Noble Ventricular Cell Model 1998
Penny
Noble
Oxford University
Model Status
This version of the model has been curated and unit checked and is known to run in PCEnv, COR and Jsim. A PCEnv session file is also available for this model.
Model Structure
The Noble98 (Noble et al. 1998) model of the guinea-pig ventricular cell was a development of the Noble91 (Noble et al. 1991) model and included representation of the components of IK, (IKr and IKs), the persistent sodium current and a dyadic space between the sarcolemma and the sarcoplasmic reticulum. In several important respects this model was a major improvement on the earlier model. However on rigorous testing for new applications problems associated with the calcium dynamics equations were found in the new model.
The model demonstrated here is an attempt at 'correcting' the inability of Noble98 to reproduce a mechanism of initiation of Early After-Depolarizations (EADs), the voltage-dependence of calcium release from the sarcoplasmic reticulum (SR) and also to improve the shape of the calcium transient.
model diagram
Schematic diagram of the cell model.
Journal of Physiology
Department of Physiology, Anatomy & Genetics, University of Oxford
keyword
calcium dynamics
cardiac
electrophysiology
ventricular myocyte
guinea pig
penny.noble@dpag.ox.ac.uk
2007-09-06T10:33:50+12:00
This version of the model has been curated and unit checked and is known to run in PCEnv, COR and Jsim. A PCEnv session file is also available for this model.
James
Lawson
Richard
100000
0.001
Penny
Noble
2007-05-17T00:00:00+00:00
INaCads was not included in the dCads/dt ODE and hence the system was out
of balance. This issue has been fixed in version 05
2001-01-01
Units checked, curated.
Penny
Noble
The Noble98 (Noble et al. 1998) model of the guinea-pig ventricular cell was a development of the Noble91 (Noble et al. 1991) model and included representation of the components of IK, (IKr and IKs), the persistent sodium current and a dyadic space between the sarcolemma and the sarcoplasmic reticulum. In several important respects this model was a major improvement on the earlier model. However on rigorous testing for new applications problems associated with the calcium dynamics equations were found in the new model.
The model demonstrated here is an attempt at 'correcting' the inability of Noble98 to reproduce a mechanism of initiation of Early After-Depolarizations (EADs), the voltage-dependence of calcium release from the sarcoplasmic reticulum (SR) and also to improve the shape of the calcium transient.
James Lawson
Penny
Noble
J
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
2007-12-04T15:19:56+13:00
Dennis
Noble
Remodelling of Calcium Dynamics in Guinea-Pig Ventricular Cells
James Lawson
2008-05-14T03:19:46+12:00
Penny
Noble
J
Oxford University
Department of Physiology, Anatomy & Genetics