C C There are a total of 23 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 22 entries in the constant variable array. C C C VOI is time in component environment (millisecond). C STATES(1) is V in component membrane (millivolt). C CONSTS(1) is RToF in component membrane (millivolt). C CONSTS(2) is K_c in component membrane (millimolar). C CONSTS(3) is K_i in component membrane (millimolar). C CONSTS(4) is Na_c in component membrane (millimolar). C CONSTS(5) is Na_i in component membrane (millimolar). C ALGBRC(6) is i_ns in component non_specific_current (picoA_per_picoF). C ALGBRC(11) is i_to in component transient_outward_K_current (picoA_per_picoF). C ALGBRC(21) is i_K1 in component inward_rectifier (picoA_per_picoF). C ALGBRC(16) is i_Kur in component ultra_rapid_K_current (picoA_per_picoF). C ALGBRC(22) is i_b_Na in component background_currents (picoA_per_picoF). C ALGBRC(23) is i_NaK in component sodium_potassium_pump (picoA_per_picoF). C ALGBRC(1) is i_Stim in component membrane (picoA_per_picoF). C CONSTS(6) is stim_start in component membrane (millisecond). C CONSTS(7) is stim_end in component membrane (millisecond). C CONSTS(8) is stim_period in component membrane (millisecond). C CONSTS(9) is stim_duration in component membrane (millisecond). C CONSTS(10) is stim_amplitude in component membrane (picoA_per_picoF). C CONSTS(11) is g_ns in component non_specific_current (nanoS_per_picoF). C CONSTS(21) is E_K in component transient_outward_K_current (millivolt). C CONSTS(12) is g_to in component transient_outward_K_current (nanoS_per_picoF). C STATES(2) is oa in component transient_outward_K_current_oa_gate (dimensionless). C STATES(3) is oi in component transient_outward_K_current_oi_gate (dimensionless). C ALGBRC(2) is alpha_oa in component transient_outward_K_current_oa_gate (per_millisecond). C ALGBRC(7) is beta_oa in component transient_outward_K_current_oa_gate (per_millisecond). C ALGBRC(17) is tau_oa in component transient_outward_K_current_oa_gate (millisecond). C ALGBRC(12) is oa_inf in component transient_outward_K_current_oa_gate (dimensionless). C ALGBRC(3) is alpha_oi in component transient_outward_K_current_oi_gate (per_millisecond). C ALGBRC(8) is beta_oi in component transient_outward_K_current_oi_gate (per_millisecond). C ALGBRC(18) is tau_oi in component transient_outward_K_current_oi_gate (millisecond). C ALGBRC(13) is oi_inf in component transient_outward_K_current_oi_gate (dimensionless). C CONSTS(13) is g_Kur in component ultra_rapid_K_current (nanoS_per_picoF). C STATES(4) is ua in component ultra_rapid_K_current_ua_gate (dimensionless). C STATES(5) is ui in component ultra_rapid_K_current_ui_gate (dimensionless). C ALGBRC(4) is alpha_ua in component ultra_rapid_K_current_ua_gate (per_millisecond). C ALGBRC(9) is beta_ua in component ultra_rapid_K_current_ua_gate (per_millisecond). C ALGBRC(19) is tau_ua in component ultra_rapid_K_current_ua_gate (millisecond). C ALGBRC(14) is ua_inf in component ultra_rapid_K_current_ua_gate (dimensionless). C ALGBRC(5) is alpha_ui in component ultra_rapid_K_current_ui_gate (per_millisecond). C ALGBRC(10) is beta_ui in component ultra_rapid_K_current_ui_gate (per_millisecond). C ALGBRC(20) is tau_ui in component ultra_rapid_K_current_ui_gate (millisecond). C ALGBRC(15) is ui_inf in component ultra_rapid_K_current_ui_gate (dimensionless). C CONSTS(14) is g_K1 in component inward_rectifier (nanoS_per_picoF). C CONSTS(15) is g_b_Na in component background_currents (nanoS_per_picoF). C CONSTS(22) is E_Na in component background_currents (millivolt). C CONSTS(16) is k_NaK_K in component sodium_potassium_pump (millimolar). C CONSTS(17) is k_NaK_Na in component sodium_potassium_pump (millimolar). C CONSTS(18) is i_NaK_max in component sodium_potassium_pump (picoA_per_picoF). C CONSTS(19) is V_rev in component sodium_potassium_pump (millivolt). C CONSTS(20) is B in component sodium_potassium_pump (millivolt). C RATES(1) is d/dt V in component membrane (millivolt). C RATES(2) is d/dt oa in component transient_outward_K_current_oa_gate (dimensionless). C RATES(3) is d/dt oi in component transient_outward_K_current_oi_gate (dimensionless). C RATES(4) is d/dt ua in component ultra_rapid_K_current_ua_gate (dimensionless). C RATES(5) is d/dt ui in component ultra_rapid_K_current_ui_gate (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -80 CONSTS(1) = 26.54 CONSTS(2) = 5.4 CONSTS(3) = 139 CONSTS(4) = 140 CONSTS(5) = 11.2 CONSTS(6) = 100 CONSTS(7) = 10000 CONSTS(8) = 5000 CONSTS(9) = 2 CONSTS(10) = -100 CONSTS(11) = 0.018 CONSTS(12) = 0.01652 STATES(2) = 0.2488 STATES(3) = 0.1866 CONSTS(13) = 0.6 STATES(4) = 0.9933 STATES(5) = 0.0999 CONSTS(14) = 0.03 CONSTS(15) = 0.00607 CONSTS(16) = 1 CONSTS(17) = 11 CONSTS(18) = 2.002 CONSTS(19) = -150 CONSTS(20) = -200 CONSTS(21) = CONSTS(1)*log(CONSTS(2)/CONSTS(3)) CONSTS(22) = CONSTS(1)*log(CONSTS(4)/CONSTS(5)) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 0.650000/(EXP((STATES(1)+10.0000)/- 8.50000)+EXP((STATES(1) - 30.0000)/- 59.0000)) ALGBRC(7) = 0.650000/(2.50000+EXP((STATES(1)+82.0000)/17.0000)) ALGBRC(17) = 15.0000/(ALGBRC(2)+ALGBRC(7)) ALGBRC(12) = 1.00000/(1.00000+EXP((STATES(1)+20.4700)/- 17.5400)) RATES(2) = (ALGBRC(12) - STATES(2))/ALGBRC(17) ALGBRC(3) = 1.00000/(18.5300+EXP((STATES(1)+113.700)/10.9500)) ALGBRC(8) = 1.00000/(35.5600+EXP((STATES(1)+1.26000)/- 7.44000)) ALGBRC(18) = 15.0000/(ALGBRC(3)+ALGBRC(8)) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+43.1000)/5.30000)) RATES(3) = (ALGBRC(13) - STATES(3))/ALGBRC(18) ALGBRC(4) = 0.650000/(EXP((STATES(1)+10.0000)/- 8.50000)+EXP((STATES(1) - 30.0000)/- 59.0000)) ALGBRC(9) = 0.650000/(2.50000+EXP((STATES(1)+82.0000)/17.0000)) ALGBRC(19) = 1.00000/(ALGBRC(4)+ALGBRC(9)) ALGBRC(14) = 1.00000/(1.00000+EXP((STATES(1)+33.3000)/- 9.60000)) RATES(4) = (ALGBRC(14) - STATES(4))/ALGBRC(19) ALGBRC(5) = 1.00000/(21.0000+EXP((STATES(1) - 185.000)/28.0000)) ALGBRC(10) = 1.00000/EXP((STATES(1) - 158.000)/- 16.0000) ALGBRC(20) = 5.00000/(ALGBRC(5)+ALGBRC(10)) ALGBRC(15) = 1.00000/(1.00000+EXP((STATES(1) - 99.4500)/27.4800)) RATES(5) = (ALGBRC(15) - STATES(5))/ALGBRC(20) ALGBRC(6) = CONSTS(11)*STATES(1) ALGBRC(11) = CONSTS(12)*STATES(2) ** 3.00000*STATES(3)*(STATES(1) - CONSTS(21)) ALGBRC(21) = ( CONSTS(14)*(STATES(1)+86.7500))/(1.00000+EXP((STATES(1)+20.0000)/20.0000)) ALGBRC(16) = ( CONSTS(13)*0.00500000+0.0500000/(1.00000+EXP(- (STATES(1) - 15.0000)/13.0000)))*STATES(4) ** 3.00000*STATES(5)*(STATES(1) - CONSTS(21)) ALGBRC(22) = CONSTS(15)*(STATES(1) - CONSTS(22)) ALGBRC(23) = ( (( (( CONSTS(18)*CONSTS(2))/(CONSTS(2)+CONSTS(16)))*CONSTS(5) ** 1.50000)/(CONSTS(5) ** 1.50000+CONSTS(17) ** 1.50000))*(STATES(1) - CONSTS(19)))/(STATES(1) - CONSTS(20)) ALGBRC(1) = TERNRY(VOI.GE.CONSTS(6).AND.VOI.LE.CONSTS(7).AND.(VOI - CONSTS(6)) - INT((VOI - CONSTS(6))/CONSTS(8))*CONSTS(8).LE.CONSTS(9), CONSTS(10), 0.00000) RATES(1) = - (ALGBRC(6)+ALGBRC(16)+ALGBRC(11)+ALGBRC(21)+ALGBRC(22)+ALGBRC(23)+ALGBRC(1)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 0.650000/(EXP((STATES(1)+10.0000)/- 8.50000)+EXP((STATES(1) - 30.0000)/- 59.0000)) ALGBRC(7) = 0.650000/(2.50000+EXP((STATES(1)+82.0000)/17.0000)) ALGBRC(17) = 15.0000/(ALGBRC(2)+ALGBRC(7)) ALGBRC(12) = 1.00000/(1.00000+EXP((STATES(1)+20.4700)/- 17.5400)) ALGBRC(3) = 1.00000/(18.5300+EXP((STATES(1)+113.700)/10.9500)) ALGBRC(8) = 1.00000/(35.5600+EXP((STATES(1)+1.26000)/- 7.44000)) ALGBRC(18) = 15.0000/(ALGBRC(3)+ALGBRC(8)) ALGBRC(13) = 1.00000/(1.00000+EXP((STATES(1)+43.1000)/5.30000)) ALGBRC(4) = 0.650000/(EXP((STATES(1)+10.0000)/- 8.50000)+EXP((STATES(1) - 30.0000)/- 59.0000)) ALGBRC(9) = 0.650000/(2.50000+EXP((STATES(1)+82.0000)/17.0000)) ALGBRC(19) = 1.00000/(ALGBRC(4)+ALGBRC(9)) ALGBRC(14) = 1.00000/(1.00000+EXP((STATES(1)+33.3000)/- 9.60000)) ALGBRC(5) = 1.00000/(21.0000+EXP((STATES(1) - 185.000)/28.0000)) ALGBRC(10) = 1.00000/EXP((STATES(1) - 158.000)/- 16.0000) ALGBRC(20) = 5.00000/(ALGBRC(5)+ALGBRC(10)) ALGBRC(15) = 1.00000/(1.00000+EXP((STATES(1) - 99.4500)/27.4800)) ALGBRC(6) = CONSTS(11)*STATES(1) ALGBRC(11) = CONSTS(12)*STATES(2) ** 3.00000*STATES(3)*(STATES(1) - CONSTS(21)) ALGBRC(21) = ( CONSTS(14)*(STATES(1)+86.7500))/(1.00000+EXP((STATES(1)+20.0000)/20.0000)) ALGBRC(16) = ( CONSTS(13)*0.00500000+0.0500000/(1.00000+EXP(- (STATES(1) - 15.0000)/13.0000)))*STATES(4) ** 3.00000*STATES(5)*(STATES(1) - CONSTS(21)) ALGBRC(22) = CONSTS(15)*(STATES(1) - CONSTS(22)) ALGBRC(23) = ( (( (( CONSTS(18)*CONSTS(2))/(CONSTS(2)+CONSTS(16)))*CONSTS(5) ** 1.50000)/(CONSTS(5) ** 1.50000+CONSTS(17) ** 1.50000))*(STATES(1) - CONSTS(19)))/(STATES(1) - CONSTS(20)) ALGBRC(1) = TERNRY(VOI.GE.CONSTS(6).AND.VOI.LE.CONSTS(7).AND.(VOI - CONSTS(6)) - INT((VOI - CONSTS(6))/CONSTS(8))*CONSTS(8).LE.CONSTS(9), CONSTS(10), 0.00000) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END