Mitochondrial Ca2+ Handling
Catherine
Lloyd
Bioengineering Institute, University of Auckland
Model Status
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
Model Structure
In 1997 Gerhard Magnus and Joel Keizer published a minimal mathematical model to describe Ca2+ handling by mitochondria in the pancreatic beta-cell. Their kinetic model includes six transport mechanisms in the inner mitochondrial membrane, including proton pumping via respiration and proton pumping by the F0F1-ATPase, a proton leak, adenine nucleotide exchange, the Ca2+ uniporter and Na+/Ca2+ exchange (see below).
The complete original paper reference is cited below:
Minimal model of beta-cell mitochondrial Ca2+ handling, Gerhard Magnus and Joel Keizer, 1997,
American Journal of Physiology
, 273, C717-C733. PubMed ID: 9277370
The raw CellML description of the mitochondrial Ca2+ handling model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.
diagram of the mitochondrial Ca2+ handling model showing ionic currents across the mitochondrial membrane
A schematic representation of the ion fluxes through the mitochondrial inner membrane that are included in the Magnus-Keizer minimal model.
the cellml rendering of the mitochondrial Ca2+ handling model
The network defined in the CellML description of the mitochondrial Ca2+ handling model.
calcium dynamics
electrophysiology
beta cell
Pancreatic Beta-Cell
mitochondria
Catherine
Lloyd
May
The University of Auckland
The Bioengineering Research Group
Corrected units.
Autumn
Cuellar
A.
Joel
Keizer
E
Catherine
Lloyd
May
Catherine
Lloyd
May
2002-01-21
Minimal Model of beta-cell mitochondrial Ca2+ handling
273
C717
C733
2003-04-09
2003-08-12
Corrected equations: JH_F1 in F0_F1_ATPase component, J_uni in
Ca_uniporter component.
2002-03-01
Catherine
Lloyd
May
This is the CellML description of Gerhard Magnus and Joel Keizer's
1997 minimal model of beta-call mitochondrial Ca2+ handling. They
developed a simplified mathematical model to describe Ca2+ handling by
mitochondria in pancreatic beta-cells.
Added publication date information.
1997-08
Minimal model of beta-cell mitochondrial Ca2+ handling
Pancreatic Beta-cell
Catherine Lloyd
2002-07-22
Corrected several equations.
Added more metadata.
Updated metadata to conform to the 16/1/02 CellML Metadata 1.0
Specification.
The University of Auckland, Bioengineering Research Group
c.lloyd@auckland.ac.nz
Gerhard
Magnus
9277370
Autumn
Cuellar
A
Catherine
Lloyd
May
2002-01-11
American Journal of Physoiology
keyword
2002-02-26