function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =51; end % There are a total of 13 entries in each of the rate and state variable arrays. % There are a total of 58 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('t in component environment (ms)'); LEGEND_CONSTANTS(:,1) = strpad('R in component environment (mJ_per_mole_kelvin)'); LEGEND_CONSTANTS(:,2) = strpad('T in component environment (kelvin)'); LEGEND_CONSTANTS(:,3) = strpad('F in component environment (coulomb_per_mole)'); LEGEND_CONSTANTS(:,49) = strpad('V_tau in component environment (mV)'); LEGEND_CONSTANTS(:,4) = strpad('Ca_o in component environment (mM)'); LEGEND_CONSTANTS(:,5) = strpad('Na_o in component environment (mM)'); LEGEND_CONSTANTS(:,6) = strpad('K_o in component environment (mM)'); LEGEND_CONSTANTS(:,50) = strpad('vol_cyt in component environment (pl)'); LEGEND_CONSTANTS(:,7) = strpad('vol_pmu in component environment (pl)'); LEGEND_CONSTANTS(:,8) = strpad('fr_cyt in component environment (dimensionless)'); LEGEND_STATES(:,1) = strpad('V in component Membrane (mV)'); LEGEND_ALGEBRAIC(:,1) = strpad('VD in component Membrane (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('C_sp in component Membrane (pF_per_sqcm)'); LEGEND_STATES(:,2) = strpad('Ca_i in component Cytosol (mM)'); LEGEND_STATES(:,3) = strpad('Na_i in component Cytosol (mM)'); LEGEND_STATES(:,4) = strpad('K_i in component Cytosol (mM)'); LEGEND_ALGEBRAIC(:,3) = strpad('V_Ca in component Membrane (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('V_Na in component Membrane (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('V_K in component Membrane (dimensionless)'); LEGEND_CONSTANTS(:,56) = strpad('A_pmu in component Membrane (sqcm)'); LEGEND_CONSTANTS(:,10) = strpad('SVR_pmu in component Membrane (per_cm)'); LEGEND_ALGEBRAIC(:,41) = strpad('J_Ca in component calcium_dynamics (mM_per_ms)'); LEGEND_ALGEBRAIC(:,49) = strpad('J_Na in component sodium_dynamics (mM_per_ms)'); LEGEND_ALGEBRAIC(:,51) = strpad('J_K in component potassium_dynamics (mM_per_ms)'); LEGEND_CONSTANTS(:,11) = strpad('atp in component Cytosol (mM)'); LEGEND_ALGEBRAIC(:,40) = strpad('J_ca in component calcium_dynamics (mM_per_ms)'); LEGEND_ALGEBRAIC(:,20) = strpad('I_CaL in component L_type_Ca_channel (pA)'); LEGEND_ALGEBRAIC(:,35) = strpad('I_pmca in component PMCA (pA)'); LEGEND_ALGEBRAIC(:,39) = strpad('I_xm in component NaCa (pA)'); LEGEND_ALGEBRAIC(:,16) = strpad('J_calb in component calcium_buffer_dynamics (mM_per_ms)'); LEGEND_ALGEBRAIC(:,18) = strpad('J_cam in component calcium_buffer_dynamics (mM_per_ms)'); LEGEND_ALGEBRAIC(:,22) = strpad('I_Na in component transient_Na_channel (pA)'); LEGEND_ALGEBRAIC(:,23) = strpad('I_Nalk in component Leak_Na_channel (pA)'); LEGEND_ALGEBRAIC(:,24) = strpad('I_NaHCN in component HCN_channel (pA)'); LEGEND_ALGEBRAIC(:,47) = strpad('I_nk in component sodium_pump (pA)'); LEGEND_ALGEBRAIC(:,31) = strpad('I_K in component potassium_dynamics (pA)'); LEGEND_ALGEBRAIC(:,26) = strpad('I_Ksk in component SK_K_channel (pA)'); LEGEND_ALGEBRAIC(:,28) = strpad('I_Kdr in component DR_K_channel (pA)'); LEGEND_ALGEBRAIC(:,30) = strpad('I_Kir in component IR_K_channel (pA)'); LEGEND_STATES(:,5) = strpad('Calb in component calcium_buffer_dynamics (mM)'); LEGEND_STATES(:,6) = strpad('Cam in component calcium_buffer_dynamics (mM)'); LEGEND_CONSTANTS(:,12) = strpad('Calbtot in component calcium_buffer_dynamics (mM)'); LEGEND_CONSTANTS(:,13) = strpad('Camtot in component calcium_buffer_dynamics (mM)'); LEGEND_ALGEBRAIC(:,15) = strpad('CaCalb in component calcium_buffer_dynamics (mM)'); LEGEND_ALGEBRAIC(:,17) = strpad('CaCam in component calcium_buffer_dynamics (mM)'); LEGEND_CONSTANTS(:,14) = strpad('kcal_1 in component calcium_buffer_dynamics (per_mM_ms)'); LEGEND_CONSTANTS(:,15) = strpad('kcal_2 in component calcium_buffer_dynamics (per_ms)'); LEGEND_ALGEBRAIC(:,9) = strpad('kcam_cb in component calcium_buffer_dynamics (per_ms)'); LEGEND_CONSTANTS(:,16) = strpad('kcam_cd in component calcium_buffer_dynamics (per_ms)'); LEGEND_ALGEBRAIC(:,11) = strpad('kcam_nb in component calcium_buffer_dynamics (per_ms)'); LEGEND_CONSTANTS(:,17) = strpad('kcam_nd in component calcium_buffer_dynamics (per_ms)'); LEGEND_ALGEBRAIC(:,13) = strpad('alpha_cam in component calcium_buffer_dynamics (per_ms)'); LEGEND_ALGEBRAIC(:,14) = strpad('beta_cam in component calcium_buffer_dynamics (per_ms)'); LEGEND_STATES(:,7) = strpad('m_cal in component L_type_Ca_channel (dimensionless)'); LEGEND_ALGEBRAIC(:,19) = strpad('h_cal in component L_type_Ca_channel (dimensionless)'); LEGEND_CONSTANTS(:,18) = strpad('g_cal in component L_type_Ca_channel (pA_per_mM)'); LEGEND_CONSTANTS(:,19) = strpad('g_na in component transient_Na_channel (pA_per_mM)'); LEGEND_ALGEBRAIC(:,21) = strpad('O_na in component transient_Na_channel (dimensionless)'); LEGEND_STATES(:,8) = strpad('m_na in component transient_Na_channel (dimensionless)'); LEGEND_STATES(:,9) = strpad('h_na in component transient_Na_channel (dimensionless)'); LEGEND_CONSTANTS(:,20) = strpad('A_mna in component transient_Na_channel (per_ms)'); LEGEND_CONSTANTS(:,21) = strpad('B_mna in component transient_Na_channel (per_ms)'); LEGEND_CONSTANTS(:,22) = strpad('A_hna in component transient_Na_channel (per_ms)'); LEGEND_CONSTANTS(:,23) = strpad('B_hna in component transient_Na_channel (per_ms)'); LEGEND_CONSTANTS(:,24) = strpad('za_mna in component transient_Na_channel (dimensionless)'); LEGEND_CONSTANTS(:,25) = strpad('zb_mna in component transient_Na_channel (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('za_hna in component transient_Na_channel (dimensionless)'); LEGEND_CONSTANTS(:,27) = strpad('zb_hna in component transient_Na_channel (dimensionless)'); LEGEND_CONSTANTS(:,28) = strpad('g_nalk in component Leak_Na_channel (pA_per_mM)'); LEGEND_CONSTANTS(:,29) = strpad('g_nahcn in component HCN_channel (pA_per_mM)'); LEGEND_STATES(:,10) = strpad('O_hcn in component HCN_channel (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('kf_hcn in component HCN_channel (per_ms)'); LEGEND_ALGEBRAIC(:,12) = strpad('kr_hcn in component HCN_channel (per_ms)'); LEGEND_ALGEBRAIC(:,2) = strpad('kf_free in component HCN_channel (per_ms)'); LEGEND_ALGEBRAIC(:,4) = strpad('kr_free in component HCN_channel (per_ms)'); LEGEND_ALGEBRAIC(:,6) = strpad('kf_bnd in component HCN_channel (per_ms)'); LEGEND_ALGEBRAIC(:,10) = strpad('kr_bnd in component HCN_channel (per_ms)'); LEGEND_CONSTANTS(:,51) = strpad('P_c in component HCN_channel (dimensionless)'); LEGEND_CONSTANTS(:,52) = strpad('P_o in component HCN_channel (dimensionless)'); LEGEND_CONSTANTS(:,30) = strpad('cAMP in component HCN_channel (mM)'); LEGEND_ALGEBRAIC(:,25) = strpad('O_sk in component SK_K_channel (dimensionless)'); LEGEND_CONSTANTS(:,31) = strpad('g_ksk in component SK_K_channel (pA_per_mM)'); LEGEND_ALGEBRAIC(:,27) = strpad('O_kdr in component DR_K_channel (dimensionless)'); LEGEND_STATES(:,11) = strpad('m_kdr in component DR_K_channel (dimensionless)'); LEGEND_CONSTANTS(:,32) = strpad('g_kdr in component DR_K_channel (nS)'); LEGEND_ALGEBRAIC(:,29) = strpad('O_kir in component IR_K_channel (dimensionless)'); LEGEND_CONSTANTS(:,33) = strpad('g_kir in component IR_K_channel (nS)'); LEGEND_STATES(:,12) = strpad('y_pc in component PMCA (dimensionless)'); LEGEND_ALGEBRAIC(:,32) = strpad('K_pmca in component PMCA (pA)'); LEGEND_CONSTANTS(:,53) = strpad('k_1pc in component PMCA (per_ms)'); LEGEND_CONSTANTS(:,34) = strpad('k_2pc in component PMCA (per_ms)'); LEGEND_CONSTANTS(:,35) = strpad('k_3pc in component PMCA (per_ms)'); LEGEND_CONSTANTS(:,36) = strpad('k_4pc in component PMCA (per_ms)'); LEGEND_ALGEBRAIC(:,34) = strpad('P_E1Spc in component PMCA (dimensionless)'); LEGEND_CONSTANTS(:,54) = strpad('P_E2Spc in component PMCA (dimensionless)'); LEGEND_ALGEBRAIC(:,36) = strpad('P_E1pc in component PMCA (dimensionless)'); LEGEND_CONSTANTS(:,57) = strpad('P_E2pc in component PMCA (dimensionless)'); LEGEND_ALGEBRAIC(:,38) = strpad('alpha_pc in component PMCA (per_ms)'); LEGEND_CONSTANTS(:,58) = strpad('beta_pc in component PMCA (per_ms)'); LEGEND_ALGEBRAIC(:,33) = strpad('K_pci in component PMCA (mM)'); LEGEND_CONSTANTS(:,37) = strpad('K_pco in component PMCA (mM)'); LEGEND_CONSTANTS(:,38) = strpad('k_pmca in component PMCA (dimensionless)'); LEGEND_CONSTANTS(:,39) = strpad('del in component NaCa (dimensionless)'); LEGEND_CONSTANTS(:,40) = strpad('k_xm in component NaCa (pA)'); LEGEND_ALGEBRAIC(:,37) = strpad('Dr in component NaCa (mM4)'); LEGEND_ALGEBRAIC(:,42) = strpad('Na_eff in component sodium_pump (mM)'); LEGEND_STATES(:,13) = strpad('y_nk in component sodium_pump (dimensionless)'); LEGEND_ALGEBRAIC(:,45) = strpad('alpha_nk in component sodium_pump (per_ms)'); LEGEND_ALGEBRAIC(:,50) = strpad('beta_nk in component sodium_pump (per_ms)'); LEGEND_ALGEBRAIC(:,43) = strpad('P_E1Snk in component sodium_pump (dimensionless)'); LEGEND_ALGEBRAIC(:,46) = strpad('P_E2Snk in component sodium_pump (dimensionless)'); LEGEND_ALGEBRAIC(:,44) = strpad('P_E1Dnk in component sodium_pump (dimensionless)'); LEGEND_ALGEBRAIC(:,48) = strpad('P_E2Dnk in component sodium_pump (dimensionless)'); LEGEND_CONSTANTS(:,55) = strpad('k_1nk in component sodium_pump (per_ms)'); LEGEND_CONSTANTS(:,41) = strpad('k_2nk in component sodium_pump (per_ms)'); LEGEND_CONSTANTS(:,42) = strpad('k_3nk in component sodium_pump (per_ms)'); LEGEND_CONSTANTS(:,43) = strpad('k_4nk in component sodium_pump (per_ms)'); LEGEND_CONSTANTS(:,44) = strpad('K_nknai in component sodium_pump (mM)'); LEGEND_CONSTANTS(:,45) = strpad('K_nknao in component sodium_pump (mM)'); LEGEND_CONSTANTS(:,46) = strpad('K_nkki in component sodium_pump (mM)'); LEGEND_CONSTANTS(:,47) = strpad('K_nkko in component sodium_pump (mM)'); LEGEND_CONSTANTS(:,48) = strpad('k_nk in component sodium_pump (pA)'); LEGEND_RATES(:,1) = strpad('d/dt V in component Membrane (mV)'); LEGEND_RATES(:,2) = strpad('d/dt Ca_i in component Cytosol (mM)'); LEGEND_RATES(:,3) = strpad('d/dt Na_i in component Cytosol (mM)'); LEGEND_RATES(:,4) = strpad('d/dt K_i in component Cytosol (mM)'); LEGEND_RATES(:,5) = strpad('d/dt Calb in component calcium_buffer_dynamics (mM)'); LEGEND_RATES(:,6) = strpad('d/dt Cam in component calcium_buffer_dynamics (mM)'); LEGEND_RATES(:,7) = strpad('d/dt m_cal in component L_type_Ca_channel (dimensionless)'); LEGEND_RATES(:,8) = strpad('d/dt m_na in component transient_Na_channel (dimensionless)'); LEGEND_RATES(:,9) = strpad('d/dt h_na in component transient_Na_channel (dimensionless)'); LEGEND_RATES(:,10) = strpad('d/dt O_hcn in component HCN_channel (dimensionless)'); LEGEND_RATES(:,11) = strpad('d/dt m_kdr in component DR_K_channel (dimensionless)'); LEGEND_RATES(:,12) = strpad('d/dt y_pc in component PMCA (dimensionless)'); LEGEND_RATES(:,13) = strpad('d/dt y_nk in component sodium_pump (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 8314.472; CONSTANTS(:,2) = 310.15; CONSTANTS(:,3) = 96485.30929; CONSTANTS(:,4) = 1.8; CONSTANTS(:,5) = 137; CONSTANTS(:,6) = 5.4; CONSTANTS(:,7) = 5; CONSTANTS(:,8) = 0.5; STATES(:,1) = -49.42; CONSTANTS(:,9) = 0.9e6; STATES(:,2) = 0.000188; STATES(:,3) = 4.6876; STATES(:,4) = 126.05893; CONSTANTS(:,10) = 1.6667e4; CONSTANTS(:,11) = 2; STATES(:,5) = 0.0026; STATES(:,6) = 0.0222; CONSTANTS(:,12) = 0.005; CONSTANTS(:,13) = 0.0235; CONSTANTS(:,14) = 10; CONSTANTS(:,15) = 2e-3; CONSTANTS(:,16) = 0.003; CONSTANTS(:,17) = 3; STATES(:,7) = 0.006271; CONSTANTS(:,18) = 2101.2; CONSTANTS(:,19) = 907.68; STATES(:,8) = 0.0952; STATES(:,9) = 0.1848; CONSTANTS(:,20) = 1.9651; CONSTANTS(:,21) = 0.0424; CONSTANTS(:,22) = 9.566e-5; CONSTANTS(:,23) = 0.5296; CONSTANTS(:,24) = 1.7127; CONSTANTS(:,25) = 1.5581; CONSTANTS(:,26) = -2.4317; CONSTANTS(:,27) = -1.1868; CONSTANTS(:,28) = 0.0053; CONSTANTS(:,29) = 51.1; STATES(:,10) = 0.003; CONSTANTS(:,30) = 1e-5; CONSTANTS(:,31) = 2.2515; STATES(:,11) = 0.0932; CONSTANTS(:,32) = 31.237; CONSTANTS(:,33) = 13.816; STATES(:,12) = 0.483; CONSTANTS(:,34) = 0.001; CONSTANTS(:,35) = 0.001; CONSTANTS(:,36) = 1; CONSTANTS(:,37) = 2; CONSTANTS(:,38) = 2.233; CONSTANTS(:,39) = 0.35; CONSTANTS(:,40) = 0.0166; STATES(:,13) = 0.6213; CONSTANTS(:,41) = 0.04; CONSTANTS(:,42) = 0.01; CONSTANTS(:,43) = 0.165; CONSTANTS(:,44) = 4.05; CONSTANTS(:,45) = 69.8; CONSTANTS(:,46) = 32.88; CONSTANTS(:,47) = 0.258; CONSTANTS(:,48) = 1085.7; CONSTANTS(:,49) = ( CONSTANTS(:,1).*CONSTANTS(:,2))./CONSTANTS(:,3); CONSTANTS(:,50) = CONSTANTS(:,8).*CONSTANTS(:,7); CONSTANTS(:,51) = 1.00000./(1.00000+CONSTANTS(:,30)./0.00116300); CONSTANTS(:,52) = 1.00000./(1.00000+CONSTANTS(:,30)./1.45000e-05); CONSTANTS(:,53) = 1.00000./(1.00000+0.100000./CONSTANTS(:,11)); CONSTANTS(:,54) = 1.00000./(1.00000+CONSTANTS(:,37)./CONSTANTS(:,4)); CONSTANTS(:,55) = 0.370000./(1.00000+0.0940000./CONSTANTS(:,11)); CONSTANTS(:,56) = ( CONSTANTS(:,10).*CONSTANTS(:,7).*0.00100000.*0.00100000.*0.00100000)./1.00000; CONSTANTS(:,57) = 1.00000 - CONSTANTS(:,54); CONSTANTS(:,58) = CONSTANTS(:,34).*CONSTANTS(:,54)+ CONSTANTS(:,36).*CONSTANTS(:,57); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,7) = (1.00000./(1.00000+exp( - (STATES(:,1)+15.0000)./7.00000)) - STATES(:,7))./( 7.68000.*exp( - power((STATES(:,1)+65.0000)./17.3300, 2.00000))+0.723100); RATES(:,11) = (1.00000./(1.00000+exp( - (STATES(:,1)+25.0000)./12.0000)) - STATES(:,11))./(18.0000./(1.00000+exp((STATES(:,1)+39.0000)./8.00000))+1.00000); ALGEBRAIC(:,1) = STATES(:,1)./CONSTANTS(:,49); RATES(:,8) = CONSTANTS(:,20).*exp( CONSTANTS(:,24).*ALGEBRAIC(:,1)).*(1.00000 - STATES(:,8)) - CONSTANTS(:,21).*exp( - CONSTANTS(:,25).*ALGEBRAIC(:,1)).*STATES(:,8); RATES(:,9) = CONSTANTS(:,22).*exp( CONSTANTS(:,26).*ALGEBRAIC(:,1)).*(1.00000 - STATES(:,9)) - CONSTANTS(:,23).*exp( - CONSTANTS(:,27).*ALGEBRAIC(:,1)).*STATES(:,9); ALGEBRAIC(:,2) = 0.00600000./(1.00000+exp((STATES(:,1)+87.7000)./6.45000)); ALGEBRAIC(:,6) = 0.0268000./(1.00000+exp((STATES(:,1)+94.2000)./13.3000)); ALGEBRAIC(:,8) = ALGEBRAIC(:,2).*CONSTANTS(:,51)+ ALGEBRAIC(:,6).*(1.00000 - CONSTANTS(:,51)); ALGEBRAIC(:,4) = 0.0800000./(1.00000+exp( - (STATES(:,1)+51.7000)./7.00000)); ALGEBRAIC(:,10) = 0.0800000./(1.00000+exp( - (STATES(:,1)+35.5000)./7.00000)); ALGEBRAIC(:,12) = ALGEBRAIC(:,4).*CONSTANTS(:,52)+ ALGEBRAIC(:,10).*(1.00000 - CONSTANTS(:,52)); RATES(:,10) = ALGEBRAIC(:,8).*(1.00000 - STATES(:,10)) - ALGEBRAIC(:,12).*STATES(:,10); ALGEBRAIC(:,15) = CONSTANTS(:,12) - STATES(:,5); ALGEBRAIC(:,16) = CONSTANTS(:,14).*STATES(:,5).*STATES(:,2) - CONSTANTS(:,15).*ALGEBRAIC(:,15); RATES(:,5) = - ALGEBRAIC(:,16); ALGEBRAIC(:,17) = CONSTANTS(:,13) - STATES(:,6); ALGEBRAIC(:,9) = 12000.0.*power(STATES(:,2), 2.00000); ALGEBRAIC(:,11) = 3.70000e+06.*power(STATES(:,2), 2.00000); ALGEBRAIC(:,13) = ALGEBRAIC(:,9).*ALGEBRAIC(:,11).*(1.00000./(ALGEBRAIC(:,9)+CONSTANTS(:,17))+1.00000./(CONSTANTS(:,16)+CONSTANTS(:,17))); ALGEBRAIC(:,14) = CONSTANTS(:,16).*CONSTANTS(:,17).*(1.00000./(ALGEBRAIC(:,9)+CONSTANTS(:,17))+1.00000./(CONSTANTS(:,16)+CONSTANTS(:,17))); ALGEBRAIC(:,18) = ALGEBRAIC(:,13).*STATES(:,6) - ALGEBRAIC(:,14).*ALGEBRAIC(:,17); RATES(:,6) = - ALGEBRAIC(:,18); ALGEBRAIC(:,33) = (173.600./(1.00000+ALGEBRAIC(:,17)./5.00000e-05)+6.40000).*1.00000e-05; ALGEBRAIC(:,34) = 1.00000./(1.00000+ALGEBRAIC(:,33)./STATES(:,2)); ALGEBRAIC(:,36) = 1.00000 - ALGEBRAIC(:,34); ALGEBRAIC(:,38) = CONSTANTS(:,53).*ALGEBRAIC(:,34)+ CONSTANTS(:,35).*ALGEBRAIC(:,36); RATES(:,12) = CONSTANTS(:,58).*(1.00000 - STATES(:,12)) - ALGEBRAIC(:,38).*STATES(:,12); ALGEBRAIC(:,3) = 0.500000.*log(CONSTANTS(:,4)./STATES(:,2)); ALGEBRAIC(:,19) = 0.000450000./(0.000450000+STATES(:,2)); ALGEBRAIC(:,20) = ( CONSTANTS(:,18).*STATES(:,7).*ALGEBRAIC(:,19).*power(( STATES(:,2).*CONSTANTS(:,4)), 1.0 ./ 2).* sinh(ALGEBRAIC(:,1) - ALGEBRAIC(:,3)))./( sinh(ALGEBRAIC(:,1))./ALGEBRAIC(:,1)); ALGEBRAIC(:,32) = CONSTANTS(:,38).*(( 10.5600.*ALGEBRAIC(:,17))./(ALGEBRAIC(:,17)+5.00000e-05)+1.20000); ALGEBRAIC(:,35) = ALGEBRAIC(:,32).*( CONSTANTS(:,53).*ALGEBRAIC(:,34).*STATES(:,12) - CONSTANTS(:,34).*CONSTANTS(:,54).*(1.00000 - STATES(:,12))).*1.00000; ALGEBRAIC(:,37) = (1.00000+ 0.00100000.*( power(STATES(:,3), 3.00000).*CONSTANTS(:,4)+ power(CONSTANTS(:,5), 3.00000).*STATES(:,2))).*(1.00000+STATES(:,2)./0.00690000); ALGEBRAIC(:,39) = ( CONSTANTS(:,40).*( power(STATES(:,3), 3.00000).*CONSTANTS(:,4).*exp( CONSTANTS(:,39).*ALGEBRAIC(:,1)) - power(CONSTANTS(:,5), 3.00000).*STATES(:,2).*exp( (CONSTANTS(:,39) - 1.00000).*ALGEBRAIC(:,1))))./ALGEBRAIC(:,37); ALGEBRAIC(:,40) = ( - 1.00000./( 2.00000.*CONSTANTS(:,3).*CONSTANTS(:,50))).*((ALGEBRAIC(:,20)+ 2.00000.*ALGEBRAIC(:,35)) - 2.00000.*ALGEBRAIC(:,39)); ALGEBRAIC(:,41) = ALGEBRAIC(:,40) - (ALGEBRAIC(:,16)+ 4.00000.*ALGEBRAIC(:,18)); RATES(:,2) = ALGEBRAIC(:,41); ALGEBRAIC(:,5) = log(CONSTANTS(:,5)./STATES(:,3)); ALGEBRAIC(:,21) = power(STATES(:,8), 3.00000).*STATES(:,9); ALGEBRAIC(:,22) = ( CONSTANTS(:,19).*ALGEBRAIC(:,21).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,23) = ( CONSTANTS(:,28).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,24) = ( CONSTANTS(:,29).*STATES(:,10).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,43) = 1.00000./(1.00000+ (CONSTANTS(:,44)./STATES(:,3)).*(1.00000+STATES(:,4)./CONSTANTS(:,46))); ALGEBRAIC(:,42) = CONSTANTS(:,5).*exp( - 0.820000.*ALGEBRAIC(:,1)); ALGEBRAIC(:,46) = 1.00000./(1.00000+ (CONSTANTS(:,45)./ALGEBRAIC(:,42)).*(1.00000+CONSTANTS(:,6)./CONSTANTS(:,47))); ALGEBRAIC(:,47) = CONSTANTS(:,48).*( CONSTANTS(:,55).*ALGEBRAIC(:,43).*STATES(:,13) - CONSTANTS(:,41).*ALGEBRAIC(:,46).*(1.00000 - STATES(:,13))).*1.00000; ALGEBRAIC(:,49) = ( - 1.00000./( CONSTANTS(:,3).*CONSTANTS(:,50))).*( 3.00000.*ALGEBRAIC(:,47)+ 3.00000.*ALGEBRAIC(:,39)+ALGEBRAIC(:,22)+ALGEBRAIC(:,23)+ALGEBRAIC(:,24)); RATES(:,3) = ALGEBRAIC(:,49); ALGEBRAIC(:,44) = 1.00000./(1.00000+ (CONSTANTS(:,46)./STATES(:,4)).*(1.00000+STATES(:,3)./CONSTANTS(:,44))); ALGEBRAIC(:,45) = CONSTANTS(:,55).*ALGEBRAIC(:,43)+ CONSTANTS(:,42).*ALGEBRAIC(:,44); ALGEBRAIC(:,48) = 1.00000./(1.00000+ (CONSTANTS(:,47)./CONSTANTS(:,6)).*(1.00000+ALGEBRAIC(:,42)./CONSTANTS(:,45))); ALGEBRAIC(:,50) = CONSTANTS(:,41).*ALGEBRAIC(:,46)+ CONSTANTS(:,43).*ALGEBRAIC(:,48); RATES(:,13) = ALGEBRAIC(:,50).*(1.00000 - STATES(:,13)) - ALGEBRAIC(:,45).*STATES(:,13); ALGEBRAIC(:,7) = log(CONSTANTS(:,6)./STATES(:,4)); ALGEBRAIC(:,25) = power(STATES(:,2), 4.20000)./(power(0.000350000, 4.20000)+power(STATES(:,2), 4.20000)); ALGEBRAIC(:,26) = ( CONSTANTS(:,31).*ALGEBRAIC(:,25).*power(( STATES(:,4).*CONSTANTS(:,6)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,7))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,27) = power(STATES(:,11), 3.00000); ALGEBRAIC(:,28) = CONSTANTS(:,32).*ALGEBRAIC(:,27).*(STATES(:,1) - ALGEBRAIC(:,7).*CONSTANTS(:,49)); ALGEBRAIC(:,29) = 1.00000./(1.00000+exp((STATES(:,1)+85.0000)./12.1000)); ALGEBRAIC(:,30) = CONSTANTS(:,33).*ALGEBRAIC(:,29).*(STATES(:,1) - ALGEBRAIC(:,7).*CONSTANTS(:,49)); ALGEBRAIC(:,31) = ALGEBRAIC(:,26)+ALGEBRAIC(:,28)+ALGEBRAIC(:,30); ALGEBRAIC(:,51) = ( - 1.00000./( CONSTANTS(:,3).*CONSTANTS(:,50))).*(ALGEBRAIC(:,31) - 2.00000.*ALGEBRAIC(:,47)); RATES(:,1) = (( CONSTANTS(:,3).*CONSTANTS(:,50))./( CONSTANTS(:,9).*CONSTANTS(:,56))).*(ALGEBRAIC(:,49)+ALGEBRAIC(:,51)+ 2.00000.*ALGEBRAIC(:,41)); RATES(:,4) = ALGEBRAIC(:,51); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = STATES(:,1)./CONSTANTS(:,49); ALGEBRAIC(:,2) = 0.00600000./(1.00000+exp((STATES(:,1)+87.7000)./6.45000)); ALGEBRAIC(:,6) = 0.0268000./(1.00000+exp((STATES(:,1)+94.2000)./13.3000)); ALGEBRAIC(:,8) = ALGEBRAIC(:,2).*CONSTANTS(:,51)+ ALGEBRAIC(:,6).*(1.00000 - CONSTANTS(:,51)); ALGEBRAIC(:,4) = 0.0800000./(1.00000+exp( - (STATES(:,1)+51.7000)./7.00000)); ALGEBRAIC(:,10) = 0.0800000./(1.00000+exp( - (STATES(:,1)+35.5000)./7.00000)); ALGEBRAIC(:,12) = ALGEBRAIC(:,4).*CONSTANTS(:,52)+ ALGEBRAIC(:,10).*(1.00000 - CONSTANTS(:,52)); ALGEBRAIC(:,15) = CONSTANTS(:,12) - STATES(:,5); ALGEBRAIC(:,16) = CONSTANTS(:,14).*STATES(:,5).*STATES(:,2) - CONSTANTS(:,15).*ALGEBRAIC(:,15); ALGEBRAIC(:,17) = CONSTANTS(:,13) - STATES(:,6); ALGEBRAIC(:,9) = 12000.0.*power(STATES(:,2), 2.00000); ALGEBRAIC(:,11) = 3.70000e+06.*power(STATES(:,2), 2.00000); ALGEBRAIC(:,13) = ALGEBRAIC(:,9).*ALGEBRAIC(:,11).*(1.00000./(ALGEBRAIC(:,9)+CONSTANTS(:,17))+1.00000./(CONSTANTS(:,16)+CONSTANTS(:,17))); ALGEBRAIC(:,14) = CONSTANTS(:,16).*CONSTANTS(:,17).*(1.00000./(ALGEBRAIC(:,9)+CONSTANTS(:,17))+1.00000./(CONSTANTS(:,16)+CONSTANTS(:,17))); ALGEBRAIC(:,18) = ALGEBRAIC(:,13).*STATES(:,6) - ALGEBRAIC(:,14).*ALGEBRAIC(:,17); ALGEBRAIC(:,33) = (173.600./(1.00000+ALGEBRAIC(:,17)./5.00000e-05)+6.40000).*1.00000e-05; ALGEBRAIC(:,34) = 1.00000./(1.00000+ALGEBRAIC(:,33)./STATES(:,2)); ALGEBRAIC(:,36) = 1.00000 - ALGEBRAIC(:,34); ALGEBRAIC(:,38) = CONSTANTS(:,53).*ALGEBRAIC(:,34)+ CONSTANTS(:,35).*ALGEBRAIC(:,36); ALGEBRAIC(:,3) = 0.500000.*log(CONSTANTS(:,4)./STATES(:,2)); ALGEBRAIC(:,19) = 0.000450000./(0.000450000+STATES(:,2)); ALGEBRAIC(:,20) = ( CONSTANTS(:,18).*STATES(:,7).*ALGEBRAIC(:,19).*power(( STATES(:,2).*CONSTANTS(:,4)), 1.0 ./ 2).* sinh(ALGEBRAIC(:,1) - ALGEBRAIC(:,3)))./( sinh(ALGEBRAIC(:,1))./ALGEBRAIC(:,1)); ALGEBRAIC(:,32) = CONSTANTS(:,38).*(( 10.5600.*ALGEBRAIC(:,17))./(ALGEBRAIC(:,17)+5.00000e-05)+1.20000); ALGEBRAIC(:,35) = ALGEBRAIC(:,32).*( CONSTANTS(:,53).*ALGEBRAIC(:,34).*STATES(:,12) - CONSTANTS(:,34).*CONSTANTS(:,54).*(1.00000 - STATES(:,12))).*1.00000; ALGEBRAIC(:,37) = (1.00000+ 0.00100000.*( power(STATES(:,3), 3.00000).*CONSTANTS(:,4)+ power(CONSTANTS(:,5), 3.00000).*STATES(:,2))).*(1.00000+STATES(:,2)./0.00690000); ALGEBRAIC(:,39) = ( CONSTANTS(:,40).*( power(STATES(:,3), 3.00000).*CONSTANTS(:,4).*exp( CONSTANTS(:,39).*ALGEBRAIC(:,1)) - power(CONSTANTS(:,5), 3.00000).*STATES(:,2).*exp( (CONSTANTS(:,39) - 1.00000).*ALGEBRAIC(:,1))))./ALGEBRAIC(:,37); ALGEBRAIC(:,40) = ( - 1.00000./( 2.00000.*CONSTANTS(:,3).*CONSTANTS(:,50))).*((ALGEBRAIC(:,20)+ 2.00000.*ALGEBRAIC(:,35)) - 2.00000.*ALGEBRAIC(:,39)); ALGEBRAIC(:,41) = ALGEBRAIC(:,40) - (ALGEBRAIC(:,16)+ 4.00000.*ALGEBRAIC(:,18)); ALGEBRAIC(:,5) = log(CONSTANTS(:,5)./STATES(:,3)); ALGEBRAIC(:,21) = power(STATES(:,8), 3.00000).*STATES(:,9); ALGEBRAIC(:,22) = ( CONSTANTS(:,19).*ALGEBRAIC(:,21).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,23) = ( CONSTANTS(:,28).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,24) = ( CONSTANTS(:,29).*STATES(:,10).*power(( STATES(:,3).*CONSTANTS(:,5)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,5))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,43) = 1.00000./(1.00000+ (CONSTANTS(:,44)./STATES(:,3)).*(1.00000+STATES(:,4)./CONSTANTS(:,46))); ALGEBRAIC(:,42) = CONSTANTS(:,5).*exp( - 0.820000.*ALGEBRAIC(:,1)); ALGEBRAIC(:,46) = 1.00000./(1.00000+ (CONSTANTS(:,45)./ALGEBRAIC(:,42)).*(1.00000+CONSTANTS(:,6)./CONSTANTS(:,47))); ALGEBRAIC(:,47) = CONSTANTS(:,48).*( CONSTANTS(:,55).*ALGEBRAIC(:,43).*STATES(:,13) - CONSTANTS(:,41).*ALGEBRAIC(:,46).*(1.00000 - STATES(:,13))).*1.00000; ALGEBRAIC(:,49) = ( - 1.00000./( CONSTANTS(:,3).*CONSTANTS(:,50))).*( 3.00000.*ALGEBRAIC(:,47)+ 3.00000.*ALGEBRAIC(:,39)+ALGEBRAIC(:,22)+ALGEBRAIC(:,23)+ALGEBRAIC(:,24)); ALGEBRAIC(:,44) = 1.00000./(1.00000+ (CONSTANTS(:,46)./STATES(:,4)).*(1.00000+STATES(:,3)./CONSTANTS(:,44))); ALGEBRAIC(:,45) = CONSTANTS(:,55).*ALGEBRAIC(:,43)+ CONSTANTS(:,42).*ALGEBRAIC(:,44); ALGEBRAIC(:,48) = 1.00000./(1.00000+ (CONSTANTS(:,47)./CONSTANTS(:,6)).*(1.00000+ALGEBRAIC(:,42)./CONSTANTS(:,45))); ALGEBRAIC(:,50) = CONSTANTS(:,41).*ALGEBRAIC(:,46)+ CONSTANTS(:,43).*ALGEBRAIC(:,48); ALGEBRAIC(:,7) = log(CONSTANTS(:,6)./STATES(:,4)); ALGEBRAIC(:,25) = power(STATES(:,2), 4.20000)./(power(0.000350000, 4.20000)+power(STATES(:,2), 4.20000)); ALGEBRAIC(:,26) = ( CONSTANTS(:,31).*ALGEBRAIC(:,25).*power(( STATES(:,4).*CONSTANTS(:,6)), 1.0 ./ 2).* sinh( 0.500000.*(ALGEBRAIC(:,1) - ALGEBRAIC(:,7))))./( sinh( 0.500000.*ALGEBRAIC(:,1))./( 0.500000.*ALGEBRAIC(:,1))); ALGEBRAIC(:,27) = power(STATES(:,11), 3.00000); ALGEBRAIC(:,28) = CONSTANTS(:,32).*ALGEBRAIC(:,27).*(STATES(:,1) - ALGEBRAIC(:,7).*CONSTANTS(:,49)); ALGEBRAIC(:,29) = 1.00000./(1.00000+exp((STATES(:,1)+85.0000)./12.1000)); ALGEBRAIC(:,30) = CONSTANTS(:,33).*ALGEBRAIC(:,29).*(STATES(:,1) - ALGEBRAIC(:,7).*CONSTANTS(:,49)); ALGEBRAIC(:,31) = ALGEBRAIC(:,26)+ALGEBRAIC(:,28)+ALGEBRAIC(:,30); ALGEBRAIC(:,51) = ( - 1.00000./( CONSTANTS(:,3).*CONSTANTS(:,50))).*(ALGEBRAIC(:,31) - 2.00000.*ALGEBRAIC(:,47)); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end