C C There are a total of 3 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 23 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is RA in component RA (nanomolar). C CONSTS(22) is v_s1 in component v_s1 (flux). C CONSTS(1) is k_d1 in component model_parameters (second_order_rate_constant). C CONSTS(2) is C in component RA (nanomolar). C CONSTS(3) is k_d5 in component RA (first_order_rate_constant). C STATES(2) is M_C in component M_C (nanomolar). C CONSTS(4) is V_0 in component M_C (flux). C CONSTS(5) is V_sC in component M_C (flux). C STATES(3) is F in component F (nanomolar). C CONSTS(6) is n in component M_C (dimensionless). C CONSTS(7) is K_A in component M_C (nanomolar). C CONSTS(8) is k_d3 in component model_parameters (first_order_rate_constant). C STATES(4) is C in component C (nanomolar). C CONSTS(9) is k_s2 in component model_parameters (first_order_rate_constant). C CONSTS(10) is k_d2 in component model_parameters (first_order_rate_constant). C CONSTS(11) is k_s3 in component model_parameters (first_order_rate_constant). C CONSTS(23) is M_F in component M_F (nanomolar). C CONSTS(12) is m in component F (dimensionless). C CONSTS(13) is K_I in component F (nanomolar). C CONSTS(14) is k_d4 in component model_parameters (first_order_rate_constant). C CONSTS(15) is k_s1 in component model_parameters (first_order_rate_constant). C CONSTS(16) is RALDH2_0 in component model_parameters (nanomolar). C CONSTS(17) is x in component model_parameters (dimensionless). C CONSTS(18) is L in component model_parameters (dimensionless). C CONSTS(19) is M_0 in component model_parameters (nanomolar). C ALGBRC(1) is alpha_1 in component alpha_1 (dimensionless). C CONSTS(20) is K_r1 in component model_parameters (nanomolar). C ALGBRC(2) is alpha_2 in component alpha_2 (dimensionless). C CONSTS(21) is K_r2 in component model_parameters (nanomolar). C ALGBRC(3) is rho in component rho (dimensionless). C RATES(1) is d/dt RA in component RA (nanomolar). C RATES(2) is d/dt M_C in component M_C (nanomolar). C RATES(4) is d/dt C in component C (nanomolar). C RATES(3) is d/dt F in component F (nanomolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.1 CONSTS(1) = 1 CONSTS(2) = 0.1 CONSTS(3) = 0 STATES(2) = 0.1 CONSTS(4) = 0.365 CONSTS(5) = 7.1 STATES(3) = 0.0001 CONSTS(6) = 2 CONSTS(7) = 0.2 CONSTS(8) = 1 STATES(4) = 0.1 CONSTS(9) = 1 CONSTS(10) = 0.28 CONSTS(11) = 1 CONSTS(12) = 2 CONSTS(13) = 0.2 CONSTS(14) = 1 CONSTS(15) = 1 CONSTS(16) = 7.1 CONSTS(17) = 15 CONSTS(18) = 50 CONSTS(19) = 5 CONSTS(20) = 1 CONSTS(21) = 1 CONSTS(22) = CONSTS(15)*CONSTS(16)*(1.00000 - CONSTS(17)/CONSTS(18)) CONSTS(23) = ( CONSTS(19)*CONSTS(17))/CONSTS(18) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = (CONSTS(22) - CONSTS(1)*CONSTS(2)*STATES(1)) - CONSTS(3)*STATES(1) RATES(2) = (CONSTS(4)+( CONSTS(5)*STATES(3) ** CONSTS(6))/(CONSTS(7) ** CONSTS(6)+STATES(3) ** CONSTS(6))) - CONSTS(8)*STATES(2) RATES(4) = CONSTS(9)*STATES(2) - CONSTS(10)*STATES(4) RATES(3) = ( CONSTS(11)*CONSTS(23)*CONSTS(13) ** CONSTS(12))/(CONSTS(13) ** CONSTS(12)+STATES(1) ** CONSTS(12)) - CONSTS(14)*STATES(3) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(1)/(STATES(1)+CONSTS(20)) ALGBRC(2) = STATES(3)/(STATES(3)+CONSTS(21)) ALGBRC(3) = ALGBRC(2)/ALGBRC(1) RETURN END