Modelling Human Gastric Acid Secretion
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
Model Structure
Acid secretion from parietal cells in the stomach is a highly regulated, complex, and dynamic process which is optimised to facilitate food digestion. It involves both the central and the enteric nervous systems (CNS and ENS respectively), in addition to a network of paracrine and endocrine cells. The overall aim is to maintain stomach luminal pH within a narrow range such that food digestion is optimised.
Four cell populations and their secretory products form the core acid secretory process in humans. These four cell populations are gastrin (G)- and somatostatin (D)-secreting cells, endochromaffin-like (ECL) cells, and parietal cells. G and ECL cell products stimulate acid secretion (positive feedback) and D cells inhibit acid release (negative feedback). Exactly how these feedback loops interact is species specific, however, the basic requirement for acid secretion is conserved amongst species. Mathematical modelling provides a powerful tool for investigating the integrated system, and it is also immune to the inconsistencies of in vivo and in vitro experimental studies.
In the Joseph et al. 2003 publication described here, the authors use a novel mathematical model to describe the complex system of gastric acid regulation (see and below). They use experimental data to validate their model simulations, and then go onto use the model to study conditions that are not yet experimentally reproducible.
The model has been described here in CellML (the raw CellML description of the Joseph et al. 2003 model can be downloaded in various formats as described in ).
The complete original paper reference is cited below:
A model for integrative study of human gastric acid secretion, Ian M.P. Joseph, Yana Zavros, Juanita L. Merchant, and Denise Kirschner, 2003,
Journal of Applied Physiology
, 94, 1602-1618. (Full text (HTML) and PDF versions of the article are available to subscibers on the Journal of Applied Physiology website.) PubMed ID: 12433865
cell diagram1
Development of G, D, ECL, and parietal cells from the underlying antral and corpus stem cells. A: differentiation within the antrum and B: differentiation within the corpus.
Asc
antral stem cells
Csc
corpus stem cells
G
G cells
DA
antral D cells
DC
corpus D cells
E
ECL cells
P
parietal cells
GtnA
antral gastrin
GtnC
corpus gastrin
SA
antral somatostatin
SC
corpus somatostatin
HC
corpus histamine
AC
corpus gastric acid
AA
antral gastric acid
BC
corpus bicarbonate
BA
corpus bicarbonate
NC
central neural activity
NE
enteric neural activity
gastric
acid secretion
gastric acid
parietal cell
c.lloyd@auckland.ac.nz
A model for integrative study of human gastric acid secretion
94
1602
1618
The University of Auckland, Bioengineering Institute
Juanita
Merchant
L
Ian
Joseph
M
P
Journal of Applied Physiology
This is the CellML description of Joseph et al.'s 2003 mathematical model of human gastric acid secretion.
12433865
Joseph et al.'s 2003 mathematical model of human gastric acid secretion.
2004-04-09
Yana
Zavros
The University of Auckland
The Bioengineering Institute
2003-04
Catherine Lloyd
keyword
Catherine
Lloyd
May
Denise
Kirschner