/* There are a total of 32 entries in the algebraic variable array. There are a total of 23 entries in each of the rate and state variable arrays. There are a total of 50 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is EGF in component EGF (nanomolar). * ALGEBRAIC[0] is v1 in component v1 (flux). * STATES[1] is R in component R (nanomolar). * STATES[2] is Ra in component Ra (nanomolar). * ALGEBRAIC[8] is v2 in component v2 (flux). * STATES[3] is R2 in component R2 (nanomolar). * ALGEBRAIC[9] is v3 in component v3 (flux). * ALGEBRAIC[10] is v4 in component v4 (flux). * STATES[4] is RP in component RP (nanomolar). * ALGEBRAIC[13] is v7 in component v7 (flux). * ALGEBRAIC[18] is v11 in component v11 (flux). * ALGEBRAIC[22] is v15 in component v15 (flux). * ALGEBRAIC[25] is v18 in component v18 (flux). * ALGEBRAIC[27] is v20 in component v20 (flux). * ALGEBRAIC[11] is v5 in component v5 (flux). * ALGEBRAIC[14] is v9 in component v9 (flux). * ALGEBRAIC[20] is v13 in component v13 (flux). * STATES[5] is R_PL in component R_PL (nanomolar). * ALGEBRAIC[12] is v6 in component v6 (flux). * STATES[6] is R_PLP in component R_PLP (nanomolar). * STATES[7] is R_G in component R_G (nanomolar). * ALGEBRAIC[16] is v10 in component v10 (flux). * STATES[8] is R_G_S in component R_G_S (nanomolar). * STATES[9] is R_Sh in component R_Sh (nanomolar). * ALGEBRAIC[21] is v14 in component v14 (flux). * STATES[10] is R_ShP in component R_ShP (nanomolar). * ALGEBRAIC[31] is v24 in component v24 (flux). * ALGEBRAIC[24] is v17 in component v17 (flux). * STATES[11] is R_Sh_G in component R_Sh_G (nanomolar). * ALGEBRAIC[26] is v19 in component v19 (flux). * STATES[12] is R_Sh_G_S in component R_Sh_G_S (nanomolar). * STATES[13] is G_S in component G_S (nanomolar). * ALGEBRAIC[30] is v23 in component v23 (flux). * ALGEBRAIC[19] is v12 in component v12 (flux). * STATES[14] is ShP in component ShP (nanomolar). * ALGEBRAIC[28] is v21 in component v21 (flux). * ALGEBRAIC[23] is v16 in component v16 (flux). * STATES[15] is Sh_G in component Sh_G (nanomolar). * ALGEBRAIC[29] is v22 in component v22 (flux). * STATES[16] is Sh_G_S in component Sh_G_S (nanomolar). * STATES[17] is PLC_gamma in component PLC_gamma (nanomolar). * ALGEBRAIC[15] is v8 in component v8 (flux). * STATES[18] is PLC_gamma_P in component PLC_gamma_P (nanomolar). * ALGEBRAIC[17] is v25 in component v25 (flux). * STATES[19] is PLC_gamma_P_I in component PLC_gamma_P_I (nanomolar). * STATES[20] is Grb in component Grb (nanomolar). * STATES[21] is Shc in component Shc (nanomolar). * STATES[22] is SOS in component SOS (nanomolar). * CONSTANTS[0] is k1 in component v1 (second_order_rate_constant). * CONSTANTS[1] is k1_ in component v1 (first_order_rate_constant). * CONSTANTS[2] is k2 in component v2 (second_order_rate_constant). * CONSTANTS[3] is k2_ in component v2 (first_order_rate_constant). * CONSTANTS[4] is k3 in component v3 (first_order_rate_constant). * CONSTANTS[5] is k3_ in component v3 (first_order_rate_constant). * CONSTANTS[6] is K4 in component v4 (nanomolar). * CONSTANTS[7] is V4 in component v4 (flux). * CONSTANTS[8] is k5 in component v5 (second_order_rate_constant). * CONSTANTS[9] is k5_ in component v5 (first_order_rate_constant). * CONSTANTS[10] is k6 in component v6 (first_order_rate_constant). * CONSTANTS[11] is k6_ in component v6 (first_order_rate_constant). * CONSTANTS[12] is k7 in component v7 (first_order_rate_constant). * CONSTANTS[13] is k7_ in component v7 (second_order_rate_constant). * CONSTANTS[14] is K8 in component v8 (nanomolar). * CONSTANTS[15] is V8 in component v8 (flux). * CONSTANTS[16] is k9 in component v9 (second_order_rate_constant). * CONSTANTS[17] is k9_ in component v9 (first_order_rate_constant). * CONSTANTS[18] is k10 in component v10 (second_order_rate_constant). * CONSTANTS[19] is k10_ in component v10 (first_order_rate_constant). * CONSTANTS[20] is k11 in component v11 (first_order_rate_constant). * CONSTANTS[21] is k11_ in component v11 (second_order_rate_constant). * CONSTANTS[22] is k12 in component v12 (first_order_rate_constant). * CONSTANTS[23] is k12_ in component v12 (second_order_rate_constant). * CONSTANTS[24] is k13 in component v13 (second_order_rate_constant). * CONSTANTS[25] is k13_ in component v13 (first_order_rate_constant). * CONSTANTS[26] is k14 in component v14 (first_order_rate_constant). * CONSTANTS[27] is k14_ in component v14 (first_order_rate_constant). * CONSTANTS[28] is k15 in component v15 (first_order_rate_constant). * CONSTANTS[29] is k15_ in component v15 (second_order_rate_constant). * CONSTANTS[30] is K16 in component v16 (nanomolar). * CONSTANTS[31] is V16 in component v16 (flux). * CONSTANTS[32] is k17 in component v17 (second_order_rate_constant). * CONSTANTS[33] is k17_ in component v17 (first_order_rate_constant). * CONSTANTS[34] is k18 in component v18 (first_order_rate_constant). * CONSTANTS[35] is k18_ in component v18 (second_order_rate_constant). * CONSTANTS[36] is k19 in component v19 (second_order_rate_constant). * CONSTANTS[37] is k19_ in component v19 (first_order_rate_constant). * CONSTANTS[38] is k20 in component v20 (first_order_rate_constant). * CONSTANTS[39] is k20_ in component v20 (second_order_rate_constant). * CONSTANTS[40] is k21 in component v21 (second_order_rate_constant). * CONSTANTS[41] is k21_ in component v21 (first_order_rate_constant). * CONSTANTS[42] is k22 in component v22 (second_order_rate_constant). * CONSTANTS[43] is k22_ in component v22 (first_order_rate_constant). * CONSTANTS[44] is k23 in component v23 (first_order_rate_constant). * CONSTANTS[45] is k23_ in component v23 (second_order_rate_constant). * CONSTANTS[46] is k24 in component v24 (second_order_rate_constant). * CONSTANTS[47] is k24_ in component v24 (first_order_rate_constant). * CONSTANTS[48] is k25 in component v25 (first_order_rate_constant). * CONSTANTS[49] is k25_ in component v25 (first_order_rate_constant). * ALGEBRAIC[1] is totEGFRphos in component combined_concs (nanomolar). * ALGEBRAIC[2] is totPLCgammaphos in component combined_concs (nanomolar). * ALGEBRAIC[3] is totGrb_EGFR in component combined_concs (nanomolar). * ALGEBRAIC[4] is totGrb_Shc in component combined_concs (nanomolar). * ALGEBRAIC[5] is totShcphos in component combined_concs (nanomolar). * ALGEBRAIC[6] is totShc_EGFR in component combined_concs (nanomolar). * ALGEBRAIC[7] is totSOS_EGFR in component combined_concs (nanomolar). * RATES[0] is d/dt EGF in component EGF (nanomolar). * RATES[1] is d/dt R in component R (nanomolar). * RATES[2] is d/dt Ra in component Ra (nanomolar). * RATES[3] is d/dt R2 in component R2 (nanomolar). * RATES[4] is d/dt RP in component RP (nanomolar). * RATES[5] is d/dt R_PL in component R_PL (nanomolar). * RATES[6] is d/dt R_PLP in component R_PLP (nanomolar). * RATES[7] is d/dt R_G in component R_G (nanomolar). * RATES[8] is d/dt R_G_S in component R_G_S (nanomolar). * RATES[9] is d/dt R_Sh in component R_Sh (nanomolar). * RATES[10] is d/dt R_ShP in component R_ShP (nanomolar). * RATES[11] is d/dt R_Sh_G in component R_Sh_G (nanomolar). * RATES[12] is d/dt R_Sh_G_S in component R_Sh_G_S (nanomolar). * RATES[13] is d/dt G_S in component G_S (nanomolar). * RATES[14] is d/dt ShP in component ShP (nanomolar). * RATES[15] is d/dt Sh_G in component Sh_G (nanomolar). * RATES[16] is d/dt Sh_G_S in component Sh_G_S (nanomolar). * RATES[17] is d/dt PLC_gamma in component PLC_gamma (nanomolar). * RATES[18] is d/dt PLC_gamma_P in component PLC_gamma_P (nanomolar). * RATES[19] is d/dt PLC_gamma_P_I in component PLC_gamma_P_I (nanomolar). * RATES[20] is d/dt Grb in component Grb (nanomolar). * RATES[21] is d/dt Shc in component Shc (nanomolar). * RATES[22] is d/dt SOS in component SOS (nanomolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 680; STATES[1] = 100; STATES[2] = 0; STATES[3] = 0; STATES[4] = 0; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0; STATES[10] = 0; STATES[11] = 0; STATES[12] = 0; STATES[13] = 0; STATES[14] = 0; STATES[15] = 0; STATES[16] = 0; STATES[17] = 105; STATES[18] = 0; STATES[19] = 0; STATES[20] = 85; STATES[21] = 150; STATES[22] = 34; CONSTANTS[0] = 0.003; CONSTANTS[1] = 0.06; CONSTANTS[2] = 0.01; CONSTANTS[3] = 0.1; CONSTANTS[4] = 1; CONSTANTS[5] = 0.01; CONSTANTS[6] = 50; CONSTANTS[7] = 450; CONSTANTS[8] = 0.06; CONSTANTS[9] = 0.2; CONSTANTS[10] = 1; CONSTANTS[11] = 0.05; CONSTANTS[12] = 0.3; CONSTANTS[13] = 0.006; CONSTANTS[14] = 100; CONSTANTS[15] = 1; CONSTANTS[16] = 0.003; CONSTANTS[17] = 0.05; CONSTANTS[18] = 0.01; CONSTANTS[19] = 0.06; CONSTANTS[20] = 0.03; CONSTANTS[21] = 4.5e-3; CONSTANTS[22] = 1.5e-3; CONSTANTS[23] = 1e-4; CONSTANTS[24] = 0.09; CONSTANTS[25] = 0.6; CONSTANTS[26] = 6; CONSTANTS[27] = 0.06; CONSTANTS[28] = 0.3; CONSTANTS[29] = 9e-4; CONSTANTS[30] = 340; CONSTANTS[31] = 1.7; CONSTANTS[32] = 0.003; CONSTANTS[33] = 0.1; CONSTANTS[34] = 0.3; CONSTANTS[35] = 9e-4; CONSTANTS[36] = 0.01; CONSTANTS[37] = 2.14e-2; CONSTANTS[38] = 0.12; CONSTANTS[39] = 2.4e-4; CONSTANTS[40] = 0.003; CONSTANTS[41] = 0.1; CONSTANTS[42] = 0.03; CONSTANTS[43] = 0.064; CONSTANTS[44] = 0.1; CONSTANTS[45] = 0.021; CONSTANTS[46] = 0.009; CONSTANTS[47] = 4.29e-2; CONSTANTS[48] = 1; CONSTANTS[49] = 0.03; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]*STATES[0] - CONSTANTS[1]*STATES[2]; RATES[0] = - ALGEBRAIC[0]; RATES[1] = - ALGEBRAIC[0]; ALGEBRAIC[8] = CONSTANTS[2]*STATES[2]*STATES[2] - CONSTANTS[3]*STATES[3]; RATES[2] = ALGEBRAIC[0] - 2.00000*ALGEBRAIC[8]; ALGEBRAIC[9] = CONSTANTS[4]*STATES[3] - CONSTANTS[5]*STATES[4]; ALGEBRAIC[10] = ( CONSTANTS[7]*STATES[4])/(CONSTANTS[6]+STATES[4]); RATES[3] = (ALGEBRAIC[8]+ALGEBRAIC[10]) - ALGEBRAIC[9]; ALGEBRAIC[11] = CONSTANTS[8]*STATES[4]*STATES[17] - CONSTANTS[9]*STATES[5]; ALGEBRAIC[12] = CONSTANTS[10]*STATES[5] - CONSTANTS[11]*STATES[6]; RATES[5] = ALGEBRAIC[11] - ALGEBRAIC[12]; ALGEBRAIC[13] = CONSTANTS[12]*STATES[6] - CONSTANTS[13]*STATES[4]*STATES[18]; RATES[6] = ALGEBRAIC[12] - ALGEBRAIC[13]; ALGEBRAIC[15] = ( CONSTANTS[15]*STATES[18])/(CONSTANTS[14]+STATES[18]); RATES[17] = ALGEBRAIC[15] - ALGEBRAIC[11]; ALGEBRAIC[14] = CONSTANTS[16]*STATES[4]*STATES[20] - CONSTANTS[17]*STATES[7]; ALGEBRAIC[16] = CONSTANTS[18]*STATES[7]*STATES[22] - CONSTANTS[19]*STATES[8]; RATES[7] = ALGEBRAIC[14] - ALGEBRAIC[16]; ALGEBRAIC[17] = CONSTANTS[48]*STATES[18] - CONSTANTS[49]*STATES[19]; RATES[18] = ALGEBRAIC[13] - (ALGEBRAIC[15]+ALGEBRAIC[17]); RATES[19] = ALGEBRAIC[17]; ALGEBRAIC[18] = CONSTANTS[20]*STATES[8] - CONSTANTS[21]*STATES[4]*STATES[13]; RATES[8] = ALGEBRAIC[16] - ALGEBRAIC[18]; ALGEBRAIC[20] = CONSTANTS[24]*STATES[4]*STATES[21] - CONSTANTS[25]*STATES[9]; ALGEBRAIC[21] = CONSTANTS[26]*STATES[9] - CONSTANTS[27]*STATES[10]; RATES[9] = ALGEBRAIC[20] - ALGEBRAIC[21]; ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[14])/(CONSTANTS[30]+STATES[14]); RATES[21] = ALGEBRAIC[23] - ALGEBRAIC[20]; ALGEBRAIC[25] = CONSTANTS[34]*STATES[11] - CONSTANTS[35]*STATES[4]*STATES[15]; ALGEBRAIC[24] = CONSTANTS[32]*STATES[10]*STATES[20] - CONSTANTS[33]*STATES[11]; ALGEBRAIC[26] = CONSTANTS[36]*STATES[11]*STATES[22] - CONSTANTS[37]*STATES[12]; RATES[11] = ALGEBRAIC[24] - (ALGEBRAIC[25]+ALGEBRAIC[26]); ALGEBRAIC[22] = CONSTANTS[28]*STATES[10] - CONSTANTS[29]*STATES[14]*STATES[4]; ALGEBRAIC[27] = CONSTANTS[38]*STATES[12] - CONSTANTS[39]*STATES[16]*STATES[4]; RATES[4] = (ALGEBRAIC[9]+ALGEBRAIC[13]+ALGEBRAIC[18]+ALGEBRAIC[22]+ALGEBRAIC[25]+ALGEBRAIC[27]) - (ALGEBRAIC[10]+ALGEBRAIC[11]+ALGEBRAIC[14]+ALGEBRAIC[20]); ALGEBRAIC[19] = CONSTANTS[22]*STATES[13] - CONSTANTS[23]*STATES[20]*STATES[22]; ALGEBRAIC[28] = CONSTANTS[40]*STATES[14]*STATES[20] - CONSTANTS[41]*STATES[15]; RATES[20] = ALGEBRAIC[19] - (ALGEBRAIC[14]+ALGEBRAIC[24]+ALGEBRAIC[28]); ALGEBRAIC[29] = CONSTANTS[42]*STATES[15]*STATES[22] - CONSTANTS[43]*STATES[16]; RATES[15] = (ALGEBRAIC[25]+ALGEBRAIC[28]) - ALGEBRAIC[29]; RATES[22] = ALGEBRAIC[19] - (ALGEBRAIC[16]+ALGEBRAIC[26]+ALGEBRAIC[29]); ALGEBRAIC[30] = CONSTANTS[44]*STATES[16] - CONSTANTS[45]*STATES[14]*STATES[13]; RATES[14] = (ALGEBRAIC[22]+ALGEBRAIC[30]) - (ALGEBRAIC[28]+ALGEBRAIC[23]); RATES[16] = (ALGEBRAIC[27]+ALGEBRAIC[29]) - ALGEBRAIC[30]; ALGEBRAIC[31] = CONSTANTS[46]*STATES[10]*STATES[13] - CONSTANTS[47]*STATES[12]; RATES[10] = ALGEBRAIC[21] - (ALGEBRAIC[31]+ALGEBRAIC[22]+ALGEBRAIC[24]); RATES[12] = (ALGEBRAIC[26]+ALGEBRAIC[31]) - ALGEBRAIC[27]; RATES[13] = (ALGEBRAIC[18]+ALGEBRAIC[30]) - (ALGEBRAIC[19]+ALGEBRAIC[31]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*STATES[1]*STATES[0] - CONSTANTS[1]*STATES[2]; ALGEBRAIC[8] = CONSTANTS[2]*STATES[2]*STATES[2] - CONSTANTS[3]*STATES[3]; ALGEBRAIC[9] = CONSTANTS[4]*STATES[3] - CONSTANTS[5]*STATES[4]; ALGEBRAIC[10] = ( CONSTANTS[7]*STATES[4])/(CONSTANTS[6]+STATES[4]); ALGEBRAIC[11] = CONSTANTS[8]*STATES[4]*STATES[17] - CONSTANTS[9]*STATES[5]; ALGEBRAIC[12] = CONSTANTS[10]*STATES[5] - CONSTANTS[11]*STATES[6]; ALGEBRAIC[13] = CONSTANTS[12]*STATES[6] - CONSTANTS[13]*STATES[4]*STATES[18]; ALGEBRAIC[15] = ( CONSTANTS[15]*STATES[18])/(CONSTANTS[14]+STATES[18]); ALGEBRAIC[14] = CONSTANTS[16]*STATES[4]*STATES[20] - CONSTANTS[17]*STATES[7]; ALGEBRAIC[16] = CONSTANTS[18]*STATES[7]*STATES[22] - CONSTANTS[19]*STATES[8]; ALGEBRAIC[17] = CONSTANTS[48]*STATES[18] - CONSTANTS[49]*STATES[19]; ALGEBRAIC[18] = CONSTANTS[20]*STATES[8] - CONSTANTS[21]*STATES[4]*STATES[13]; ALGEBRAIC[20] = CONSTANTS[24]*STATES[4]*STATES[21] - CONSTANTS[25]*STATES[9]; ALGEBRAIC[21] = CONSTANTS[26]*STATES[9] - CONSTANTS[27]*STATES[10]; ALGEBRAIC[23] = ( CONSTANTS[31]*STATES[14])/(CONSTANTS[30]+STATES[14]); ALGEBRAIC[25] = CONSTANTS[34]*STATES[11] - CONSTANTS[35]*STATES[4]*STATES[15]; ALGEBRAIC[24] = CONSTANTS[32]*STATES[10]*STATES[20] - CONSTANTS[33]*STATES[11]; ALGEBRAIC[26] = CONSTANTS[36]*STATES[11]*STATES[22] - CONSTANTS[37]*STATES[12]; ALGEBRAIC[22] = CONSTANTS[28]*STATES[10] - CONSTANTS[29]*STATES[14]*STATES[4]; ALGEBRAIC[27] = CONSTANTS[38]*STATES[12] - CONSTANTS[39]*STATES[16]*STATES[4]; ALGEBRAIC[19] = CONSTANTS[22]*STATES[13] - CONSTANTS[23]*STATES[20]*STATES[22]; ALGEBRAIC[28] = CONSTANTS[40]*STATES[14]*STATES[20] - CONSTANTS[41]*STATES[15]; ALGEBRAIC[29] = CONSTANTS[42]*STATES[15]*STATES[22] - CONSTANTS[43]*STATES[16]; ALGEBRAIC[30] = CONSTANTS[44]*STATES[16] - CONSTANTS[45]*STATES[14]*STATES[13]; ALGEBRAIC[31] = CONSTANTS[46]*STATES[10]*STATES[13] - CONSTANTS[47]*STATES[12]; ALGEBRAIC[1] = 2.00000*(STATES[4]+STATES[5]+STATES[6]+STATES[7]+STATES[8]+STATES[9]+STATES[10]+STATES[11]+STATES[12]); ALGEBRAIC[2] = STATES[6]+STATES[18]; ALGEBRAIC[3] = STATES[7]+STATES[8]+STATES[11]+STATES[12]; ALGEBRAIC[4] = STATES[11]+STATES[15]+STATES[12]+STATES[16]; ALGEBRAIC[5] = STATES[10]+STATES[11]+STATES[12]+STATES[14]+STATES[15]+STATES[16]; ALGEBRAIC[6] = STATES[10]+STATES[11]+STATES[12]; ALGEBRAIC[7] = STATES[8]+STATES[12]; }