- Author:
- Hanne <Hanne@hanne-nielsens-macbook.local>
- Date:
- 2009-12-14 14:29:24+13:00
- Desc:
- Added images in ai and svg format, removed non pub med references
- Permanent Source URI:
- http://models.cellml.org/workspace/revilla_garcia-ramos_2003/rawfile/d8fd5d70b06c7f99ec609b3f6e2294ec64aea543/revilla_garcia-ramos_2003.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : revilla_model_2003.xml
CREATED : 25th October 2004
LAST MODIFIED : 25th October 2004
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Revilla and Garcia-Ramos's 2003 dynamic model for HIV-1 therapy.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="revilla_garcia-ramos_2003_version01" name="revilla_garcia-ramos_2003_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Dynamic Model For HIV-1 Therapy</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Current therapies for acquired immunodeficiency syndrome (AIDS) include inhibitors of the enzymes required for the replication of the human immunodeficiency virus (HIV-1). An alternative therapeutic approach uses genetically modified viruses which are then capable of regulating infections by other viruses. The genetically modified virus is able to infect and kill host cells which are already infected with HIV-1, resulting in a decrease in the viral load.
</para>
<para>
This information has been obtained from <emphasis>in vitro</emphasis> experiments. The potential effectiveness of this treatment for reducing viral load <emphasis>in vivo</emphasis> has not been tested. In the study described here, Revilla and Garcia-Ramos model the potential interactions between HIV-1, its host cell, and a recombinant virus in an <emphasis>in vivo</emphasis> context (see the figure below). Model simulations suggest that the use of recombinant viruses could be effective as a treatment for reducing an individual's HIV-1 load.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
Fighting a virus with a virus: a dynamic model for HIV-1 therapy, Tomas Revilla and Gisela Garcia-Ramos, 2003, <emphasis>Mathematical Biosciences</emphasis>, 185, 191-203. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12941536&dopt=Abstract">PubMed ID: 12941536</ulink>
</para>
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<title>cell diagram</title>
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<imagedata fileref="revilla_2003.png"/>
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<caption>Schematic diagram of a model for a double viral infection. Pathogen viral particles V infect normal host cells X, producing single-infected cells Y. These are then infected with the recombinant virus W to become double-infected cells Z. Double-infected cells can produce recombinant viral particles but not pathogen viral particles</caption>
</informalfigure>
</sect1>
</article>
</documentation>
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Fighting a virus with a virus: a dynamic model for HIV-1 therapy
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The University of Auckland, Bioengineering Institute
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Revilla and Garcia-Ramos's 2003 dynamic model for HIV-1 therapy.
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