A multiple stimulus protocol component has been added to this model to allow simulations of trains of action potentials. Several variables have also been given cmeta:ids to allow them to be referenced in a PCEnv session file.
0.001
5
bdf15
50000
This model has been curated by Penny Noble and is known to run in PCEnv and COR. It is able to produce the results of the model published in the Matsuoka 2003 paper but still contains some unit discrepancies.
electrophysiology
calcium dynamics
cardiac
canine
ventricular myocyte
heart failure
tachycardia
excitation-contraction coupling
Ventricular Myocyte
Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II Model Studies
84
586
571
Raimond
Winslow
L
James Lawson
units checked, curated
O'Rorke
Brian
1999-03-19 00:00
2006-05-15T00:00:00+00:00
John
Rice
J
Department of Physiology, Anatomy & Genetics, University of Oxford
penny.noble@dpag.ox.ac.uk
Penny
J
Noble
Oxford University
Department of Physiology, Anatomy & Genetics
Richard
Lawson
James
Noble
J
Penny
2007-10-30T11:32:02+13:00
Circulation Research
10082479
keyword
2008-02-25T12:32:09+13:00
This is the CellML description of Winslow et al's mathematical model of ionic fluxes and Ca regulation in normal and failing ventricular myocytes. This model is derived from Jafri et al's guinea pig ventricular model (1998) with modifications to better represent the conditions in a canine midmyocardial ventricular cell.
Marban
Eduardo
Catherine Lloyd
S
M
Jafri