/* There are a total of 66 entries in the algebraic variable array. There are a total of 42 entries in each of the rate and state variable arrays. There are a total of 94 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is Casp8 in component Casp8 (micromolar). * STATES[1] is Casp8Bid in component Casp8 (micromolar). * STATES[2] is FeLnNO in component FeLn (micromolar). * STATES[3] is Bid in component Bid (micromolar). * ALGEBRAIC[2] is J_0 in component Casp8 (flux). * ALGEBRAIC[0] is J_f0 in component Casp8 (flux). * ALGEBRAIC[1] is J_Casp8 in component Casp8 (flux). * ALGEBRAIC[3] is r_20NO in component Casp8 (flux). * ALGEBRAIC[61] is r_19NO in component PTPC (flux). * CONSTANTS[0] is k_f0 in component model_constant (first_order_rate_constant). * CONSTANTS[1] is k_10 in component model_constant (second_order_rate_constant). * CONSTANTS[2] is k_00 in component model_constant (first_order_rate_constant). * CONSTANTS[3] is u in component model_constant (first_order_rate_constant). * CONSTANTS[4] is k_20NO in component model_constant (second_order_rate_constant). * STATES[4] is Apaf_1 in component Apaf_1 (micromolar). * STATES[5] is CytcApaf_1 in component CytcApaf_1 (micromolar). * STATES[6] is Cytc in component Cytc (micromolar). * ALGEBRAIC[4] is J_Apaf_1 in component Apaf_1 (flux). * ALGEBRAIC[5] is J_1 in component Apaf_1 (flux). * CONSTANTS[5] is P_Apaf_1 in component model_constant (flux). * CONSTANTS[6] is k_11 in component model_constant (second_order_rate_constant). * CONSTANTS[7] is k_01 in component model_constant (first_order_rate_constant). * STATES[7] is Apop in component Apop (micromolar). * ALGEBRAIC[7] is J_1b in component CytcApaf_1 (flux). * CONSTANTS[8] is k_11b in component model_constant (rate). * CONSTANTS[9] is k_01b in component model_constant (first_order_rate_constant). * CONSTANTS[10] is p in component model_constant (dimensionless). * STATES[8] is Cytc_mito in component Cytc_mito (micromolar). * STATES[9] is PTPC in component PTPC (micromolar). * ALGEBRAIC[8] is PTPC_act in component Cytc (micromolar). * CONSTANTS[11] is PTPC_0 in component model_constant (micromolar). * ALGEBRAIC[12] is J_14 in component Cytc_mito (flux). * ALGEBRAIC[6] is J_Cytc in component Cytc (flux). * CONSTANTS[12] is k_1 in component model_constant (second_order_rate_constant). * STATES[10] is Bax_2 in component Bax_2 (micromolar). * ALGEBRAIC[10] is J_Cytc_mito in component Cytc_mito (flux). * CONSTANTS[13] is P_Cytc_mito in component model_constant (flux). * CONSTANTS[14] is k14 in component model_constant (second_order_rate_constant). * ALGEBRAIC[17] is J_12b in component tBidBax (flux). * ALGEBRAIC[9] is J_Bax_2 in component Bax_2 (flux). * STATES[11] is tBid_mito in component tBid_mito (micromolar). * STATES[12] is Bax in component Bax (micromolar). * ALGEBRAIC[14] is J_11 in component tBid (flux). * ALGEBRAIC[13] is J_12a in component tBid_mito (flux). * ALGEBRAIC[11] is J_tBid_mito in component tBid_mito (flux). * CONSTANTS[15] is k12a in component model_constant (second_order_rate_constant). * STATES[13] is tBid in component tBid (micromolar). * ALGEBRAIC[25] is J_f8 in component Casp3Bid (flux). * ALGEBRAIC[15] is J_tBid in component tBid (flux). * CONSTANTS[16] is k11 in component model_constant (first_order_rate_constant). * STATES[14] is tBidBax in component tBidBax (micromolar). * ALGEBRAIC[16] is J_tBidBax in component tBidBax (flux). * CONSTANTS[17] is k12b in component model_constant (second_order_rate_constant). * STATES[15] is Bcl_2 in component Bcl_2 (micromolar). * ALGEBRAIC[19] is J_13 in component Bax (flux). * ALGEBRAIC[18] is J_Bax in component Bax (flux). * CONSTANTS[91] is P_Bax in component Bax (flux). * CONSTANTS[18] is k13 in component model_constant (second_order_rate_constant). * CONSTANTS[19] is P_oBax in component model_constant (flux). * CONSTANTS[20] is p53 in component model_constant (micromolar). * CONSTANTS[21] is p53_thresh in component model_constant (micromolar). * CONSTANTS[22] is u_Bax in component model_constant (first_order_rate_constant). * STATES[16] is Casp3 in component Casp3 (micromolar). * STATES[17] is Casp3Bcl_2 in component Casp3Bcl_2 (micromolar). * ALGEBRAIC[20] is J_9 in component Bcl_2 (flux). * ALGEBRAIC[22] is J_Bcl_2 in component Bcl_2 (flux). * CONSTANTS[23] is k_19 in component model_constant (second_order_rate_constant). * CONSTANTS[24] is k_09 in component model_constant (first_order_rate_constant). * CONSTANTS[92] is P_Bcl_2 in component Bcl_2 (flux). * CONSTANTS[25] is P_oBcl_2 in component model_constant (flux). * CONSTANTS[26] is u_Bcl_2 in component model_constant (first_order_rate_constant). * ALGEBRAIC[21] is J_f9 in component Casp3Bcl_2 (flux). * CONSTANTS[27] is k_f9 in component model_constant (first_order_rate_constant). * STATES[18] is Casp3Bid in component Casp3Bid (micromolar). * ALGEBRAIC[23] is J_8 in component Casp3Bid (flux). * CONSTANTS[28] is k_18 in component model_constant (second_order_rate_constant). * CONSTANTS[29] is k_08 in component model_constant (first_order_rate_constant). * CONSTANTS[30] is k_f8 in component model_constant (first_order_rate_constant). * ALGEBRAIC[24] is J_Bid in component Bid (flux). * CONSTANTS[31] is P_Bid in component model_constant (flux). * STATES[19] is IAP in component IAP (micromolar). * STATES[20] is Casp3IAP in component Casp3 (micromolar). * ALGEBRAIC[34] is J_f6 in component Casp9Pro3 (flux). * ALGEBRAIC[33] is J_f6b in component ApopCasp9_2Pro3 (flux). * ALGEBRAIC[27] is J_7 in component Casp3 (flux). * ALGEBRAIC[26] is J_Casp3 in component Casp3 (flux). * ALGEBRAIC[65] is r_22NO in component FeLn (flux). * CONSTANTS[32] is k_17 in component model_constant (second_order_rate_constant). * CONSTANTS[33] is k_07 in component model_constant (first_order_rate_constant). * ALGEBRAIC[29] is J_2 in component Pro9 (flux). * ALGEBRAIC[42] is J_4b in component ApopCasp9 (flux). * STATES[21] is Pro9 in component Pro9 (micromolar). * STATES[22] is ApopPro9 in component Pro9 (micromolar). * STATES[23] is ApopPro9_2 in component ApopPro9_2 (micromolar). * ALGEBRAIC[30] is J_3 in component Pro9 (flux). * ALGEBRAIC[28] is J_Pro9 in component Pro9 (flux). * CONSTANTS[34] is k_12 in component model_constant (second_order_rate_constant). * CONSTANTS[35] is k_02 in component model_constant (first_order_rate_constant). * CONSTANTS[36] is k_13 in component model_constant (second_order_rate_constant). * CONSTANTS[37] is k_03 in component model_constant (first_order_rate_constant). * CONSTANTS[38] is P_Pro9 in component model_constant (flux). * ALGEBRAIC[31] is J_f3 in component ApopPro9_2 (flux). * CONSTANTS[39] is k_f3 in component model_constant (first_order_rate_constant). * STATES[24] is ApopCasp9_2Pro3 in component ApopCasp9_2Pro3 (micromolar). * STATES[25] is ApopCasp9_2 in component ApopCasp9_2 (micromolar). * STATES[26] is Pro3 in component Pro3 (micromolar). * ALGEBRAIC[32] is J_6b in component ApopCasp9_2Pro3 (flux). * CONSTANTS[40] is k_16b in component model_constant (second_order_rate_constant). * CONSTANTS[41] is k_06b in component model_constant (first_order_rate_constant). * CONSTANTS[42] is k_f6b in component model_constant (first_order_rate_constant). * STATES[27] is Casp9Pro3 in component Casp9Pro3 (micromolar). * ALGEBRAIC[35] is J_6 in component Pro3 (flux). * CONSTANTS[43] is k_f6 in component model_constant (first_order_rate_constant). * STATES[28] is Casp9 in component Casp9 (micromolar). * ALGEBRAIC[36] is J_Pro3 in component Pro3 (flux). * CONSTANTS[44] is k_16 in component model_constant (second_order_rate_constant). * CONSTANTS[45] is k_06 in component model_constant (first_order_rate_constant). * CONSTANTS[46] is P_Pro3 in component model_constant (flux). * STATES[29] is Casp9IAP in component IAP (micromolar). * STATES[30] is ApopCasp9IAP in component IAP (micromolar). * STATES[31] is ApopCasp9_2IAP in component IAP (micromolar). * STATES[32] is ApopCasp9 in component ApopCasp9 (micromolar). * ALGEBRAIC[37] is J_5 in component IAP (flux). * ALGEBRAIC[38] is J_5b in component IAP (flux). * ALGEBRAIC[39] is J_5c in component IAP (flux). * ALGEBRAIC[41] is J_IAP in component IAP (flux). * CONSTANTS[47] is P_IAP in component model_constant (flux). * CONSTANTS[48] is k_15 in component model_constant (second_order_rate_constant). * CONSTANTS[49] is k_05 in component model_constant (first_order_rate_constant). * CONSTANTS[50] is k_15b in component model_constant (second_order_rate_constant). * CONSTANTS[51] is k_05b in component model_constant (first_order_rate_constant). * CONSTANTS[52] is k_15c in component model_constant (second_order_rate_constant). * CONSTANTS[53] is k_05c in component model_constant (first_order_rate_constant). * ALGEBRAIC[40] is J_4 in component ApopCasp9 (flux). * CONSTANTS[54] is k_14 in component model_constant (first_order_rate_constant). * CONSTANTS[55] is k_04 in component model_constant (second_order_rate_constant). * CONSTANTS[56] is k_14b in component model_constant (first_order_rate_constant). * CONSTANTS[57] is k_04b in component model_constant (second_order_rate_constant). * ALGEBRAIC[43] is J_Casp9 in component Casp9 (flux). * ALGEBRAIC[64] is r_21NO in component FeLn (flux). * STATES[33] is NO in component NO (micromolar). * STATES[34] is O_2m in component O_2m (micromolar). * CONSTANTS[58] is O_2 in component NO (micromolar). * STATES[35] is NO_2 in component NO (micromolar). * STATES[36] is N2O3 in component N2O3 (micromolar). * STATES[37] is GSNO in component GSNO (micromolar). * STATES[38] is CcOX in component NO (micromolar). * STATES[39] is FeLn in component FeLn (micromolar). * CONSTANTS[90] is r_1NO in component NO (flux). * ALGEBRAIC[44] is r_4NO in component NO (flux). * ALGEBRAIC[45] is r_12aNO in component NO (flux). * ALGEBRAIC[46] is r_12bNOp in component NO (flux). * ALGEBRAIC[47] is r_12bNOm in component NO (flux). * ALGEBRAIC[48] is r_14NO in component NO (flux). * ALGEBRAIC[49] is r_15NO in component NO (flux). * ALGEBRAIC[50] is r_16NO in component NO (flux). * CONSTANTS[59] is k_1NO in component model_constant (flux). * CONSTANTS[60] is k_4NO in component model_constant (second_order_rate_constant). * CONSTANTS[61] is k_12aNO in component model_constant (rate2). * CONSTANTS[62] is k_12bNOp in component model_constant (second_order_rate_constant). * CONSTANTS[63] is k_12bNOm in component model_constant (first_order_rate_constant). * CONSTANTS[64] is k_14NO in component model_constant (first_order_rate_constant). * CONSTANTS[65] is k_15NO in component model_constant (second_order_rate_constant). * CONSTANTS[66] is k_16NO in component model_constant (second_order_rate_constant). * CONSTANTS[67] is SOD in component O_2m (micromolar). * CONSTANTS[93] is r_2NO in component O_2m (flux). * ALGEBRAIC[51] is r_5NO in component O_2m (flux). * ALGEBRAIC[52] is r_10NO in component O_2m (flux). * CONSTANTS[68] is k_2NO in component model_constant (flux). * CONSTANTS[69] is k_5NO in component model_constant (second_order_rate_constant). * CONSTANTS[70] is k_10NO in component model_constant (rate2). * STATES[40] is ONOO_m in component ONOO_m (micromolar). * STATES[41] is GSH in component GSH (micromolar). * CONSTANTS[71] is GPX in component ONOO_m (micromolar). * CONSTANTS[72] is CO_2 in component ONOO_m (micromolar). * CONSTANTS[73] is Cyt_c in component ONOO_m (micromolar). * ALGEBRAIC[53] is r_6NO in component ONOO_m (flux). * ALGEBRAIC[54] is r_7NO in component ONOO_m (flux). * ALGEBRAIC[57] is r_8NO in component ONOO_m (flux). * ALGEBRAIC[60] is r_9NO in component ONOO_m (flux). * ALGEBRAIC[63] is r_18NO in component ONOO_m (flux). * CONSTANTS[74] is k_6NO in component model_constant (second_order_rate_constant). * CONSTANTS[75] is k_7NO in component model_constant (second_order_rate_constant). * CONSTANTS[76] is k_8NO in component model_constant (second_order_rate_constant). * CONSTANTS[77] is k_9NO in component model_constant (second_order_rate_constant). * CONSTANTS[78] is k_18NO in component model_constant (second_order_rate_constant). * ALGEBRAIC[55] is GSSG in component GSH (micromolar). * CONSTANTS[79] is FeLn_0 in component model_constant (micromolar). * CONSTANTS[80] is GSH_0 in component model_constant (micromolar). * ALGEBRAIC[56] is r_11NO in component GSH (flux). * ALGEBRAIC[59] is r_m in component GSH (flux). * ALGEBRAIC[62] is r_17NO in component GSH (flux). * CONSTANTS[81] is k_11NO in component model_constant (second_order_rate_constant). * CONSTANTS[82] is v_m in component model_constant (flux). * CONSTANTS[83] is k_m in component model_constant (micromolar). * CONSTANTS[84] is k_17NO in component model_constant (second_order_rate_constant). * ALGEBRAIC[58] is r_13NO in component N2O3 (flux). * CONSTANTS[85] is k_13NO in component model_constant (first_order_rate_constant). * CONSTANTS[86] is k_21NO in component model_constant (second_order_rate_constant). * CONSTANTS[87] is k_22NO in component model_constant (second_order_rate_constant). * CONSTANTS[88] is k_19NO in component model_constant (second_order_rate_constant). * CONSTANTS[89] is k_17bNO in component model_constant (second_order_rate_constant). * RATES[0] is d/dt Casp8 in component Casp8 (micromolar). * RATES[1] is d/dt Casp8Bid in component Casp8 (micromolar). * RATES[4] is d/dt Apaf_1 in component Apaf_1 (micromolar). * RATES[5] is d/dt CytcApaf_1 in component CytcApaf_1 (micromolar). * RATES[6] is d/dt Cytc in component Cytc (micromolar). * RATES[8] is d/dt Cytc_mito in component Cytc_mito (micromolar). * RATES[10] is d/dt Bax_2 in component Bax_2 (micromolar). * RATES[11] is d/dt tBid_mito in component tBid_mito (micromolar). * RATES[13] is d/dt tBid in component tBid (micromolar). * RATES[14] is d/dt tBidBax in component tBidBax (micromolar). * RATES[12] is d/dt Bax in component Bax (micromolar). * RATES[15] is d/dt Bcl_2 in component Bcl_2 (micromolar). * RATES[17] is d/dt Casp3Bcl_2 in component Casp3Bcl_2 (micromolar). * RATES[18] is d/dt Casp3Bid in component Casp3Bid (micromolar). * RATES[3] is d/dt Bid in component Bid (micromolar). * RATES[20] is d/dt Casp3IAP in component Casp3 (micromolar). * RATES[16] is d/dt Casp3 in component Casp3 (micromolar). * RATES[7] is d/dt Apop in component Apop (micromolar). * RATES[21] is d/dt Pro9 in component Pro9 (micromolar). * RATES[22] is d/dt ApopPro9 in component Pro9 (micromolar). * RATES[23] is d/dt ApopPro9_2 in component ApopPro9_2 (micromolar). * RATES[24] is d/dt ApopCasp9_2Pro3 in component ApopCasp9_2Pro3 (micromolar). * RATES[27] is d/dt Casp9Pro3 in component Casp9Pro3 (micromolar). * RATES[26] is d/dt Pro3 in component Pro3 (micromolar). * RATES[29] is d/dt Casp9IAP in component IAP (micromolar). * RATES[30] is d/dt ApopCasp9IAP in component IAP (micromolar). * RATES[31] is d/dt ApopCasp9_2IAP in component IAP (micromolar). * RATES[19] is d/dt IAP in component IAP (micromolar). * RATES[32] is d/dt ApopCasp9 in component ApopCasp9 (micromolar). * RATES[28] is d/dt Casp9 in component Casp9 (micromolar). * RATES[25] is d/dt ApopCasp9_2 in component ApopCasp9_2 (micromolar). * RATES[33] is d/dt NO in component NO (micromolar). * RATES[38] is d/dt CcOX in component NO (micromolar). * RATES[35] is d/dt NO_2 in component NO (micromolar). * RATES[34] is d/dt O_2m in component O_2m (micromolar). * RATES[40] is d/dt ONOO_m in component ONOO_m (micromolar). * RATES[41] is d/dt GSH in component GSH (micromolar). * RATES[37] is d/dt GSNO in component GSNO (micromolar). * RATES[36] is d/dt N2O3 in component N2O3 (micromolar). * RATES[39] is d/dt FeLn in component FeLn (micromolar). * RATES[2] is d/dt FeLnNO in component FeLn (micromolar). * RATES[9] is d/dt PTPC in component PTPC (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0; STATES[1] = 0; STATES[2] = 0; STATES[3] = 0.004; CONSTANTS[0] = 0.1; CONSTANTS[1] = 10; CONSTANTS[2] = 0.5; CONSTANTS[3] = 0.006; CONSTANTS[4] = 66; STATES[4] = 0.004; STATES[5] = 0; STATES[6] = 0; CONSTANTS[5] = 0.0003; CONSTANTS[6] = 5; CONSTANTS[7] = 0.5; STATES[7] = 0; CONSTANTS[8] = 50000; CONSTANTS[9] = 0.5; CONSTANTS[10] = 4; STATES[8] = 0.004; STATES[9] = 0; CONSTANTS[11] = 0; CONSTANTS[12] = 1; STATES[10] = 0; CONSTANTS[13] = 0.0003; CONSTANTS[14] = 10; STATES[11] = 0; STATES[12] = 0.004; CONSTANTS[15] = 10; STATES[13] = 0; CONSTANTS[16] = 10; STATES[14] = 0; CONSTANTS[17] = 10; STATES[15] = 0.004; CONSTANTS[18] = 10; CONSTANTS[19] = 0.00003; CONSTANTS[20] = 0.0066; CONSTANTS[21] = 0.004; CONSTANTS[22] = 0.006; STATES[16] = 0; STATES[17] = 0; CONSTANTS[23] = 10; CONSTANTS[24] = 0.5; CONSTANTS[25] = 0.00008; CONSTANTS[26] = 0.006; CONSTANTS[27] = 0.1; STATES[18] = 0; CONSTANTS[28] = 10; CONSTANTS[29] = 0.5; CONSTANTS[30] = 0.1; CONSTANTS[31] = 0.00003; STATES[19] = 0.004; STATES[20] = 0; CONSTANTS[32] = 5; CONSTANTS[33] = 0.0035; STATES[21] = 0.004; STATES[22] = 0; STATES[23] = 0; CONSTANTS[34] = 10; CONSTANTS[35] = 0.5; CONSTANTS[36] = 10; CONSTANTS[37] = 0.5; CONSTANTS[38] = 0.0003; CONSTANTS[39] = 0.1; STATES[24] = 0; STATES[25] = 0; STATES[26] = 0.004; CONSTANTS[40] = 10; CONSTANTS[41] = 0.5; CONSTANTS[42] = 0.1; STATES[27] = 0; CONSTANTS[43] = 0.001; STATES[28] = 0; CONSTANTS[44] = 10; CONSTANTS[45] = 0.5; CONSTANTS[46] = 0.0003; STATES[29] = 0; STATES[30] = 0; STATES[31] = 0; STATES[32] = 0; CONSTANTS[47] = 0.00003; CONSTANTS[48] = 5; CONSTANTS[49] = 0.0035; CONSTANTS[50] = 5; CONSTANTS[51] = 0.0035; CONSTANTS[52] = 5; CONSTANTS[53] = 0.0035; CONSTANTS[54] = 5; CONSTANTS[55] = 0.5; CONSTANTS[56] = 5; CONSTANTS[57] = 0.5; STATES[33] = 0; STATES[34] = 35; CONSTANTS[58] = 35; STATES[35] = 0; STATES[36] = 0; STATES[37] = 0; STATES[38] = 0.1; STATES[39] = 0.05; CONSTANTS[59] = 1; CONSTANTS[60] = 6700; CONSTANTS[61] = 0.000006; CONSTANTS[62] = 1100; CONSTANTS[63] = 81000; CONSTANTS[64] = 0.0002; CONSTANTS[65] = 100; CONSTANTS[66] = 1.21; CONSTANTS[67] = 10; CONSTANTS[68] = 0.1; CONSTANTS[69] = 2400; CONSTANTS[70] = 0.0006; STATES[40] = 0; STATES[41] = 10000; CONSTANTS[71] = 5.8; CONSTANTS[72] = 1000; CONSTANTS[73] = 400; CONSTANTS[74] = 0.00135; CONSTANTS[75] = 2; CONSTANTS[76] = 0.058; CONSTANTS[77] = 0.025; CONSTANTS[78] = 1; CONSTANTS[79] = 0.05; CONSTANTS[80] = 10000; CONSTANTS[81] = 66; CONSTANTS[82] = 320; CONSTANTS[83] = 50; CONSTANTS[84] = 66; CONSTANTS[85] = 1600; CONSTANTS[86] = 66; CONSTANTS[87] = 66; CONSTANTS[88] = 10; CONSTANTS[89] = 0.0002; CONSTANTS[90] = CONSTANTS[59]; CONSTANTS[91] = CONSTANTS[19]*(1.00000+pow(CONSTANTS[20], 4.00000)/(pow(CONSTANTS[20], 4.00000)+pow(CONSTANTS[21], 4.00000))); CONSTANTS[92] = ( CONSTANTS[25]*pow(CONSTANTS[21], 4.00000))/(pow(CONSTANTS[20], 4.00000)+pow(CONSTANTS[21], 4.00000)); CONSTANTS[93] = CONSTANTS[68]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[1]*STATES[0]*STATES[3] - CONSTANTS[2]*STATES[1]; ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]; RATES[1] = ALGEBRAIC[2] - ALGEBRAIC[0]; ALGEBRAIC[4] = CONSTANTS[5] - CONSTANTS[3]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[6]*STATES[6]*STATES[4] - CONSTANTS[7]*STATES[5]; RATES[4] = - ALGEBRAIC[5]+ALGEBRAIC[4]; ALGEBRAIC[7] = CONSTANTS[8]*pow(STATES[5], CONSTANTS[10]) - CONSTANTS[9]*STATES[7]; RATES[5] = ALGEBRAIC[5] - 7.00000*ALGEBRAIC[7]; ALGEBRAIC[8] = CONSTANTS[11] - STATES[9]; ALGEBRAIC[12] = CONSTANTS[14]*STATES[10]*STATES[8]; ALGEBRAIC[6] = - CONSTANTS[3]*STATES[6]; RATES[6] = (ALGEBRAIC[12] - ALGEBRAIC[5])+ALGEBRAIC[6]+ CONSTANTS[12]*ALGEBRAIC[8]*STATES[8]; ALGEBRAIC[10] = CONSTANTS[13] - CONSTANTS[3]*STATES[8]; RATES[8] = - ALGEBRAIC[12]+ALGEBRAIC[10]; ALGEBRAIC[14] = CONSTANTS[16]*STATES[13]; ALGEBRAIC[13] = CONSTANTS[15]*STATES[11]*STATES[12]; ALGEBRAIC[11] = - CONSTANTS[3]*STATES[11]; RATES[11] = (ALGEBRAIC[14] - ALGEBRAIC[13])+ALGEBRAIC[11]; ALGEBRAIC[17] = CONSTANTS[17]*STATES[14]*STATES[12]; ALGEBRAIC[9] = - CONSTANTS[3]*STATES[10]; RATES[10] = ALGEBRAIC[17]+ALGEBRAIC[9]; ALGEBRAIC[16] = - CONSTANTS[3]*STATES[14]; RATES[14] = (ALGEBRAIC[13] - ALGEBRAIC[17])+ALGEBRAIC[16]; ALGEBRAIC[19] = CONSTANTS[18]*STATES[15]*STATES[12]; ALGEBRAIC[18] = CONSTANTS[91] - CONSTANTS[22]*STATES[12]; RATES[12] = ((- ALGEBRAIC[13] - ALGEBRAIC[17]) - ALGEBRAIC[19])+ALGEBRAIC[18]; ALGEBRAIC[20] = CONSTANTS[23]*STATES[16]*STATES[15] - CONSTANTS[24]*STATES[17]; ALGEBRAIC[22] = CONSTANTS[92] - CONSTANTS[26]*STATES[15]; RATES[15] = (- ALGEBRAIC[20] - ALGEBRAIC[19])+ALGEBRAIC[22]; ALGEBRAIC[21] = CONSTANTS[27]*STATES[17]; RATES[17] = ALGEBRAIC[20] - ALGEBRAIC[21]; ALGEBRAIC[25] = CONSTANTS[30]*STATES[18]; ALGEBRAIC[15] = - CONSTANTS[3]*STATES[13]; RATES[13] = ((ALGEBRAIC[0]+ALGEBRAIC[25]) - ALGEBRAIC[14])+ALGEBRAIC[17]+ALGEBRAIC[15]; ALGEBRAIC[23] = CONSTANTS[28]*STATES[16]*STATES[3] - CONSTANTS[29]*STATES[18]; RATES[18] = ALGEBRAIC[23] - ALGEBRAIC[25]; ALGEBRAIC[24] = CONSTANTS[31] - CONSTANTS[3]*STATES[3]; RATES[3] = (- ALGEBRAIC[2] - ALGEBRAIC[23])+ALGEBRAIC[24]; ALGEBRAIC[27] = CONSTANTS[32]*STATES[16]*STATES[19] - CONSTANTS[33]*STATES[20]; RATES[20] = ALGEBRAIC[27]; ALGEBRAIC[29] = CONSTANTS[34]*STATES[7]*STATES[21] - CONSTANTS[35]*STATES[22]; ALGEBRAIC[30] = CONSTANTS[36]*STATES[22]*STATES[21] - CONSTANTS[37]*STATES[23]; ALGEBRAIC[28] = CONSTANTS[38] - CONSTANTS[3]*STATES[21]; RATES[21] = (- ALGEBRAIC[29] - ALGEBRAIC[30])+ALGEBRAIC[28]; RATES[22] = ALGEBRAIC[29] - ALGEBRAIC[30]; ALGEBRAIC[31] = CONSTANTS[39]*STATES[23]; RATES[23] = ALGEBRAIC[30] - ALGEBRAIC[31]; ALGEBRAIC[33] = CONSTANTS[42]*STATES[24]; ALGEBRAIC[32] = CONSTANTS[40]*STATES[25]*STATES[26] - CONSTANTS[41]*STATES[24]; RATES[24] = ALGEBRAIC[32] - ALGEBRAIC[33]; ALGEBRAIC[34] = CONSTANTS[43]*STATES[27]; ALGEBRAIC[35] = CONSTANTS[44]*STATES[28]*STATES[26] - CONSTANTS[45]*STATES[27]; RATES[27] = ALGEBRAIC[35] - ALGEBRAIC[34]; ALGEBRAIC[36] = CONSTANTS[46] - CONSTANTS[3]*STATES[26]; RATES[26] = (- ALGEBRAIC[35] - ALGEBRAIC[32])+ALGEBRAIC[36]; ALGEBRAIC[37] = CONSTANTS[48]*STATES[28]*STATES[19] - CONSTANTS[49]*STATES[29]; RATES[29] = ALGEBRAIC[37]; ALGEBRAIC[38] = CONSTANTS[50]*STATES[32]*STATES[19] - CONSTANTS[51]*STATES[30]; RATES[30] = ALGEBRAIC[38]; ALGEBRAIC[39] = CONSTANTS[52]*STATES[25]*STATES[19] - CONSTANTS[53]*STATES[31]; RATES[31] = ALGEBRAIC[39]; ALGEBRAIC[41] = CONSTANTS[47] - CONSTANTS[3]*STATES[19]; RATES[19] = (((- ALGEBRAIC[37] - ALGEBRAIC[38]) - ALGEBRAIC[39]) - ALGEBRAIC[27])+ALGEBRAIC[41]; ALGEBRAIC[40] = CONSTANTS[54]*STATES[25] - CONSTANTS[55]*STATES[32]*STATES[28]; RATES[25] = (((ALGEBRAIC[31] - ALGEBRAIC[40]) - ALGEBRAIC[39]) - ALGEBRAIC[32])+ALGEBRAIC[33]; ALGEBRAIC[42] = CONSTANTS[56]*STATES[32] - CONSTANTS[57]*STATES[7]*STATES[28]; RATES[7] = (ALGEBRAIC[7] - ALGEBRAIC[29])+ALGEBRAIC[42]; RATES[32] = (ALGEBRAIC[40] - ALGEBRAIC[42]) - ALGEBRAIC[38]; ALGEBRAIC[45] = CONSTANTS[61]*pow(STATES[33], 2.00000)*CONSTANTS[58]; ALGEBRAIC[46] = CONSTANTS[62]*STATES[35]*STATES[33]; ALGEBRAIC[47] = CONSTANTS[63]*STATES[36]; RATES[35] = ( 2.00000*ALGEBRAIC[45] - ALGEBRAIC[46])+ALGEBRAIC[47]; ALGEBRAIC[49] = CONSTANTS[65]*STATES[38]*STATES[33]; RATES[38] = - ALGEBRAIC[49]; ALGEBRAIC[44] = CONSTANTS[60]*STATES[33]*STATES[34]; ALGEBRAIC[48] = CONSTANTS[64]*STATES[37]; ALGEBRAIC[50] = CONSTANTS[66]*STATES[39]*STATES[33]; RATES[33] = (((((CONSTANTS[90] - ALGEBRAIC[44]) - 2.00000*ALGEBRAIC[45]) - ALGEBRAIC[46])+ALGEBRAIC[47]+ALGEBRAIC[48]) - ALGEBRAIC[49]) - ALGEBRAIC[50]; ALGEBRAIC[51] = CONSTANTS[69]*CONSTANTS[67]*STATES[34]; ALGEBRAIC[52] = CONSTANTS[70]*pow(STATES[37], 2.00000)*STATES[34]; RATES[34] = ((CONSTANTS[93] - ALGEBRAIC[44]) - ALGEBRAIC[51]) - ALGEBRAIC[52]; ALGEBRAIC[1] = - CONSTANTS[3]*STATES[0]; ALGEBRAIC[3] = CONSTANTS[4]*STATES[2]*STATES[0]; ALGEBRAIC[61] = CONSTANTS[88]*STATES[36]*STATES[0]; RATES[0] = ((- ALGEBRAIC[2]+ALGEBRAIC[0]+ALGEBRAIC[1]) - ALGEBRAIC[61]) - ALGEBRAIC[3]; ALGEBRAIC[53] = CONSTANTS[74]*STATES[40]*STATES[41]; ALGEBRAIC[54] = CONSTANTS[75]*STATES[40]*CONSTANTS[71]; ALGEBRAIC[57] = CONSTANTS[76]*STATES[40]*CONSTANTS[72]; ALGEBRAIC[60] = CONSTANTS[77]*STATES[40]*CONSTANTS[73]; ALGEBRAIC[63] = CONSTANTS[78]*STATES[40]*STATES[9]; RATES[40] = ((((ALGEBRAIC[44] - ALGEBRAIC[53]) - ALGEBRAIC[54]) - ALGEBRAIC[57]) - ALGEBRAIC[60]) - ALGEBRAIC[63]; ALGEBRAIC[56] = CONSTANTS[81]*STATES[36]*STATES[41]; ALGEBRAIC[55] = ((CONSTANTS[80] - STATES[41]) - STATES[37])/2.00000; ALGEBRAIC[59] = ( CONSTANTS[82]*ALGEBRAIC[55])/(CONSTANTS[83]+ALGEBRAIC[55]); ALGEBRAIC[62] = CONSTANTS[84]*STATES[2]*STATES[41]; RATES[41] = ((- ALGEBRAIC[53] - ALGEBRAIC[56])+ 2.00000*ALGEBRAIC[59]) - ALGEBRAIC[62]; RATES[37] = (((ALGEBRAIC[53] - 2.00000*ALGEBRAIC[52])+ALGEBRAIC[56]) - ALGEBRAIC[48])+ALGEBRAIC[62]; ALGEBRAIC[58] = CONSTANTS[85]*STATES[36]; RATES[36] = (((- ALGEBRAIC[56]+ALGEBRAIC[46]) - ALGEBRAIC[47]) - ALGEBRAIC[58]) - ALGEBRAIC[61]; RATES[9] = - ALGEBRAIC[61]; ALGEBRAIC[43] = - CONSTANTS[3]*STATES[28]; ALGEBRAIC[64] = CONSTANTS[86]*STATES[2]*STATES[28]; RATES[28] = ((((ALGEBRAIC[40]+ALGEBRAIC[42]) - ALGEBRAIC[37]) - ALGEBRAIC[35])+ALGEBRAIC[34]+ALGEBRAIC[43]) - ALGEBRAIC[64]; ALGEBRAIC[26] = - CONSTANTS[3]*STATES[16]; ALGEBRAIC[65] = CONSTANTS[87]*STATES[2]*STATES[16]; RATES[16] = ((((((ALGEBRAIC[34]+ALGEBRAIC[33]) - ALGEBRAIC[27]) - ALGEBRAIC[23])+ALGEBRAIC[25]) - ALGEBRAIC[20])+ALGEBRAIC[21]+ALGEBRAIC[26]) - ALGEBRAIC[65]; RATES[39] = - ALGEBRAIC[50]+ALGEBRAIC[62]+ALGEBRAIC[3]+ALGEBRAIC[64]+ALGEBRAIC[65]; RATES[2] = (((ALGEBRAIC[50] - ALGEBRAIC[62]) - ALGEBRAIC[3]) - ALGEBRAIC[64]) - ALGEBRAIC[65]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[1]*STATES[0]*STATES[3] - CONSTANTS[2]*STATES[1]; ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]; ALGEBRAIC[4] = CONSTANTS[5] - CONSTANTS[3]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[6]*STATES[6]*STATES[4] - CONSTANTS[7]*STATES[5]; ALGEBRAIC[7] = CONSTANTS[8]*pow(STATES[5], CONSTANTS[10]) - CONSTANTS[9]*STATES[7]; ALGEBRAIC[8] = CONSTANTS[11] - STATES[9]; ALGEBRAIC[12] = CONSTANTS[14]*STATES[10]*STATES[8]; ALGEBRAIC[6] = - CONSTANTS[3]*STATES[6]; ALGEBRAIC[10] = CONSTANTS[13] - CONSTANTS[3]*STATES[8]; ALGEBRAIC[14] = CONSTANTS[16]*STATES[13]; ALGEBRAIC[13] = CONSTANTS[15]*STATES[11]*STATES[12]; ALGEBRAIC[11] = - CONSTANTS[3]*STATES[11]; ALGEBRAIC[17] = CONSTANTS[17]*STATES[14]*STATES[12]; ALGEBRAIC[9] = - CONSTANTS[3]*STATES[10]; ALGEBRAIC[16] = - CONSTANTS[3]*STATES[14]; ALGEBRAIC[19] = CONSTANTS[18]*STATES[15]*STATES[12]; ALGEBRAIC[18] = CONSTANTS[91] - CONSTANTS[22]*STATES[12]; ALGEBRAIC[20] = CONSTANTS[23]*STATES[16]*STATES[15] - CONSTANTS[24]*STATES[17]; ALGEBRAIC[22] = CONSTANTS[92] - CONSTANTS[26]*STATES[15]; ALGEBRAIC[21] = CONSTANTS[27]*STATES[17]; ALGEBRAIC[25] = CONSTANTS[30]*STATES[18]; ALGEBRAIC[15] = - CONSTANTS[3]*STATES[13]; ALGEBRAIC[23] = CONSTANTS[28]*STATES[16]*STATES[3] - CONSTANTS[29]*STATES[18]; ALGEBRAIC[24] = CONSTANTS[31] - CONSTANTS[3]*STATES[3]; ALGEBRAIC[27] = CONSTANTS[32]*STATES[16]*STATES[19] - CONSTANTS[33]*STATES[20]; ALGEBRAIC[29] = CONSTANTS[34]*STATES[7]*STATES[21] - CONSTANTS[35]*STATES[22]; ALGEBRAIC[30] = CONSTANTS[36]*STATES[22]*STATES[21] - CONSTANTS[37]*STATES[23]; ALGEBRAIC[28] = CONSTANTS[38] - CONSTANTS[3]*STATES[21]; ALGEBRAIC[31] = CONSTANTS[39]*STATES[23]; ALGEBRAIC[33] = CONSTANTS[42]*STATES[24]; ALGEBRAIC[32] = CONSTANTS[40]*STATES[25]*STATES[26] - CONSTANTS[41]*STATES[24]; ALGEBRAIC[34] = CONSTANTS[43]*STATES[27]; ALGEBRAIC[35] = CONSTANTS[44]*STATES[28]*STATES[26] - CONSTANTS[45]*STATES[27]; ALGEBRAIC[36] = CONSTANTS[46] - CONSTANTS[3]*STATES[26]; ALGEBRAIC[37] = CONSTANTS[48]*STATES[28]*STATES[19] - CONSTANTS[49]*STATES[29]; ALGEBRAIC[38] = CONSTANTS[50]*STATES[32]*STATES[19] - CONSTANTS[51]*STATES[30]; ALGEBRAIC[39] = CONSTANTS[52]*STATES[25]*STATES[19] - CONSTANTS[53]*STATES[31]; ALGEBRAIC[41] = CONSTANTS[47] - CONSTANTS[3]*STATES[19]; ALGEBRAIC[40] = CONSTANTS[54]*STATES[25] - CONSTANTS[55]*STATES[32]*STATES[28]; ALGEBRAIC[42] = CONSTANTS[56]*STATES[32] - CONSTANTS[57]*STATES[7]*STATES[28]; ALGEBRAIC[45] = CONSTANTS[61]*pow(STATES[33], 2.00000)*CONSTANTS[58]; ALGEBRAIC[46] = CONSTANTS[62]*STATES[35]*STATES[33]; ALGEBRAIC[47] = CONSTANTS[63]*STATES[36]; ALGEBRAIC[49] = CONSTANTS[65]*STATES[38]*STATES[33]; ALGEBRAIC[44] = CONSTANTS[60]*STATES[33]*STATES[34]; ALGEBRAIC[48] = CONSTANTS[64]*STATES[37]; ALGEBRAIC[50] = CONSTANTS[66]*STATES[39]*STATES[33]; ALGEBRAIC[51] = CONSTANTS[69]*CONSTANTS[67]*STATES[34]; ALGEBRAIC[52] = CONSTANTS[70]*pow(STATES[37], 2.00000)*STATES[34]; ALGEBRAIC[1] = - CONSTANTS[3]*STATES[0]; ALGEBRAIC[3] = CONSTANTS[4]*STATES[2]*STATES[0]; ALGEBRAIC[61] = CONSTANTS[88]*STATES[36]*STATES[0]; ALGEBRAIC[53] = CONSTANTS[74]*STATES[40]*STATES[41]; ALGEBRAIC[54] = CONSTANTS[75]*STATES[40]*CONSTANTS[71]; ALGEBRAIC[57] = CONSTANTS[76]*STATES[40]*CONSTANTS[72]; ALGEBRAIC[60] = CONSTANTS[77]*STATES[40]*CONSTANTS[73]; ALGEBRAIC[63] = CONSTANTS[78]*STATES[40]*STATES[9]; ALGEBRAIC[56] = CONSTANTS[81]*STATES[36]*STATES[41]; ALGEBRAIC[55] = ((CONSTANTS[80] - STATES[41]) - STATES[37])/2.00000; ALGEBRAIC[59] = ( CONSTANTS[82]*ALGEBRAIC[55])/(CONSTANTS[83]+ALGEBRAIC[55]); ALGEBRAIC[62] = CONSTANTS[84]*STATES[2]*STATES[41]; ALGEBRAIC[58] = CONSTANTS[85]*STATES[36]; ALGEBRAIC[43] = - CONSTANTS[3]*STATES[28]; ALGEBRAIC[64] = CONSTANTS[86]*STATES[2]*STATES[28]; ALGEBRAIC[26] = - CONSTANTS[3]*STATES[16]; ALGEBRAIC[65] = CONSTANTS[87]*STATES[2]*STATES[16]; }