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C C There are a total of 4 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 13 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is C in component C (micromolar). C STATES(2) is X in component X (dimensionless). C CONSTS(1) is kd in component model_parameters (first_order_rate_constant). C CONSTS(2) is Kd in component model_parameters (micromolar). C CONSTS(3) is vi in component model_parameters (flux). C CONSTS(4) is vd in component model_parameters (flux). C STATES(3) is M in component M (dimensionless). C ALGBRC(1) is M_star in component M_star (dimensionless). C ALGBRC(3) is V1 in component model_parameters (first_order_rate_constant). C CONSTS(5) is V2 in component model_parameters (first_order_rate_constant). C CONSTS(6) is K1 in component model_parameters (dimensionless). C CONSTS(7) is K2 in component model_parameters (dimensionless). C ALGBRC(2) is X_star in component X_star (dimensionless). C ALGBRC(4) is V3 in component model_parameters (first_order_rate_constant). C CONSTS(8) is V4 in component model_parameters (first_order_rate_constant). C CONSTS(9) is K3 in component model_parameters (dimensionless). C CONSTS(10) is K4 in component model_parameters (dimensionless). C CONSTS(11) is Kc in component model_parameters (micromolar). C CONSTS(12) is VM1 in component model_parameters (first_order_rate_constant). C CONSTS(13) is VM3 in component model_parameters (first_order_rate_constant). C RATES(1) is d/dt C in component C (micromolar). C RATES(3) is d/dt M in component M (dimensionless). C RATES(2) is d/dt X in component X (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.01 STATES(2) = 0.01 CONSTS(1) = 0.01 CONSTS(2) = 0.02 CONSTS(3) = 0.025 CONSTS(4) = 0.25 STATES(3) = 0.01 CONSTS(5) = 1.5 CONSTS(6) = 0.005 CONSTS(7) = 0.005 CONSTS(8) = 0.5 CONSTS(9) = 0.005 CONSTS(10) = 0.005 CONSTS(11) = 0.5 CONSTS(12) = 3 CONSTS(13) = 1 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = (CONSTS(3) - ( CONSTS(4)*STATES(2)*STATES(1))/(CONSTS(2)+STATES(1))) - CONSTS(1)*STATES(1) ALGBRC(1) = 1.00000 - STATES(3) ALGBRC(3) = ( CONSTS(12)*STATES(1))/(CONSTS(11)+STATES(1)) RATES(3) = ( ALGBRC(3)*ALGBRC(1))/(CONSTS(6)+ALGBRC(1)) - ( CONSTS(5)*STATES(3))/(CONSTS(7)+STATES(3)) ALGBRC(2) = 1.00000 - STATES(2) ALGBRC(4) = STATES(3)*CONSTS(13) RATES(2) = ( ALGBRC(4)*ALGBRC(2))/(CONSTS(9)+ALGBRC(2)) - ( CONSTS(8)*STATES(2))/(CONSTS(10)+STATES(2)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = 1.00000 - STATES(3) ALGBRC(3) = ( CONSTS(12)*STATES(1))/(CONSTS(11)+STATES(1)) ALGBRC(2) = 1.00000 - STATES(2) ALGBRC(4) = STATES(3)*CONSTS(13) RETURN END