/* There are a total of 3 entries in the algebraic variable array. There are a total of 11 entries in each of the rate and state variable arrays. There are a total of 21 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is EGF in component EGF (dimensionless). * CONSTANTS[1] is inhibitor in component inhibitor (dimensionless). * CONSTANTS[2] is pro_EGFR in component pro_EGFR (dimensionless). * STATES[0] is EGFR in component EGFR (dimensionless). * STATES[1] is EGF_EGFR in component EGF_EGFR (dimensionless). * STATES[2] is EGFR_i in component EGFR_i (dimensionless). * CONSTANTS[3] is EGF_binding_kb in component model_parameters (first_order_rate_constant). * CONSTANTS[4] is EGF_binding_kf in component model_parameters (first_order_rate_constant). * CONSTANTS[5] is inhibitor_binding_kb in component model_parameters (first_order_rate_constant). * CONSTANTS[6] is inhibitor_binding_kf in component model_parameters (first_order_rate_constant). * CONSTANTS[7] is EGFR_turnover in component model_parameters (first_order_rate_constant). * STATES[3] is EGF_EGFR_i in component EGF_EGFR_i (dimensionless). * CONSTANTS[8] is k1_EGFR_phosphorylation in component model_parameters (first_order_rate_constant). * STATES[4] is pEGFR in component pEGFR (dimensionless). * STATES[5] is pEGFR_Akt in component pEGFR_Akt (dimensionless). * STATES[6] is Akt in component Akt (dimensionless). * CONSTANTS[9] is k1_pEGFR_degradation in component model_parameters (first_order_rate_constant). * CONSTANTS[10] is k1_Akt_phosphorylation in component model_parameters (first_order_rate_constant). * CONSTANTS[11] is k1_pEGFR_Akt in component model_parameters (first_order_rate_constant). * CONSTANTS[12] is k2_pEGFR_Akt in component model_parameters (first_order_rate_constant). * STATES[7] is pAkt in component pAkt (dimensionless). * CONSTANTS[13] is k1_pAkt_dephosphorylation in component model_parameters (first_order_rate_constant). * STATES[8] is S6 in component S6 (dimensionless). * STATES[9] is pAkt_S6 in component pAkt_S6 (dimensionless). * CONSTANTS[14] is k1_pAkt_S6 in component model_parameters (first_order_rate_constant). * CONSTANTS[15] is k2_pAkt_S6 in component model_parameters (first_order_rate_constant). * CONSTANTS[16] is k1_S6_phosphorylation in component model_parameters (first_order_rate_constant). * STATES[10] is pS6 in component pS6 (dimensionless). * CONSTANTS[17] is k1_pS6_dephosphorylation in component model_parameters (first_order_rate_constant). * ALGEBRAIC[0] is pEGFR_total in component pEGFR_total (dimensionless). * CONSTANTS[18] is pEGFR_scalefactor in component pEGFR_total (dimensionless). * ALGEBRAIC[1] is pAkt_total in component pAkt_total (dimensionless). * CONSTANTS[19] is pAkt_scalefactor in component pAkt_total (dimensionless). * ALGEBRAIC[2] is pS6_total in component pS6_total (dimensionless). * CONSTANTS[20] is pS6_scalefactor in component pS6_total (dimensionless). * RATES[0] is d/dt EGFR in component EGFR (dimensionless). * RATES[1] is d/dt EGF_EGFR in component EGF_EGFR (dimensionless). * RATES[2] is d/dt EGFR_i in component EGFR_i (dimensionless). * RATES[3] is d/dt EGF_EGFR_i in component EGF_EGFR_i (dimensionless). * RATES[4] is d/dt pEGFR in component pEGFR (dimensionless). * RATES[5] is d/dt pEGFR_Akt in component pEGFR_Akt (dimensionless). * RATES[6] is d/dt Akt in component Akt (dimensionless). * RATES[7] is d/dt pAkt in component pAkt (dimensionless). * RATES[9] is d/dt pAkt_S6 in component pAkt_S6 (dimensionless). * RATES[8] is d/dt S6 in component S6 (dimensionless). * RATES[10] is d/dt pS6 in component pS6 (dimensionless). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 30.0; CONSTANTS[1] = 15.0; CONSTANTS[2] = 6.81902e-4; STATES[0] = 68190.000000002; STATES[1] = 0.0; STATES[2] = 0.0; CONSTANTS[3] = 4.07490e-2; CONSTANTS[4] = 6.73816e-3; CONSTANTS[5] = 5.25097e-5; CONSTANTS[6] = 2.434663e-5; CONSTANTS[7] = 1.06386129269658e-4; STATES[3] = 0.0; CONSTANTS[8] = 1.92391e-2; STATES[4] = 0.0; STATES[5] = 0.0; STATES[6] = 4.33090e-2; CONSTANTS[9] = 9.97194e-2; CONSTANTS[10] = 3.05684e-2; CONSTANTS[11] = 1.55430e-5; CONSTANTS[12] = 5.17473e-3; STATES[7] = 0.0; CONSTANTS[13] = 3.27962e-2; STATES[8] = 3.54317e0; STATES[9] = 0.0; CONSTANTS[14] = 2.10189e-6; CONSTANTS[15] = 5.17940e-15; CONSTANTS[16] = 1.21498e-3; STATES[10] = 0.0; CONSTANTS[17] = 1.13102e-3; CONSTANTS[18] = 1.81735e-4; CONSTANTS[19] = 6.00588e1; CONSTANTS[20] = 4.98862e4; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[9] = 0.1001; RATES[8] = 0.1001; RATES[10] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ( CONSTANTS[3]*STATES[1]+ CONSTANTS[5]*STATES[2]+ CONSTANTS[7]*(CONSTANTS[2] - STATES[0])) - ( CONSTANTS[4]*CONSTANTS[0]*STATES[0]+ CONSTANTS[6]*CONSTANTS[1]*STATES[0]); resid[1] = RATES[1] - ( CONSTANTS[4]*CONSTANTS[0]*STATES[0]+ CONSTANTS[5]*STATES[3]) - ( CONSTANTS[3]*STATES[1]+ CONSTANTS[6]*CONSTANTS[1]*STATES[1]+ CONSTANTS[8]*STATES[1]); resid[2] = RATES[2] - ( CONSTANTS[3]*STATES[3]+ CONSTANTS[6]*CONSTANTS[1]*STATES[0]) - ( CONSTANTS[4]*CONSTANTS[0]*STATES[2]+ CONSTANTS[5]*STATES[2]+ CONSTANTS[7]*STATES[2]); resid[3] = RATES[3] - ( CONSTANTS[4]*CONSTANTS[0]*STATES[2]+ CONSTANTS[6]*CONSTANTS[1]*STATES[1]) - ( CONSTANTS[3]*STATES[3]+ CONSTANTS[5]*STATES[3]); resid[4] = RATES[4] - ( CONSTANTS[8]*STATES[1]+ CONSTANTS[10]*STATES[5]+ CONSTANTS[12]*STATES[5]) - ( CONSTANTS[9]*STATES[4]+ CONSTANTS[11]*STATES[4]*STATES[6]); resid[5] = RATES[5] - CONSTANTS[11]*STATES[4]*STATES[6] - ( CONSTANTS[12]*STATES[5]+ CONSTANTS[10]*STATES[5]); resid[6] = RATES[6] - ( CONSTANTS[12]*STATES[5]+ CONSTANTS[13]*STATES[7]) - CONSTANTS[11]*STATES[4]*STATES[6]; resid[7] = RATES[7] - ( CONSTANTS[10]*STATES[5]+ CONSTANTS[15]*STATES[9]+ CONSTANTS[16]*STATES[9]) - ( CONSTANTS[13]*STATES[7]+ CONSTANTS[14]*STATES[7]*STATES[8]); resid[8] = RATES[9] - CONSTANTS[14]*STATES[7]*STATES[8] - ( CONSTANTS[15]*STATES[9]+ CONSTANTS[16]*STATES[9]); resid[9] = RATES[8] - ( CONSTANTS[15]*STATES[9]+ CONSTANTS[17]*STATES[10]) - CONSTANTS[14]*STATES[7]*STATES[8]; resid[10] = RATES[10] - CONSTANTS[16]*STATES[9] - CONSTANTS[17]*STATES[10]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[4]+STATES[5])*CONSTANTS[18]; ALGEBRAIC[1] = (STATES[7]+STATES[9])*CONSTANTS[19]; ALGEBRAIC[2] = STATES[10]*CONSTANTS[20]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }