Location: Viswanathan, Shaw, Rudy, 1999 @ d4ce8458da7e / viswanathan_shaw_rudy_1999_a.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2010-11-05 12:28:50+13:00
Desc:
Fixed links to the images so they are visible in the exposures.
Permanent Source URI:
http://models.cellml.org/workspace/viswanathan_shaw_rudy_1999/rawfile/d4ce8458da7e3e081a2600355838ec3f6e3f3c3f/viswanathan_shaw_rudy_1999_a.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 25/10/2010 at 14:35:58 using:

COR (0.9.31.1393)
Copyright 2002-2010 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="viswanathan_1999_M" name="viswanathan_1999_M">
	<documentation xmlns="http://cellml.org/tmp-documentation">
		<article>
			<articleinfo>
				<title>Updated Luo-Rudy Mammalian Ventricular Model II</title>
				<author>
					<firstname>Catherine</firstname>
					<surname>Lloyd</surname>
					<affiliation>
						<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
					</affiliation>
				</author>
			</articleinfo>
			<section id="sec_status">
				<title>Model Status</title>
				<para>
            This version was created by Penny Noble of Oxford University and is known to run in PCEnv and COR. 
This is the M-CELL VARIANT of the model.
          </para>
			</section>
			<sect1 id="sec_structure">
				<title>Model Structure</title>
				<para>ABSTRACT: BACKGROUND: A growing body of evidence suggests that heterogeneity of ion channel expression and electrophysiological characteristics is an important property of the ventricular myocardium. The 2 components of the delayed rectifier potassium current, IKr (rapid) and IKs (slow), play a dominant role in the repolarization of the action potential and are important determinants of its duration. METHODS AND RESULTS: In this report, the effects of heterogeneities of IKr and IKs on action potential duration (APD) and its rate dependence (adaptation) are studied with the use of the LRd model of a mammalian ventricular cell. Results demonstrate the importance of IKs density variations in heterogeneity of repolarization. Cells with reduced IKs (eg, mid-myocardial M cells) display long APD and steep dependence of APD on rate. Mechanistically, accumulation of IKs activation and increased sodium calcium exchange current, INaCa, secondary to Na+ accumulation at a fast rate underlie the steep APD-rate relation of these cells. When cells are electrotonically coupled in a multicellular fiber through resistive gap junction, APD differences are reduced. The results demonstrate strong dependence of APD heterogeneity on the degree of intercellular coupling even in the normal physiological range. Highly reduced coupling maximizes APD heterogeneity. CONCLUSIONS: Heterogeneity of IKs:IKr density strongly influences APD and its rate dependence. However, in the intact myocardium, the degree of gap-junction coupling may be an important factor that determines the manifestation of APD heterogeneity and dispersion of repolarization. The clinical significance of this study is in the context of repolarization abnormalities and associated arrhythmias (eg, long QT syndrome and torsade de pointes).
</para>
				<para>
The complete paper reference is cited below:
</para>
				<para>
					Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study, Prakash C. Viswanathan, BE; Robin M. Shaw, PhD; and Yoram Rudy, PhD, 1999,
						<emphasis>Circulation</emphasis>, 99, 2466-2474.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10318671&amp;dopt=Abstract">PubMed ID: 10318671</ulink>
				</para>
				<informalfigure float="0" id="fig_cell_diagram_shaw">
					<mediaobject>
						<imageobject>
							<objectinfo>
								<title>cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
							</objectinfo>
							<imagedata fileref="viswanathan_1999.png"/>
						</imageobject>
					</mediaobject>
					<caption>
A schematic diagram of the 1999 Viswanathan et al. model.</caption>
				</informalfigure>
			</sect1>
		</article>
	</documentation>
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="rdf:#a4f975dc-eda5-4569-bf66-4d4a5a4feb7d"><ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#ece3816d-14e5-40bf-9ba9-f8bdd3486a07"/></ORG><EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#94f32f7a-62de-4ef3-915c-320415dbf385"/></EMAIL><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#1f138056-71a8-4890-b349-85cf2c6c7066"/></N></rdf:Description><rdf:Description rdf:about="rdf:#citationAuthorsSeq"><rdf:_3><rdf:Description rdf:about="rdf:#author3Vcard"/></rdf:_3><rdf:_1><rdf:Description rdf:about="rdf:#author1Vcard"/></rdf:_1><rdf:_2><rdf:Description rdf:about="rdf:#author2Vcard"/></rdf:_2><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n1"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n2"/></boundIntervals></rdf:Description><rdf:Description rdf:about="rdf:#author3Vcard"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author3VcardN"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="#viswanathan_1999"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></simulation><cmeta:comment><rdf:Description rdf:about="rdf:#a2b7ef84-7363-410a-92c4-d75abe31a88b"/></cmeta:comment><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#75e9adc3-55fc-4345-9083-41e7b04884e4"/></reference><reference xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:nodeID="n3"/></reference><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">unknown</title></rdf:Description><rdf:Description rdf:about="rdf:#author1Vcard"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author1VcardN"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#author2Vcard"><N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#"><rdf:Description rdf:about="rdf:#author2VcardN"/></N><rdf:type><rdf:Description rdf:about="http://www.cellml.org/bqs/1.0#Person"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#author2VcardN"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">R</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Shaw</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">M</Other></rdf:Description><rdf:Description rdf:about="rdf:#1f138056-71a8-4890-b349-85cf2c6c7066"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</Other></rdf:Description><rdf:Description rdf:nodeID="n4"><rdf:_3 xml:lang="en">ventricular myocyte</rdf:_3><rdf:_1 xml:lang="en">iks</rdf:_1><rdf:_2 xml:lang="en">ikr</rdf:_2><rdf:_4 xml:lang="en">calcium dynamics</rdf:_4><rdf:_7 xml:lang="en">cardiac</rdf:_7><rdf:_5 xml:lang="en">Ventricular Myocyte</rdf:_5><rdf:_6 xml:lang="en">electrophysiology</rdf:_6><rdf:type><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/></rdf:type></rdf:Description><rdf:Description rdf:nodeID="n2"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n5"/></rdf:first></rdf:Description><rdf:Description rdf:nodeID="n6"><subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">keyword</subject_type><rdf:value><rdf:Description rdf:nodeID="n4"/></rdf:value></rdf:Description><rdf:Description rdf:about="rdf:#author3VcardN"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Y</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Rudy</Family></rdf:Description><rdf:Description rdf:nodeID="n3"><subject xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:nodeID="n6"/></subject></rdf:Description><rdf:Description rdf:about="rdf:#author1VcardN"><Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">P</Given><Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">Viswanathan</Family><Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">C</Other></rdf:Description><rdf:Description rdf:about="rdf:#578684b1-e822-4d34-b602-6607f3f51a51"><FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</FN></rdf:Description><rdf:Description rdf:about="rdf:#d98ab5fb-679a-4d8b-bb5f-9e67d1246cca"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">2006-01-01</W3CDTF></rdf:Description><rdf:Description rdf:about="rdf:#aaf01d89-e67c-4bf3-86cc-b495e7b859c1"><W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en">1999-05-11</W3CDTF></rdf:Description><rdf:Description rdf:nodeID="n5"><pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en">100000</pointDensity><maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">0.1</maximumStepSize><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">1</endingValue></rdf:Description><rdf:Description rdf:about="rdf:#94f32f7a-62de-4ef3-915c-320415dbf385"><rdf:value xml:lang="en">unknown</rdf:value><rdf:type><rdf:Description rdf:about="http://imc.org/vCard/3.0#internet"/></rdf:type></rdf:Description><rdf:Description rdf:about="rdf:#161056d4-7433-4bba-a20d-c4ada101016c"><volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">99 18</volume><last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">2474</last_page><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#citationAuthorsSeq"/></creator><issued xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#aaf01d89-e67c-4bf3-86cc-b495e7b859c1"/></issued><first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">2466</first_page><Journal xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#9936e7e5-1ebf-4441-b0b1-87514d3debbf"/></Journal><issue xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">unknown</issue><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study</title></rdf:Description><rdf:Description rdf:about="rdf:#a2b7ef84-7363-410a-92c4-d75abe31a88b"><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#578684b1-e822-4d34-b602-6607f3f51a51"/></creator><rdf:value xml:lang="en">unknown</rdf:value></rdf:Description><rdf:Description rdf:about=""><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study (Midmyocardial Cell Model)</title>
			<created xmlns="http://purl.org/dc/terms/"><rdf:Description rdf:about="rdf:#d98ab5fb-679a-4d8b-bb5f-9e67d1246cca"/></created><creator xmlns="http://purl.org/dc/elements/1.1/"><rdf:Description rdf:about="rdf:#a4f975dc-eda5-4569-bf66-4d4a5a4feb7d"/></creator></rdf:Description><rdf:Description rdf:about="rdf:#ece3816d-14e5-40bf-9ba9-f8bdd3486a07"><Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</Orgname><Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en">unknown</Orgunit></rdf:Description><rdf:Description rdf:about="rdf:#75e9adc3-55fc-4345-9083-41e7b04884e4"><Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en">10318671</Pubmed_id><JournalArticle xmlns="http://www.cellml.org/bqs/1.0#"><rdf:Description rdf:about="rdf:#161056d4-7433-4bba-a20d-c4ada101016c"/></JournalArticle></rdf:Description><rdf:Description rdf:about="rdf:#9936e7e5-1ebf-4441-b0b1-87514d3debbf"><title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en">Circulation</title></rdf:Description></rdf:RDF>   <units name="ms">
      <unit prefix="milli" units="second"/>
   </units>
   <units name="per_ms">
      <unit exponent="-1" units="ms"/>
   </units>
   <units name="millivolt">
      <unit prefix="milli" units="volt"/>
   </units>
   <units name="per_millivolt">
      <unit exponent="-1" units="millivolt"/>
   </units>
   <units name="ms_per_millivolt">
      <unit units="ms"/>
      <unit units="per_millivolt"/>
   </units>
   <units name="per_millivolt_ms">
      <unit units="per_millivolt"/>
      <unit units="per_ms"/>
   </units>
   <units name="millivolt_per_ms">
      <unit units="millivolt"/>
      <unit units="per_ms"/>
   </units>
   <units name="milliS_per_microF">
      <unit prefix="milli" units="siemens"/>
      <unit exponent="-1" prefix="micro" units="farad"/>
   </units>
   <units name="cm2">
      <unit exponent="2" prefix="centi" units="metre"/>
   </units>
   <units name="milliS_per_cm2">
      <unit prefix="milli" units="siemens"/>
      <unit exponent="-2" prefix="centi" units="metre"/>
   </units>
   <units name="nanoS_per_cm2">
      <unit prefix="nano" units="siemens"/>
      <unit exponent="-2" prefix="centi" units="metre"/>
   </units>
   <units name="microF_per_cm2">
      <unit units="microF"/>
      <unit exponent="-2" prefix="centi" units="metre"/>
   </units>
   <units name="microF">
      <unit prefix="micro" units="farad"/>
   </units>
   <units name="microA_per_microF">
      <unit prefix="micro" units="ampere"/>
      <unit exponent="-1" prefix="micro" units="farad"/>
   </units>
   <units name="millimolar_per_ms">
      <unit prefix="milli" units="mole"/>
      <unit exponent="-1" units="litre"/>
      <unit units="per_ms"/>
   </units>
   <units name="millimolar">
      <unit prefix="milli" units="mole"/>
      <unit exponent="-1" units="litre"/>
   </units>
   <units name="mM4">
      <unit exponent="4" units="millimolar"/>
   </units>
   <units name="micromolar">
      <unit prefix="micro" units="mole"/>
      <unit exponent="-1" units="litre"/>
   </units>
   <units name="joule_per_kilomole_kelvin">
      <unit units="joule"/>
      <unit exponent="-1" prefix="kilo" units="mole"/>
      <unit exponent="-1" units="kelvin"/>
   </units>
   <units name="coulomb_per_mole">
      <unit units="coulomb"/>
      <unit exponent="-1" units="mole"/>
   </units>
   <units name="mm">
      <unit prefix="milli" units="metre"/>
   </units>
   <units name="micro_litre">
      <unit prefix="micro" units="litre"/>
   </units>
   <units name="litre_per_farad_ms">
      <unit units="litre"/>
      <unit exponent="-1" units="farad"/>
      <unit units="per_ms"/>
   </units>
   <component name="environment">
      <variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
   </component>
   <component name="membrane">
      <variable cmeta:id="membrane_V" initial_value="-88.32552" name="V" public_interface="out" units="millivolt"/>
      <variable initial_value="8314" name="R" public_interface="out" units="joule_per_kilomole_kelvin"/>
      <variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
      <variable initial_value="96485" name="F" public_interface="out" units="coulomb_per_mole"/>
      <variable name="I_st" units="microA_per_microF"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_L" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kp" public_interface="in" units="microA_per_microF"/>
      <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_ns_Ca" public_interface="in" units="microA_per_microF"/>
      <variable name="dVdt" public_interface="out" units="millivolt_per_ms"/>
      <variable initial_value="100" name="stim_start" units="ms"/>
      <variable initial_value="99999000" name="stim_end" units="ms"/>
      <variable initial_value="1000" name="stim_period" units="ms"/>
      <variable initial_value="2" name="stim_duration" units="ms"/>
      <variable initial_value="-25.5" name="stim_amplitude" units="microA_per_microF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_st</ci>
            <piecewise>
               <piece>
                  <ci>stim_amplitude</ci>
                  <apply>
                     <and/>
                     <apply>
                        <geq/>
                        <ci>time</ci>
                        <ci>stim_start</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <ci>time</ci>
                        <ci>stim_end</ci>
                     </apply>
                     <apply>
                        <leq/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>time</ci>
                              <ci>stim_start</ci>
                           </apply>
                           <apply>
                              <times/>
                              <apply>
                                 <floor/>
                                 <apply>
                                    <divide/>
                                    <apply>
                                       <minus/>
                                       <ci>time</ci>
                                       <ci>stim_start</ci>
                                    </apply>
                                    <ci>stim_period</ci>
                                 </apply>
                              </apply>
                              <ci>stim_period</ci>
                           </apply>
                        </apply>
                        <ci>stim_duration</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microA_per_microF">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>V</ci>
            </apply>
            <ci>dVdt</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dVdt</ci>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <ci>i_Na</ci>
                  <ci>i_Ca_L</ci>
                  <ci>i_Ca_T</ci>
                  <ci>i_Kr</ci>
                  <ci>i_Ks</ci>
                  <ci>i_K_ATP</ci>
                  <ci>i_to</ci>
                  <ci>i_K1</ci>
                  <ci>i_Kp</ci>
                  <ci>i_p_Ca</ci>
                  <ci>i_Na_b</ci>
                  <ci>i_Ca_b</ci>
                  <ci>i_NaK</ci>
                  <ci>i_NaCa</ci>
                  <ci>i_ns_Ca</ci>
                  <ci>I_st</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current">
      <variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="microA_per_microF"/>
      <variable name="E_Na" public_interface="out" units="millivolt"/>
      <variable initial_value="16" name="g_Na" units="milliS_per_microF"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="m" private_interface="in" units="dimensionless"/>
      <variable name="h" private_interface="in" units="dimensionless"/>
      <variable name="j" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Na</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Nao</ci>
                     <ci>Nai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Na</ci>
            <apply>
               <times/>
               <ci>g_Na</ci>
               <apply>
                  <power/>
                  <ci>m</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>h</ci>
               <ci>j</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_m_gate">
      <variable initial_value="0.0008858" name="m" public_interface="out" units="dimensionless"/>
      <variable name="alpha_m" units="per_ms"/>
      <variable name="beta_m" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable initial_value="1e-5" name="delta_m" units="millivolt"/>
      <variable name="E0_m" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_m</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">47.13</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_m</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">0.32</cn>
                        <ci>E0_m</ci>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <ci>E0_m</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <geq/>
                     <apply>
                        <abs/>
                        <ci>E0_m</ci>
                     </apply>
                     <ci>delta_m</ci>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">3.2</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_m</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.08</cn>
               <apply>
                  <exp/>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>m</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>m</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_h_gate">
      <variable initial_value="0.992806" name="h" public_interface="out" units="dimensionless"/>
      <variable name="alpha_h" units="per_ms"/>
      <variable name="beta_h" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.135</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">80</cn>
                              <ci>V</ci>
                           </apply>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.8</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_h</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">3.56</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.079</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">310000</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.35</cn>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">0.13</cn>
                        <apply>
                           <plus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.66</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">11.1</cn>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>h</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_h</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>h</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_h</ci>
                  <ci>h</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="fast_sodium_current_j_gate">
      <variable initial_value="0.99511469" name="j" public_interface="out" units="dimensionless"/>
      <variable name="alpha_j" units="per_ms"/>
      <variable name="beta_j" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">127140</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2444</cn>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt_ms">3.474   <sep/>
                                 -5</cn>
                                 <apply>
                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.04391</cn>
                                       </apply>
                                       <ci>V</ci>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">37.78</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.311</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">79.23</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">2.535   <sep/>
                                 -7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable cmeta:id="L_type_Ca_channel_i_Ca_L" name="i_Ca_L" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaCa" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaK" public_interface="out" units="microA_per_microF"/>
      <variable name="i_CaNa" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.75" name="gamma_Nai" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Nao" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ki" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.75" name="gamma_Ko" public_interface="out" units="dimensionless"/>
      <variable name="I_CaCa" units="microA_per_microF"/>
      <variable name="I_CaK" units="microA_per_microF"/>
      <variable name="I_CaNa" units="microA_per_microF"/>
      <variable initial_value="0.00054" name="P_Ca" units="litre_per_farad_ms"/>
      <variable initial_value="6.75e-7" name="P_Na" units="litre_per_farad_ms"/>
      <variable initial_value="1.93e-7" name="P_K" units="litre_per_farad_ms"/>
      <variable initial_value="1" name="gamma_Cai" units="dimensionless"/>
      <variable initial_value="0.341" name="gamma_Cao" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Cai" private_interface="out" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="d" private_interface="in" units="dimensionless"/>
      <variable name="f" private_interface="in" units="dimensionless"/>
      <variable name="f_Ca" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_CaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Cai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Na</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_K</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaCa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaNa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaK</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaCa</ci>
               <ci>i_CaK</ci>
               <ci>i_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable initial_value="3.538268e-6" name="d" public_interface="out" units="dimensionless"/>
      <variable name="alpha_d" units="per_ms"/>
      <variable name="beta_d" units="per_ms"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="E0_d" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>E0_d</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">0.035</cn>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <apply>
                        <abs/>
                        <ci>E0_d</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millivolt">1   <sep/>
                     -5</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>d_infinity</ci>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <minus/>
                                    <ci>E0_d</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">6.24</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt_ms">0.035</cn>
                        <ci>E0_d</ci>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <divide/>
               <ci>d_infinity</ci>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>d_infinity</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_d</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>d</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_d</ci>
                  <ci>d</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable initial_value="0.995259" name="f" public_interface="out" units="dimensionless"/>
      <variable name="alpha_f" units="per_ms"/>
      <variable name="beta_f" units="per_ms"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">32</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <apply>
               <divide/>
               <ci>f_infinity</ci>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <ci>f_infinity</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_f</ci>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <ci>f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_f</ci>
                  <ci>f</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_Ca_gate">
      <variable name="f_Ca" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.0006" name="Km_Ca" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cai</ci>
                     <ci>Km_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable cmeta:id="T_type_Ca_channel_i_Ca_T" name="i_Ca_T" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.05" name="g_CaT" units="milliS_per_microF"/>
      <variable name="E_Ca" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="b" private_interface="in" units="dimensionless"/>
      <variable name="g" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_b_gate">
      <variable initial_value="0.0010301" name="b" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="b_inf" units="dimensionless"/>
      <variable name="tau_b" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">10.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <plus/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">3.7</cn>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">6.1</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_inf</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_g_gate">
      <variable initial_value="0.9341828" name="g" public_interface="out" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="g_inf" units="dimensionless"/>
      <variable name="tau_g" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_inf</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_g</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms_per_millivolt">0.875</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">12</cn>
                  </apply>
                  <apply>
                     <leq/>
                     <ci>V</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">12</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_inf</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Kr" units="milliS_per_microF"/>
      <variable name="Rect" units="dimensionless"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="xr" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.02614</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Rect</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">9</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>Rect</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current_xr_gate">
      <variable initial_value="0.0007500578" name="xr" public_interface="out" units="dimensionless"/>
      <variable name="xr_infinity" units="dimensionless"/>
      <variable name="tau_xr" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">21.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.123</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">14.2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">38.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="microA_per_microF"/>
      <variable name="g_Ks" units="milliS_per_microF"/>
      <variable name="E_Ks" units="millivolt"/>
      <variable initial_value="0.01833" name="PNaK" units="dimensionless"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="xs1" private_interface="in" units="dimensionless"/>
      <variable name="xs2" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.125</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="millimolar">3.8   <sep/>
                              -5</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs1_gate">
      <variable initial_value="0.0421517" name="xs1" public_interface="out" units="dimensionless"/>
      <variable name="xs1_infinity" units="dimensionless"/>
      <variable name="tau_xs1" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19   <sep/>
                        -5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs2_gate">
      <variable initial_value="0.08866" name="xs2" public_interface="out" units="dimensionless"/>
      <variable name="xs2_infinity" units="dimensionless"/>
      <variable name="tau_xs2" units="ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="ms">4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="per_millivolt">7.19   <sep/>
                        -5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="microA_per_microF"/>
      <variable name="E_K" private_interface="out" public_interface="out" units="millivolt"/>
      <variable name="g_K1" units="milliS_per_microF"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="K1_infinity" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.75</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_K1_gate">
      <variable name="K1_infinity" public_interface="out" units="dimensionless"/>
      <variable name="alpha_K1" units="per_ms"/>
      <variable name="beta_K1" units="per_ms"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.49124</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.08032</cn>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.476</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">594.31</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="plateau_potassium_current">
      <variable cmeta:id="plateau_potassium_current_i_Kp" name="i_Kp" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.00552" name="g_Kp" units="milliS_per_microF"/>
      <variable name="Kp" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ATP_sensitive_potassium_current">
      <variable cmeta:id="ATP_sensitive_potassium_current_i_K_ATP" name="i_K_ATP" public_interface="out" units="microA_per_microF"/>
      <variable name="g_K_ATP" units="milliS_per_microF"/>
      <variable initial_value="0.24" name="nATP" units="dimensionless"/>
      <variable initial_value="5e-5" name="nicholsarea" units="dimensionless"/>
      <variable initial_value="3" name="ATPi" units="millimolar"/>
      <variable initial_value="2" name="hATP" units="dimensionless"/>
      <variable initial_value="0.00025" name="kATP" units="millimolar"/>
      <variable name="pATP" units="dimensionless"/>
      <variable name="GKbaraATP" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_ATP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.000193</cn>
               <ci>nicholsarea</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pATP</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <ci>kATP</ci>
                     </apply>
                     <ci>hATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GKbaraATP</ci>
            <apply>
               <times/>
               <ci>g_K_ATP</ci>
               <ci>pATP</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">4</cn>
                  </apply>
                  <ci>nATP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_ATP</ci>
            <apply>
               <times/>
               <ci>GKbaraATP</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable name="i_to" public_interface="out" units="microA_per_microF"/>
      <variable name="g_to" units="milliS_per_microF"/>
      <variable name="E_K" public_interface="in" units="millivolt"/>
      <variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
      <variable name="time" private_interface="out" public_interface="in" units="ms"/>
      <variable name="rvdv" units="dimensionless"/>
      <variable name="zdv" private_interface="in" units="dimensionless"/>
      <variable name="ydv" private_interface="in" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="milliS_per_microF">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rvdv</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">100</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>zdv</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ydv</ci>
               <ci>rvdv</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_zdv_gate">
      <variable initial_value="0.01198974" name="zdv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_zdv" units="per_ms"/>
      <variable name="beta_zdv" units="per_ms"/>
      <variable name="tau_zdv" units="ms"/>
      <variable name="zdv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">40</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_zdv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>zdv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_zdv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>zdv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>zdv_ss</ci>
                  <ci>zdv</ci>
               </apply>
               <ci>tau_zdv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_ydv_gate">
      <variable initial_value="0.97497" name="ydv" public_interface="out" units="dimensionless"/>
      <variable name="alpha_ydv" units="per_ms"/>
      <variable name="beta_ydv" units="per_ms"/>
      <variable name="tau_ydv" units="ms"/>
      <variable name="ydv_ss" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="time" public_interface="in" units="ms"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.015</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">60</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ydv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">25</cn>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ydv</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ydv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_ydv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ydv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ydv_ss</ci>
                  <ci>ydv</ci>
               </apply>
               <ci>tau_ydv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump">
      <variable cmeta:id="sarcolemmal_calcium_pump_i_p_Ca" name="i_p_Ca" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="K_mpCa" units="millimolar"/>
      <variable initial_value="1.15" name="I_pCa" units="microA_per_microF"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable cmeta:id="sodium_background_current_i_Na_b" name="i_Na_b" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.004" name="g_Nab" units="milliS_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="E_Na" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable cmeta:id="calcium_background_current_i_Ca_b" name="i_Ca_b" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="0.003016" name="g_Cab" units="milliS_per_microF"/>
      <variable name="E_Ca" public_interface="out" units="millivolt"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable cmeta:id="sodium_potassium_pump_i_NaK" name="i_NaK" public_interface="out" units="microA_per_microF"/>
      <variable initial_value="2" name="I_NaK" units="microA_per_microF"/>
      <variable name="f_NaK" units="dimensionless"/>
      <variable initial_value="10" name="K_mNai" units="millimolar"/>
      <variable initial_value="1.5" name="K_mKo" units="millimolar"/>
      <variable name="sigma" units="dimensionless"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>I_NaK</ci>
                        <ci>f_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     </apply>
                     <apply>
                        <plus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>K_mNai</ci>
                              <ci>Nai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
                  <ci>Ko</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>K_mKo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_specific_calcium_activated_current">
      <variable cmeta:id="non_specific_calcium_activated_current_i_ns_Ca" name="i_ns_Ca" public_interface="out" units="microA_per_microF"/>
      <variable name="i_ns_Na" public_interface="out" units="microA_per_microF"/>
      <variable name="i_ns_K" public_interface="out" units="microA_per_microF"/>
      <variable name="P_ns_Ca" units="litre_per_farad_ms"/>
      <variable name="gamma_Nai" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Nao" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ki" public_interface="in" units="dimensionless"/>
      <variable name="gamma_Ko" public_interface="in" units="dimensionless"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Ko" public_interface="in" units="millimolar"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Ki" public_interface="in" units="millimolar"/>
      <variable name="I_ns_Na" units="microA_per_microF"/>
      <variable name="I_ns_K" units="microA_per_microF"/>
      <variable initial_value="0.0012" name="K_m_ns_Ca" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>P_ns_Ca</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="litre_per_farad_ms">1.75   <sep/>
               -7</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger">
      <variable cmeta:id="Na_Ca_exchanger_i_NaCa" name="i_NaCa" public_interface="out" units="microA_per_microF"/>
      <variable name="V" public_interface="in" units="millivolt"/>
      <variable name="R" public_interface="in" units="joule_per_kilomole_kelvin"/>
      <variable name="T" public_interface="in" units="kelvin"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="Nai" public_interface="in" units="millimolar"/>
      <variable name="Nao" public_interface="in" units="millimolar"/>
      <variable name="Cai" public_interface="in" units="millimolar"/>
      <variable name="Cao" public_interface="in" units="millimolar"/>
      <variable initial_value="3" name="n_NaCa" public_interface="out" units="dimensionless"/>
      <variable initial_value="0.002" name="K_NaCa" units="microA_per_microF"/>
      <variable initial_value="0.001" name="d_NaCa" units="dimensionless"/>
      <variable initial_value="0.5" name="gamma" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>K_NaCa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>gamma</ci>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <apply>
                                    <minus/>
                                    <ci>gamma</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                                 </apply>
                                 <apply>
                                    <minus/>
                                    <ci>n_NaCa</ci>
                                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                                 </apply>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nao</ci>
                           <ci>n_NaCa</ci>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM4">1</cn>
                     <apply>
                        <times/>
                        <ci>d_NaCa</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <times/>
                              <ci>Cai</ci>
                              <apply>
                                 <power/>
                                 <ci>Nao</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                           <apply>
                              <times/>
                              <ci>Cao</ci>
                              <apply>
                                 <power/>
                                 <ci>Nai</ci>
                                 <ci>n_NaCa</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <ci>Cai</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar">0.0069</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_dynamics">
      <variable cmeta:id="calcium_dynamics_i_rel" name="i_rel" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_up" name="i_up" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_leak" name="i_leak" public_interface="out" units="millimolar_per_ms"/>
      <variable cmeta:id="calcium_dynamics_i_tr" name="i_tr" public_interface="out" units="millimolar_per_ms"/>
      <variable name="G_rel" units="per_ms"/>
      <variable initial_value="60000" name="G_rel_max" units="per_ms"/>
      <variable initial_value="4000" name="G_rel_overload" units="per_ms"/>
      <variable initial_value="0.18" name="tau_tr" units="ms"/>
      <variable initial_value="0.0008" name="K_mrel" units="millimolar"/>
      <variable initial_value="0.00018" name="delta_Ca_ith" units="millimolar"/>
      <variable initial_value="10" name="CSQN_max" units="millimolar"/>
      <variable initial_value="0.8" name="K_mCSQN" units="millimolar"/>
      <variable initial_value="0.00092" name="K_mup" units="millimolar"/>
      <variable name="K_leak" units="per_ms"/>
      <variable initial_value="5" name="I_up" units="millimolar_per_ms"/>
      <variable initial_value="15" name="Ca_NSR_max" units="millimolar"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable initial_value="0.00034209" name="Cai" public_interface="out" units="millimolar"/>
      <variable initial_value="1.8" name="Cao" public_interface="out" units="millimolar"/>
      <variable initial_value="0.8204291" name="Ca_JSR" public_interface="out" units="millimolar"/>
      <variable initial_value="2.7872629" name="Ca_NSR" public_interface="out" units="millimolar"/>
      <variable name="V_myo" public_interface="in" units="micro_litre"/>
      <variable name="A_cap" public_interface="in" units="cm2"/>
      <variable name="V_JSR" units="micro_litre"/>
      <variable name="V_NSR" units="micro_litre"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_p_Ca" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ca_T" public_interface="in" units="microA_per_microF"/>
      <variable initial_value="0.0005" name="K_mTn" units="millimolar"/>
      <variable initial_value="0.00238" name="K_mCMDN" units="millimolar"/>
      <variable initial_value="0.07" name="Tn_max" units="millimolar"/>
      <variable initial_value="0.05" name="CMDN_max" units="millimolar"/>
      <variable name="dVdt" public_interface="in" units="millivolt_per_ms"/>
      <variable initial_value="3.7458e-87" name="APtrack" units="dimensionless"/>
      <variable initial_value="2.07066e-86" name="APtrack2" units="dimensionless"/>
      <variable initial_value="0.01924195" name="APtrack3" units="dimensionless"/>
      <variable initial_value="1.660129e-87" name="Cainfluxtrack" units="millimolar"/>
      <variable initial_value="1.97626e-323" name="OVRLDtrack" units="dimensionless"/>
      <variable initial_value="-2.470328e-323" name="OVRLDtrack2" units="dimensionless"/>
      <variable initial_value="2.2645e-282" name="OVRLDtrack3" units="dimensionless"/>
      <variable initial_value="0.7" name="CSQNthresh" units="dimensionless"/>
      <variable initial_value="0.98" name="Logicthresh" units="dimensionless"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0048</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
               </apply>
               <ci>V_myo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.0552</cn>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
               </apply>
               <ci>V_myo</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack</ci>
                     </apply>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>dVdt</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millivolt_per_ms">150</cn>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>APtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack2</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack2</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack2</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.18</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>APtrack2</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>APtrack3</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">100</cn>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>APtrack3</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                        <ci>APtrack3</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <lt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.18</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.01</cn>
                     </apply>
                     <ci>APtrack3</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cainfluxtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                        </apply>
                        <ci>A_cap</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_CaCa</ci>
                                 <ci>i_Ca_T</ci>
                              </apply>
                              <ci>i_NaCa</ci>
                           </apply>
                           <ci>i_p_Ca</ci>
                           <ci>i_Ca_b</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>APtrack</ci>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                  </apply>
               </piece>
               <piece>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="millimolar_per_ms">0</cn>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>APtrack2</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.01</cn>
                     </apply>
                     <apply>
                        <leq/>
                        <ci>APtrack</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.2</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>Cainfluxtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <apply>
                           <divide/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <apply>
                              <plus/>
                              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                              <apply>
                                 <divide/>
                                 <ci>K_mCSQN</ci>
                                 <ci>Ca_JSR</ci>
                              </apply>
                           </apply>
                        </apply>
                        <ci>CSQNthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack3</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.37</cn>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>APtrack3</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.37</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>OVRLDtrack</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack2</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack2</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack2</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.5</cn>
                     </apply>
                     <ci>OVRLDtrack2</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>OVRLDtrack3</ci>
            </apply>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">50</cn>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack3</ci>
                     </apply>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                     <apply>
                        <lt/>
                        <ci>OVRLDtrack3</ci>
                        <ci>Logicthresh</ci>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0.01</cn>
                     </apply>
                     <ci>OVRLDtrack3</ci>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>G_rel</ci>
            <piecewise>
               <piece>
                  <apply>
                     <times/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>G_rel_max</ci>
                           <apply>
                              <minus/>
                              <ci>Cainfluxtrack</ci>
                              <ci>delta_Ca_ith</ci>
                           </apply>
                        </apply>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>K_mrel</ci>
                              <ci>Cainfluxtrack</ci>
                           </apply>
                           <ci>delta_Ca_ith</ci>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>APtrack2</ci>
                     </apply>
                     <ci>APtrack2</ci>
                  </apply>
                  <apply>
                     <gt/>
                     <ci>Cainfluxtrack</ci>
                     <ci>delta_Ca_ith</ci>
                  </apply>
               </piece>
               <piece>
                  <apply>
                     <times/>
                     <ci>G_rel_overload</ci>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>OVRLDtrack2</ci>
                     </apply>
                     <ci>OVRLDtrack2</ci>
                  </apply>
                  <apply>
                     <and/>
                     <apply>
                        <leq/>
                        <ci>Cainfluxtrack</ci>
                        <ci>delta_Ca_ith</ci>
                     </apply>
                     <apply>
                        <gt/>
                        <ci>OVRLDtrack2</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>i_rel</ci>
            <apply>
               <times/>
               <ci>G_rel</ci>
               <apply>
                  <minus/>
                  <ci>Ca_JSR</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Cai</ci>
                  <ci>K_mup</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_leak</ci>
            <apply>
               <divide/>
               <ci>I_up</ci>
               <ci>Ca_NSR_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>K_leak</ci>
               <ci>Ca_NSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Ca_NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_JSR</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CSQN_max</ci>
                           <ci>K_mCSQN</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mCSQN</ci>
                              <ci>Ca_JSR</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>i_tr</ci>
                  <ci>i_rel</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_NSR</ci>
            </apply>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>i_tr</ci>
                           </apply>
                           <ci>V_JSR</ci>
                        </apply>
                        <ci>V_NSR</ci>
                     </apply>
                     <ci>i_leak</ci>
                  </apply>
                  <ci>i_up</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cai</ci>
            </apply>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.001</cn>
                  <apply>
                     <plus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>CMDN_max</ci>
                           <ci>K_mCMDN</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mCMDN</ci>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Tn_max</ci>
                           <ci>K_mTn</ci>
                        </apply>
                        <apply>
                           <power/>
                           <apply>
                              <plus/>
                              <ci>K_mTn</ci>
                              <ci>Cai</ci>
                           </apply>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">1</cn>
                        </apply>
                        <ci>A_cap</ci>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>i_CaCa</ci>
                                 <ci>i_Ca_T</ci>
                              </apply>
                              <ci>i_NaCa</ci>
                           </apply>
                           <ci>i_p_Ca</ci>
                           <ci>i_Ca_b</ci>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                        <ci>V_myo</ci>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>i_rel</ci>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_myo</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_leak</ci>
                           <ci>i_up</ci>
                        </apply>
                        <ci>V_NSR</ci>
                     </apply>
                     <ci>V_myo</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable initial_value="14.177596" name="Nai" public_interface="out" units="millimolar"/>
      <variable initial_value="132" name="Nao" public_interface="out" units="millimolar"/>
      <variable initial_value="138.37949" name="Ki" public_interface="out" units="millimolar"/>
      <variable initial_value="4.5" name="Ko" public_interface="out" units="millimolar"/>
      <variable initial_value="1.434e-7" name="A_cap" public_interface="out" units="cm2"/>
      <variable initial_value="0.001" name="preplength" units="mm"/>
      <variable initial_value="1.1e-4" name="radius" units="mm"/>
      <variable name="volume" units="micro_litre"/>
      <variable name="V_myo" public_interface="out" units="micro_litre"/>
      <variable name="time" public_interface="in" units="ms"/>
      <variable name="F" public_interface="in" units="coulomb_per_mole"/>
      <variable name="i_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaNa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Na_b" public_interface="in" units="microA_per_microF"/>
      <variable name="i_ns_Na" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaCa" public_interface="in" units="microA_per_microF"/>
      <variable name="i_NaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_CaK" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kr" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Ks" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K1" public_interface="in" units="microA_per_microF"/>
      <variable name="i_Kp" public_interface="in" units="microA_per_microF"/>
      <variable name="i_K_ATP" public_interface="in" units="microA_per_microF"/>
      <variable name="i_ns_K" public_interface="in" units="microA_per_microF"/>
      <variable name="i_to" public_interface="in" units="microA_per_microF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>volume</ci>
            <apply>
               <times/>
               <pi/>
               <ci>preplength</ci>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_myo</ci>
            <apply>
               <times/>
               <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.68</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">0.001</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_Na</ci>
                     <ci>i_CaNa</ci>
                     <ci>i_Na_b</ci>
                     <ci>i_ns_Na</ci>
                     <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_NaK</ci>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="microF_per_cm2">0.001</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_CaK</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_K1</ci>
                     <ci>i_Kp</ci>
                     <ci>i_K_ATP</ci>
                     <ci>i_to</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="membrane">
         <component_ref component="fast_sodium_current">
            <component_ref component="fast_sodium_current_m_gate"/>
            <component_ref component="fast_sodium_current_h_gate"/>
            <component_ref component="fast_sodium_current_j_gate"/>
         </component_ref>
         <component_ref component="L_type_Ca_channel">
            <component_ref component="L_type_Ca_channel_d_gate"/>
            <component_ref component="L_type_Ca_channel_f_gate"/>
            <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
         </component_ref>
         <component_ref component="T_type_Ca_channel">
            <component_ref component="T_type_Ca_channel_b_gate"/>
            <component_ref component="T_type_Ca_channel_g_gate"/>
         </component_ref>
         <component_ref component="rapid_delayed_rectifier_potassium_current">
            <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
         </component_ref>
         <component_ref component="slow_delayed_rectifier_potassium_current">
            <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
            <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
         </component_ref>
         <component_ref component="time_independent_potassium_current">
            <component_ref component="time_independent_potassium_current_K1_gate"/>
         </component_ref>
         <component_ref component="transient_outward_current">
            <component_ref component="transient_outward_current_zdv_gate"/>
            <component_ref component="transient_outward_current_ydv_gate"/>
         </component_ref>
         <component_ref component="Na_Ca_exchanger"/>
         <component_ref component="plateau_potassium_current"/>
         <component_ref component="ATP_sensitive_potassium_current"/>
         <component_ref component="sarcolemmal_calcium_pump"/>
         <component_ref component="sodium_background_current"/>
         <component_ref component="calcium_background_current"/>
         <component_ref component="sodium_potassium_pump"/>
         <component_ref component="non_specific_calcium_activated_current"/>
         <component_ref component="ionic_concentrations"/>
         <component_ref component="calcium_dynamics"/>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_b_gate"/>
         <component_ref component="T_type_Ca_channel_g_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_potassium_current">
         <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_potassium_current">
         <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
         <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
      <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_zdv_gate"/>
         <component_ref component="transient_outward_current_ydv_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_1="membrane" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="ionic_concentrations" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dynamics" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="fast_sodium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="L_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="T_type_Ca_channel"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ATP_sensitive_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="transient_outward_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="plateau_potassium_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sarcolemmal_calcium_pump"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_background_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="sodium_potassium_pump"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="non_specific_calcium_activated_current"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="i_ns_Ca" variable_2="i_ns_Ca"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="ionic_concentrations"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection>
      <map_components component_1="membrane" component_2="calcium_dynamics"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="dVdt" variable_2="dVdt"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
      <map_variables variable_1="E_Na" variable_2="E_Na"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="i_CaNa" variable_2="i_CaNa"/>
      <map_variables variable_1="i_CaK" variable_2="i_CaK"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="calcium_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="i_CaCa" variable_2="i_CaCa"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="calcium_dynamics"/>
      <map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_to" variable_2="i_to"/>
   </connection>
   <connection>
      <map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="Na_Ca_exchanger" component_2="calcium_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection>
      <map_components component_1="ATP_sensitive_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_K_ATP" variable_2="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_1="plateau_potassium_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="ATP_sensitive_potassium_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="time_independent_potassium_current"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection>
      <map_components component_1="plateau_potassium_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection>
      <map_components component_1="sarcolemmal_calcium_pump" component_2="calcium_dynamics"/>
      <map_variables variable_1="i_p_Ca" variable_2="i_p_Ca"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="calcium_background_current"/>
      <map_variables variable_1="E_Ca" variable_2="E_Ca"/>
   </connection>
   <connection>
      <map_components component_1="sodium_background_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="i_Na_b" variable_2="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_1="calcium_background_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="i_Ca_b" variable_2="i_Ca_b"/>
   </connection>
   <connection>
      <map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="ionic_concentrations"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="i_ns_Na" variable_2="i_ns_Na"/>
      <map_variables variable_1="i_ns_K" variable_2="i_ns_K"/>
   </connection>
   <connection>
      <map_components component_1="non_specific_calcium_activated_current" component_2="calcium_dynamics"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="non_specific_calcium_activated_current"/>
      <map_variables variable_1="gamma_Nao" variable_2="gamma_Nao"/>
      <map_variables variable_1="gamma_Nai" variable_2="gamma_Nai"/>
      <map_variables variable_1="gamma_Ko" variable_2="gamma_Ko"/>
      <map_variables variable_1="gamma_Ki" variable_2="gamma_Ki"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_d_gate"/>
      <map_variables variable_1="d" variable_2="d"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_gate"/>
      <map_variables variable_1="f" variable_2="f"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_f_Ca_gate"/>
      <map_variables variable_1="f_Ca" variable_2="f_Ca"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_b_gate"/>
      <map_variables variable_1="b" variable_2="b"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_g_gate"/>
      <map_variables variable_1="g" variable_2="g"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      <map_variables variable_1="xr" variable_2="xr"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="slow_delayed_rectifier_potassium_current_xs1_gate"/>
      <map_variables variable_1="xs1" variable_2="xs1"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="slow_delayed_rectifier_potassium_current" component_2="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      <map_variables variable_1="xs2" variable_2="xs2"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="time_independent_potassium_current" component_2="time_independent_potassium_current_K1_gate"/>
      <map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="transient_outward_current_ydv_gate"/>
      <map_variables variable_1="ydv" variable_2="ydv"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="transient_outward_current" component_2="transient_outward_current_zdv_gate"/>
      <map_variables variable_1="zdv" variable_2="zdv"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection>
      <map_components component_1="calcium_dynamics" component_2="ionic_concentrations"/>
      <map_variables variable_1="V_myo" variable_2="V_myo"/>
      <map_variables variable_1="A_cap" variable_2="A_cap"/>
   </connection>
</model>