<?xml version='1.0'?>
<!-- This CellML file was generated from:
Ostby, Ivar, et al. "Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space." PLoS Comput Biol 5.1 (2009): e1000272.-->
<model cmeta:id="Ostby_2009_NBC" name="Ostby_2009_NBC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
</import>
<import xlink:href="Ostby_2009_NBC.cellml">
<component component_ref="NBC" name="NBC"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="concentrations">
<variable name="time" public_interface="in" units="second"/>
<variable initial_value="-0.032" name="V_m" public_interface="out" units="volt"/>
<variable initial_value="15.0" name="Na_int" public_interface="out" units="mM"/>
<variable initial_value="146.0" name="Na_ext" public_interface="out" units="mM"/>
<variable initial_value="9.0" name="HCO3_int" public_interface="out" units="mM"/>
<variable initial_value="15.0" name="HCO3_ext" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_int</ci>
</apply>
<cn cellml:units="mM_per_s">1.0</cn>
</apply>
</math>
</component>
<component name="fluxes">
<variable name="J_NBC_Na" public_interface="in" units="mM_per_s"/>
<variable name="J_NBC_HCO3" public_interface="in" units="mM_per_s"/>
</component>
<connection>
<map_components component_1="concentrations" component_2="NBC"/>
<map_variables variable_1="Na_int" variable_2="Na_int"/>
<map_variables variable_1="Na_ext" variable_2="Na_ext"/>
<map_variables variable_1="HCO3_int" variable_2="HCO3_int"/>
<map_variables variable_1="HCO3_ext" variable_2="HCO3_ext"/>
<map_variables variable_1="V_m" variable_2="V_m"/>
</connection>
<connection>
<map_components component_1="fluxes" component_2="NBC"/>
<map_variables variable_1="J_NBC_Na" variable_2="J_NBC_Na"/>
<map_variables variable_1="J_NBC_HCO3" variable_2="J_NBC_HCO3"/>
</connection>
<connection>
<map_components component_1="concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>