/* There are a total of 5 entries in the algebraic variable array. There are a total of 2 entries in each of the rate and state variable arrays. There are a total of 7 entries in the constant variable array. */ /* * VOI is time in component environment (second). * ALGEBRAIC[0] is kappa_L1 in component rate_constants (per_second). * CONSTANTS[0] is kappa_P1 in component rate_constants (per_second). * ALGEBRAIC[3] is kappa_L2 in component rate_constants (per_second). * CONSTANTS[1] is kappa_P2 in component rate_constants (per_second). * CONSTANTS[2] is kappa_L2_0 in component rate_constants (per_second). * CONSTANTS[3] is kappa_L2_1 in component rate_constants (per_second). * ALGEBRAIC[1] is Kd_Ca in component rate_constants (nanomolar). * CONSTANTS[4] is n in component rate_constants (dimensionless). * STATES[0] is Ca_i in component cytosolic_calcium (nanomolar). * CONSTANTS[5] is Ca_o in component cytosolic_calcium (nanomolar). * ALGEBRAIC[2] is Ca_i_ss in component cytosolic_calcium (nanomolar). * CONSTANTS[6] is gamma in component cytosolic_calcium (dimensionless). * STATES[1] is Ca_s in component subspace_calcium (nanomolar). * ALGEBRAIC[4] is Ca_s_ss in component subspace_calcium (nanomolar). * RATES[0] is d/dt Ca_i in component cytosolic_calcium (nanomolar). * RATES[1] is d/dt Ca_s in component subspace_calcium (nanomolar). * There are a total of 4 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0.132; CONSTANTS[1] = 3.78; CONSTANTS[2] = 0.054; CONSTANTS[3] = 2.4; CONSTANTS[4] = 3; STATES[0] = 75; CONSTANTS[5] = 2000000.0; CONSTANTS[6] = 0.24; STATES[1] = 5300.0; RATES[0] = 0.1001; RATES[1] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - - (ALGEBRAIC[0]+CONSTANTS[0]+ CONSTANTS[6]*(ALGEBRAIC[3]+CONSTANTS[1]))*STATES[0]+ CONSTANTS[6]*ALGEBRAIC[3]*STATES[1]+ ALGEBRAIC[0]*CONSTANTS[5]; resid[1] = RATES[1] - (ALGEBRAIC[3]+CONSTANTS[1])*STATES[0] - ALGEBRAIC[3]*STATES[1]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[5]/(1.00000+CONSTANTS[0]/ALGEBRAIC[0]); ALGEBRAIC[4] = ALGEBRAIC[2]*(1.00000+CONSTANTS[1]/ALGEBRAIC[3]); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>=0.00000&&CONDVAR[1]<0.00000 ? 5.00000e-06 : 2.00000e-05); ALGEBRAIC[1] = (CONDVAR[2]>=0.00000&&CONDVAR[3]<0.00000 ? 1.00000 : 0.500000); ALGEBRAIC[3] = CONSTANTS[2]+CONSTANTS[3]/(1.00000+pow(( 1000.00*ALGEBRAIC[1])/STATES[0], CONSTANTS[4])); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - 0.00000; CONDVAR[1] = VOI - 40.0000; CONDVAR[2] = VOI - 0.00000; CONDVAR[3] = VOI - 80.0000; }