Location: Leloup, Goldbeter, 2004 @ e69c28888983 / leloup_2004_1.1model.cellml

Author:
Mona Zhu
Date:
2011-01-10 16:12 +1300
Desc:
Adding 1.1 model first time
Permanent Source URI:
http://models.cellml.org/workspace/leloup_goldbeter_2004/rawfile/e69c28888983e70560ba63a8e3493637a67ca5fc/leloup_2004_1.1model.cellml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="leloup_2004_1.1model">

  <units name="hour">
    <unit multiplier="3600.0" units="second"/>
  </units>

  <units name="nanomolar">
    <unit prefix="nano" units="mole"/>
    <unit exponent="-1" units="litre"/>
  </units>

  <units name="flux">
    <unit units="nanomolar"/>
    <unit exponent="-1" units="hour"/>
  </units>

  <units name="first_order_rate_constant">
    <unit exponent="-1" units="hour"/>
  </units>

  <units name="second_order_rate_constant">
    <unit exponent="-1" units="nanomolar"/>
    <unit exponent="-1" units="hour"/>
  </units>
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    <variable name="Kd" private_interface="out" public_interface="in" units="nanomolar"/>
    <variable name="kdn" private_interface="out" public_interface="in" units="first_order_rate_constant"/>
    <variable name="V3B" private_interface="out" public_interface="in" units="flux"/>
    <variable name="V4B" private_interface="out" public_interface="in" units="flux"/>
    <variable name="vdBN" private_interface="out" public_interface="in" units="flux"/>
    <variable name="BN" private_interface="out" public_interface="in" units="nanomolar"/>
    <variable name="time" private_interface="out" public_interface="in" units="hour"/>
    
    
  <variable initial_value="0.1" name="BNP_init" private_interface="out" units="nanomolar"/></component><component xmlns:cmeta="http://www.cellml.org/metadata/1.1#" cmeta:id="IN" name="IN">
      
    <variable cmeta:id="IN_IN" initial_value="IN_init" name="IN" public_interface="out" units="nanomolar"/>
    
    <variable name="Kd" public_interface="in" units="nanomolar"/>
    <variable name="kdn" public_interface="in" units="first_order_rate_constant"/>
    <variable name="k7" public_interface="in" units="second_order_rate_constant"/>
    <variable name="k8" public_interface="in" units="first_order_rate_constant"/>
    <variable name="vdIN" public_interface="in" units="flux"/>
    <variable name="PCN" public_interface="in" units="nanomolar"/>
    <variable name="BN" public_interface="in" units="nanomolar"/>
    <variable name="time" public_interface="in" units="hour"/>
    
    
  <variable initial_value="0.1" name="IN_init" units="nanomolar"/><math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <apply>
          <diff/> 
          <bvar>
            <ci>time</ci>
          </bvar> 
          <ci> IN </ci> 
        </apply>
        <apply>
          <minus/>
          <apply>
            <times/>
            <ci> k7 </ci>
            <ci> BN </ci>
            <ci> PCN </ci>
          </apply>
          <apply>
            <plus/>
            <apply>
              <times/>
              <ci> k8 </ci>
              <ci> IN </ci>
            </apply> 
            <apply>
              <times/>
              <ci> vdIN </ci> 
              <apply>
                <divide/>
                <ci> IN </ci>
                <apply>
                  <plus/>
                  <ci> Kd </ci>
                  <ci> IN </ci>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <ci> kdn </ci>
              <ci> IN </ci>
            </apply> 
          </apply>
        </apply>
      </apply>
    </math></component><component name="model_parameters"> 
    <variable initial_value="0.8" name="k1" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.2" name="k2" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.8" name="k3" public_interface="out" units="second_order_rate_constant"/>
    <variable initial_value="0.2" name="k4" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.4" name="k5" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.2" name="k6" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.5" name="k7" public_interface="out" units="second_order_rate_constant"/>
    <variable initial_value="0.1" name="k8" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.01" name="kdnc" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="0.01" name="kdn" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="1.0" name="kstot" units="first_order_rate_constant"/>
    <variable name="ksB" public_interface="out" units="first_order_rate_constant"/>
    <variable name="ksC" public_interface="out" units="first_order_rate_constant"/>
    <variable name="ksP" public_interface="out" units="first_order_rate_constant"/>
    <variable initial_value="4.0" name="m" public_interface="out" units="dimensionless"/>
    <variable initial_value="4.0" name="n" public_interface="out" units="dimensionless"/>
    <variable initial_value="1.0" name="vstot" public_interface="out" units="flux"/>
    <variable initial_value="0.3" name="Kd" public_interface="out" units="nanomolar"/>
    <variable initial_value="0.3" name="Kdp" public_interface="out" units="nanomolar"/>
    <variable initial_value="0.1" name="Kp" public_interface="out" units="nanomolar"/>
    <variable initial_value="0.6" name="Vphos" units="flux"/>
    <variable initial_value="1.0" name="V1B" public_interface="out" units="flux"/>
    <variable initial_value="0.6" name="V1C" public_interface="out" units="flux"/>
    <variable name="V1P" public_interface="out" units="flux"/>
    <variable name="V1PC" public_interface="out" units="flux"/>
    <variable initial_value="0.1" name="V2B" public_interface="out" units="flux"/>
    <variable initial_value="0.1" name="V2C" public_interface="out" units="flux"/>
    <variable initial_value="0.3" name="V2P" public_interface="out" units="flux"/>
    <variable initial_value="0.1" name="V2PC" public_interface="out" units="flux"/>
    <variable initial_value="1.0" name="V3B" public_interface="out" units="flux"/>
    <variable name="V3PC" public_interface="out" units="flux"/>
    <variable initial_value="0.2" name="V4B" public_interface="out" units="flux"/>
    <variable initial_value="0.1" name="V4PC" public_interface="out" units="flux"/>
    <variable initial_value="1.0" name="vdBC" public_interface="out" units="flux"/>
    <variable initial_value="0.5" name="vdBN" public_interface="out" units="flux"/>
    <variable initial_value="0.7" name="vdCC" public_interface="out" units="flux"/>
    <variable initial_value="0.8" name="vdIN" public_interface="out" units="flux"/>
    <variable initial_value="0.7" name="vdPC" public_interface="out" units="flux"/>
    <variable initial_value="1.0" name="vdPCC" public_interface="out" units="flux"/>
    <variable initial_value="1.0" name="vdPCN" public_interface="out" units="flux"/>
   
    <math xmlns="http://www.w3.org/1998/Math/MathML"> 
      <apply>
        <eq/> 
        <ci> ksB </ci> 
        <ci> kstot </ci>
      </apply>

      <apply>
        <eq/> 
        <ci> ksC </ci> 
        <ci> kstot </ci>
      </apply>

      <apply>
        <eq/> 
        <ci> ksP </ci> 
        <apply>
          <times/>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless"> 0.5 </cn>
          <ci> kstot </ci>
        </apply>
      </apply>

      <apply>
        <eq/> 
        <ci> V1P </ci> 
        <ci> Vphos </ci>
      </apply>

      <apply>
        <eq/> 
        <ci> V1PC </ci> 
        <ci> Vphos </ci>
      </apply>

      <apply>
        <eq/> 
        <ci> V3PC </ci> 
        <ci> Vphos </ci>
      </apply>
    </math>
  </component><connection>
    <map_components component_1="MP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="MC" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="MB" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PC" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="CC" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PCP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="CCP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PCC" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PCN" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PCCP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="PCNP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="BC" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="BCP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="BN" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="BNP" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection><connection>
    <map_components component_1="IN" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <connection>
    <map_components component_1="MP" component_2="BN"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection> 

  <connection>
    <map_components component_1="MP" component_2="model_parameters"/>
    <map_variables variable_1="n" variable_2="n"/>
    <map_variables variable_1="vstot" variable_2="vstot"/>
  </connection>

  <connection>
    <map_components component_1="MC" component_2="BN"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection> 

  <connection>
    <map_components component_1="MC" component_2="model_parameters"/>
    <map_variables variable_1="n" variable_2="n"/>
    <map_variables variable_1="vstot" variable_2="vstot"/>
  </connection>

  <connection>
    <map_components component_1="MB" component_2="BN"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection> 

  <connection>
    <map_components component_1="MB" component_2="model_parameters"/>
    <map_variables variable_1="m" variable_2="m"/>
    <map_variables variable_1="vstot" variable_2="vstot"/>
  </connection>

  <connection>
    <map_components component_1="PC" component_2="MP"/>
    <map_variables variable_1="MP" variable_2="MP"/>
  </connection> 

  <connection>
    <map_components component_1="PC" component_2="PCP"/>
    <map_variables variable_1="PC" variable_2="PC"/>
    <map_variables variable_1="PCP" variable_2="PCP"/>
  </connection> 

  <connection>
    <map_components component_1="PC" component_2="PCC"/>
    <map_variables variable_1="PC" variable_2="PC"/>
    <map_variables variable_1="PCC" variable_2="PCC"/>
  </connection>

  <connection>
    <map_components component_1="PC" component_2="CC"/>
    <map_variables variable_1="PC" variable_2="PC"/>
    <map_variables variable_1="CC" variable_2="CC"/>
  </connection>  

  <connection>
    <map_components component_1="PC" component_2="model_parameters"/>
    <map_variables variable_1="ksP" variable_2="ksP"/>
    <map_variables variable_1="V1P" variable_2="V1P"/>
    <map_variables variable_1="V2P" variable_2="V2P"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k3" variable_2="k3"/>
    <map_variables variable_1="k4" variable_2="k4"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="CC" component_2="MC"/>
    <map_variables variable_1="MC" variable_2="MC"/>
  </connection> 

  <connection>
    <map_components component_1="CC" component_2="CCP"/>
    <map_variables variable_1="CC" variable_2="CC"/>
    <map_variables variable_1="CCP" variable_2="CCP"/>
  </connection> 

  <connection>
    <map_components component_1="CC" component_2="PCC"/>
    <map_variables variable_1="CC" variable_2="CC"/>
    <map_variables variable_1="PCC" variable_2="PCC"/>
  </connection>

  <connection>
    <map_components component_1="CC" component_2="model_parameters"/>
    <map_variables variable_1="ksC" variable_2="ksC"/>
    <map_variables variable_1="V1C" variable_2="V1C"/>
    <map_variables variable_1="V2C" variable_2="V2C"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k3" variable_2="k3"/>
    <map_variables variable_1="k4" variable_2="k4"/>
    <map_variables variable_1="kdnc" variable_2="kdnc"/>
  </connection>

  <connection>
    <map_components component_1="PCP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V1P" variable_2="V1P"/>
    <map_variables variable_1="V2P" variable_2="V2P"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdPC" variable_2="vdPC"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="CCP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V1C" variable_2="V1C"/>
    <map_variables variable_1="V2C" variable_2="V2C"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdCC" variable_2="vdCC"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="PCC" component_2="PCCP"/>
    <map_variables variable_1="PCC" variable_2="PCC"/>
    <map_variables variable_1="PCCP" variable_2="PCCP"/>
  </connection> 

  <connection>
    <map_components component_1="PCC" component_2="PCN"/>
    <map_variables variable_1="PCC" variable_2="PCC"/>
    <map_variables variable_1="PCN" variable_2="PCN"/>
  </connection>

  <connection>
    <map_components component_1="PCC" component_2="model_parameters"/>
    <map_variables variable_1="k1" variable_2="k1"/>
    <map_variables variable_1="k2" variable_2="k2"/>
    <map_variables variable_1="V1PC" variable_2="V1PC"/>
    <map_variables variable_1="V2PC" variable_2="V2PC"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k3" variable_2="k3"/>
    <map_variables variable_1="k4" variable_2="k4"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="PCN" component_2="BN"/>
    <map_variables variable_1="PCN" variable_2="PCN"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection>

  <connection>
    <map_components component_1="PCN" component_2="IN"/>
    <map_variables variable_1="PCN" variable_2="PCN"/>
    <map_variables variable_1="IN" variable_2="IN"/>
  </connection>  

  <connection>
    <map_components component_1="PCNP" component_2="PCN"/>
    <map_variables variable_1="PCNP" variable_2="PCNP"/>
    <map_variables variable_1="PCN" variable_2="PCN"/>
  </connection>

  <connection>
    <map_components component_1="PCN" component_2="model_parameters"/>
    <map_variables variable_1="k1" variable_2="k1"/>
    <map_variables variable_1="k2" variable_2="k2"/>
    <map_variables variable_1="V3PC" variable_2="V3PC"/>
    <map_variables variable_1="V4PC" variable_2="V4PC"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k7" variable_2="k7"/>
    <map_variables variable_1="k8" variable_2="k8"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="PCCP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V1PC" variable_2="V1PC"/>
    <map_variables variable_1="V2PC" variable_2="V2PC"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdPCC" variable_2="vdPCC"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="PCNP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V3PC" variable_2="V3PC"/>
    <map_variables variable_1="V4PC" variable_2="V4PC"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdPCN" variable_2="vdPCN"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="BC" component_2="MB"/>
    <map_variables variable_1="MB" variable_2="MB"/>
  </connection> 

  <connection>
    <map_components component_1="BC" component_2="BCP"/>
    <map_variables variable_1="BC" variable_2="BC"/>
    <map_variables variable_1="BCP" variable_2="BCP"/>
  </connection> 

  <connection>
    <map_components component_1="BC" component_2="BN"/>
    <map_variables variable_1="BC" variable_2="BC"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection>

  <connection>
    <map_components component_1="BC" component_2="model_parameters"/>
    <map_variables variable_1="ksB" variable_2="ksB"/>
    <map_variables variable_1="V1B" variable_2="V1B"/>
    <map_variables variable_1="V2B" variable_2="V2B"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k5" variable_2="k5"/>
    <map_variables variable_1="k6" variable_2="k6"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="BCP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V1B" variable_2="V1B"/>
    <map_variables variable_1="V2B" variable_2="V2B"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdBC" variable_2="vdBC"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="BN" component_2="BNP"/>
    <map_variables variable_1="BN" variable_2="BN"/>
    <map_variables variable_1="BNP" variable_2="BNP"/>
  </connection> 

  <connection>
    <map_components component_1="IN" component_2="BN"/>
    <map_variables variable_1="IN" variable_2="IN"/>
    <map_variables variable_1="BN" variable_2="BN"/>
  </connection>

  <connection>
    <map_components component_1="BN" component_2="model_parameters"/>
    <map_variables variable_1="k7" variable_2="k7"/>
    <map_variables variable_1="k8" variable_2="k8"/>
    <map_variables variable_1="V3B" variable_2="V3B"/>
    <map_variables variable_1="V4B" variable_2="V4B"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="k5" variable_2="k5"/>
    <map_variables variable_1="k6" variable_2="k6"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="BNP" component_2="model_parameters"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="V3B" variable_2="V3B"/>
    <map_variables variable_1="V4B" variable_2="V4B"/>
    <map_variables variable_1="Kp" variable_2="Kp"/>
    <map_variables variable_1="Kdp" variable_2="Kdp"/>
    <map_variables variable_1="vdBN" variable_2="vdBN"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection>

  <connection>
    <map_components component_1="IN" component_2="model_parameters"/>
    <map_variables variable_1="k7" variable_2="k7"/>
    <map_variables variable_1="k8" variable_2="k8"/>
    <map_variables variable_1="Kd" variable_2="Kd"/>
    <map_variables variable_1="vdIN" variable_2="vdIN"/>
    <map_variables variable_1="kdn" variable_2="kdn"/>
  </connection><group><relationship_ref relationship="encapsulation"/><component_ref component="MP"><component_ref component="M_P"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="MC"><component_ref component="M_C"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="MB"><component_ref component="M_B"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="PC"><component_ref component="P_C"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="CC"><component_ref component="C_C"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="PCP"><component_ref component="P_CP"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="CCP"><component_ref component="C_CP"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="PCN"><component_ref component="PC_N"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="PCCP"><component_ref component="PC_CP"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="PCNP"><component_ref component="PC_NP"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="BCP"><component_ref component="B_CP"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="BN"><component_ref component="B_N"/></component_ref></group><group><relationship_ref relationship="encapsulation"/><component_ref component="BNP"><component_ref component="B_NP"/></component_ref></group><connection><map_components component_1="M_P" component_2="MP"/><map_variables variable_1="M" variable_2="MP"/><map_variables variable_1="vs" variable_2="vsP"/><map_variables variable_1="vm" variable_2="vmP"/><map_variables variable_1="kdm" variable_2="kdmp"/><map_variables variable_1="B" variable_2="KAP"/><map_variables variable_1="Km" variable_2="KmP"/><map_variables variable_1="c" variable_2="n"/><map_variables variable_1="A" variable_2="BN"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="M_init" variable_2="MP_init"/></connection><connection><map_components component_1="M_C" component_2="MC"/><map_variables variable_1="M" variable_2="MC"/><map_variables variable_1="vs" variable_2="vsC"/><map_variables variable_1="vm" variable_2="vmC"/><map_variables variable_1="kdm" variable_2="kdmc"/><map_variables variable_1="B" variable_2="KAC"/><map_variables variable_1="Km" variable_2="KmC"/><map_variables variable_1="c" variable_2="n"/><map_variables variable_1="A" variable_2="BN"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="M_init" variable_2="MC_init"/></connection><connection><map_components component_1="M_B" component_2="MB"/><map_variables variable_1="M" variable_2="MB"/><map_variables variable_1="vs" variable_2="vsB"/><map_variables variable_1="vm" variable_2="vmB"/><map_variables variable_1="kdm" variable_2="kdmb"/><map_variables variable_1="B" variable_2="BN"/><map_variables variable_1="Km" variable_2="KmB"/><map_variables variable_1="c" variable_2="m"/><map_variables variable_1="A" variable_2="KIB"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="M_init" variable_2="MB_init"/></connection><connection><map_components component_1="P_C" component_2="PC"/><map_variables variable_1="YC" variable_2="PC"/><map_variables variable_1="ks" variable_2="ksP"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="ka" variable_2="k4"/><map_variables variable_1="kb" variable_2="k3"/><map_variables variable_1="kd" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V1P"/><map_variables variable_1="V2" variable_2="V2P"/><map_variables variable_1="YCP" variable_2="PCP"/><map_variables variable_1="A" variable_2="PCC"/><map_variables variable_1="M" variable_2="MP"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="B" variable_2="CC"/><map_variables variable_1="YC_init" variable_2="PC_init"/></connection><connection><map_components component_1="C_C" component_2="CC"/><map_variables variable_1="YC" variable_2="CC"/><map_variables variable_1="ks" variable_2="ksC"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="ka" variable_2="k4"/><map_variables variable_1="kb" variable_2="k3"/><map_variables variable_1="kd" variable_2="kdnc"/><map_variables variable_1="V1" variable_2="V1C"/><map_variables variable_1="V2" variable_2="V2C"/><map_variables variable_1="YCP" variable_2="CCP"/><map_variables variable_1="A" variable_2="PCC"/><map_variables variable_1="M" variable_2="MC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="B" variable_2="PC"/><map_variables variable_1="YC_init" variable_2="CC_init"/></connection><connection><map_components component_1="P_CP" component_2="PCP"/><map_variables variable_1="YCP" variable_2="PCP"/><map_variables variable_1="vd" variable_2="vdPC"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V1P"/><map_variables variable_1="V2" variable_2="V2P"/><map_variables variable_1="YC" variable_2="PC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="PCP_init"/></connection><connection><map_components component_1="C_CP" component_2="CCP"/><map_variables variable_1="YCP" variable_2="CCP"/><map_variables variable_1="vd" variable_2="vdCC"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V1C"/><map_variables variable_1="V2" variable_2="V2C"/><map_variables variable_1="YC" variable_2="CC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="CCP_init"/></connection><connection><map_components component_1="PC_CP" component_2="PCCP"/><map_variables variable_1="YCP" variable_2="PCCP"/><map_variables variable_1="vd" variable_2="vdPCC"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V1PC"/><map_variables variable_1="V2" variable_2="V2PC"/><map_variables variable_1="YC" variable_2="PCC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="PCCP_init"/></connection><connection><map_components component_1="PC_NP" component_2="PCNP"/><map_variables variable_1="YCP" variable_2="PCNP"/><map_variables variable_1="vd" variable_2="vdPCN"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V3PC"/><map_variables variable_1="V2" variable_2="V4PC"/><map_variables variable_1="YC" variable_2="PCN"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="PCNP_init"/></connection><connection><map_components component_1="B_CP" component_2="BCP"/><map_variables variable_1="YCP" variable_2="BCP"/><map_variables variable_1="vd" variable_2="vdBC"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V1B"/><map_variables variable_1="V2" variable_2="V2B"/><map_variables variable_1="YC" variable_2="BC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="BCP_init"/></connection><connection><map_components component_1="B_NP" component_2="BNP"/><map_variables variable_1="YCP" variable_2="BNP"/><map_variables variable_1="vd" variable_2="vdBN"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="Kd" variable_2="Kd"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V3B"/><map_variables variable_1="V2" variable_2="V4B"/><map_variables variable_1="YC" variable_2="BN"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="YCP_init" variable_2="BNP_init"/></connection><connection><map_components component_1="PC_N" component_2="PCN"/><map_variables variable_1="Y" variable_2="PCN"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="kc" variable_2="k7"/><map_variables variable_1="ke" variable_2="k8"/><map_variables variable_1="kb" variable_2="k1"/><map_variables variable_1="ka" variable_2="k2"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V3PC"/><map_variables variable_1="V2" variable_2="V4PC"/><map_variables variable_1="YP" variable_2="PCNP"/><map_variables variable_1="E" variable_2="IN"/><map_variables variable_1="A" variable_2="PCC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="C" variable_2="BN"/><map_variables variable_1="Y_init" variable_2="PCN_init"/></connection><connection><map_components component_1="B_N" component_2="BN"/><map_variables variable_1="Y" variable_2="BN"/><map_variables variable_1="Kp" variable_2="Kp"/><map_variables variable_1="Kdp" variable_2="Kdp"/><map_variables variable_1="kc" variable_2="k7"/><map_variables variable_1="ke" variable_2="k8"/><map_variables variable_1="kb" variable_2="k5"/><map_variables variable_1="ka" variable_2="k6"/><map_variables variable_1="kdn" variable_2="kdn"/><map_variables variable_1="V1" variable_2="V3B"/><map_variables variable_1="V2" variable_2="V4B"/><map_variables variable_1="YP" variable_2="BNP"/><map_variables variable_1="E" variable_2="IN"/><map_variables variable_1="A" variable_2="BC"/><map_variables variable_1="time" variable_2="time"/><map_variables variable_1="C" variable_2="PCN"/><map_variables variable_1="Y_init" variable_2="BN_init"/></connection></model>