Distribution of a Persistent Sodium Current Across theVentricular Wall in Guinea Pigs
Penny
Noble
Oxford University
Model Status
This model has been curated and unit-checked and is known to run in COR and PCEnv. This variant is parameterised for the cardiac EPICARDIAL CELL.
Model Structure
ABSTRACT: A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes bywhole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium,midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P,0.05) smaller IpNathan subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density betweensubepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion ofaction potential duration across the ventricular wall."
The original paper reference is cited below:
Distribution of a persistent sodium current across the ventricular wall in guinea pigs, Bernhard F.A.S. Sakmann, Anthony J. Spindler, Simon M. Bryant, Klaus W. Linz and Denis Noble, 2000, Circulation Research, 87, (10), 910-914. PubMed ID: 11073887
model diagram
Schematic diagram of the Sakmann et al. 2000 cardiac cell model.
LinzKW2000-11-00 00:00Penny Nobleelectrophysiologypersistent sodium currentguinea-pigcardiacguinea pigventricular myocytepenny.noble@dpag.ox.ac.uk91091487Distribution of a persistent sodium current across the ventricular wall in guinea pigs.NoblePennyCorrections to naming of the models and IK equations.keyword2008-05-13T04:01:55+12:00SpindlerAJSakmannBFNobleDThis model was based on the paper "Distribution of a Persistent Sodium Current Across theVentricular Wall in Guinea Pigs" by Bernhard F.A.S. Sakmann, Anthony J. Spindler, Simon M. Bryant, Klaus W. Linz and Denis Noble.
Reference: Circulation Research 2000 Nov 10;87(10):910-4.
The following is the abstract from the paper:
"A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes bywhole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium,midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P,0.05) smaller IpNathan subendocardial and subepicardial myocytes. There was no significant difference in IpNa current density betweensubepicardial and subendocardial cells. Computer modeling studies support a role of this current in the dispersion ofaction potential duration across the ventricular wall."Distribution of a persistent sodium current across the ventricular wall in guinea pigs (Epicardial Cell)University of OxfordCirculation Research2100000.1BryantSMNoblePenny2008-05-13T00:00:00+00:0011073887