998983" name="y" public_interface="out" units="dimensionless"/>
      <variable name="y_infinity" units="dimensionless"/>
      <variable name="tau_y" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>y</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>y_infinity</ci>
                  <ci>y</ci>
               </apply>
               <ci>tau_y</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>y_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">55</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">7.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">21</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_y</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">20</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">600</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">9.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_dependent_potassium_current">
      <variable name="i_K" public_interface="out" units="uA_per_mm2"/>
      <variable name="g_K" units="mS_per_mm2"/>
      <variable initial_value="0.001128" name="g_K_max" units="mS_per_mm2"/>
      <variable name="E_K" units="mV"/>
      <variable initial_value="0.01833" name="P_NaK" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="mV"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="X" private_interface="in" units="dimensionless"/>
      <variable name="Xi" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K</ci>
            <apply>
               <times/>
               <ci>g_K_max</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>P_NaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>P_NaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K</ci>
            <apply>
               <times/>
               <ci>g_K</ci>
               <ci>Xi</ci>
               <apply>
                  <power/>
                  <ci>X</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_dependent_potassium_current_X_gate">
      <variable initial_value="0.000928836" name="X" public_interface="out" units="dimensionless"/>
      <variable name="alpha_X" units="per_ms"/>
      <variable name="beta_X" units="per_ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_X</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV_ms">0.0000719</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.148</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_X</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV_ms">0.000131</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.0687</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">30</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>X</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_X</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>X</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_X</ci>
                  <ci>X</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_dependent_potassium_current_Xi_gate">
      <variable name="Xi" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Xi</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">56.26</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">32.1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable name="i_K1" public_interface="out" units="uA_per_mm2"/>
      <variable name="E_K1" private_interface="out" public_interface="out" units="mV"/>
      <variable name="g_K1" units="mS_per_mm2"/>
      <variable initial_value="7.5e-3" name="g_K1_max" units="mS_per_mm2"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="mV"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="K1_infinity" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>g_K1_max</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K1</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_K1_gate">
      <variable name="K1_infinity" public_interface="out" units="dimensionless"/>
      <variable name="alpha_K1" units="per_ms"/>
      <variable name="beta_K1" units="per_ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="E_K1" public_interface="in" units="mV"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K1</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.49124</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.08032</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">5.476</cn>
                              </apply>
                              <ci>E_K1</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.06175</cn>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <plus/>
                                 <ci>E_K1</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">594.31</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_mV">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K1</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="plateau_potassium_current">
      <variable name="i_Kp" public_interface="out" units="uA_per_mm2"/>
      <variable name="E_Kp" units="mV"/>
      <variable initial_value="8.28e-5" name="g_Kp" units="mS_per_mm2"/>
      <variable name="Kp" units="dimensionless"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="E_K1" public_interface="in" units="mV"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Kp</ci>
            <ci>E_K1</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Kp</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger">
      <variable name="i_NaCa" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="50" name="k_NaCa" units="uA_per_mm2"/>
      <variable initial_value="87.5" name="K_mNa" units="mM"/>
      <variable initial_value="1.38" name="K_mCa" units="mM"/>
      <variable initial_value="0.1" name="k_sat" units="dimensionless"/>
      <variable initial_value="0.35" name="eta" units="dimensionless"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>k_NaCa</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <power/>
                                    <ci>K_mNa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                                 <apply>
                                    <power/>
                                    <ci>Nao</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                                 </apply>
                              </apply>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>K_mCa</ci>
                           <ci>Cao</ci>
                        </apply>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <ci>k_sat</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>eta</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>eta</ci>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cao</ci>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump">
      <variable name="i_p_Ca" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="0.5e-3" name="K_mpCa" units="mM"/>
      <variable initial_value="1.15e-2" name="I_pCa" units="uA_per_mm2"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable name="i_Na_b" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="1.41e-5" name="g_Nab" units="mS_per_mm2"/>
      <variable name="E_NaN" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="E_Na" public_interface="in" units="mV"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_NaN</ci>
            <ci>E_Na</ci>
         </apply>
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_NaN</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable name="i_Ca_b" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="6.032e-5" name="g_Cab" units="mS_per_mm2"/>
      <variable name="E_CaN" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="Cao" public_interface="in" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_CaN</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_CaN</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable name="i_NaK" public_interface="out" units="uA_per_mm2"/>
      <variable initial_value="0.013" name="I_NaK" units="uA_per_mm2"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable initial_value="10" name="K_mNai" units="mM"/>
      <variable initial_value="1.5" name="K_mKo" units="mM"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>I_NaK</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>K_mNai</ci>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ko</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>K_mKo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_specific_calcium_activated_current">
      <variable name="i_ns_Ca" public_interface="out" units="uA_per_mm2"/>
      <variable name="i_ns_Na" public_interface="out" units="uA_per_mm2"/>
      <variable name="i_ns_K" public_interface="out" units="uA_per_mm2"/>
      <variable name="I_ns_Na" units="uA_per_mm2"/>
      <variable name="I_ns_K" units="uA_per_mm2"/>
      <variable initial_value="1.2e-3" name="K_m_ns_Ca" units="mM"/>
      <variable initial_value="1.75e-9" name="P_ns_Ca" units="mm_per_ms"/>
      <variable name="EnsCa" units="mV"/>
      <variable name="VnsCa" units="mV"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Cai" public_interface="in" units="mM"/>
      <variable name="V" public_interface="in" units="mV"/>
      <variable name="R" public_interface="in" units="gas_constant_units"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="Nao" public_interface="in" units="mM"/>
      <variable name="Ko" public_interface="in" units="mM"/>
      <variable name="Nai" public_interface="in" units="mM"/>
      <variable name="Ki" public_interface="in" units="mM"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>EnsCa</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <ci>Nao</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <ci>Nai</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>VnsCa</ci>
            <apply>
               <minus/>
               <ci>V</ci>
               <ci>EnsCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="balancing">1</cn>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>VnsCa</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>VnsCa</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>VnsCa</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="balancing">1</cn>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>VnsCa</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>VnsCa</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.75</cn>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>VnsCa</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_subsystem">
      <variable cmeta:id="calcium_subsystem_Cai" initial_value="9.94893e-11" name="Cai" public_interface="out" units="mM"/>
      <variable initial_value="1.36058e-4" name="Ca_SS" public_interface="out" units="mM"/>
      <variable initial_value="546.69" name="Am" public_interface="out" units="per_mm"/>
      <variable initial_value="0.92" name="V_myo" public_interface="out" units="dimensionless"/>
      <variable name="RyR_open" units="dimensionless"/>
      <variable initial_value="1.19168e-3" name="P_O1" units="dimensionless"/>
      <variable initial_value="6.30613e-9" name="P_O2" units="dimensionless"/>
      <variable initial_value="0.762527" name="P_C1" units="dimensionless"/>
      <variable initial_value="0.236283" name="P_C2" units="dimensionless"/>
      <variable initial_value="1.8" name="v1" units="per_ms"/>
      <variable initial_value="0.58e-4" name="v2" units="per_ms"/>
      <variable initial_value="1.8e-3" name="v3" units="mM_per_ms"/>
      <variable initial_value="4" name="nCa" units="dimensionless"/>
      <variable initial_value="3" name="mCa" units="dimensionless"/>
      <variable initial_value="1.215e10" name="k_a_plus" units="per_mM4_per_ms"/>
      <variable initial_value="0.1425" name="k_a_minus" units="per_ms"/>
      <variable initial_value="4.05e7" name="k_b_plus" units="per_mM3_per_ms"/>
      <variable initial_value="1.93" name="k_b_minus" units="per_ms"/>
      <variable initial_value="0.018" name="k_c_plus" units="per_ms"/>
      <variable initial_value="0.0008" name="k_c_minus" units="per_ms"/>
      <variable initial_value="20" name="k_htrpn_plus" units="per_mM_per_ms"/>
      <variable initial_value="0.066e-3" name="k_htrpn_minus" units="per_ms"/>
      <variable initial_value="40" name="k_ltrpn_plus" units="per_mM_per_ms"/>
      <variable initial_value="0.04" name="k_ltrpn_minus" units="per_ms"/>
      <variable initial_value="34.48" name="tau_tr" units="ms"/>
      <variable initial_value="1.17504" name="Ca_JSR" units="mM"/>
      <variable initial_value="1.243891" name="Ca_NSR" units="mM"/>
      <variable name="V_JSR" units="dimensionless"/>
      <variable name="V_NSR" units="dimensionless"/>
      <variable name="V_SS" units="dimensionless"/>
      <variable initial_value="0.5e-3" name="K_mup" units="mM"/>
      <variable initial_value="2.38e-3" name="K_mCMDN" units="mM"/>
      <variable initial_value="0.8" name="K_mCSQN" units="mM"/>
      <variable initial_value="3.125" name="tau_xfer" units="ms"/>
      <variable initial_value="0.14" name="HTRPN_tot" units="mM"/>
      <variable initial_value="0.07" name="LTRPN_tot" units="mM"/>
      <variable initial_value="0.13598" name="HTRPNCa" units="mM"/>
      <variable initial_value="0.00635" name="LTRPNCa" units="mM"/>
      <variable initial_value="15" name="CSQN_tot" units="mM"/>
      <variable initial_value="0.05" name="CMDN_tot" units="mM"/>
      <variable name="Bi" units="dimensionless"/>
      <variable name="B_SS" units="dimensionless"/>
      <variable name="B_JSR" units="dimensionless"/>
      <variable name="J_rel" units="mM_per_ms"/>
      <variable name="J_leak" units="mM_per_ms"/>
      <variable name="J_up" units="mM_per_ms"/>
      <variable name="J_tr" units="mM_per_ms"/>
      <variable name="J_xfer" units="mM_per_ms"/>
      <variable name="J_trpn" units="mM_per_ms"/>
      <variable name="J_htrpn" units="mM_per_ms"/>
      <variable name="J_ltrpn" units="mM_per_ms"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="i_Ca_b" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_Ca_L_Ca" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_p_Ca" public_interface="in" units="uA_per_mm2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_SS</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">5.828e-5</cn>
               <ci>V_myo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.081</cn>
               <ci>V_myo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00464</cn>
               <ci>V_myo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_rel</ci>
            <apply>
               <times/>
               <ci>v1</ci>
               <ci>RyR_open</ci>
               <apply>
                  <minus/>
                  <ci>Ca_JSR</ci>
                  <ci>Ca_SS</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>RyR_open</ci>
            <apply>
               <plus/>
               <ci>P_O1</ci>
               <ci>P_O2</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_C1</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>k_a_plus</ci>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Ca_SS</ci>
                     <ci>nCa</ci>
                  </apply>
                  <ci>P_C1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_a_minus</ci>
                  <ci>P_O1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O1</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <ci>k_a_plus</ci>
                     <apply>
                        <power/>
                        <ci>Ca_SS</ci>
                        <ci>nCa</ci>
                     </apply>
                     <ci>P_C1</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>k_a_minus</ci>
                        <ci>P_O1</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k_b_plus</ci>
                        <apply>
                           <power/>
                           <ci>Ca_SS</ci>
                           <ci>mCa</ci>
                        </apply>
                        <ci>P_O1</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>k_c_plus</ci>
                        <ci>P_O1</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_b_minus</ci>
                  <ci>P_O2</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_c_minus</ci>
                  <ci>P_C2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_O2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_b_plus</ci>
                  <apply>
                     <power/>
                     <ci>Ca_SS</ci>
                     <ci>mCa</ci>
                  </apply>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_b_minus</ci>
                  <ci>P_O2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>P_C2</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_c_plus</ci>
                  <ci>P_O1</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>k_c_minus</ci>
                  <ci>P_C2</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_leak</ci>
            <apply>
               <times/>
               <ci>v2</ci>
               <apply>
                  <minus/>
                  <ci>Ca_NSR</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>v3</ci>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <power/>
                     <ci>K_mup</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
                  <apply>
                     <power/>
                     <ci>Cai</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_xfer</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_SS</ci>
                  <ci>Cai</ci>
               </apply>
               <ci>tau_xfer</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_htrpn</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_htrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>HTRPN_tot</ci>
                     <ci>HTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_htrpn_minus</ci>
                  <ci>HTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_ltrpn</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>k_ltrpn_plus</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>LTRPN_tot</ci>
                     <ci>LTRPNCa</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_ltrpn_minus</ci>
                  <ci>LTRPNCa</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>J_trpn</ci>
            <apply>
               <plus/>
               <ci>J_htrpn</ci>
               <ci>J_ltrpn</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>HTRPNCa</ci>
            </apply>
            <ci>J_htrpn</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>LTRPNCa</ci>
            </apply>
            <ci>J_ltrpn</ci>
         </apply>
         <apply>
            <eq/>
            <ci>Bi</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDN_tot</ci>
                        <ci>K_mCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>K_mCMDN</ci>
                           <ci>Cai</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>B_SS</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CMDN_tot</ci>
                        <ci>K_mCMDN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>K_mCMDN</ci>
                           <ci>Ca_SS</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>B_JSR</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>CSQN_tot</ci>
                        <ci>K_mCSQN</ci>
                     </apply>
                     <apply>
                        <power/>
                        <apply>
                           <plus/>
                           <ci>K_mCSQN</ci>
                           <ci>Ca_JSR</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cai</ci>
            </apply>
            <apply>
               <times/>
               <ci>Bi</ci>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>J_leak</ci>
                     <ci>J_xfer</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>J_up</ci>
                     <ci>J_trpn</ci>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>i_Ca_b</ci>
                                 <apply>
                                    <times/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                    <ci>i_NaCa</ci>
                                 </apply>
                              </apply>
                              <ci>i_p_Ca</ci>
                           </apply>
                           <ci>Am</ci>
                        </apply>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>V_myo</ci>
                           <ci>F</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SS</ci>
            </apply>
            <apply>
               <times/>
               <ci>B_SS</ci>
               <apply>
                  <minus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>J_rel</ci>
                           <ci>V_JSR</ci>
                        </apply>
                        <ci>V_SS</ci>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>J_xfer</ci>
                           <ci>V_myo</ci>
                        </apply>
                        <ci>V_SS</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_Ca_L_Ca</ci>
                        <ci>Am</ci>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>V_SS</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_JSR</ci>
            </apply>
            <apply>
               <times/>
               <ci>B_JSR</ci>
               <apply>
                  <minus/>
                  <ci>J_tr</ci>
                  <ci>J_rel</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_NSR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>J_up</ci>
                        <ci>J_leak</ci>
                     </apply>
                     <ci>V_myo</ci>
                  </apply>
                  <ci>V_NSR</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>J_tr</ci>
                     <ci>V_JSR</ci>
                  </apply>
                  <ci>V_NSR</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable initial_value="10.2042" name="Nai" public_interface="out" units="mM"/>
      <variable initial_value="140" name="Nao" public_interface="out" units="mM"/>
      <variable initial_value="143.727" name="Ki" public_interface="out" units="mM"/>
      <variable initial_value="5.4" name="Ko" public_interface="out" units="mM"/>
      <variable initial_value="1.8" name="Cao" public_interface="out" units="mM"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="faradays_constant_units"/>
      <variable name="i_Na" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_Na_b" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_ns_Na" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_NaCa" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_NaK" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_Ca_L_K" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_K" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_K1" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_Kp" public_interface="in" units="uA_per_mm2"/>
      <variable name="i_ns_K" public_interface="in" units="uA_per_mm2"/>
      <variable name="Am" public_interface="in" units="per_mm"/>
      <variable name="V_myo" public_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_Na</ci>
                        <ci>i_Na_b</ci>
                        <ci>i_ns_Na</ci>
                        <apply>
                           <times/>
                           <ci>i_NaCa</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                        <apply>
                           <times/>
                           <ci>i_NaK</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Am</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <apply>
                        <plus/>
                        <ci>i_Ca_L_K</ci>
                        <ci>i_K</ci>
                        <ci>i_K1</ci>
                        <ci>i_Kp</ci>
                        <ci>i_ns_K</ci>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>i_NaK</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Am</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ko</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <ci>i_Ca_L_K</ci>
                     <ci>i_K</ci>
                     <ci>i_K1</ci>
                     <ci>i_Kp</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>Am</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="fast_sodium_current">
            <component_ref component="fast_sodium_current_m_gate"/>
            <component_ref component="fast_sodium_current_h_gate"/>
            <component_ref component="fast_sodium_current_j_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_y_gate"/>
         </component_ref>
         <component_ref component="time_dependent_potassium_current">
            <component_ref component="time_dependent_potassium_current_X_gate"/>
            <component_ref component="time_dependent_potassium_current_Xi_gate"/>
         </component_ref>
         <component_ref component="Na_Ca_exchanger"/>
         <component_ref component="time_independent_potassium_current">
            <component_ref component="time_independent_potassium_current_K1_gate"/>
         </component_ref>
         <component_ref component="plateau_potassium_current"/>
         <component_ref component="sarcolemmal_calcium_pump"/>
         <component_ref component="sodium_background_current"/>
         <component_ref component="calcium_background_current"/>
         <component_ref component="sodium_potassium_pump"/>
         <component_ref component="non_specific_calcium_activated_current"/>
         <component_ref component="calcium_subsystem"/>
         <component_ref component="ionic_concentrations"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_y_gate"/>
      </component_ref>
      <component_ref component="time_dependent_potassium_current">
         <component_ref component="time_dependent_potassium_current_X_gate"/>
         <component_ref component="time_dependent_potassium_current_Xi_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="time_dependent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="Na_Ca_exchanger" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="plateau_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sarcolemmal_calcium_pump" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_background_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_subsystem" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L_Ca" variable_2="i_Ca_L_Ca"/>
      <map_variables variable_1="i_Ca_L_K" variable_2="i_Ca_L_K"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_dependent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K" variable_2="i_K"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="plateau_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_subsystem"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ionic_concentrations"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="calcium_subsystem"/>
      <map_variables variable_1="Ca_SS" variable_2="Ca_SS"/>
      <map_variables variable_1="i_Ca_L_Ca" variable_2="i_Ca_L_Ca"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Ca_L_K" variable_2="i_Ca_L_K"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="time_dependent_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_K" variable_2="i_K"/>
   </connection>
   <connection>
      <map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="Na_Ca_exchanger" component_2="calcium_subsystem"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K1" variable_2="E_K1"/>
   </connection>
   <connection>
      <map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="sarcolemmal_calcium_pump" component_2="calcium_subsystem"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="calcium_subsystem"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
      <map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="calcium_subsystem"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="calcium_subsystem"/>
      <map_variables variable_1="Am" variable_2="Am"/>
      <map_variables variable_1="V_myo" variable_2="V_myo"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_y_gate"/>
      <map_variables variable_1="y" variable_2="y"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_X_gate"/>
      <map_variables variable_1="X" variable_2="X"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="time_dependent_potassium_current" component_2="time_dependent_potassium_current_Xi_gate"/>
      <map_variables variable_1="Xi" variable_2="Xi"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="E_K1" variable_2="E_K1"/>
      <map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
   </connection>





<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#1775b7a7-7ada-46ea-a2ba-390a0ee912be"><rdf:value xml:lang="en">The nonspecific calcium activated current describes a channel which
            is activated by calcium ions, but is permeable to only sodium and
            potassium ions.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#6ef85e73-a236-458b-a884-b9048c08a25c"><rdf:value xml:lang="en">The time-dependent potassium current has an X^2 dependence on it's
            activation gate, and an Xi inactivation gate. This channel is also
            assumed permeable to sodium ions.</rdf:value></rdf:Description><rdf:Description rdf:about="#alpha_j_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#09bc439b-1d42-4289-bad1-ada2102458ca"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#64f3554c-3ce1-48ba-a505-31747a85ff7b"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#21b6861a-2143-4c1b-a408-49b106284dbe"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#9a872fdc-5a08-4acd-9567-8ffea18211ab"/></cmeta:modifier><rdf:value xml:lang="en">Corrected equations.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7bc72e28-d28c-4160-b5c3-f9aa39b2c081"><rdf:value xml:lang="en">The voltage-dependent inactivation gate for the fast sodium current
            - the h gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#dm_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0a2d9210-8282-4cb8-ba81-57ba73f665c4"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#71085380-f51b-49cb-a65b-1979f7a8d7a7"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#3719ca67-804e-48db-8107-8fc15b437ad3"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#11123e2e-bde4-4dd2-83a8-da3dbf026407"/></cmeta:modifier><rdf:value xml:lang="en">This model has been curated and the output checked against the original paper.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#d77b30f8-bc47-4ff6-9789-9a9b183df857"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#4b84685c-44dc-44c7-b908-38e08c75f7af"><rdf:value xml:lang="en">Calculation of the plateau potassium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#238b37c0-734c-4302-a362-9308923fe95c"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2002-01-04</W3CDTF></rdf:Description><rdf:Description rdf:about="#VnsCa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#99ea7d04-14f7-4f8f-a325-9b54ef8b2075"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#9c32c531-ccd3-45f2-92aa-931008c32918"><rdf:value xml:lang="en">Keep track of the concentration of calcium ions bound to high and
            low affinity troponin binding sites.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#e0bd7381-4ec8-492f-996c-8d97fc5a72e5"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#9fc3abe3-2c03-4489-8e83-726c4a8131e6"><rdf:value xml:lang="en">Calculate the calcium flux from the diffusion of calcium out of the
            restricted subspace into the myoplasm.</rdf:value></rdf:Description><rdf:Description rdf:about="#Bi_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#13a28452-e692-483c-9aa7-02e6c73e7464"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#31a7b29d-24cf-4ddc-8c12-a73fba720be1"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Noble</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Penny</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">J</Other></rdf:Description><rdf:Description rdf:about="rdf:#4a1b3e75-9ca4-48ee-b22d-1e7795d75a7d"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="#alpha_m_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0d6f844f-69d8-4d90-b8d7-ad63b27dd018"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#potassium_internal_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#b2d117d3-c431-4efc-956c-62608568025c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#19de6dea-e3a4-4725-9338-7f60e692e850"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Biophysical Journal</title></rdf:Description><rdf:Description rdf:about="rdf:#0a2d9210-8282-4cb8-ba81-57ba73f665c4"><rdf:value xml:lang="en">The kinetics of the m gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#jafri_1998"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">The Jafri-Rice-Winslow Model for Calcium Regulation in the Ventricular
        Myocyte, 1997</title><cmeta:comment><rdf:Description rdf:about="rdf:#b1179327-5f99-4cfe-a215-e645b1a9f16f"/></cmeta:comment><cmeta:bio_entity xml:lang="en">Ventricular Myocyte</cmeta:bio_entity><cmeta:species xml:lang="en">Mammalia</cmeta:species><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:about="rdf:#$9jbrV3"/></simulation><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n1"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#4587df3a-08b0-46ae-99bc-67d5a2bdd139"/></reference></rdf:Description><rdf:Description rdf:about="rdf:#09bc439b-1d42-4289-bad1-ada2102458ca"><rdf:value xml:lang="en">The opening rate of the j gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#dj_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#eb0ea281-b5e1-4386-9d7a-ebeaa4ea9477"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#non_specific_calcium_activated_current"><cmeta:comment><rdf:Description rdf:about="rdf:#1775b7a7-7ada-46ea-a2ba-390a0ee912be"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#C0_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#6c2141e9-882d-4886-962f-5a9b8afc349e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#dbe501ef-01c1-4bcb-bd8d-e51013ca0dd1"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Winslow</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Raimond</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">L</Other></rdf:Description><rdf:Description rdf:about="rdf:#da9e53fa-43be-462f-9e62-f707ef6f7e19"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#2775d603-cc9c-4d0d-8f6a-794b4c5c838c"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#cd120ba1-6c08-4ce5-98fb-f801a999d130"/></cmeta:modifier><rdf:value xml:lang="en">Corrected equations: alpha_j_calculation and beta_j_calculation in 
          fast_sodium_current_j_gate, alpha_X_calculation and beta_X_calculation           in time_dependent_potassium_current_X_gate, and f_NaK_calculation and 
          i_NaK_calculation in Ca_release_current_from_JSR.</rdf:value></rdf:Description><rdf:Description rdf:nodeID="n2"><rdf:value><rdf:Description rdf:nodeID="n3"/></rdf:value><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type></rdf:Description><rdf:Description rdf:about="#P_C1_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#11c8815a-fed4-4f76-8be7-2df9b3cddac5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#C_Ca0_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#683e3709-a3fe-4eb9-95e4-bb3566e9f6f1"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#11c8815a-fed4-4f76-8be7-2df9b3cddac5"><rdf:value xml:lang="en">The kinetic equations governing the transitions between the four
            states used to model the RyR's.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#482f5aa5-751c-4f08-a861-f0012b5a46b6"><rdf:value xml:lang="en">Calculation of the maximal channel conductance, dependent on
            extracellular potassium concentration.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#398816f5-c23b-4cf8-bac4-0528e4302905"><rdf:value xml:lang="en">The kinetics of calcium binding to the myoplasm buffer troponin -
            both high and low affinity binding sites.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#3a228af7-a587-44ff-a2f8-3fb836f3ddbe"><rdf:value xml:lang="en">The Na/Ca exchanger component describes how a protein molecule in
            the cell surface membrane transports Na ions into the cytosol and
            exports Ca ions into the extracellular volume, in a ratio of 3:1
            respectively.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#d586f61f-418e-4c58-b02c-d2e6a2a57d3d"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7d147585-9321-4c13-b0d9-65e00347bcf5"/></N></rdf:Description><rdf:Description rdf:about="#dX_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5580b920-d04c-4598-bfc0-4503e68356d0"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#12722d36-293a-4b83-8b20-06f18b5826ea"><rdf:value xml:lang="en">The time-independent inactivation gate for the time-dependent
            potassium channel.</rdf:value></rdf:Description><rdf:Description rdf:about="#dh_dt_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#bf72189f-a875-4906-8eb1-514525848cbb"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#99ea7d04-14f7-4f8f-a325-9b54ef8b2075"><rdf:value xml:lang="en">The potential offset for the channel.</rdf:value></rdf:Description><rdf:Description rdf:about="#fast_sodium_current_m_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#3e450836-34ec-4a41-bc56-d275ff567a6d"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#da6198e9-5668-4bee-a76e-6da5db8c80ec"><rdf:value xml:lang="en">The plateau potassium current component contains the equations which
            describe the contribution of a time independent [K]o-insensitive
            channel at plateau potentials.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#66e14b47-9a73-4697-bc55-a241e8496dd9"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load</title><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#c1eac369-66b1-4be0-8a0a-568845c120bb"/></creator><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#41088e5c-001c-4930-87f3-41113ce0a73c"/></issued><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">74</volume><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">1149</first_page><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#19de6dea-e3a4-4725-9338-7f60e692e850"/></Journal><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">1168</last_page></rdf:Description><rdf:Description rdf:about="rdf:#219f5ab0-c1bc-4800-99db-37938c290bd3"><rdf:value xml:lang="en">Calculate the uptake flux into the NSR from the myoplasm.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5eb96e50-3a06-4319-a449-e041479a023f"><rdf:value xml:lang="en">The JWR model creates a new mathematical model to describe the
            L-type calcium channel that is based on the experimentally observed
            mode-switching behaviour of the channel. Inactivation occurs as
            calcium ion binding induces the channel to switch (from mode normal)
            to a mode in which transitions to open states are extremely slow
            (mode Ca). The channel has one voltage inactivation gate, y. As well
            as Ca, the channel is assumed permeable to K ions also.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7cafd8c7-9113-4800-ac32-1d8ac7921f3d"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lawson</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">James</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Richard</Other></rdf:Description><rdf:Description rdf:about="rdf:#5321b474-ca6b-4aa0-81d4-0490640fefa8"><rdf:value xml:lang="en">The reversal potential for the background sodium channel.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#bd11fa50-e8f0-4d3f-90ea-730f01895492"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2002-02-28</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#62efef11-6d63-4ae6-ae94-5caa43b3e590"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jafri</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">M</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Saleet</Other></rdf:Description><rdf:Description rdf:about="#fast_sodium_current_h_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#7bc72e28-d28c-4160-b5c3-f9aa39b2c081"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#1647eb04-92c1-4804-aab6-6fcfb410ad2c"><rdf:value xml:lang="en">The time-independent potassium current.</rdf:value></rdf:Description><rdf:Description rdf:about="#L_type_Ca_channel_y_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#381202dd-b46a-4f25-a29b-f5fb8775c135"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#9744ad5e-875e-46a5-8a9c-b2c39cc30222"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#f692acee-8164-4826-bc05-63a80b8146e5"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#d586f61f-418e-4c58-b02c-d2e6a2a57d3d"/></cmeta:modifier><rdf:value xml:lang="en">Changed tau_y_calculation after checking mathml using the validator.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#282e1a65-80d4-4c22-9ea4-7fa13d1b885b"><rdf:value xml:lang="en">The closing rate of the j gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#554d1c26-d6f6-47e5-bb23-84be70838675"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#bd11fa50-e8f0-4d3f-90ea-730f01895492"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#919037b1-961d-4081-93ac-a5f50d172ed8"/></cmeta:modifier><rdf:value xml:lang="en">Corrected several equations, variable units and their initial values.</rdf:value></rdf:Description><rdf:Description rdf:about="#i_Na_b_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#2eeac2c4-b1fd-4c67-9abc-062101ce6d2b"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#0d6f844f-69d8-4d90-b8d7-ad63b27dd018"><rdf:value xml:lang="en">The opening rate of the m gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#E_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0369ac4e-eed4-49da-ae19-79542aa70493"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#f690db2d-eb3d-4974-a518-dc77ff82de98"><rdf:value xml:lang="en">Calculation of the Na/K pump current.</rdf:value></rdf:Description><rdf:Description rdf:about="#time_dependent_potassium_current_Xi_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#12722d36-293a-4b83-8b20-06f18b5826ea"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#beta_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#283ef951-972e-447c-a607-28aa80255764"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#i_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#e24c338d-ca40-48a7-b588-19037f4fc73a"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#L_type_Ca_channel"><cmeta:comment><rdf:Description rdf:about="rdf:#5eb96e50-3a06-4319-a449-e041479a023f"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#e5230b09-57bf-4174-b900-23270a1719a5"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The University of Auckland</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">The Bioengineering Research Group</Orgunit></rdf:Description><rdf:Description rdf:about="#sodium_potassium_pump"><cmeta:comment><rdf:Description rdf:about="rdf:#8845e476-c0c5-4d31-a07d-501ec259885e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#5d6c233b-69dc-4344-922f-95ad5138ca76"><rdf:value xml:lang="en">The maximal calcium current through the channel.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#f996f632-013a-44f4-b739-8b14712ebdf3"><rdf:value xml:lang="en">The sodium reversal potential.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5367cdd4-0e34-41d4-82c4-8e8d261ed246"><rdf:value xml:lang="en">The main component of the model which defines the action potential.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#41088e5c-001c-4930-87f3-41113ce0a73c"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">1998-03-01</W3CDTF></rdf:Description><rdf:Description rdf:about="#K1_infinity_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#6cb2ccac-6d26-4142-bfea-c5f71bec19a7"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#b9feaea5-58dc-43a5-99d5-a1771da0192c"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2001-09-24T00:00:00+00:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#ba5287c0-312e-4d0e-bc0b-aa6be1cef3d3"><rdf:value xml:lang="en">This model has been curated by Penny Noble of Oxford University and is known to run in PCEnv and COR. A PCEnv session is also associated with this file.</rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#a419d974-2051-4e1c-b370-57c43b3b2619"/></creator></rdf:Description><rdf:Description rdf:about="#y_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5210dece-3135-4c13-9a3e-b75a3d82ea67"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#beta_X_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#ff4606f2-8637-46ad-b862-69e0b88de05e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#c490f6a1-536d-45b9-b576-97e01c51d188"><rdf:value xml:lang="en">Calculate the leakage flux from the NSR into the myoplasm.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#0369ac4e-eed4-49da-ae19-79542aa70493"><rdf:value xml:lang="en">The following equation calculates the reversal potential of the
            time-independent potassium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7ddfbcc9-9bcb-4fe4-ad8e-71f0f6cac2b0"><rdf:value xml:lang="en">The calcium pump current.</rdf:value></rdf:Description><rdf:Description rdf:about="#time_dependent_potassium_current_X_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#dcbb6aa9-ae72-4aa1-abe4-441cfc3eb735"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#02790508-bb45-42b1-b6da-39202a32797c"><rdf:value xml:lang="en">Calculation of the background calcium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#683e3709-a3fe-4eb9-95e4-bb3566e9f6f1"><rdf:value xml:lang="en">The kinetics of the state transitions in mode Ca.
            Calcium binding to the Ca channel induces a conformational change
            from normal mode to mode Ca. This effectively inhibits the
            conduction of calcium ions because in mode Ca, the calcium channel
            makes the transition to the open, conducting state (O) extremely
            slowly.</rdf:value></rdf:Description><rdf:Description rdf:about="#calcium_background_current"><cmeta:comment><rdf:Description rdf:about="rdf:#381df5ee-2bac-4704-83f3-032825cce1ea"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#c1eac369-66b1-4be0-8a0a-568845c120bb"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_2><rdf:Description rdf:about="rdf:#c5ed76e6-f850-4094-94a8-058454d12da8"/></rdf:_2><rdf:_3><rdf:Description rdf:about="rdf:#182c2ef5-f840-4ff6-8fbf-73e2a0eb1569"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#6b77f513-f747-4175-a0e7-1df27321d34f"/></rdf:_1></rdf:Description><rdf:Description rdf:about="#beta_h_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#f482e965-99de-48a1-9852-4c2d7ed54695"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#IStim_for_cmiss_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#86d5770b-672b-4dd4-a4c6-73015fb1641e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#b0fbc344-49e1-43f6-95a7-a2851c375fa8"><rdf:value xml:lang="en">The descriptions of the rate of change of [Na]i and [K]i are the
            same as the LR-II model.</rdf:value></rdf:Description><rdf:Description rdf:about="#i_ns_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4883548f-e381-4a8d-bdfe-2e6add011c43"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#e10d779d-5ea9-4866-a2a8-42119c7918e5"><rdf:value xml:lang="en">The sodium background current is a time-independent diffusion of
            Na ions down their electrochemical gradient, through the cell
            surface membrane into the cytosol.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#0886d6e7-b4ed-4a05-877b-655f07f13c23"><rdf:value xml:lang="en">The opening rate of the h gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#beta_m_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0f1ed0e4-6d3c-4b56-98fd-fc7c0d93e2e4"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#13ebb9eb-5ba8-4942-99b3-cbe891cb9d52"><rdf:value xml:lang="en">Xi is the inward rectification parameter and is given by the
            following equation.</rdf:value></rdf:Description><rdf:Description rdf:about="#membrane"><cmeta:comment><rdf:Description rdf:about="rdf:#5367cdd4-0e34-41d4-82c4-8e8d261ed246"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#8d17d79c-9e87-4ff1-877c-cf4000b524fc"><rdf:value xml:lang="en">Calculation of the maximal channel conductance, dependent on
            extracellular potassium concentration.</rdf:value></rdf:Description><rdf:Description rdf:about="#E_CaN_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#390c1948-87ea-4ad5-b84b-e66a3e842826"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#i_ns_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#7cbd6926-4079-4627-aeb4-980877d15eca"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#835c7777-1095-4391-89ed-42f400cea57d"><rdf:value xml:lang="en">The maximal sodium component current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#6500dd73-a4b9-4662-b0c1-9f430353267a"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#373a86d2-0230-4aa9-bb3d-d655c58c8c0f"><rdf:value xml:lang="en">The calcium release flux from the JSR into the restricted subspace
            is governed by the fraction of RyR channels in an open state.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#c1809e54-6320-4eae-9d42-372675b76ca5"><rdf:value xml:lang="en">The reversal potential of the channel.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#db0581ea-d6d8-4ca9-acbf-4f86cef69467"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#5f5294aa-fcbb-4861-bc45-a1635c90631e"/></N></rdf:Description><rdf:Description rdf:about="#alpha_X_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#bd9fdeb3-53d0-4e83-aef8-0442dd315536"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#Na_Ca_exchanger_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4e609ca2-bc3f-4ed6-9eb3-4bf9e2cdc962"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#f482e965-99de-48a1-9852-4c2d7ed54695"><rdf:value xml:lang="en">The closing rate of the h gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#11123e2e-bde4-4dd2-83a8-da3dbf026407"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#31a7b29d-24cf-4ddc-8c12-a73fba720be1"/></N></rdf:Description><rdf:Description rdf:about="#RyR_open_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#3d74ad55-3a32-4a31-a3ef-1da4d0955353"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#i_p_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#7ddfbcc9-9bcb-4fe4-ad8e-71f0f6cac2b0"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#alpha_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#aee41d98-40e6-4b37-843c-d37f7b7132d9"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#J_xfer_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#9fc3abe3-2c03-4489-8e83-726c4a8131e6"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#g_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#482f5aa5-751c-4f08-a861-f0012b5a46b6"/></cmeta:comment></rdf:Description><rdf:Description rdf:nodeID="n1"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n2"/></subject></rdf:Description><rdf:Description rdf:about="#plateau_potassium_current"><cmeta:comment><rdf:Description rdf:about="rdf:#da6198e9-5668-4bee-a76e-6da5db8c80ec"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#fde43366-9d9e-4268-9644-d413b3e990b3"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2001-10-19</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#author2VcardN"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Rice</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">John</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jeremy</Other></rdf:Description><rdf:Description rdf:about="rdf:#bf72189f-a875-4906-8eb1-514525848cbb"><rdf:value xml:lang="en">The kinetics of the h gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#i_ns_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5845a0e2-5166-485a-8890-5f5ed5d38b27"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#5210dece-3135-4c13-9a3e-b75a3d82ea67"><rdf:value xml:lang="en">The kinetics of the y gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#e24c338d-ca40-48a7-b588-19037f4fc73a"><rdf:value xml:lang="en">Calculation of the fast sodium current using the three
            Hodkin-Huxley type voltage-dependent gating variables m, h, and j.</rdf:value></rdf:Description><rdf:Description rdf:about="#J_rel_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#373a86d2-0230-4aa9-bb3d-d655c58c8c0f"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#fast_sodium_current"><cmeta:comment><rdf:Description rdf:about="rdf:#e50a5ea4-de41-4321-8f12-1ae320cbcff5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#sodium_background_current"><cmeta:comment><rdf:Description rdf:about="rdf:#e10d779d-5ea9-4866-a2a8-42119c7918e5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#dcbb6aa9-ae72-4aa1-abe4-441cfc3eb735"><rdf:value xml:lang="en">The voltage- and time-dependent activation gate for the
            time-dependent potassium current - the X gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#3b7f1b20-e9b7-4a74-a776-5a6e53787c98"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#d77b30f8-bc47-4ff6-9789-9a9b183df857"/></N></rdf:Description><rdf:Description rdf:about="#E_NaN_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5321b474-ca6b-4aa0-81d4-0490640fefa8"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#26691a20-5078-45b0-bc43-ff8d704f6501"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2002-05-06</W3CDTF></rdf:Description><rdf:Description rdf:about="#alpha_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1f01afbb-c1b6-438f-97d0-c3969915c018"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#alpha_h_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#0886d6e7-b4ed-4a05-877b-655f07f13c23"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#83ead578-fd46-417f-b817-8c8279dbfa6b"><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type><rdf:value xml:lang="en">c.lloyd@auckland.ac.nz</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#1f01afbb-c1b6-438f-97d0-c3969915c018"><rdf:value xml:lang="en">Rate constants for state changes in mode normal.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#257afbc7-f3ab-4fcb-b9d1-a7e592ed1877"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#4dd9aa78-8ef7-4c9e-81f4-c1788f3ed068"/></N></rdf:Description><rdf:Description rdf:about="#sodium_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#8fef7c77-6810-4289-97d0-2d35d54914cc"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#c0812b47-3f4c-45a4-9f3d-efcefb112b80"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#7cafd8c7-9113-4800-ac32-1d8ac7921f3d"/></N></rdf:Description><rdf:Description rdf:about="rdf:#83613dfa-9eed-4d6e-a6d7-37a6a027d55b"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#ff8579a7-9c55-459d-9d39-981cc3f4dc4f"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#c0812b47-3f4c-45a4-9f3d-efcefb112b80"/></cmeta:modifier><rdf:value xml:lang="en">Several variables have been given cmeta:id's to allow creation of a PCEnv session file.</rdf:value></rdf:Description><rdf:Description rdf:about="#fast_sodium_current_j_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#68023ec0-d242-4459-80e7-845fb91c4dca"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#3e450836-34ec-4a41-bc56-d275ff567a6d"><rdf:value xml:lang="en">The voltage-dependent activation gate for the fast sodium current -
            the m gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#4c24f963-b2b3-4b4c-a1b7-3bac71e76097"><rdf:value xml:lang="en">Calculate the current.</rdf:value></rdf:Description><rdf:Description rdf:about="#time_dependent_potassium_current"><cmeta:comment><rdf:Description rdf:about="rdf:#6ef85e73-a236-458b-a884-b9048c08a25c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#ff8579a7-9c55-459d-9d39-981cc3f4dc4f"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-06-22T12:55:26+12:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#6b77f513-f747-4175-a0e7-1df27321d34f"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#62efef11-6d63-4ae6-ae94-5caa43b3e590"/></N></rdf:Description><rdf:Description rdf:about="#calcium_internal_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#dd0f94a1-be17-4d3c-bf38-7db4369c0bb7"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#53293fee-69c3-4129-8cee-9ee80381c4f8"><rdf:value xml:lang="en">Calculation of the calcium current component of the total channel
            current, given as the maximal current multiplied by the
            voltage-dependent inactivation gate and the open probability of the
            channel based on the mode-switching model.</rdf:value></rdf:Description><rdf:Description rdf:about="#calcium_subsystem"><cmeta:comment><rdf:Description rdf:about="rdf:#b19917af-867f-44ba-ab12-31486eab52de"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#243419e0-6d85-4733-9b4c-f8546f83b7a4"><rdf:value xml:lang="en">Calculation of the potassium current component of the total channel
            current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#86d5770b-672b-4dd4-a4c6-73015fb1641e"><rdf:value xml:lang="en">This is a dummy equation that we simply use to make grabbing the
            value in CMISS much easier.</rdf:value></rdf:Description><rdf:Description rdf:about="#I_ns_Na_max_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#835c7777-1095-4391-89ed-42f400cea57d"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#$9jbrV3"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:about="rdf:#$ajbrV3"/></boundIntervals></rdf:Description><rdf:Description rdf:about="#i_Ca_L_Ca_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#53293fee-69c3-4129-8cee-9ee80381c4f8"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#d4ed6796-21bc-4d5a-84d7-7d0f669c1d5e"><rdf:value xml:lang="en">The time constants for the K1 gate are small enough that the gating
            variable can be approximated with it's steady-state value.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#author1Vcard"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author1VcardN"/></N></rdf:Description><rdf:Description rdf:about="rdf:#8fef7c77-6810-4289-97d0-2d35d54914cc"><rdf:value xml:lang="en">The rate of change of intracellular sodium ion concentration.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#c5ed76e6-f850-4094-94a8-058454d12da8"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#6f8f25bf-ceec-4bde-a126-693248ef5655"/></N></rdf:Description><rdf:Description rdf:about="#i_Ca_L_Ca_max_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5d6c233b-69dc-4344-922f-95ad5138ca76"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#4883548f-e381-4a8d-bdfe-2e6add011c43"><rdf:value xml:lang="en">The potassium component of the channel's current.</rdf:value></rdf:Description><rdf:Description rdf:about="#Na_Ca_exchanger"><cmeta:comment><rdf:Description rdf:about="rdf:#3a228af7-a587-44ff-a2f8-3fb836f3ddbe"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#author3VcardN"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Winslow</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Raimond</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">L</Other></rdf:Description><rdf:Description rdf:about="rdf:#5580b920-d04c-4598-bfc0-4503e68356d0"><rdf:value xml:lang="en">The kinetics of the X gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#952ad3db-d625-49c2-83c1-be70e9dc46bd"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#26691a20-5078-45b0-bc43-ff8d704f6501"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#3b7f1b20-e9b7-4a74-a776-5a6e53787c98"/></cmeta:modifier><rdf:value xml:lang="en">Added some initial values from Penny Noble's documentation.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#e1d81e5c-d287-4425-8b52-0aafe161881b"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine Lloyd</FN></rdf:Description><rdf:Description rdf:about="#potassium_external_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#19e507f5-2e34-4938-ba36-ab0660d9a60f"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#77d0a8bd-bbdb-48de-81e8-c3711fe2cf16"><rdf:value xml:lang="en">Rate constant for switching between mode normal and mode Ca.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#a419d974-2051-4e1c-b370-57c43b3b2619"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">James Lawson</FN></rdf:Description><rdf:Description rdf:about="rdf:#6c2141e9-882d-4886-962f-5a9b8afc349e"><rdf:value xml:lang="en">The kinetics of the state transitions in mode normal.
            In the normal mode, the calcium channel is able to make the
            transition to the open, conducting state (O) from the closed state
            (C) at a normal rate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5845a0e2-5166-485a-8890-5f5ed5d38b27"><rdf:value xml:lang="en">The total nonspecific calcium activated current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#author1VcardN"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jafri</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">M</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Saleet</Other></rdf:Description><rdf:Description rdf:about="rdf:#9c262e7e-ab38-4fd7-bd1a-dc1038ecfde3"><rdf:value xml:lang="en">The potassium permeability of the channel, which depends on the
            calcium current component.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#182c2ef5-f840-4ff6-8fbf-73e2a0eb1569"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#dbe501ef-01c1-4bcb-bd8d-e51013ca0dd1"/></N></rdf:Description><rdf:Description rdf:about="#i_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#033e0120-32a3-460a-b3ed-e608fc10acb9"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#J_tr_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#903f5c62-f8f7-4436-9a15-9a235803802d"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#$ajbrV3"><rdf:first><rdf:Description rdf:about="rdf:#$bjbrV3"/></rdf:first><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest></rdf:Description><rdf:Description rdf:about="rdf:#e74a1709-d4ab-43c0-83c3-922c33b716b1"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#cd120ba1-6c08-4ce5-98fb-f801a999d130"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#e74a1709-d4ab-43c0-83c3-922c33b716b1"/></N></rdf:Description><rdf:Description rdf:about="rdf:#e18e006b-41c2-4008-adee-cba1521d1d4d"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#fde43366-9d9e-4268-9644-d413b3e990b3"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#257afbc7-f3ab-4fcb-b9d1-a7e592ed1877"/></cmeta:modifier><rdf:value xml:lang="en">Removed document type definition as this is declared as optional
          according to the W3C recommendation.</rdf:value></rdf:Description><rdf:Description rdf:about="#time_independent_potassium_current_K1_gate"><cmeta:comment><rdf:Description rdf:about="rdf:#d4ed6796-21bc-4d5a-84d7-7d0f669c1d5e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#author3Vcard"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author3VcardN"/></N></rdf:Description><rdf:Description rdf:about="#I_ns_K_max_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5fefa518-4317-4642-9cb0-70a5c95a481e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#6cb2ccac-6d26-4142-bfea-c5f71bec19a7"><rdf:value xml:lang="en">The steady-state approximation for the K1 gating kinetics.</rdf:value></rdf:Description><rdf:Description rdf:about="#J_htrpn_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#398816f5-c23b-4cf8-bac4-0528e4302905"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#6f8f25bf-ceec-4bde-a126-693248ef5655"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Rice</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">John</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Jeremy</Other></rdf:Description><rdf:Description rdf:about="#i_K1_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4c24f963-b2b3-4b4c-a1b7-3bac71e76097"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#21b6861a-2143-4c1b-a408-49b106284dbe"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2003-07-30</W3CDTF></rdf:Description><rdf:Description rdf:about="#Kp_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#d8bc8fb4-700e-4586-9204-f6044de0ab3e"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#$bjbrV3"><algorithm xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">bdf15</algorithm><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">3000</endingValue><pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">100000</pointDensity><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.2</maximumStepSize></rdf:Description><rdf:Description rdf:about="rdf:#5fefa518-4317-4642-9cb0-70a5c95a481e"><rdf:value xml:lang="en">The maximal potassium component current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#aee41d98-40e6-4b37-843c-d37f7b7132d9"><rdf:value xml:lang="en">The opening rate of the K1 gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#V_SS_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#76fd3acd-1b94-4d41-b8cc-72eac01422bc"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#8845e476-c0c5-4d31-a07d-501ec259885e"><rdf:value xml:lang="en">The sodium potassium pump is an active protein in the cell membrane
            which couples the free energy released by the hydrolysis of ATP to
            the movement of Na and K ions against their electrochemical
            gradients through the cell membrane.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#68023ec0-d242-4459-80e7-845fb91c4dca"><rdf:value xml:lang="en">The voltage-dependent slow inactivation gate for the fast sodium
            current - the j gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#4e609ca2-bc3f-4ed6-9eb3-4bf9e2cdc962"><rdf:value xml:lang="en">Calculation of the Na/Ca exchanger current.</rdf:value></rdf:Description><rdf:Description rdf:about="#E_Na_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#f996f632-013a-44f4-b739-8b14712ebdf3"/></cmeta:comment></rdf:Description><rdf:Description rdf:about=""><cmeta:modification><rdf:Description rdf:about="rdf:#9744ad5e-875e-46a5-8a9c-b2c39cc30222"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#06a944f9-8b49-4d4c-8e8e-4c798a7bdf45"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#71085380-f51b-49cb-a65b-1979f7a8d7a7"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#952ad3db-d625-49c2-83c1-be70e9dc46bd"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#554d1c26-d6f6-47e5-bb23-84be70838675"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#83613dfa-9eed-4d6e-a6d7-37a6a027d55b"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#5e99f692-2c7a-4340-8804-3d057306f63e"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#e18e006b-41c2-4008-adee-cba1521d1d4d"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#64f3554c-3ce1-48ba-a505-31747a85ff7b"/></cmeta:modification><cmeta:modification><rdf:Description rdf:about="rdf:#da9e53fa-43be-462f-9e62-f707ef6f7e19"/></cmeta:modification><created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#b9feaea5-58dc-43a5-99d5-a1771da0192c"/></created><publisher xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">The University of Auckland, Bioengineering Research Group</publisher><cmeta:comment><rdf:Description rdf:about="rdf:#ba5287c0-312e-4d0e-bc0b-aa6be1cef3d3"/></cmeta:comment><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#c2b51632-c624-4623-a48a-2e99b50d983b"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#7d147585-9321-4c13-b0d9-65e00347bcf5"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#f692acee-8164-4826-bc05-63a80b8146e5"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2001-12-07</W3CDTF></rdf:Description><rdf:Description rdf:about="#HTRPNCa_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#9c32c531-ccd3-45f2-92aa-931008c32918"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#ionic_concentrations"><cmeta:comment><rdf:Description rdf:about="rdf:#b0fbc344-49e1-43f6-95a7-a2851c375fa8"/></cmeta:comment></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type><rdf:_2 xml:lang="en">calcium dynamics</rdf:_2><rdf:_3 xml:lang="en">electrophysiology</rdf:_3><rdf:_1 xml:lang="en">Ventricular Myocyte</rdf:_1><rdf:_4 xml:lang="en">ryanodine receptor</rdf:_4></rdf:Description><rdf:Description rdf:about="rdf:#b2d117d3-c431-4efc-956c-62608568025c"><rdf:value xml:lang="en">The rate of change of intracellular potassium ion concentration.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#d8bc8fb4-700e-4586-9204-f6044de0ab3e"><rdf:value xml:lang="en">The activation variable.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#citationAuthorsSeq"><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type><rdf:_2><rdf:Description rdf:about="rdf:#author2Vcard"/></rdf:_2><rdf:_3><rdf:Description rdf:about="rdf:#author3Vcard"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#author1Vcard"/></rdf:_1></rdf:Description><rdf:Description rdf:about="rdf:#bd9fdeb3-53d0-4e83-aef8-0442dd315536"><rdf:value xml:lang="en">The opening rate of the X gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5503cefb-15ec-4084-9f59-a87f88601ce3"><rdf:value xml:lang="en">The kinetics of the transmembrane potential, defined as the sum of
            all the sarcolemmal currents and an applied stimulus current.</rdf:value></rdf:Description><rdf:Description rdf:about="#i_Ca_b_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#02790508-bb45-42b1-b6da-39202a32797c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#19e507f5-2e34-4938-ba36-ab0660d9a60f"><rdf:value xml:lang="en">The rate of change of extracellular potassium ion concentration.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#381202dd-b46a-4f25-a29b-f5fb8775c135"><rdf:value xml:lang="en">The voltage-dependent inactivation gate for the L-type calcium
            channel - the y gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#alpha_a_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1814fb0f-f79f-4e7c-8d1f-2449b1fb8720"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#e50a5ea4-de41-4321-8f12-1ae320cbcff5"><rdf:value xml:lang="en">The fast sodium current component contains the differential
            equations governing the influx of sodium ions through the cell
            surface membrane into the cell.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#3d74ad55-3a32-4a31-a3ef-1da4d0955353"><rdf:value xml:lang="en">The "open" RyR's are those P_O1 and P_O2 states.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#2eeac2c4-b1fd-4c67-9abc-062101ce6d2b"><rdf:value xml:lang="en">Calculation of the background sodium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#7cbd6926-4079-4627-aeb4-980877d15eca"><rdf:value xml:lang="en">The sodium component of the channel's current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#ff4606f2-8637-46ad-b862-69e0b88de05e"><rdf:value xml:lang="en">The closing rate of the X gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#60792332-37ac-45fd-aa50-b8c1a538327d"><rdf:value xml:lang="en">The reversal potential of the channel.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#author2Vcard"><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author2VcardN"/></N></rdf:Description><rdf:Description rdf:about="rdf:#1814fb0f-f79f-4e7c-8d1f-2449b1fb8720"><rdf:value xml:lang="en">Rate constants for state changes in mode Ca (corresponding to
            alpha-prime and beta-prime in the JRW paper).</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#390c1948-87ea-4ad5-b84b-e66a3e842826"><rdf:value xml:lang="en">The reversal potential for the background calcium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#5e99f692-2c7a-4340-8804-3d057306f63e"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#238b37c0-734c-4302-a362-9308923fe95c"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#81e8230e-d58b-46cf-987f-6bddcd7ce222"/></cmeta:modifier><rdf:value xml:lang="en">Altered some of the connections.</rdf:value></rdf:Description><rdf:Description rdf:about="#g_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#8d17d79c-9e87-4ff1-877c-cf4000b524fc"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#time_independent_potassium_current"><cmeta:comment><rdf:Description rdf:about="rdf:#1647eb04-92c1-4804-aab6-6fcfb410ad2c"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#p_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#9c262e7e-ab38-4fd7-bd1a-dc1038ecfde3"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#dd0f94a1-be17-4d3c-bf38-7db4369c0bb7"><rdf:value xml:lang="en">The kinetics of the calcium ion concentration changes in the various
            compartments of the model.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#81e8230e-d58b-46cf-987f-6bddcd7ce222"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#6500dd73-a4b9-4662-b0c1-9f430353267a"/></N></rdf:Description><rdf:Description rdf:about="#i_Kp_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#4b84685c-44dc-44c7-b908-38e08c75f7af"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#283ef951-972e-447c-a607-28aa80255764"><rdf:value xml:lang="en">The closing rate of the K1 gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#13a28452-e692-483c-9aa7-02e6c73e7464"><rdf:value xml:lang="en">Calcium is buffered by calmodulin (CMDN) in the subspace and
            myoplasm, and by calsequestrin (CSQN) in the JSR. These are fast
            buffers and their effect is modelled using the rapid buffering
            approximation.</rdf:value></rdf:Description><rdf:Description rdf:about="#J_leak_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#c490f6a1-536d-45b9-b576-97e01c51d188"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#c2b51632-c624-4623-a48a-2e99b50d983b"><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#83ead578-fd46-417f-b817-8c8279dbfa6b"/></EMAIL><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#a3184457-fc32-424b-a737-d2e175838c61"/></N><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#e5230b09-57bf-4174-b900-23270a1719a5"/></ORG></rdf:Description><rdf:Description rdf:about="rdf:#a3184457-fc32-424b-a737-d2e175838c61"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="#Xi_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#13ebb9eb-5ba8-4942-99b3-cbe891cb9d52"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#membrane_voltage_diff_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#5503cefb-15ec-4084-9f59-a87f88601ce3"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#381df5ee-2bac-4704-83f3-032825cce1ea"><rdf:value xml:lang="en">The calcium background current describes a time-independent
            diffusion of Ca ions down their electrochemical gradient through the
            cell surface membrane into the cytosol. However, calcium is not
            allowed to accumulate to high intracellular concentrations. This
            influx is balanced by the Ca ion extrusion through the Na-Ca
            exchanger and the sarcolemmal Ca pump.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#9a872fdc-5a08-4acd-9567-8ffea18211ab"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#4a1b3e75-9ca4-48ee-b22d-1e7795d75a7d"/></N></rdf:Description><rdf:Description rdf:about="rdf:#b1179327-5f99-4cfe-a215-e645b1a9f16f"><rdf:value xml:lang="en">This is the CellML description of Jafri, Rice and Winslow's mathematical model for calcium regulation in the ventricular myocyte. It is based on an accurate model of the membrane currents and adds a more sophisticated model of calcium handling. The JRW model is based on the LR-II model for ventricular action potentials, with several modifications.</rdf:value><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#e1d81e5c-d287-4425-8b52-0aafe161881b"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#b19917af-867f-44ba-ab12-31486eab52de"><rdf:value xml:lang="en">In the JRW model, subcellular calcium regulatory mechanisms are
            described in detail. There are six calcium fluxes to consider;
            J_rel, J_leak, J_up, J_tr, J_xfer and J_trpn. In addition, three
            membrane current fluxes are also necessary for the formulation of
            calcium regulation; i_p_Ca, i_Ca_L_Ca and i_NaCa.</rdf:value></rdf:Description><rdf:Description rdf:about="#f_NaK_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#f690db2d-eb3d-4974-a518-dc77ff82de98"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#0f1ed0e4-6d3c-4b56-98fd-fc7c0d93e2e4"><rdf:value xml:lang="en">The closing rate of the m gate.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#1b23ea30-5d66-4460-91b7-248fa4a6231b"><rdf:value xml:lang="en">The channel's reversal potential.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#2775d603-cc9c-4d0d-8f6a-794b4c5c838c"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2003-06-04</W3CDTF></rdf:Description><rdf:Description rdf:about="#beta_j_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#282e1a65-80d4-4c22-9ea4-7fa13d1b885b"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#919037b1-961d-4081-93ac-a5f50d172ed8"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#e0bd7381-4ec8-492f-996c-8d97fc5a72e5"/></N></rdf:Description><rdf:Description rdf:about="#J_up_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#219f5ab0-c1bc-4800-99db-37938c290bd3"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#35001bc1-312d-4aea-96da-2acbd8b8c2ba"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2002-02-25</W3CDTF></rdf:Description><rdf:Description rdf:about="#E_Kp_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#1b23ea30-5d66-4460-91b7-248fa4a6231b"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#903f5c62-f8f7-4436-9a15-9a235803802d"><rdf:value xml:lang="en">Calculate the translocation flux between the uptake (NSR) and
            release (JSR) stores.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#4587df3a-08b0-46ae-99bc-67d5a2bdd139"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">9512016</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#66e14b47-9a73-4697-bc55-a241e8496dd9"/></JournalArticle></rdf:Description><rdf:Description rdf:about="#EnsCa_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#60792332-37ac-45fd-aa50-b8c1a538327d"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#76fd3acd-1b94-4d41-b8cc-72eac01422bc"><rdf:value xml:lang="en">Calculate some volume fractions as proportions of the total
            myoplasmic volume.</rdf:value></rdf:Description><rdf:Description rdf:about="#gamma_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#77d0a8bd-bbdb-48de-81e8-c3711fe2cf16"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="#E_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#c1809e54-6320-4eae-9d42-372675b76ca5"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#2a82804c-14ac-4488-96b4-897538ff88fd"><rdf:value xml:lang="en">The sarcolemmal calcium pump is an additional mechanism for removing
            Ca ions from the myoplasm to help maintain a low intracellular
            calcium concentration when at rest.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#033e0120-32a3-460a-b3ed-e608fc10acb9"><rdf:value xml:lang="en">Calculation of the time-dependent potassium current.</rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#4dd9aa78-8ef7-4c9e-81f4-c1788f3ed068"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description><rdf:Description rdf:about="rdf:#06a944f9-8b49-4d4c-8e8e-4c798a7bdf45"><modified xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#35001bc1-312d-4aea-96da-2acbd8b8c2ba"/></modified><cmeta:modifier><rdf:Description rdf:about="rdf:#db0581ea-d6d8-4ca9-acbf-4f86cef69467"/></cmeta:modifier><rdf:value xml:lang="en">Corrected several equations.</rdf:value></rdf:Description><rdf:Description rdf:about="#i_Ca_L_K_calculation_eq"><cmeta:comment><rdf:Description rdf:about="rdf:#243419e0-6d85-4733-9b4c-f8546f83b7a4"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#3719ca67-804e-48db-8107-8fc15b437ad3"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2007-05-24T11:52:30+12:00</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#eb0ea281-b5e1-4386-9d7a-ebeaa4ea9477"><rdf:value xml:lang="en">The kinetics of the j gate.</rdf:value></rdf:Description><rdf:Description rdf:about="#sarcolemmal_calcium_pump"><cmeta:comment><rdf:Description rdf:about="rdf:#2a82804c-14ac-4488-96b4-897538ff88fd"/></cmeta:comment></rdf:Description><rdf:Description rdf:about="rdf:#5f5294aa-fcbb-4861-bc45-a1635c90631e"><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Lloyd</Family><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Catherine</Given><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">May</Other></rdf:Description></rdf:RDF></model>