C C There are a total of 3 entries in the algebraic variable array. C There are a total of 11 entries in each of the rate and state variable arrays. C There are a total of 21 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is EGF in component EGF (dimensionless). C CONSTS(2) is inhibitor in component inhibitor (dimensionless). C CONSTS(3) is pro_EGFR in component pro_EGFR (dimensionless). C STATES(1) is EGFR in component EGFR (dimensionless). C STATES(2) is EGF_EGFR in component EGF_EGFR (dimensionless). C STATES(3) is EGFR_i in component EGFR_i (dimensionless). C CONSTS(4) is EGF_binding_kb in component model_parameters (first_order_rate_constant). C CONSTS(5) is EGF_binding_kf in component model_parameters (first_order_rate_constant). C CONSTS(6) is inhibitor_binding_kb in component model_parameters (first_order_rate_constant). C CONSTS(7) is inhibitor_binding_kf in component model_parameters (first_order_rate_constant). C CONSTS(8) is EGFR_turnover in component model_parameters (first_order_rate_constant). C STATES(4) is EGF_EGFR_i in component EGF_EGFR_i (dimensionless). C CONSTS(9) is k1_EGFR_phosphorylation in component model_parameters (first_order_rate_constant). C STATES(5) is pEGFR in component pEGFR (dimensionless). C STATES(6) is pEGFR_Akt in component pEGFR_Akt (dimensionless). C STATES(7) is Akt in component Akt (dimensionless). C CONSTS(10) is k1_pEGFR_degradation in component model_parameters (first_order_rate_constant). C CONSTS(11) is k1_Akt_phosphorylation in component model_parameters (first_order_rate_constant). C CONSTS(12) is k1_pEGFR_Akt in component model_parameters (first_order_rate_constant). C CONSTS(13) is k2_pEGFR_Akt in component model_parameters (first_order_rate_constant). C STATES(8) is pAkt in component pAkt (dimensionless). C CONSTS(14) is k1_pAkt_dephosphorylation in component model_parameters (first_order_rate_constant). C STATES(9) is S6 in component S6 (dimensionless). C STATES(10) is pAkt_S6 in component pAkt_S6 (dimensionless). C CONSTS(15) is k1_pAkt_S6 in component model_parameters (first_order_rate_constant). C CONSTS(16) is k2_pAkt_S6 in component model_parameters (first_order_rate_constant). C CONSTS(17) is k1_S6_phosphorylation in component model_parameters (first_order_rate_constant). C STATES(11) is pS6 in component pS6 (dimensionless). C CONSTS(18) is k1_pS6_dephosphorylation in component model_parameters (first_order_rate_constant). C ALGBRC(1) is pEGFR_total in component pEGFR_total (dimensionless). C CONSTS(19) is pEGFR_scalefactor in component pEGFR_total (dimensionless). C ALGBRC(2) is pAkt_total in component pAkt_total (dimensionless). C CONSTS(20) is pAkt_scalefactor in component pAkt_total (dimensionless). C ALGBRC(3) is pS6_total in component pS6_total (dimensionless). C CONSTS(21) is pS6_scalefactor in component pS6_total (dimensionless). C RATES(1) is d/dt EGFR in component EGFR (dimensionless). C RATES(2) is d/dt EGF_EGFR in component EGF_EGFR (dimensionless). C RATES(3) is d/dt EGFR_i in component EGFR_i (dimensionless). C RATES(4) is d/dt EGF_EGFR_i in component EGF_EGFR_i (dimensionless). C RATES(5) is d/dt pEGFR in component pEGFR (dimensionless). C RATES(6) is d/dt pEGFR_Akt in component pEGFR_Akt (dimensionless). C RATES(7) is d/dt Akt in component Akt (dimensionless). C RATES(8) is d/dt pAkt in component pAkt (dimensionless). C RATES(10) is d/dt pAkt_S6 in component pAkt_S6 (dimensionless). C RATES(9) is d/dt S6 in component S6 (dimensionless). C RATES(11) is d/dt pS6 in component pS6 (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 30.0 CONSTS(2) = 15.0 CONSTS(3) = 6.81902e-4 STATES(1) = 68190.000000002 STATES(2) = 0.0 STATES(3) = 0.0 CONSTS(4) = 4.07490e-2 CONSTS(5) = 6.73816e-3 CONSTS(6) = 5.25097e-5 CONSTS(7) = 2.434663e-5 CONSTS(8) = 1.06386129269658e-4 STATES(4) = 0.0 CONSTS(9) = 1.92391e-2 STATES(5) = 0.0 STATES(6) = 0.0 STATES(7) = 4.33090e-2 CONSTS(10) = 9.97194e-2 CONSTS(11) = 3.05684e-2 CONSTS(12) = 1.55430e-5 CONSTS(13) = 5.17473e-3 STATES(8) = 0.0 CONSTS(14) = 3.27962e-2 STATES(9) = 3.54317e0 STATES(10) = 0.0 CONSTS(15) = 2.10189e-6 CONSTS(16) = 5.17940e-15 CONSTS(17) = 1.21498e-3 STATES(11) = 0.0 CONSTS(18) = 1.13102e-3 CONSTS(19) = 1.81735e-4 CONSTS(20) = 6.00588e1 CONSTS(21) = 4.98862e4 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( CONSTS(4)*STATES(2)+ CONSTS(6)*STATES(3)+ CONSTS(8)*(CONSTS(3) - STATES(1))) - ( CONSTS(5)*CONSTS(1)*STATES(1)+ CONSTS(7)*CONSTS(2)*STATES(1)) RATES(2) = ( CONSTS(5)*CONSTS(1)*STATES(1)+ CONSTS(6)*STATES(4)) - ( CONSTS(4)*STATES(2)+ CONSTS(7)*CONSTS(2)*STATES(2)+ CONSTS(9)*STATES(2)) RATES(3) = ( CONSTS(4)*STATES(4)+ CONSTS(7)*CONSTS(2)*STATES(1)) - ( CONSTS(5)*CONSTS(1)*STATES(3)+ CONSTS(6)*STATES(3)+ CONSTS(8)*STATES(3)) RATES(4) = ( CONSTS(5)*CONSTS(1)*STATES(3)+ CONSTS(7)*CONSTS(2)*STATES(2)) - ( CONSTS(4)*STATES(4)+ CONSTS(6)*STATES(4)) RATES(5) = ( CONSTS(9)*STATES(2)+ CONSTS(11)*STATES(6)+ CONSTS(13)*STATES(6)) - ( CONSTS(10)*STATES(5)+ CONSTS(12)*STATES(5)*STATES(7)) RATES(6) = CONSTS(12)*STATES(5)*STATES(7) - ( CONSTS(13)*STATES(6)+ CONSTS(11)*STATES(6)) RATES(7) = ( CONSTS(13)*STATES(6)+ CONSTS(14)*STATES(8)) - CONSTS(12)*STATES(5)*STATES(7) RATES(8) = ( CONSTS(11)*STATES(6)+ CONSTS(16)*STATES(10)+ CONSTS(17)*STATES(10)) - ( CONSTS(14)*STATES(8)+ CONSTS(15)*STATES(8)*STATES(9)) RATES(10) = CONSTS(15)*STATES(8)*STATES(9) - ( CONSTS(16)*STATES(10)+ CONSTS(17)*STATES(10)) RATES(9) = ( CONSTS(16)*STATES(10)+ CONSTS(18)*STATES(11)) - CONSTS(15)*STATES(8)*STATES(9) RATES(11) = CONSTS(17)*STATES(10) - CONSTS(18)*STATES(11) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = (STATES(5)+STATES(6))*CONSTS(19) ALGBRC(2) = (STATES(8)+STATES(10))*CONSTS(20) ALGBRC(3) = STATES(11)*CONSTS(21) RETURN END