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/* There are a total of 12 entries in the algebraic variable array. There are a total of 4 entries in each of the rate and state variable arrays. There are a total of 8 entries in the constant variable array. */ /* * VOI is time in component time (ms). * CONSTANTS[0] is IStim in component stimulus_protocol (uA_per_mmsq). * CONSTANTS[1] is g_K_add in component parameters (mS_per_mmsq). * STATES[0] is V in component membrane (mV). * CONSTANTS[2] is Cm in component membrane (uF_per_mm2). * ALGEBRAIC[0] is i_Na in component sodium_channel (uA_per_mm2). * ALGEBRAIC[10] is i_K in component potassium_channel (uA_per_mm2). * ALGEBRAIC[11] is i_Leak in component leakage_current (uA_per_mm2). * CONSTANTS[7] is IStimC in component membrane (uA_per_mm2). * CONSTANTS[3] is g_Na_max in component sodium_channel (mS_per_mm2). * ALGEBRAIC[1] is g_Na in component sodium_channel (mS_per_mm2). * CONSTANTS[4] is E_Na in component sodium_channel (mV). * STATES[1] is m in component sodium_channel_m_gate (dimensionless). * STATES[2] is h in component sodium_channel_h_gate (dimensionless). * ALGEBRAIC[2] is alpha_m in component sodium_channel_m_gate (per_ms). * ALGEBRAIC[6] is beta_m in component sodium_channel_m_gate (per_ms). * ALGEBRAIC[3] is alpha_h in component sodium_channel_h_gate (per_ms). * ALGEBRAIC[7] is beta_h in component sodium_channel_h_gate (per_ms). * ALGEBRAIC[5] is g_K1 in component potassium_channel (mS_per_mm2). * ALGEBRAIC[9] is g_K2 in component potassium_channel (mS_per_mm2). * STATES[3] is n in component potassium_channel_n_gate (dimensionless). * ALGEBRAIC[4] is alpha_n in component potassium_channel_n_gate (per_ms). * ALGEBRAIC[8] is beta_n in component potassium_channel_n_gate (per_ms). * CONSTANTS[5] is g_L in component leakage_current (mS_per_mm2). * CONSTANTS[6] is E_L in component leakage_current (mV). * RATES[0] is d/dt V in component membrane (mV). * RATES[1] is d/dt m in component sodium_channel_m_gate (dimensionless). * RATES[2] is d/dt h in component sodium_channel_h_gate (dimensionless). * RATES[3] is d/dt n in component potassium_channel_n_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.0; CONSTANTS[1] = 0.0002; STATES[0] = -73.8; CONSTANTS[2] = 0.12; CONSTANTS[3] = 4.0; CONSTANTS[4] = 40.0; STATES[1] = 0.05; STATES[2] = 0.785; STATES[3] = 0.0935; CONSTANTS[5] = 0.0; CONSTANTS[6] = -60.0; CONSTANTS[7] = CONSTANTS[0]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = ( 0.100000*(- STATES[0] - 48.0000))/(exp((- STATES[0] - 48.0000)/15.0000) - 1.00000); ALGEBRAIC[6] = ( 0.120000*(STATES[0]+8.00000))/(exp((STATES[0]+8.00000)/5.00000) - 1.00000); RATES[1] = ALGEBRAIC[2]*(1.00000 - STATES[1]) - ALGEBRAIC[6]*STATES[1]; ALGEBRAIC[3] = 0.170000*exp((- STATES[0] - 90.0000)/20.0000); ALGEBRAIC[7] = 1.00000/(1.00000+exp((- STATES[0] - 42.0000)/10.0000)); RATES[2] = ALGEBRAIC[3]*(1.00000 - STATES[2]) - ALGEBRAIC[7]*STATES[2]; ALGEBRAIC[4] = ( 0.000100000*(- STATES[0] - 50.0000))/(exp((- STATES[0] - 50.0000)/10.0000) - 1.00000); ALGEBRAIC[8] = 0.00200000*exp((- STATES[0] - 90.0000)/80.0000); RATES[3] = ALGEBRAIC[4]*(1.00000 - STATES[3]) - ALGEBRAIC[8]*STATES[3]; ALGEBRAIC[0] = ( CONSTANTS[3]*pow(STATES[1], 3.00000)*STATES[2]+0.00140000)*(STATES[0] - CONSTANTS[4]); ALGEBRAIC[5] = 0.0120000*exp((- STATES[0] - 90.0000)/50.0000)+ 0.000150000*exp((STATES[0]+90.0000)/60.0000); ALGEBRAIC[9] = 0.0120000*pow(STATES[3], 4.00000); ALGEBRAIC[10] = (ALGEBRAIC[5]+ALGEBRAIC[9]+CONSTANTS[1])*(STATES[0]+100.000); ALGEBRAIC[11] = CONSTANTS[5]*(STATES[0] - CONSTANTS[6]); RATES[0] = (CONSTANTS[0] - (ALGEBRAIC[0]+ALGEBRAIC[10]+ALGEBRAIC[11]))/CONSTANTS[2]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = ( 0.100000*(- STATES[0] - 48.0000))/(exp((- STATES[0] - 48.0000)/15.0000) - 1.00000); ALGEBRAIC[6] = ( 0.120000*(STATES[0]+8.00000))/(exp((STATES[0]+8.00000)/5.00000) - 1.00000); ALGEBRAIC[3] = 0.170000*exp((- STATES[0] - 90.0000)/20.0000); ALGEBRAIC[7] = 1.00000/(1.00000+exp((- STATES[0] - 42.0000)/10.0000)); ALGEBRAIC[4] = ( 0.000100000*(- STATES[0] - 50.0000))/(exp((- STATES[0] - 50.0000)/10.0000) - 1.00000); ALGEBRAIC[8] = 0.00200000*exp((- STATES[0] - 90.0000)/80.0000); ALGEBRAIC[0] = ( CONSTANTS[3]*pow(STATES[1], 3.00000)*STATES[2]+0.00140000)*(STATES[0] - CONSTANTS[4]); ALGEBRAIC[5] = 0.0120000*exp((- STATES[0] - 90.0000)/50.0000)+ 0.000150000*exp((STATES[0]+90.0000)/60.0000); ALGEBRAIC[9] = 0.0120000*pow(STATES[3], 4.00000); ALGEBRAIC[10] = (ALGEBRAIC[5]+ALGEBRAIC[9]+CONSTANTS[1])*(STATES[0]+100.000); ALGEBRAIC[11] = CONSTANTS[5]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[1] = pow(STATES[1], 3.00000)*STATES[2]*CONSTANTS[3]; }