- Author:
- Catherine Lloyd <c.lloyd@auckland.ac.nz>
- Date:
- 2010-06-23 21:03:31+12:00
- Desc:
- Removed specific path to Hanne's hard drive from session b.
- Permanent Source URI:
- http://models.cellml.org/workspace/pasek_simurda_christe_2006/rawfile/ef00e23f867d0766a70061f78c969de378619ee2/pasek_model_2006_tubular_membrane.cellml
<?xml version="1.0" encoding="utf-8"?>
<model name="pasek_model_2006_tubular_membrane" cmeta:id="pasek_model_2006_tubular_membrane" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<units name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="per_millivolt_second">
<unit units="millivolt" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millivolt2">
<unit units="volt" prefix="milli" exponent="-2"/>
</units>
<units name="milliS">
<unit units="siemens" prefix="milli"/>
</units>
<units name="milliS_per_cm2">
<unit units="siemens" prefix="milli"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units name="microA_per_cm2">
<unit units="ampere" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units name="cm2">
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units name="cm_per_second">
<unit units="metre" prefix="centi"/>
<unit units="second" exponent="-1"/>
</units>
<units name="cm3_per_second">
<unit units="metre" prefix="centi" exponent="3"/>
<unit units="second" exponent="-1"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="microA">
<unit units="ampere" prefix="micro"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar_per_second">
<unit units="millimolar" exponent="-1"/>
<unit units="second" exponent="-1"/>
</units>
<units name="per_millimolar3_per_second">
<unit units="millimolar" exponent="-3"/>
<unit units="second" exponent="-1"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="microA_per_millimolar">
<unit units="microA"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit units="kelvin" exponent="-1"/>
<unit units="mole" prefix="kilo" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="mole_per_coulomb">
<unit units="coulomb_per_mole" exponent="-1"/>
</units>
<units name="micro_litre">
<unit units="litre" prefix="micro"/>
</units>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
In order to facilitate the import of this tubular membrane model by the main Pasek 2008 model I will encapsulate the current model in a top component called "tubular_membrane".
</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Catherine Lloyd</vCard:FN>
</dc:creator>
</cmeta:comment>
<component name="tubular_membrane" cmeta:id="tubular_membrane">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/0P/PP-rdf-syntax-ns#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/">
<rdf:Description rdf:about="tubular_membrane">
<dc:title>tubular_membrane</dc:title>
<dcterms:alternative>top component which encapsulates the entire tubular membrane model</dcterms:alternative>
</rdf:Description>
</rdf:RDF>
<variable name="Vm_t" units="millivolt" public_interface="out" private_interface="in"/>
<variable name="i_Na_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_Ca_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_Kto_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_Kss_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_fNa_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_fK_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_K1_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_BNa_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_BK_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_BCa_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_NaK_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_NaCa_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="i_CaP_t" units="microA" public_interface="out" private_interface="in"/>
<variable name="time" public_interface="in" private_interface="out" units="second"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in" private_interface="out"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in" private_interface="out"/>
<variable name="Na_t" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_t" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="K_t" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Na_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_ss" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="K_i" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="i_circ" units="microA" public_interface="in" private_interface="out"/>
<variable name="Cmt" units="microF" public_interface="in" private_interface="out"/>
<variable name="Sms" units="cm2" public_interface="in" private_interface="out"/>
<variable name="Smt" units="cm2" public_interface="in" private_interface="out"/>
</component>
<!-- 1.1 connections -->
<connection>
<map_components component_1="membrane" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="Vm_t" variable_1="Vm_t"/>
<map_variables variable_1="i_circ" variable_2="i_circ"/>
<map_variables variable_2="Cmt" variable_1="Cmt"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Na_t" variable_1="Na_t"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_2="K_t" variable_1="K_t"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
<map_variables variable_1="i_Na_t" variable_2="i_Na_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="calcium_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Ca_t" variable_1="Ca_t"/>
<map_variables variable_2="Ca_ss" variable_1="Ca_ss"/>
<map_variables variable_1="i_Ca_t" variable_2="i_Ca_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="K_t" variable_1="K_t"/>
<map_variables variable_2="K_i" variable_1="K_i"/>
<map_variables variable_1="i_Kto_t" variable_2="i_Kto_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="i_Kss_t" variable_2="i_Kss_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="K_t" variable_1="K_t"/>
<map_variables variable_1="i_K1_t" variable_2="i_K1_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="i_fNa_t" variable_2="i_fNa_t"/>
<map_variables variable_1="i_fK_t" variable_2="i_fK_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="sarcolemmal_calcium_pump_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="i_CaP_t" variable_2="i_CaP_t"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="Na_Ca_ion_exchanger_current" component_2="tubular_membrane"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_2="Na_t" variable_1="Na_t"/>
<map_variables variable_2="Ca_t" variable_1="Ca_t"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="Ca_i" variable_1="Ca_i"/>
<map_variables variable_1="i_NaCa_t" variable_2="i_NaCa_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="tubular_membrane"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Na_t" variable_1="Na_t"/>
<map_variables variable_2="Na_i" variable_1="Na_i"/>
<map_variables variable_2="K_t" variable_1="K_t"/>
<map_variables variable_1="i_NaK_t" variable_2="i_NaK_t"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="tubular_membrane"/>
<map_variables variable_2="R" variable_1="R"/>
<map_variables variable_2="T" variable_1="T"/>
<map_variables variable_2="F" variable_1="F"/>
<map_variables variable_2="Ca_t" variable_1="Ca_t"/>
<map_variables variable_1="i_BNa_t" variable_2="i_BNa_t"/>
<map_variables variable_1="i_BK_t" variable_2="i_BK_t"/>
<map_variables variable_1="i_BCa_t" variable_2="i_BCa_t"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_2="Sms" variable_1="Sms"/>
<map_variables variable_2="Smt" variable_1="Smt"/>
</connection>
<!-- surface membrane model -->
<component name="membrane">
<variable name="Vm_t" units="millivolt" initial_value="-7.9709536e1" public_interface="out"/>
<variable name="Cmt" units="microF" public_interface="in"/>
<variable name="i_circ" units="microA" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="i_Na_t" units="microA" public_interface="in"/>
<variable name="i_Ca_t" units="microA" public_interface="in"/>
<variable name="i_Kto_t" units="microA" public_interface="in"/>
<variable name="i_Kss_t" units="microA" public_interface="in"/>
<variable name="i_f_t" units="microA" public_interface="in"/>
<variable name="i_K1_t" units="microA" public_interface="in"/>
<variable name="i_B_t" units="microA" public_interface="in"/>
<variable name="i_NaK_t" units="microA" public_interface="in"/>
<variable name="i_NaCa_t" units="microA" public_interface="in"/>
<variable name="i_CaP_t" units="microA" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Vm_t</ci>
</apply>
<apply><times/>
<cn cellml:units="dimensionless">1000</cn>
<apply><divide/>
<apply><minus/>
<apply><plus/>
<ci>i_circ</ci>
<ci>i_Na_t</ci>
<ci>i_Ca_t</ci>
<ci>i_Kto_t</ci>
<ci>i_Kss_t</ci>
<ci>i_f_t</ci>
<ci>i_K1_t</ci>
<ci>i_B_t</ci>
<ci>i_NaK_t</ci>
<ci>i_NaCa_t</ci>
<ci>i_CaP_t</ci>
</apply>
</apply>
<ci>Cmt</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current">
<variable name="i_Na_t" units="microA" public_interface="out"/>
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="g_Na" units="milliS_per_cm2" initial_value="10.0"/>
<variable name="g_Nat" units="milliS"/>
<variable name="fNat" units="dimensionless" initial_value="0.56"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_t" units="millimolar" public_interface="in"/>
<variable name="K_i" units="millimolar" public_interface="in"/>
<variable name="K_t" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm_t" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Na_t</ci>
<ci>Na_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_t</ci>
<apply>
<times/>
<ci>g_Nat</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<apply>
<times/>
<apply>
<log/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Na_t</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_t</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Na_i</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>g_Nat</ci>
<apply><times/>
<ci>g_Na</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fNat</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_m_gate">
<variable name="m" units="dimensionless" initial_value="2.1832694e-6" public_interface="out"/>
<variable name="alpha_m" units="per_second"/>
<variable name="beta_m" units="per_second"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">117.26</cn>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">59.3</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.55</cn>
</apply>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">59.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_second">3800</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.072</cn>
</apply>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">61</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_current_h_gate">
<variable name="h" units="dimensionless" initial_value="5.8232717e-1" public_interface="out"/>
<variable name="alpha_h" units="per_second"/>
<variable name="beta_h" units="per_second"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<apply>
<divide/>
<cn cellml:units="per_second">284.4</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0812</cn>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">115.9</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_second">18.77</cn>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">64.4</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.22</cn>
</apply>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">64.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_current">
<variable name="i_Ca_t" units="microA" public_interface="out"/>
<variable name="Co" units="dimensionless" initial_value="2.5436520e-6"/>
<variable name="C_cast" units="dimensionless" initial_value="9.9570063e-1"/>
<variable name="C1" units="dimensionless" initial_value="9.9785393e-1"/>
<variable name="C2" units="dimensionless" initial_value="9.9994546e-1"/>
<variable name="tauCo" units="second"/>
<variable name="tauC_cast" units="second" initial_value="0.009"/>
<variable name="tauC1" units="second"/>
<variable name="tauC2" units="second"/>
<variable name="Co_inf" units="dimensionless"/>
<variable name="C_cast_inf" units="dimensionless"/>
<variable name="C1_inf" units="dimensionless"/>
<variable name="C2_inf" units="dimensionless"/>
<variable name="g_Ca" units="cm_per_second" initial_value="0.00021"/>
<variable name="g_Cat" units="cm3_per_second"/>
<variable name="fCat" units="dimensionless" initial_value="0.87"/>
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<minus/>
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<ci>C1_inf</ci>
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<plus/>
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<cn cellml:units="millivolt">25</cn>
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<divide/>
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<minus/>
<ci>C1_inf</ci>
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<ci>tauC1</ci>
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<ci>C2_inf</ci>
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<plus/>
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<plus/>
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<cn cellml:units="millivolt">5.4</cn>
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<eq/>
<ci>tauC2</ci>
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<plus/>
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<times/>
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<exp/>
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<minus/>
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<power/>
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<divide/>
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<plus/>
<ci>Vm_t</ci>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
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<plus/>
<ci>Vm_t</ci>
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<apply>
<minus/>
<cn cellml:units="millivolt">5</cn>
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<apply>
<divide/>
<cn cellml:units="second">0.015</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
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<plus/>
<ci>Vm_t</ci>
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<cn cellml:units="millivolt">25</cn>
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<cn cellml:units="second">0.0017</cn>
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<eq/>
<apply>
<diff/>
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<ci>time</ci>
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<ci>C2</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>C2_inf</ci>
<ci>C2</ci>
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<ci>tauC2</ci>
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<eq/>
<ci>C_cast_inf</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<divide/>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>C_cast</ci>
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<divide/>
<apply>
<minus/>
<ci>C_cast_inf</ci>
<ci>C_cast</ci>
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<ci>tauC_cast</ci>
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<ci>g_Cat</ci>
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<ci>g_Ca</ci>
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<ci>Sms</ci>
<ci>Smt</ci>
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<ci>g_Cat</ci>
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<ci>Vm_t</ci>
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<ci>R</ci>
<ci>T</ci>
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<ci>Vm_t</ci>
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<ci>Ca_t</ci>
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<ci>R</ci>
<ci>T</ci>
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<cn cellml:units="dimensionless">1</cn>
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<apply><plus/>
<cn cellml:units="dimensionless">0.9</cn>
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<ci>C1</ci>
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<ci>C2</ci>
</apply>
</apply>
</apply>
</apply>
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<component name="Ca_independent_transient_outward_K_current">
<variable name="i_Kto_t" units="microA" public_interface="out"/>
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<variable name="Smt" units="cm2" public_interface="in"/>
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<variable name="K_i" units="millimolar" public_interface="in"/>
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<variable name="s" units="dimensionless" private_interface="in"/>
<variable name="s_slow" units="dimensionless" private_interface="in"/>
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<eq/>
<ci>E_K</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
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<ln/>
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<ci>K_i</ci>
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<eq/>
<ci>i_Kto_t</ci>
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<plus/>
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<times/>
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<times/>
<ci>b</ci>
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<minus/>
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<ci>g_Kto</ci>
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<ci>Sms</ci>
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<ci>fKtot</ci>
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</apply>
</math>
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<component name="Ca_independent_transient_outward_K_current_r_gate">
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<variable name="tau_r" units="second"/>
<variable name="r_max" units="dimensionless"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<eq/>
<ci>r_max</ci>
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<cn cellml:units="dimensionless">1</cn>
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<plus/>
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<exp/>
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<divide/>
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<plus/>
<ci>Vm_t</ci>
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<minus/>
<cn cellml:units="millivolt">11.42</cn>
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<ci>tau_r</ci>
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<plus/>
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<times/>
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<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
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<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">50</cn>
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<times/>
<cn cellml:units="dimensionless">98.9</cn>
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<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
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<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">38</cn>
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</apply>
</apply>
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<eq/>
<apply>
<diff/>
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<divide/>
<apply>
<minus/>
<ci>r_max</ci>
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<ci>tau_r</ci>
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</apply>
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<component name="Ca_independent_transient_outward_K_current_s_gate">
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<variable name="tau_t" units="second"/>
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<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<eq/>
<ci>s_max</ci>
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<divide/>
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<plus/>
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<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
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<cn cellml:units="millivolt">6.8841</cn>
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<eq/>
<ci>tau_t</ci>
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<plus/>
<apply>
<times/>
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<exp/>
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<minus/>
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<power/>
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<times/>
<cn cellml:units="per_millivolt">0.0666</cn>
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<plus/>
<ci>Vm_t</ci>
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<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
<cn cellml:units="second">0.035</cn>
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<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<divide/>
<apply>
<minus/>
<ci>s_max</ci>
<ci>s</ci>
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<ci>tau_t</ci>
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</apply>
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<variable name="tau_s_slow" units="second"/>
<variable name="s_slow_max" units="dimensionless"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<eq/>
<ci>s_slow_max</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
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<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
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<cn cellml:units="millivolt">6.8841</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_slow</ci>
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<plus/>
<apply>
<times/>
<cn cellml:units="second">3.7</cn>
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<exp/>
<apply>
<minus/>
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<power/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0333</cn>
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<plus/>
<ci>Vm_t</ci>
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<cn cellml:units="dimensionless">2</cn>
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</apply>
</apply>
</apply>
<cn cellml:units="second">0.035</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>s_slow_max</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current">
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<variable name="g_Ksst" units="milliS"/>
<variable name="fKsst" units="dimensionless" initial_value="0.76"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm_t" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
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<variable name="s_ss" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>i_Kss_t</ci>
<apply>
<times/>
<ci>g_Ksst</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
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<minus/>
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<ci>g_Ksst</ci>
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<ci>g_Kss</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
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<ci>fKsst</ci>
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</apply>
</math>
</component>
<component name="steady_state_outward_K_current_r_ss_gate">
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<variable name="tau_r_ss" units="second"/>
<variable name="r_ss_max" units="dimensionless"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
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<eq/>
<ci>r_ss_max</ci>
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<divide/>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
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<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>Vm_t</ci>
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</apply>
<cn cellml:units="millivolt">11.82</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_ss</ci>
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<divide/>
<cn cellml:units="second">10</cn>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>Vm_t</ci>
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<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
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<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_ss_max</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_s_ss_gate">
<variable name="s_ss" units="dimensionless" initial_value="3.0773368e-1" public_interface="out"/>
<variable name="tau_s_ss" units="second"/>
<variable name="s_ss_max" units="dimensionless"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_ss_max</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">87.5</cn>
</apply>
<cn cellml:units="millivolt">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_ss</ci>
<cn cellml:units="second">2.1</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_ss_max</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier">
<variable name="i_K1_t" units="microA" public_interface="out"/>
<variable name="g_K1" units="milliS_per_cm2" initial_value="0.24"/>
<variable name="g_K1t" units="milliS"/>
<variable name="fK1t" units="dimensionless" initial_value="0.56"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="K_t" units="millimolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1_t</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1t</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>Vm_t</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">1.73</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>K_t</ci>
<cn cellml:units="millimolar">0.9988</cn>
</apply>
</apply>
<cn cellml:units="millimolar">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>g_K1t</ci>
<apply><times/>
<ci>g_K1</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fK1t</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current">
<variable name="i_f_t" units="microA" public_interface="out"/>
<variable name="i_fNa_t" units="microA" public_interface="out"/>
<variable name="i_fK_t" units="microA" public_interface="out"/>
<variable name="g_f" units="milliS_per_cm2" initial_value="0.0145"/>
<variable name="g_ft" units="milliS"/>
<variable name="fft" units="dimensionless" initial_value="0.56"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="f_Na" units="dimensionless" initial_value="0.2"/>
<variable name="f_K" units="dimensionless"/>
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Vm_t" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="y" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_K</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fNa_t</ci>
<apply>
<times/>
<ci>g_ft</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_fK_t</ci>
<apply>
<times/>
<ci>g_ft</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_t</ci>
<apply>
<times/>
<ci>g_ft</ci>
<ci>y</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_Na</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.8</cn>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>g_ft</ci>
<apply><times/>
<ci>g_f</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fft</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable name="y" units="dimensionless" initial_value="3.4357175e-3" public_interface="out"/>
<variable name="tau_y" units="second"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">138.6</cn>
</apply>
<cn cellml:units="millivolt">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.11885</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<cn cellml:units="millivolt">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5623</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Vm_t</ci>
<cn cellml:units="millivolt">80</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="background_currents">
<variable name="i_B_t" units="microA" public_interface="out"/>
<variable name="i_BNa_t" units="microA" public_interface="out"/>
<variable name="i_BCa_t" units="microA" public_interface="out"/>
<variable name="i_BK_t" units="microA" public_interface="out"/>
<variable name="g_B_Ca" units="milliS_per_cm2" initial_value="0.000648"/>
<variable name="g_B_Na" units="milliS_per_cm2" initial_value="0.0008015"/>
<variable name="g_B_K" units="milliS_per_cm2" initial_value="0.00138"/>
<variable name="g_B_Cat" units="milliS"/>
<variable name="g_B_Nat" units="milliS"/>
<variable name="g_B_Kt" units="milliS"/>
<variable name="fCabt" units="dimensionless" initial_value="0.56"/>
<variable name="fNabt" units="dimensionless" initial_value="0.56"/>
<variable name="fKbt" units="dimensionless" initial_value="0.56"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="E_Ca" units="millivolt" initial_value="65"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Ca_t" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_BNa_t</ci>
<apply>
<times/>
<ci>g_B_Nat</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_BCa_t</ci>
<apply>
<times/>
<ci>g_B_Cat</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_BK_t</ci>
<apply>
<times/>
<ci>g_B_Kt</ci>
<apply>
<minus/>
<ci>Vm_t</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_B_t</ci>
<apply>
<plus/>
<ci>i_BNa_t</ci>
<ci>i_BCa_t</ci>
<ci>i_BK_t</ci>
</apply>
</apply>
<apply><eq/>
<ci>g_B_Cat</ci>
<apply><times/>
<ci>g_B_Ca</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fCabt</ci>
</apply>
</apply>
<apply><eq/>
<ci>g_B_Nat</ci>
<apply><times/>
<ci>g_B_Na</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fNabt</ci>
</apply>
</apply>
<apply><eq/>
<ci>g_B_Kt</ci>
<apply><times/>
<ci>g_B_K</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fKbt</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK_t" units="microA" public_interface="out"/>
<variable name="i_NaK_max" units="microA_per_cm2" initial_value="1"/>
<variable name="i_NaK_max_t" units="microA"/>
<variable name="fNaKt" units="dimensionless" initial_value="0.59"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="K_m_K" units="millimolar" initial_value="1.5"/>
<variable name="K_m_Na" units="millimolar" initial_value="10"/>
<variable name="sigma" units="dimensionless"/>
<variable name="K_t" units="millimolar" public_interface="in"/>
<variable name="Na_t" units="millimolar" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Na_t</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_t</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>i_NaK_max_t</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>Vm_t</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Vm_t</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>K_t</ci>
</apply>
<apply>
<plus/>
<ci>K_t</ci>
<ci>K_m_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>K_m_Na</ci>
<ci>Na_i</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>i_NaK_max_t</ci>
<apply><times/>
<ci>i_NaK_max</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fNaKt</ci>
</apply>
</apply>
</math>
</component>
<component name="sarcolemmal_calcium_pump_current">
<variable name="i_CaP_t" units="microA" public_interface="out"/>
<variable name="i_CaP_max" units="microA_per_cm2" initial_value="0.85"/>
<variable name="i_CaP_max_t" units="microA"/>
<variable name="fCaPt" units="dimensionless" initial_value="0.56"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaP_t</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_CaP_max_t</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>Ca_i</ci>
<cn cellml:units="millimolar">0.0004</cn>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>i_CaP_max_t</ci>
<apply><times/>
<ci>i_CaP_max</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fCaPt</ci>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_ion_exchanger_current">
<variable name="i_NaCa_t" units="microA" public_interface="out"/>
<variable name="i_NaCa_max" units="microA_per_cm2" initial_value="1.8e-4"/>
<variable name="i_NaCa_max_t" units="microA"/>
<variable name="fNaCat" units="dimensionless" initial_value="0.81"/>
<variable name="Sms" units="cm2" public_interface="in"/>
<variable name="Smt" units="cm2" public_interface="in"/>
<variable name="Na_i" units="millimolar" public_interface="in"/>
<variable name="Na_t" units="millimolar" public_interface="in"/>
<variable name="Ca_i" units="millimolar" public_interface="in"/>
<variable name="Ca_t" units="millimolar" public_interface="in"/>
<variable name="Vm_t" units="millivolt" public_interface="in"/>
<variable name="time" units="second" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply><eq/>
<ci>i_NaCa_t</ci>
<apply><divide/>
<apply><times/>
<ci>i_NaCa_max_t</ci>
<apply><minus/>
<apply><times/>
<apply><exp/>
<apply><times/>
<cn cellml:units="per_millivolt">0.0187</cn>
<ci>Vm_t</ci>
</apply>
</apply>
<apply><power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_t</ci>
</apply>
<apply><times/>
<apply><exp/>
<apply><times/>
<cn cellml:units="per_millivolt">-0.0187</cn>
<ci>Vm_t</ci>
</apply>
</apply>
<apply><power/>
<ci>Na_t</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply><plus/>
<cn cellml:units="millimolar4">1</cn>
<apply><times/>
<cn cellml:units="dimensionless">0.0001</cn>
<apply><plus/>
<apply><times/>
<ci>Ca_i</ci>
<apply><power/>
<ci>Na_t</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply><times/>
<ci>Ca_t</ci>
<apply><power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply><eq/>
<ci>i_NaCa_max_t</ci>
<apply><times/>
<ci>i_NaCa_max</ci>
<apply><plus/>
<ci>Sms</ci>
<ci>Smt</ci>
</apply>
<ci>fNaCat</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
</component_ref>
<component_ref component="calcium_current"/>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="inward_rectifier"/>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="background_currents"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="Na_Ca_ion_exchanger_current"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="tubular_membrane">
<component_ref component="membrane"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
</component_ref>
<component_ref component="calcium_current"/>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="inward_rectifier"/>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="background_currents"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="sarcolemmal_calcium_pump_current"/>
<component_ref component="Na_Ca_ion_exchanger_current"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_Na_t" variable_2="i_Na_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_Ca_t" variable_2="i_Ca_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Ca_independent_transient_outward_K_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_Kto_t" variable_2="i_Kto_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_Kss_t" variable_2="i_Kss_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="inward_rectifier"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_K1_t" variable_2="i_K1_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_f_t" variable_2="i_f_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="background_currents"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_B_t" variable_2="i_B_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_NaK_t" variable_2="i_NaK_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sarcolemmal_calcium_pump_current"/>
<map_variables variable_1="i_CaP_t" variable_2="i_CaP_t"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_ion_exchanger_current"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
<map_variables variable_1="i_NaCa_t" variable_2="i_NaCa_t"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="inward_rectifier"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_gate"/>
<map_variables variable_1="s" variable_2="s"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_slow_gate"/>
<map_variables variable_1="s_slow" variable_2="s_slow"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_r_ss_gate"/>
<map_variables variable_1="r_ss" variable_2="r_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_s_ss_gate"/>
<map_variables variable_1="s_ss" variable_2="s_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Vm_t" variable_2="Vm_t"/>
</connection>
</model>
