- Author:
- James Lawson <j.lawson@auckland.ac.nz>
- Date:
- 2009-08-20 14:30:53+12:00
- Desc:
- initial commit
- Permanent Source URI:
- http://models.cellml.org/workspace/oyehaug_ostby_lloyd_omholt_einevoll_2011/rawfile/6679b711dbe6d44bdd9792f771217f0de14c31e7/oyehaug_2009_version2.cellml
<?xml version="1.0" encoding="utf-8"?>
<model xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="oyehaug_2009" cmeta:id="oyehaug_2009_2" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Potassium-mediated positive feedback in astroglia-neuron interaction</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model is a tranlsation based on the orignal paper and Matlab code. The model runs in both COR and OpenCell to recreate the published results. This particular version of the model recreates Figure 2B, with a stimulus duration of 0.4s.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: The chain of events where a neural activity-induced elevation of the extracellular space (ECS) potassium concentration ([K+]o) is followed by a decreased neuronal firing threshold which in turn causes increased neural activity, represents a positive feedback loop. Here we combine a relatively detailed model of glial membrane transport of water and ions and a Hodgkin-Huxley type neuron model to examine the effectof perturbing the magnitudes of transport rates in the glial membrane that may influence this feedback. The perturbations reflect pathological conditions and/or heterogeneity in glial membrane transporter density. When exposed to elevated [K+]o, the combined model responds either (i) by a brief period of neuronal firing followed by a rapid drop in [K+]o or (ii) by a much longer period where the neuron experiences depolarization block during which [K+]o first increases and later slowly returns to baseline levels. By solving the model equations repeatedly for a large number of empirically valid parameter sets, we find that both the high [K+]o-induced duration of neuronal firing and the prevalence of depolarization block show high sensitivities to variation in the time scale of the glial membrane dynamics and to the magnitudes of the sodium-potassium pump rate and the potassium ion channel conductance. In contrast, firing duration is much less sensitive to perturbations of the magnitude of Na+/K+/2Cl- (NKCC1) cotransporter permeability and Na+/2HCO-3 (NBC) cotransporter conductance. An analysis focusing on the model's ability to fire spontaneously discloses the feedback mechanism and allows us to predict which combinations of ion concentrations that give rise to spontaneous firing of action potentials. The results suggest that when [K+]o becomes elevated, spatiotemporal heterogenity of ion and water transport across the astroglialmembrane in the brainmay cause very different potassium clearance profiles that are possibly of biomedical importance. The above insights point to the importance of combining neuronal and astroglial models of some sophistication in order to disclose phenomena associated with the astroglia-neuron interaction.
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<imagedata fileref="oyehaug_2009.png"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the model displaying the channels, pumps and exchangers allowing ion transfer between the neuron, the extracellular matrix and the glia.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="Vm_n">
<dc:title>Vm_n</dc:title>
<dcterms:alternative>neuron membrane potential</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_NaT">
<dc:title>i_NaT</dc:title>
<dcterms:alternative>transient sodium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_NaP">
<dc:title>i_NaP</dc:title>
<dcterms:alternative>persistent sodium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_KDR">
<dc:title>i_KDR</dc:title>
<dcterms:alternative>delayed rectifier potassium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_KA">
<dc:title>i_KA</dc:title>
<dcterms:alternative>transient potassium current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_NaKATPase_n">
<dc:title>i_NaKATPase_n</dc:title>
<dcterms:alternative>neuron sodium-potassium pump</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_leakNa">
<dc:title>i_leakNa</dc:title>
<dcterms:alternative>sodium leak current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_leakK">
<dc:title>i_leakK</dc:title>
<dcterms:alternative>potassium leak current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="i_leakf">
<dc:title>i_leakf</dc:title>
<dcterms:alternative>unspecified ion leak current</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="Vm_g">
<dc:title>Vm_g</dc:title>
<dcterms:alternative>glial membrane potential</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="J_Na">
<dc:title>J_Na</dc:title>
<dcterms:alternative>glial transmembrane sodium ion flux</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="J_K">
<dc:title>J_K</dc:title>
<dcterms:alternative>glial transmembrane potassium ion flux</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="J_NaKATPase_g">
<dc:title>J_NaKATPase_g</dc:title>
<dcterms:alternative>glial transmembrane sodium-potassium ion flux via the NaK pump</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="J_NBC">
<dc:title>J_NBC</dc:title>
<dcterms:alternative>glial transmembrane sodium and bicarbonate ion flux via the NBC cotransporter</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="J_NKCC1">
<dc:title>J_NKCC1</dc:title>
<dcterms:alternative>glial transmembrane sodium potassium and chloride ion flux via the NKCC1 cotransporter</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="N_Nag">
<dc:title>N_Nag</dc:title>
<dcterms:alternative>number of sodium ions per unit glial area</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="N_Kg">
<dc:title>N_Kg</dc:title>
<dcterms:alternative>number of potassium ions per unit glial area</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="wg">
<dc:title>wg</dc:title>
<dcterms:alternative>ratio of glial volume to glial area</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="wo">
<dc:title>wo</dc:title>
<dcterms:alternative>extracellular space volume to area ratio</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="N_Nao">
<dc:title>N_Nao</dc:title>
<dcterms:alternative>number of sodium ions in the extracellular space</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="N_Ko">
<dc:title>N_Ko</dc:title>
<dcterms:alternative>number of potassium ions in the extracellular space</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="N_HCO3o">
<dc:title>N_HCO3o</dc:title>
<dcterms:alternative>number of bicarbonate ions in the extracellular space</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#">
<rdf:Description rdf:about="electric_potentials">
<dc:title>electric_potentials</dc:title>
<dcterms:alternative>electric potentials</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millivolt">
<unit units="millivolt" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millisecond">
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millisecond_millivolt">
<unit units="millisecond" exponent="-1"/>
<unit units="millivolt" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="microS_per_cm2">
<unit units="siemens" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="cm2">
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nanoA_per_cm2">
<unit units="ampere" prefix="nano"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_nanoA_second">
<unit units="millimolar"/>
<unit units="ampere" prefix="nano" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_microA_second">
<unit units="millimolar"/>
<unit units="ampere" prefix="micro" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="microF_per_cm2">
<unit units="farad" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_micrometre">
<unit units="millimolar"/>
<unit units="micrometre"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="mole_per_cm2_second">
<unit units="mole"/>
<unit units="metre" prefix="centi" exponent="-2"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="cm_per_second_millimolar">
<unit units="metre" prefix="centi"/>
<unit units="second" exponent="-1"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="micrometre_cm2">
<unit units="metre" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_cm2">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="picomole_per_cm2_millisecond">
<unit units="mole" prefix="pico"/>
<unit units="metre" prefix="centi" exponent="-2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nanomole_per_cm2">
<unit units="mole" prefix="nano"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nanomole_per_cm2_millisecond">
<unit units="mole" prefix="nano"/>
<unit units="metre" prefix="centi" exponent="-2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="cm2_micrometre">
<unit units="metre" prefix="centi" exponent="2"/>
<unit units="metre" prefix="micro"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="micrometre_per_centimetre">
<unit units="metre" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-1"/>
</units>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="environment">
<variable name="time" units="millisecond" public_interface="out"/>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Vm_n">
<variable name="Vm_n" units="millivolt" initial_value="-70" public_interface="out"/>
<variable name="i_app" units="nanoA_per_cm2"/>
<variable name="Cm" units="microF_per_cm2" initial_value="1"/>
<variable name="t0" units="millisecond" initial_value="100"/>
<variable name="t1" units="millisecond" initial_value="500"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="i_NaT" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_NaP" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_leakNa" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_KDR" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_KA" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_leakK" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_leakf" units="nanoA_per_cm2" public_interface="in"/>
<variable name="i_NaKATPase_n" units="nanoA_per_cm2" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Vm_n</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_NaT</ci>
<ci>i_NaP</ci>
<ci>i_leakNa</ci>
<ci>i_KDR</ci>
<ci>i_KA</ci>
<ci>i_leakK</ci>
<ci>i_leakf</ci>
<ci>i_NaKATPase_n</ci>
</apply>
</apply>
<ci>i_app</ci>
</apply>
</apply>
<ci>Cm</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_app</ci>
<piecewise>
<piece>
<cn cellml:units="nanoA_per_cm2">1500</cn>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>t0</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>t1</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="nanoA_per_cm2">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaT">
<variable name="i_NaT" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_NaT" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gNaT" units="microS_per_cm2" initial_value="5000"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENa_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="Vm_n" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaT</ci>
<apply>
<times/>
<ci>gNaT</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NaT</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gNaT</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaT_m_gate">
<variable name="m" units="dimensionless" initial_value="0.005" public_interface="out"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond_millivolt">0.32</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="millivolt">51.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.25</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">12.975</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond_millivolt">0.28</cn>
<apply>
<plus/>
<ci>Vm_n</ci>
<cn cellml:units="millivolt">24.89</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">4.978</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaT_h_gate">
<variable name="h" units="dimensionless" initial_value="0.9961" public_interface="out"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.128</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.056</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">2.94</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">4</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">6</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaP">
<variable name="i_NaP" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_NaP" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gNaP" units="microS_per_cm2" initial_value="150"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENa_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="Vm_n" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaP</ci>
<apply>
<times/>
<ci>gNaP</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NaP</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gNaP</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaP_m_gate">
<variable name="m" units="dimensionless" initial_value="0.0129" public_interface="out"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="tau_activation" units="millisecond" initial_value="6"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>tau_activation</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.143</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">5.67</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>tau_activation</ci>
</apply>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.143</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">5.67</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.143</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">5.67</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaP_h_gate">
<variable name="h" units="dimensionless" initial_value="0.9718" public_interface="out"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millisecond">5.12<sep/>-8</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.056</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">2.94</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn type="e-notation" cellml:units="per_millisecond">1.6<sep/>-6</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">8</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_KDR">
<variable name="i_KDR" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_KDR" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gKDR" units="microS_per_cm2" initial_value="5000"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="EK_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="Vm_n" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="n" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KDR</ci>
<apply>
<times/>
<ci>gKDR</ci>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_KDR</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gKDR</ci>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_KDR_n_gate">
<variable name="n" units="dimensionless" initial_value="0.0012" public_interface="out"/>
<variable name="alpha_n" units="per_millisecond"/>
<variable name="beta_n" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond_millivolt">0.016</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="millivolt">34.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">6.98</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.25</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.025</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">1.25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>n</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_n</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_n</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_KA">
<variable name="i_KA" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_KA" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gKA" units="microS_per_cm2" initial_value="1000"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="EK_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="Vm_n" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_KA</ci>
<apply>
<times/>
<ci>gKA</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_KA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gKA</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_KA_m_gate">
<variable name="m" units="dimensionless" initial_value="0.1193" public_interface="out"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond_millivolt">0.02</cn>
<apply>
<minus/>
<apply>
<minus/>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="millivolt">56.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">5.69</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond_millivolt">0.0175</cn>
<apply>
<plus/>
<ci>Vm_n</ci>
<cn cellml:units="millivolt">29.9</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.1</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">2.99</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_KA_h_gate">
<variable name="h" units="dimensionless" initial_value="0.1205" public_interface="out"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.016</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.056</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">4.61</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">0.5</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2</cn>
<ci>Vm_n</ci>
</apply>
<cn cellml:units="dimensionless">11.98</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_NaKATPase_n">
<variable name="i_NaKATPase_n" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_NaKATPase_n" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="I_NaKATPase_n_max" units="picomole_per_cm2_millisecond" initial_value="0.0289"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="KmNa" units="millimolar" public_interface="in"/>
<variable name="KmK" units="millimolar" public_interface="in"/>
<variable name="Nan" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaKATPase_n</ci>
<apply>
<times/>
<ci>J_NaKATPase_n</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NaKATPase_n</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>I_NaKATPase_n_max</ci>
<apply>
<power/>
<ci>Nan</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Nan</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
<apply>
<power/>
<ci>KmNa</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_leakNa">
<variable name="i_leakNa" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_leakNa" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gleakNa" units="microS_per_cm2" initial_value="20"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENa_n" units="millivolt" public_interface="in"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_leakNa</ci>
<apply>
<times/>
<ci>gleakNa</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leakNa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gleakNa</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>ENa_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_leakK">
<variable name="i_leakK" units="nanoA_per_cm2" public_interface="out"/>
<variable name="J_leakK" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gleakK" units="microS_per_cm2" initial_value="66.06"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="EK_n" units="millivolt" public_interface="in"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_leakK</ci>
<apply>
<times/>
<ci>gleakK</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leakK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gleakK</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>EK_n</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="i_leakf">
<variable name="i_leakf" units="nanoA_per_cm2" public_interface="out"/>
<variable name="gleakf" units="microS_per_cm2" initial_value="10"/>
<variable name="Ef_n" units="millivolt" public_interface="in"/>
<variable name="Vm_n" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_leakf</ci>
<apply>
<times/>
<ci>gleakf</ci>
<apply>
<minus/>
<ci>Vm_n</ci>
<ci>Ef_n</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Vm_g">
<variable name="Vm_g" units="millivolt" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENa_g" units="millivolt" public_interface="in"/>
<variable name="EK_g" units="millivolt" public_interface="in"/>
<variable name="ECl_g" units="millivolt" public_interface="in"/>
<variable name="ENBC_g" units="millivolt" public_interface="in"/>
<variable name="gNa" units="microS_per_cm2" public_interface="in"/>
<variable name="gK" units="microS_per_cm2" public_interface="in"/>
<variable name="gCl" units="microS_per_cm2" public_interface="in"/>
<variable name="gNBC" units="microS_per_cm2" public_interface="in"/>
<variable name="J_NaKATPase_g" units="picomole_per_cm2_millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vm_g</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>gNa</ci>
<ci>ENa_g</ci>
</apply>
<apply>
<times/>
<ci>gK</ci>
<ci>EK_g</ci>
</apply>
<apply>
<times/>
<ci>gCl</ci>
<ci>ECl_g</ci>
</apply>
<apply>
<times/>
<ci>gNBC</ci>
<ci>ENBC_g</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>gNa</ci>
<ci>gK</ci>
<ci>gCl</ci>
<ci>gNBC</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>J_NaKATPase_g</ci>
</apply>
<apply>
<plus/>
<ci>gNa</ci>
<ci>gK</ci>
<ci>gCl</ci>
<ci>gNBC</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="J_Na">
<variable name="J_Na" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gNa" units="microS_per_cm2" initial_value="5" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENa_g" units="millivolt" public_interface="in"/>
<variable name="Vm_g" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gNa</ci>
<apply>
<minus/>
<ci>Vm_g</ci>
<ci>ENa_g</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="J_K">
<variable name="J_K" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gK" units="microS_per_cm2" initial_value="84.81" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="EK_g" units="millivolt" public_interface="in"/>
<variable name="Vm_g" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gK</ci>
<apply>
<minus/>
<ci>Vm_g</ci>
<ci>EK_g</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="J_NaKATPase_g">
<variable name="J_NaKATPase_g" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="I_NaKATPase_g_max" units="picomole_per_cm2_millisecond" initial_value="0.0058"/>
<variable name="KmNa" units="millimolar" public_interface="in"/>
<variable name="KmK" units="millimolar" public_interface="in"/>
<variable name="Nag" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NaKATPase_g</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>I_NaKATPase_g_max</ci>
<apply>
<power/>
<ci>Nag</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Nag</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
<apply>
<power/>
<ci>KmNa</ci>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmK</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="J_NBC">
<variable name="J_NBC" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gNBC" units="microS_per_cm2" initial_value="80" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="ENBC_g" units="millivolt" public_interface="in"/>
<variable name="Vm_g" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NBC</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>gNBC</ci>
<apply>
<minus/>
<ci>Vm_g</ci>
<ci>ENBC_g</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="J_NKCC1">
<variable name="J_NKCC1" units="picomole_per_cm2_millisecond" public_interface="out"/>
<variable name="gNKCC1" units="microS_per_cm2" initial_value="2"/>
<variable name="Psi" units="millivolt" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nag" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="P_Ko" units="millimolar" public_interface="in"/>
<variable name="Kg" units="millimolar" public_interface="in"/>
<variable name="Clo" units="millimolar" public_interface="in"/>
<variable name="Clg" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NKCC1</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<power/>
<apply>
<minus/>
<ci>Ko</ci>
<ci>P_Ko</ci>
</apply>
<cn cellml:units="dimensionless">10</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<apply>
<minus/>
<ci>Ko</ci>
<ci>P_Ko</ci>
</apply>
<cn cellml:units="dimensionless">10</cn>
</apply>
<apply>
<power/>
<cn cellml:units="millimolar">0.03</cn>
<cn cellml:units="dimensionless">10</cn>
</apply>
</apply>
</apply>
<ci>Psi</ci>
<ci>gNKCC1</ci>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Kg</ci>
</apply>
<ci>Nao</ci>
</apply>
<ci>Nag</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Clo</ci>
<ci>Clg</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<ci>F</ci>
</apply>
<apply>
<gt/>
<ci>Ko</ci>
<ci>P_Ko</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="picomole_per_cm2_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="N_Nag">
<variable name="N_Nag" units="nanomole_per_cm2" initial_value="0.75" public_interface="out"/>
<variable name="dN_Nag_dt" units="nanomole_per_cm2_millisecond" public_interface="out"/>
<variable name="J_Na" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NaKATPase_g" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NKCC1" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NBC" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N_Nag</ci>
</apply>
<ci>dN_Nag_dt</ci>
</apply>
<apply>
<eq/>
<ci>dN_Nag_dt</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01</cn>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_Na</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>J_NaKATPase_g</ci>
</apply>
</apply>
<ci>J_NKCC1</ci>
<ci>J_NBC</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="N_Kg">
<variable name="N_Kg" units="nanomole_per_cm2" initial_value="5" public_interface="out"/>
<variable name="dN_Kg_dt" units="nanomole_per_cm2_millisecond" public_interface="out"/>
<variable name="J_K" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NaKATPase_g" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NKCC1" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N_Kg</ci>
</apply>
<ci>dN_Kg_dt</ci>
</apply>
<apply>
<eq/>
<ci>dN_Kg_dt</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_K</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_NaKATPase_g</ci>
</apply>
<ci>J_NKCC1</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="wg">
<variable name="wg" units="micrometre" initial_value="0.05" public_interface="out"/>
<variable name="Lp" units="cm_per_second_millimolar" public_interface="in"/>
<variable name="Xg" units="millimolar_micrometre" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Clo" units="millimolar" public_interface="in"/>
<variable name="HCO3o" units="millimolar" public_interface="in"/>
<variable name="Nag" units="millimolar" public_interface="in"/>
<variable name="Kg" units="millimolar" public_interface="in"/>
<variable name="Clg" units="millimolar" public_interface="in"/>
<variable name="HCO3g" units="millimolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>wg</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">10</cn>
<ci>Lp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Nag</ci>
<ci>Kg</ci>
<ci>Clg</ci>
<ci>HCO3g</ci>
<apply>
<divide/>
<ci>Xg</ci>
<ci>wg</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Nao</ci>
<ci>Ko</ci>
<ci>Clo</ci>
<ci>HCO3o</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="wo">
<variable name="wo" units="micrometre" public_interface="out"/>
<variable name="P_wo" units="micrometre" public_interface="in"/>
<variable name="P_wg" units="micrometre" public_interface="in"/>
<variable name="wg" units="micrometre" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>wo</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>P_wg</ci>
<ci>P_wo</ci>
</apply>
<ci>wg</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="N_Nao">
<variable name="N_Nao" units="nanomole_per_cm2" initial_value="3.65" public_interface="out"/>
<variable name="J_NaT" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NaKATPase_n" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NaP" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_leakNa" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="dN_Nag_dt" units="nanomole_per_cm2_millisecond" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N_Nao</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01</cn>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>J_NaKATPase_n</ci>
</apply>
<ci>J_NaT</ci>
<ci>J_NaP</ci>
<ci>J_leakNa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">100</cn>
<ci>dN_Nag_dt</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="N_Ko">
<variable name="N_Ko" units="nanomole_per_cm2" initial_value="0.075" public_interface="out"/>
<variable name="J_KDR" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_NaKATPase_n" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_KA" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="J_leakK" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="dN_Kg_dt" units="nanomole_per_cm2_millisecond" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N_Ko</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01</cn>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_KDR</ci>
<ci>J_KA</ci>
<ci>J_leakK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_NaKATPase_n</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">100</cn>
<ci>dN_Kg_dt</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="N_HCO3o">
<variable name="N_HCO3o" units="nanomole_per_cm2" initial_value="0.375" public_interface="out"/>
<variable name="J_NBC" units="picomole_per_cm2_millisecond" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>N_HCO3o</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.01</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>J_NBC</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="electric_potentials">
<variable name="ENa_n" units="millivolt" public_interface="out"/>
<variable name="EK_n" units="millivolt" public_interface="out"/>
<variable name="Ef_n" units="millivolt" initial_value="-70" public_interface="out"/>
<variable name="ENa_g" units="millivolt" public_interface="out"/>
<variable name="EK_g" units="millivolt" public_interface="out"/>
<variable name="ECl_g" units="millivolt" public_interface="out"/>
<variable name="ENBC_g" units="millivolt" public_interface="out"/>
<variable name="Psi" units="millivolt" public_interface="in"/>
<variable name="Nan" units="millimolar" public_interface="in"/>
<variable name="Nag" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Kn" units="millimolar" public_interface="in"/>
<variable name="Kg" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="HCO3g" units="millimolar" public_interface="in"/>
<variable name="HCO3o" units="millimolar" public_interface="in"/>
<variable name="Clg" units="millimolar" public_interface="in"/>
<variable name="Clo" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ENa_n</ci>
<apply>
<times/>
<ci>Psi</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nan</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK_n</ci>
<apply>
<times/>
<ci>Psi</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Kn</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENa_g</ci>
<apply>
<times/>
<ci>Psi</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nag</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK_g</ci>
<apply>
<times/>
<ci>Psi</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Kg</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ECl_g</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>Psi</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Clo</ci>
<ci>Clg</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ENBC_g</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Psi</ci>
</apply>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nag</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>HCO3o</ci>
<ci>HCO3g</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ion_concentrations">
<variable name="Clo" units="millimolar" public_interface="out"/>
<variable name="Cln" units="millimolar" public_interface="out"/>
<variable name="Clg" units="millimolar" public_interface="out"/>
<variable name="Nan" units="millimolar" public_interface="out"/>
<variable name="Nao" units="millimolar" public_interface="out"/>
<variable name="Nag" units="millimolar" public_interface="out"/>
<variable name="Kn" units="millimolar" public_interface="out"/>
<variable name="Ko" units="millimolar" public_interface="out"/>
<variable name="Kg" units="millimolar" public_interface="out"/>
<variable name="HCO3g" units="millimolar" public_interface="out"/>
<variable name="HCO3o" units="millimolar" public_interface="out"/>
<variable name="P_Ko" units="millimolar" initial_value="3" public_interface="out"/>
<variable name="P_Vm_g" units="millivolt" initial_value="-85"/>
<variable name="P_Clo" units="millimolar"/>
<variable name="P_Cln" units="millimolar" initial_value="50"/>
<variable name="P_Clg" units="millimolar"/>
<variable name="P_Nan" units="millimolar" initial_value="10"/>
<variable name="P_Nao" units="millimolar" initial_value="146"/>
<variable name="P_Nag" units="millimolar" initial_value="15"/>
<variable name="P_Kn" units="millimolar" initial_value="130"/>
<variable name="P_Kg" units="millimolar" initial_value="100"/>
<variable name="P_HCO3g" units="millimolar"/>
<variable name="P_HCO3o" units="millimolar" initial_value="15"/>
<variable name="P_wn" units="micrometre" initial_value="0.05"/>
<variable name="Psi" units="millivolt" public_interface="in"/>
<variable name="P_wo" units="micrometre" public_interface="in"/>
<variable name="P_wg" units="micrometre" public_interface="in"/>
<variable name="Vm_g" units="millivolt" public_interface="in"/>
<variable name="wo" units="micrometre" public_interface="in"/>
<variable name="wg" units="micrometre" public_interface="in"/>
<variable name="Xg" units="millimolar_micrometre" public_interface="in"/>
<variable name="rho" units="dimensionless" public_interface="in"/>
<variable name="N_Kg" units="nanomole_per_cm2" public_interface="in"/>
<variable name="N_Ko" units="nanomole_per_cm2" public_interface="in"/>
<variable name="N_Nag" units="nanomole_per_cm2" public_interface="in"/>
<variable name="N_Nao" units="nanomole_per_cm2" public_interface="in"/>
<variable name="N_HCO3o" units="nanomole_per_cm2" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_Clo</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>P_Nao</ci>
<ci>P_Ko</ci>
</apply>
<ci>P_HCO3o</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P_HCO3g</ci>
<apply>
<times/>
<ci>P_HCO3o</ci>
<apply>
<root/>
<apply>
<times/>
<apply>
<divide/>
<ci>P_Nao</ci>
<ci>P_Nag</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<ci>P_Vm_g</ci>
<ci>Psi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_Clg</ci>
<apply>
<times/>
<ci>P_Clo</ci>
<apply>
<exp/>
<apply>
<divide/>
<ci>P_Vm_g</ci>
<ci>Psi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kg</ci>
<apply>
<divide/>
<ci>N_Kg</ci>
<ci>wg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Ko</ci>
<apply>
<divide/>
<ci>N_Ko</ci>
<ci>wo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Kn</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>P_wn</ci>
<ci>P_Kn</ci>
</apply>
<apply>
<times/>
<ci>P_wg</ci>
<ci>P_Kg</ci>
</apply>
<apply>
<times/>
<ci>P_wo</ci>
<ci>P_Ko</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>N_Ko</ci>
<ci>N_Kg</ci>
</apply>
</apply>
<ci>P_wn</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Nag</ci>
<apply>
<divide/>
<ci>N_Nag</ci>
<ci>wg</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Nao</ci>
<apply>
<divide/>
<ci>N_Nao</ci>
<ci>wo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Nan</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>P_wn</ci>
<ci>P_Nan</ci>
</apply>
<apply>
<times/>
<ci>P_wg</ci>
<ci>P_Nag</ci>
</apply>
<apply>
<times/>
<ci>P_wo</ci>
<ci>P_Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>N_Nao</ci>
<ci>N_Nag</ci>
</apply>
</apply>
<ci>P_wn</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Clg</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>Nag</ci>
<ci>Kg</ci>
</apply>
<apply>
<plus/>
<ci>HCO3g</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>rho</ci>
<ci>Xg</ci>
</apply>
<ci>wg</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cln</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>P_Cln</ci>
<ci>Nan</ci>
</apply>
<ci>P_Nan</ci>
</apply>
<apply>
<minus/>
<ci>Kn</ci>
<ci>P_Kn</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Clo</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>P_wg</ci>
<ci>P_Clg</ci>
</apply>
<apply>
<times/>
<ci>P_wo</ci>
<ci>P_Clo</ci>
</apply>
<apply>
<times/>
<ci>P_wn</ci>
<ci>P_Cln</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>wg</ci>
<ci>Clg</ci>
</apply>
<apply>
<times/>
<ci>P_wn</ci>
<ci>Cln</ci>
</apply>
</apply>
</apply>
<ci>wo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HCO3o</ci>
<apply>
<divide/>
<ci>N_HCO3o</ci>
<ci>wo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>HCO3g</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>P_wg</ci>
<ci>P_HCO3g</ci>
</apply>
<apply>
<times/>
<ci>P_wo</ci>
<ci>P_HCO3o</ci>
</apply>
</apply>
<ci>N_HCO3o</ci>
</apply>
<ci>wg</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="model_parameters">
<variable name="Psi" units="millivolt" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" initial_value="9.649e4" public_interface="out"/>
<variable name="KmNa" units="millimolar" initial_value="10" public_interface="out"/>
<variable name="KmK" units="millimolar" initial_value="1.5" public_interface="out"/>
<variable name="gCl" units="microS_per_cm2" initial_value="50" public_interface="out"/>
<variable name="Lp" units="cm_per_second_millimolar" initial_value="2e-8" public_interface="out"/>
<variable name="Xg" units="millimolar_micrometre" initial_value="8.45" public_interface="out"/>
<variable name="rho" units="dimensionless" initial_value="0.5975" public_interface="out"/>
<variable name="P_wo" units="micrometre" initial_value="0.025" public_interface="out"/>
<variable name="P_wg" units="micrometre" initial_value="0.05" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" initial_value="8.315"/>
<variable name="T" units="kelvin" initial_value="300"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Psi</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1000</cn>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="encapsulation"/>
<component_ref component="i_NaT">
<component_ref component="i_NaT_m_gate"/>
<component_ref component="i_NaT_h_gate"/>
</component_ref>
<component_ref component="i_NaP">
<component_ref component="i_NaP_m_gate"/>
<component_ref component="i_NaP_h_gate"/>
</component_ref>
<component_ref component="i_KDR">
<component_ref component="i_KDR_n_gate"/>
</component_ref>
<component_ref component="i_KA">
<component_ref component="i_KA_m_gate"/>
<component_ref component="i_KA_h_gate"/>
</component_ref>
</group>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Vm_n" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaT" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaP" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KDR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KA" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Nag" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Kg" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="wg" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Nao" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Ko" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_HCO3o" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaT" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_NaT" variable_2="i_NaT"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaP" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_NaP" variable_2="i_NaP"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KDR" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_KDR" variable_2="i_KDR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KA" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_KA" variable_2="i_KA"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_leakNa" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_leakNa" variable_2="i_leakNa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_leakK" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_leakK" variable_2="i_leakK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_leakf" component_2="Vm_n"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
<map_variables variable_1="i_leakf" variable_2="i_leakf"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaKATPase_n" component_2="Vm_n"/>
<map_variables variable_1="i_NaKATPase_n" variable_2="i_NaKATPase_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_Na" component_2="Vm_g"/>
<map_variables variable_1="Vm_g" variable_2="Vm_g"/>
<map_variables variable_1="gNa" variable_2="gNa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_K" component_2="Vm_g"/>
<map_variables variable_1="Vm_g" variable_2="Vm_g"/>
<map_variables variable_1="gK" variable_2="gK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NBC" component_2="Vm_g"/>
<map_variables variable_1="Vm_g" variable_2="Vm_g"/>
<map_variables variable_1="gNBC" variable_2="gNBC"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="Vm_g"/>
<map_variables variable_1="gCl" variable_2="gCl"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NaKATPase_g" component_2="Vm_g"/>
<map_variables variable_1="J_NaKATPase_g" variable_2="J_NaKATPase_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_NaT"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_NaP"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_KDR"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_KA"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_leakK"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_leakNa"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="J_Na"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="J_K"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_NaT"/>
<map_variables variable_1="ENa_n" variable_2="ENa_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_NaP"/>
<map_variables variable_1="ENa_n" variable_2="ENa_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_KDR"/>
<map_variables variable_1="EK_n" variable_2="EK_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_KA"/>
<map_variables variable_1="EK_n" variable_2="EK_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_leakNa"/>
<map_variables variable_1="ENa_n" variable_2="ENa_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_leakK"/>
<map_variables variable_1="EK_n" variable_2="EK_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="i_leakf"/>
<map_variables variable_1="Ef_n" variable_2="Ef_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="Vm_g"/>
<map_variables variable_1="EK_g" variable_2="EK_g"/>
<map_variables variable_1="ENa_g" variable_2="ENa_g"/>
<map_variables variable_1="ENBC_g" variable_2="ENBC_g"/>
<map_variables variable_1="ECl_g" variable_2="ECl_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="Vm_g"/>
<map_variables variable_1="Vm_g" variable_2="Vm_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="J_Na"/>
<map_variables variable_1="ENa_g" variable_2="ENa_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="J_K"/>
<map_variables variable_1="EK_g" variable_2="EK_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="electric_potentials" component_2="J_NBC"/>
<map_variables variable_1="ENBC_g" variable_2="ENBC_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="J_NBC"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="i_NaKATPase_n"/>
<map_variables variable_1="KmNa" variable_2="KmNa"/>
<map_variables variable_1="KmK" variable_2="KmK"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="i_NaKATPase_n"/>
<map_variables variable_1="Nan" variable_2="Nan"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="J_NaKATPase_g"/>
<map_variables variable_1="KmNa" variable_2="KmNa"/>
<map_variables variable_1="KmK" variable_2="KmK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="J_NaKATPase_g"/>
<map_variables variable_1="Nag" variable_2="Nag"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="J_NKCC1"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Psi" variable_2="Psi"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="J_NKCC1"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nag" variable_2="Nag"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Kg" variable_2="Kg"/>
<map_variables variable_1="Clo" variable_2="Clo"/>
<map_variables variable_1="Clg" variable_2="Clg"/>
<map_variables variable_1="P_Ko" variable_2="P_Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="wg"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nag" variable_2="Nag"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Kg" variable_2="Kg"/>
<map_variables variable_1="Clo" variable_2="Clo"/>
<map_variables variable_1="Clg" variable_2="Clg"/>
<map_variables variable_1="HCO3o" variable_2="HCO3o"/>
<map_variables variable_1="HCO3g" variable_2="HCO3g"/>
<map_variables variable_1="wg" variable_2="wg"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="wg"/>
<map_variables variable_1="Lp" variable_2="Lp"/>
<map_variables variable_1="Xg" variable_2="Xg"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="ion_concentrations"/>
<map_variables variable_1="rho" variable_2="rho"/>
<map_variables variable_1="Xg" variable_2="Xg"/>
<map_variables variable_1="P_wg" variable_2="P_wg"/>
<map_variables variable_1="P_wo" variable_2="P_wo"/>
<map_variables variable_1="Psi" variable_2="Psi"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="wo" component_2="wg"/>
<map_variables variable_1="wg" variable_2="wg"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="wo"/>
<map_variables variable_1="wo" variable_2="wo"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="wo"/>
<map_variables variable_1="P_wg" variable_2="P_wg"/>
<map_variables variable_1="P_wo" variable_2="P_wo"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="electric_potentials"/>
<map_variables variable_1="Psi" variable_2="Psi"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="electric_potentials"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nag" variable_2="Nag"/>
<map_variables variable_1="Nan" variable_2="Nan"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Kg" variable_2="Kg"/>
<map_variables variable_1="Kn" variable_2="Kn"/>
<map_variables variable_1="Clo" variable_2="Clo"/>
<map_variables variable_1="Clg" variable_2="Clg"/>
<map_variables variable_1="HCO3o" variable_2="HCO3o"/>
<map_variables variable_1="HCO3g" variable_2="HCO3g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="N_Nag"/>
<map_variables variable_1="N_Nag" variable_2="N_Nag"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="N_Nao"/>
<map_variables variable_1="N_Nao" variable_2="N_Nao"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="N_Kg"/>
<map_variables variable_1="N_Kg" variable_2="N_Kg"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="N_Ko"/>
<map_variables variable_1="N_Ko" variable_2="N_Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_concentrations" component_2="N_HCO3o"/>
<map_variables variable_1="N_HCO3o" variable_2="N_HCO3o"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_Na" component_2="N_Nag"/>
<map_variables variable_1="J_Na" variable_2="J_Na"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NaKATPase_g" component_2="N_Nag"/>
<map_variables variable_1="J_NaKATPase_g" variable_2="J_NaKATPase_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NKCC1" component_2="N_Nag"/>
<map_variables variable_1="J_NKCC1" variable_2="J_NKCC1"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NBC" component_2="N_Nag"/>
<map_variables variable_1="J_NBC" variable_2="J_NBC"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Nao" component_2="N_Nag"/>
<map_variables variable_1="dN_Nag_dt" variable_2="dN_Nag_dt"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_K" component_2="N_Kg"/>
<map_variables variable_1="J_K" variable_2="J_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NKCC1" component_2="N_Kg"/>
<map_variables variable_1="J_NKCC1" variable_2="J_NKCC1"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NaKATPase_g" component_2="N_Kg"/>
<map_variables variable_1="J_NaKATPase_g" variable_2="J_NaKATPase_g"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="N_Ko" component_2="N_Kg"/>
<map_variables variable_1="dN_Kg_dt" variable_2="dN_Kg_dt"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaT" component_2="N_Nao"/>
<map_variables variable_1="J_NaT" variable_2="J_NaT"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaKATPase_n" component_2="N_Nao"/>
<map_variables variable_1="J_NaKATPase_n" variable_2="J_NaKATPase_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaP" component_2="N_Nao"/>
<map_variables variable_1="J_NaP" variable_2="J_NaP"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_leakNa" component_2="N_Nao"/>
<map_variables variable_1="J_leakNa" variable_2="J_leakNa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KDR" component_2="N_Ko"/>
<map_variables variable_1="J_KDR" variable_2="J_KDR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaKATPase_n" component_2="N_Ko"/>
<map_variables variable_1="J_NaKATPase_n" variable_2="J_NaKATPase_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KA" component_2="N_Ko"/>
<map_variables variable_1="J_KA" variable_2="J_KA"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_leakK" component_2="N_Ko"/>
<map_variables variable_1="J_leakK" variable_2="J_leakK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="J_NBC" component_2="N_HCO3o"/>
<map_variables variable_1="J_NBC" variable_2="J_NBC"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaT" component_2="i_NaT_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaT" component_2="i_NaT_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaP" component_2="i_NaP_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_NaP" component_2="i_NaP_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KDR" component_2="i_KDR_n_gate"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KA" component_2="i_KA_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="i_KA" component_2="i_KA_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_n" variable_2="Vm_n"/>
</connection>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#9e75dceb-cb6f-4a44-ac36-da9b34da629d">
<rdf:li rdf:resource="rdf:#169fcff3-1375-4ca9-828a-7e6436552ec6" />
<rdf:li rdf:resource="rdf:#2605a5e6-4d66-4db8-9f4d-6781a8101410" />
<rdf:li rdf:resource="rdf:#38024b0b-d176-41e9-9010-9c8dbdf0a5e8" />
<rdf:li rdf:resource="rdf:#9efe7711-a918-4f32-9115-e323198cbd54" />
<rdf:li rdf:resource="rdf:#39f539fa-9873-4ede-854a-c0bfa589c4b6" />
<rdf:li rdf:resource="rdf:#82c61aae-bbc3-4a5b-bd68-a28dafc3a5f3" />
</rdf:Seq>
<rdf:Description rdf:about="rdf:#31d559c2-9752-4ec8-b61a-aaff2c3770e6">
<vCard:Given>Liev</vCard:Given>
<vCard:Family>Oyehaug</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>Auckland Bioengineering Institute</dc:publisher>
<cmeta:comment rdf:resource="rdf:#a56cbd4f-bc34-41ad-b106-75bc4d349198" />
<dcterms:created rdf:resource="rdf:#64ae067a-4958-4683-9297-8812670ffeb3" />
<dc:creator rdf:resource="rdf:#ab2d7152-2677-4c03-b2a9-8ed3aca0c126" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#9efe7711-a918-4f32-9115-e323198cbd54">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#e7cf7b46-a0be-434a-afe6-e56f012c4a7e" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#27d672e7-e602-4d16-a84c-6529b0033074">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
<vCard:Other>May</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1fa5ee60-acc3-456c-8c86-416ecbef051c">
<vCard:Given>Stig</vCard:Given>
<vCard:Family>Omholt</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#38a00abb-c802-4379-8227-fefc01753194">
<vCard:FN />
</rdf:Description>
<rdf:Description rdf:about="rdf:#a56cbd4f-bc34-41ad-b106-75bc4d349198">
<dc:creator rdf:resource="rdf:#38a00abb-c802-4379-8227-fefc01753194" />
<rdf:value />
</rdf:Description>
<rdf:Description rdf:about="#oyehaug_2009_2">
<bqs:reference rdf:resource="rdf:#ae7727bb-e525-4797-a6be-787a8ab66e45" />
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>neurobiology</rdf:li>
<rdf:li>astroglia</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<cmeta:comment rdf:resource="rdf:#2b440321-05b8-42ed-a9aa-6fb420623739" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#64ae067a-4958-4683-9297-8812670ffeb3">
<dcterms:W3CDTF>2009-08-20T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#38024b0b-d176-41e9-9010-9c8dbdf0a5e8">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#ce8168f6-3597-4f34-93f1-e94ac362693a" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#565baca1-6b5a-40b1-9484-240a76309206">
<vCard:Given>Ivar</vCard:Given>
<vCard:Family>Ostby</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ce8168f6-3597-4f34-93f1-e94ac362693a">
<vCard:Given>Catherine</vCard:Given>
<vCard:Family>Lloyd</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e7cf7b46-a0be-434a-afe6-e56f012c4a7e">
<vCard:Given>Ole</vCard:Given>
<vCard:Family>Ottersen</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2b440321-05b8-42ed-a9aa-6fb420623739">
<dc:creator rdf:resource="rdf:#d342c70a-8efb-463b-8f7b-c320c2fded1b" />
<rdf:value />
</rdf:Description>
<rdf:Description rdf:about="rdf:#2605a5e6-4d66-4db8-9f4d-6781a8101410">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#565baca1-6b5a-40b1-9484-240a76309206" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#9445f2b0-49ee-4f9b-a492-54ad533a76be">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
<rdf:value>c.lloyd@auckland.ac.nz</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39f539fa-9873-4ede-854a-c0bfa589c4b6">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#1fa5ee60-acc3-456c-8c86-416ecbef051c" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#c0aaa7df-cd13-4f08-b22f-61c0b5556e7a">
<dcterms:W3CDTF>2009-00-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d05074df-8e7a-49a4-9e35-17b7f858587b">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>CellML Team</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#da0bf4f5-5ea9-45c1-b36c-e48ec7cb1086">
<vCard:Given>Gaute</vCard:Given>
<vCard:Family>Einevoll</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ab2d7152-2677-4c03-b2a9-8ed3aca0c126">
<vCard:ORG rdf:resource="rdf:#d05074df-8e7a-49a4-9e35-17b7f858587b" />
<vCard:EMAIL rdf:resource="rdf:#9445f2b0-49ee-4f9b-a492-54ad533a76be" />
<vCard:N rdf:resource="rdf:#27d672e7-e602-4d16-a84c-6529b0033074" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#ad8900c0-e678-4016-93fa-3a99101134af">
<dc:title />
</rdf:Description>
<rdf:Description rdf:about="rdf:#ae7727bb-e525-4797-a6be-787a8ab66e45">
<bqs:Pubmed_id />
<bqs:JournalArticle rdf:resource="rdf:#307baf49-9722-4700-8d7f-ce9f63559d2e" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#169fcff3-1375-4ca9-828a-7e6436552ec6">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#31d559c2-9752-4ec8-b61a-aaff2c3770e6" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#82c61aae-bbc3-4a5b-bd68-a28dafc3a5f3">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person" />
<vCard:N rdf:resource="rdf:#da0bf4f5-5ea9-45c1-b36c-e48ec7cb1086" />
</rdf:Description>
<rdf:Description rdf:about="rdf:#307baf49-9722-4700-8d7f-ce9f63559d2e">
<dc:creator rdf:resource="rdf:#9e75dceb-cb6f-4a44-ac36-da9b34da629d" />
<dc:title>Potassium-mediated positive feedback in astroglia-neuron interaction</dc:title>
<bqs:volume />
<bqs:first_page />
<bqs:Journal rdf:resource="rdf:#ad8900c0-e678-4016-93fa-3a99101134af" />
<dcterms:issued rdf:resource="rdf:#c0aaa7df-cd13-4f08-b22f-61c0b5556e7a" />
<bqs:last_page />
</rdf:Description>
<rdf:Description rdf:about="rdf:#d342c70a-8efb-463b-8f7b-c320c2fded1b">
<vCard:FN />
</rdf:Description>
</rdf:RDF>
</model>
