A Model For Human Ventricular Tissue
Catherine
Lloyd
Auckland Bioengineering Institute, University of Auckland
Model Status
This variant of the model was created by Penny Noble of Oxford University, and represents the parameters given for the endocardial cell variant in Ten Tusscher et al. 2004. A stimulus protocol component has been added to the model to allow simulation of trains of action potentials. This file is known to run in OpenCell and COR to recreate the published results. The units have been checked and they are consistent.
Model Structure
ABSTRACT: The experimental and clinical possibilities for studying cardiac arrhythmias in human ventricular myocardium are very limited. Therefore, the use of alternative methods such as computer simulations is of great importance. In this article we introduce a mathematical model of the action potential of human ventricular cells that, while including a high level of electrophysiological detail, is computationally cost-effective enough to be applied in large-scale spatial simulations for the study of reentrant arrhythmias. The model is based on recent experimental data on most of the major ionic currents: the fast sodium, L-type calcium, transient outward, rapid and slow delayed rectifier, and inward rectifier currents. The model includes a basic calcium dynamics, allowing for the realistic modeling of calcium transients, calcium current inactivation, and the contraction staircase. We are able to reproduce human epicardial, endocardial, and M cell action potentials and show that differences can be explained by differences in the transient outward and slow delayed rectifier currents. Our model reproduces the experimentally observed data on action potential duration restitution, which is an important characteristic for reentrant arrhythmias. The conduction velocity restitution of our model is broader than in other models and agrees better with available data. Finally, we model the dynamics of spiral wave rotation in a two-dimensional sheet of human ventricular tissue and show that the spiral wave follows a complex meandering pattern and has a period of 265 ms. We conclude that the proposed model reproduces a variety of electrophysiological behaviors and provides a basis for studies of reentrant arrhythmias in human ventricular tissue.
The original paper reference is cited below:
A model for human ventricular tissue, K.H.W.J. ten Tusscher, D. Noble, P.J. Noble, and A.V. Panfilov, 2004,
American Journal of Physiology
, 286, H1573-H1589. PubMed ID: 14656705
cell diagram
A schematic diagram of the Ten Tusscher et al. 2004 mathematical model of the human ventricular myocyte.
10000
10000
0.01
Penny's file was modified to allow it to run in PCEnv. This required rearrangement of some differential equations such that the differential was on the left hand side. This modification produces a mathematically equivalent model and the output of the pre-modified model has not been altered in any way.
James
Lawson
Richard
2007-06-18T12:53:19+12:00
P
Noble
J
D
Noble
2008-05-27T12:42:18+12:00
2007-05-05T12:55:00+12:00
James
Lawson
Richard
A
Panfilov
V
This variant represents the human endocardial cell, as defined by ten Tusscher et al. in their 2004 paper.
American Journal of Physiology Heart and Circulatory Physiology
A model for human ventricular tissue (Endocardial Cell)
Department of Physiology, Anatomy & Genetics, University of Oxford
2006-01-01
A stimulus protocol component was added to the model to allow simulation of trains of action potentials. Values for the amplitude (-52 picoA per picoF) and duration (1 ms) of the stimulus were taken from the original single stimulus in the model. The period of 1000 ms is intended to reflect beat period of the human heart, on which this model is based.
A model for human ventricular tissue
286 4
1573
1589
unknown
Penny
Noble
J
This variant of the model was created by Penny Noble of Oxford University, and represents the parameters given for the endocardial cell variant in Ten Tusscher et al. 2004. A stimulus protocol component has been added to the model to allow simulation of trains of action potentials (JL, 18/06/07). This file is known to run in PCEnv and COR.
units checked, curated
2006-11-08T00:00:00+00:00
K
Ten Tusscher
H
2007-12-06T15:15:54+13:00
unknown
unknown
unknown
14656705
Penny
Noble
J
unknown
unknown
replaced illegal - in model cmeta:id with _
Oxford University
Department of Physiology, Anatomy & Genetics
unknown
keyword
electrophysiology
ventricular
myocyte
ventricular myocyte
penny.noble@dpag.ox.ac.uk
James
Lawson
Richard
James Lawson
2004-04-01 00:00
James Lawson