/*
   There are a total of 3 entries in the algebraic variable array.
   There are a total of 11 entries in each of the rate and state variable arrays.
   There are a total of 21 entries in the constant variable array.
 */
/*
 * VOI is time in component environment (second).
 * CONSTANTS[0] is EGF in component EGF (dimensionless).
 * CONSTANTS[1] is inhibitor in component inhibitor (dimensionless).
 * CONSTANTS[2] is pro_EGFR in component pro_EGFR (dimensionless).
 * STATES[0] is EGFR in component EGFR (dimensionless).
 * STATES[1] is EGF_EGFR in component EGF_EGFR (dimensionless).
 * STATES[2] is EGFR_i in component EGFR_i (dimensionless).
 * CONSTANTS[3] is EGF_binding_kb in component model_parameters (first_order_rate_constant).
 * CONSTANTS[4] is EGF_binding_kf in component model_parameters (first_order_rate_constant).
 * CONSTANTS[5] is inhibitor_binding_kb in component model_parameters (first_order_rate_constant).
 * CONSTANTS[6] is inhibitor_binding_kf in component model_parameters (first_order_rate_constant).
 * CONSTANTS[7] is EGFR_turnover in component model_parameters (first_order_rate_constant).
 * STATES[3] is EGF_EGFR_i in component EGF_EGFR_i (dimensionless).
 * CONSTANTS[8] is k1_EGFR_phosphorylation in component model_parameters (first_order_rate_constant).
 * STATES[4] is pEGFR in component pEGFR (dimensionless).
 * STATES[5] is pEGFR_Akt in component pEGFR_Akt (dimensionless).
 * STATES[6] is Akt in component Akt (dimensionless).
 * CONSTANTS[9] is k1_pEGFR_degradation in component model_parameters (first_order_rate_constant).
 * CONSTANTS[10] is k1_Akt_phosphorylation in component model_parameters (first_order_rate_constant).
 * CONSTANTS[11] is k1_pEGFR_Akt in component model_parameters (first_order_rate_constant).
 * CONSTANTS[12] is k2_pEGFR_Akt in component model_parameters (first_order_rate_constant).
 * STATES[7] is pAkt in component pAkt (dimensionless).
 * CONSTANTS[13] is k1_pAkt_dephosphorylation in component model_parameters (first_order_rate_constant).
 * STATES[8] is S6 in component S6 (dimensionless).
 * STATES[9] is pAkt_S6 in component pAkt_S6 (dimensionless).
 * CONSTANTS[14] is k1_pAkt_S6 in component model_parameters (first_order_rate_constant).
 * CONSTANTS[15] is k2_pAkt_S6 in component model_parameters (first_order_rate_constant).
 * CONSTANTS[16] is k1_S6_phosphorylation in component model_parameters (first_order_rate_constant).
 * STATES[10] is pS6 in component pS6 (dimensionless).
 * CONSTANTS[17] is k1_pS6_dephosphorylation in component model_parameters (first_order_rate_constant).
 * ALGEBRAIC[0] is pEGFR_total in component pEGFR_total (dimensionless).
 * CONSTANTS[18] is pEGFR_scalefactor in component pEGFR_total (dimensionless).
 * ALGEBRAIC[1] is pAkt_total in component pAkt_total (dimensionless).
 * CONSTANTS[19] is pAkt_scalefactor in component pAkt_total (dimensionless).
 * ALGEBRAIC[2] is pS6_total in component pS6_total (dimensionless).
 * CONSTANTS[20] is pS6_scalefactor in component pS6_total (dimensionless).
 * RATES[0] is d/dt EGFR in component EGFR (dimensionless).
 * RATES[1] is d/dt EGF_EGFR in component EGF_EGFR (dimensionless).
 * RATES[2] is d/dt EGFR_i in component EGFR_i (dimensionless).
 * RATES[3] is d/dt EGF_EGFR_i in component EGF_EGFR_i (dimensionless).
 * RATES[4] is d/dt pEGFR in component pEGFR (dimensionless).
 * RATES[5] is d/dt pEGFR_Akt in component pEGFR_Akt (dimensionless).
 * RATES[6] is d/dt Akt in component Akt (dimensionless).
 * RATES[7] is d/dt pAkt in component pAkt (dimensionless).
 * RATES[9] is d/dt pAkt_S6 in component pAkt_S6 (dimensionless).
 * RATES[8] is d/dt S6 in component S6 (dimensionless).
 * RATES[10] is d/dt pS6 in component pS6 (dimensionless).
 */
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 30.0;
CONSTANTS[1] = 15.0;
CONSTANTS[2] = 6.81902e-4;
STATES[0] = 68190.000000002;
STATES[1] = 0.0;
STATES[2] = 0.0;
CONSTANTS[3] = 4.07490e-2;
CONSTANTS[4] = 6.73816e-3;
CONSTANTS[5] = 5.25097e-5;
CONSTANTS[6] = 2.434663e-5;
CONSTANTS[7] = 1.06386129269658e-4;
STATES[3] = 0.0;
CONSTANTS[8] = 1.92391e-2;
STATES[4] = 0.0;
STATES[5] = 0.0;
STATES[6] = 4.33090e-2;
CONSTANTS[9] = 9.97194e-2;
CONSTANTS[10] = 3.05684e-2;
CONSTANTS[11] = 1.55430e-5;
CONSTANTS[12] = 5.17473e-3;
STATES[7] = 0.0;
CONSTANTS[13] = 3.27962e-2;
STATES[8] = 3.54317e0;
STATES[9] = 0.0;
CONSTANTS[14] = 2.10189e-6;
CONSTANTS[15] = 5.17940e-15;
CONSTANTS[16] = 1.21498e-3;
STATES[10] = 0.0;
CONSTANTS[17] = 1.13102e-3;
CONSTANTS[18] = 1.81735e-4;
CONSTANTS[19] = 6.00588e1;
CONSTANTS[20] = 4.98862e4;
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
RATES[0] = ( CONSTANTS[3]*STATES[1]+ CONSTANTS[5]*STATES[2]+ CONSTANTS[7]*(CONSTANTS[2] - STATES[0])) - ( CONSTANTS[4]*CONSTANTS[0]*STATES[0]+ CONSTANTS[6]*CONSTANTS[1]*STATES[0]);
RATES[1] = ( CONSTANTS[4]*CONSTANTS[0]*STATES[0]+ CONSTANTS[5]*STATES[3]) - ( CONSTANTS[3]*STATES[1]+ CONSTANTS[6]*CONSTANTS[1]*STATES[1]+ CONSTANTS[8]*STATES[1]);
RATES[2] = ( CONSTANTS[3]*STATES[3]+ CONSTANTS[6]*CONSTANTS[1]*STATES[0]) - ( CONSTANTS[4]*CONSTANTS[0]*STATES[2]+ CONSTANTS[5]*STATES[2]+ CONSTANTS[7]*STATES[2]);
RATES[3] = ( CONSTANTS[4]*CONSTANTS[0]*STATES[2]+ CONSTANTS[6]*CONSTANTS[1]*STATES[1]) - ( CONSTANTS[3]*STATES[3]+ CONSTANTS[5]*STATES[3]);
RATES[4] = ( CONSTANTS[8]*STATES[1]+ CONSTANTS[10]*STATES[5]+ CONSTANTS[12]*STATES[5]) - ( CONSTANTS[9]*STATES[4]+ CONSTANTS[11]*STATES[4]*STATES[6]);
RATES[5] =  CONSTANTS[11]*STATES[4]*STATES[6] - ( CONSTANTS[12]*STATES[5]+ CONSTANTS[10]*STATES[5]);
RATES[6] = ( CONSTANTS[12]*STATES[5]+ CONSTANTS[13]*STATES[7]) -  CONSTANTS[11]*STATES[4]*STATES[6];
RATES[7] = ( CONSTANTS[10]*STATES[5]+ CONSTANTS[15]*STATES[9]+ CONSTANTS[16]*STATES[9]) - ( CONSTANTS[13]*STATES[7]+ CONSTANTS[14]*STATES[7]*STATES[8]);
RATES[9] =  CONSTANTS[14]*STATES[7]*STATES[8] - ( CONSTANTS[15]*STATES[9]+ CONSTANTS[16]*STATES[9]);
RATES[8] = ( CONSTANTS[15]*STATES[9]+ CONSTANTS[17]*STATES[10]) -  CONSTANTS[14]*STATES[7]*STATES[8];
RATES[10] =  CONSTANTS[16]*STATES[9] -  CONSTANTS[17]*STATES[10];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] =  (STATES[4]+STATES[5])*CONSTANTS[18];
ALGEBRAIC[1] =  (STATES[7]+STATES[9])*CONSTANTS[19];
ALGEBRAIC[2] =  STATES[10]*CONSTANTS[20];
}