Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes
Penny
Noble
Oxford University
Model Status
This version has been curated and unit checked by Penny Noble and is known to run into COR and PCEnv. This variant is parameterised for the BASIC model, excluding acetylcholine dependent modulation and electromechanical processes. This model is also associated with a PCEnv session file.
Model Structure
ABSTRACT: The guinea-pig ventricular cell model, originally developed by Noble et al in 1991, has been greatly extended to include accumulation and depletion of calcium in a diadic space between the sarcolemma and the sarcoplasmic reticulum where, according to contempory understanding, the majority of calcium-induced calcium release is triggered. The calcium in this space is also assumed to play the major role in calcium-induced inactivation of the calcium current. Delayed potassium current equations have been developed to include the rapid (IKr) and slow (IKs) components of the delayed rectifier current based on the data of of Heath and Terrar, along with data from Sanguinetti and Jurkiewicz. Length- and tension-dependent changes in mechanical and electrophysiological processes have been incorporated as described recently by Kohl et al. Drug receptor interactions have started to be developed, using the sodium channel as the first target. The new model has been tested against experimental data on action potential clamp, and on force-interval and duration-interval relations; it has been found to reliably reproduce experimental observations.
The original paper reference is cited below:
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes, Denis Noble, Anthony Varghese, Peter Kohl and Penelope Noble, 1998, Can J Cardiol, 14, 123-134. PubMed ID: 9487284
cell diagram of Noble'98 model showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum
A schematic diagram describing the current flows across the cell membrane that are captured in the Noble'98 model.
Changed stim_end in stimulus protocol from 10.1 to 1,000,000 seconds
Penny
Noble
This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 1 is parameterised for the 'basic' model.
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.
14(1)
123
134
Penny
Noble
J
D
Noble
James Lawson
1998-01-01 00:00
2007-06-22T14:01:50+12:00
Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.
Units checked, curated.
James
Lawson
Richard
keyword
diadic space
excitation-contraction coupling
Ventricular Myocyte
ventricular myocyte
electrophysiology
myofilament mechanics
cardiac
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes (Basic Model)
Department of Physiology, Anatomy & Genetics, University of Oxford
James Lawson
James
Lawson
Richard
2007-12-04T15:09:12+13:00
This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is parameterised for the BASIC model, excluding acetylcholine dependent modulation and electromechanical processes.
A
Varghese
Several variables have been given cmeta:id's to allow creation of a PCEnv session file.
Penny
Noble
J
2007-02-06T14:05:00+13:00
2007-09-06T12:57:25+12:00
2007-05-03T00:00:00+00:00
University of Oxford
Department of Physiology, Anatomy & Genetics
This model has been curated by Penny Noble of Oxford University
2007-07-18T12:58:29+12:00
Penny
Noble
J
2008-05-14T03:12:08+12:00
James
Lawson
Richard
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
9487284
P
Noble
50000
0.001
Canadian Journal of Cardiology
100000
0.001
bdf15
P
Kohl
penny.noble@dpag.ox.ac.uk