function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =65; end % There are a total of 34 entries in each of the rate and state variable arrays. % There are a total of 157 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_CONSTANTS(:,1) = strpad('t_ss in component Clamp_parameters (ms)'); LEGEND_CONSTANTS(:,2) = strpad('V_actHolding in component Clamp_parameters (mV)'); LEGEND_CONSTANTS(:,3) = strpad('V_actTest in component Clamp_parameters (mV)'); LEGEND_CONSTANTS(:,4) = strpad('Cai in component Clamp_parameters (mM)'); LEGEND_CONSTANTS(:,5) = strpad('Cao in component Clamp_parameters (mM)'); LEGEND_CONSTANTS(:,6) = strpad('Ki in component Clamp_parameters (mM)'); LEGEND_CONSTANTS(:,7) = strpad('Nai in component Clamp_parameters (mM)'); LEGEND_CONSTANTS(:,8) = strpad('T in component Clamp_parameters (kelvin)'); LEGEND_VOI = strpad('time in component time (ms)'); LEGEND_ALGEBRAIC(:,1) = strpad('V in component Patch_clamp_protocol (mV)'); LEGEND_ALGEBRAIC(:,51) = strpad('I_ion in component Clamped_current_Xi (pA)'); LEGEND_ALGEBRAIC(:,23) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,27) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,31) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,35) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,39) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,15) = strpad('I_NCX in component INCX (pA)'); LEGEND_ALGEBRAIC(:,19) = strpad('I_NaK in component INaK (pA)'); LEGEND_ALGEBRAIC(:,43) = strpad('I in component Ionic_currents (pA)'); LEGEND_ALGEBRAIC(:,47) = strpad('I in component Ionic_currents (pA)'); LEGEND_STATES(:,1) = strpad('O_CaL in component ICaL_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,2) = strpad('P_CaT in component ICaT (dimensionless)'); LEGEND_STATES(:,2) = strpad('O4 in component IBK_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,10) = strpad('P_Kv in component IKv (dimensionless)'); LEGEND_STATES(:,3) = strpad('O_Na in component INa_channel_states (dimensionless)'); LEGEND_STATES(:,4) = strpad('X in component gating_kinetics (dimensionless)'); LEGEND_STATES(:,5) = strpad('X in component gating_kinetics (dimensionless)'); LEGEND_STATES(:,6) = strpad('X in component gating_kinetics (dimensionless)'); LEGEND_STATES(:,7) = strpad('X in component gating_kinetics (dimensionless)'); LEGEND_CONSTANTS(:,9) = strpad('g_CaL in component model_parameters (nS)'); LEGEND_CONSTANTS(:,10) = strpad('R in component model_parameters (J_per_K_mol)'); LEGEND_CONSTANTS(:,11) = strpad('F in component model_parameters (C_per_mmol)'); LEGEND_CONSTANTS(:,12) = strpad('T0CaL in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,13) = strpad('T0CaT in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,14) = strpad('Q10Ca in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('C0_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('C1_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,17) = strpad('C2_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,18) = strpad('C3_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,19) = strpad('C0Ca_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,20) = strpad('C1Ca_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,21) = strpad('C2Ca_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,22) = strpad('C3Ca_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,23) = strpad('ICa_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,24) = strpad('IVs_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,25) = strpad('IVf_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,26) = strpad('IVfCa_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,27) = strpad('IVsCa_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,28) = strpad('O_CaL_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,29) = strpad('g_CaT in component model_parameters (nS)'); LEGEND_CONSTANTS(:,30) = strpad('d_CaT_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,31) = strpad('f_CaT_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,32) = strpad('tau_dCaT in component model_parameters (ms)'); LEGEND_CONSTANTS(:,33) = strpad('g_Kv in component model_parameters (nS)'); LEGEND_CONSTANTS(:,34) = strpad('T0K in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,35) = strpad('Q10K in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,36) = strpad('Ko in component model_parameters (mM)'); LEGEND_CONSTANTS(:,37) = strpad('x_Kv_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,38) = strpad('y_Kv_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,39) = strpad('tau_xKv in component model_parameters (ms)'); LEGEND_CONSTANTS(:,40) = strpad('tau_yKv in component model_parameters (ms)'); LEGEND_CONSTANTS(:,41) = strpad('g_BK in component model_parameters (nS)'); LEGEND_CONSTANTS(:,42) = strpad('BK_C0_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,43) = strpad('BK_C1_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,44) = strpad('BK_C2_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,45) = strpad('BK_C3_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,46) = strpad('BK_C4_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,47) = strpad('O0_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,48) = strpad('O1_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,49) = strpad('O2_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,50) = strpad('O3_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,51) = strpad('O4_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,52) = strpad('k_on in component model_parameters (per_ms)'); LEGEND_CONSTANTS(:,53) = strpad('k_off_C in component model_parameters (per_ms)'); LEGEND_CONSTANTS(:,54) = strpad('k_off_O in component model_parameters (per_ms)'); LEGEND_CONSTANTS(:,55) = strpad('g_Na in component model_parameters (nS)'); LEGEND_CONSTANTS(:,56) = strpad('T0Na in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,57) = strpad('Q10Na in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,58) = strpad('Nao in component model_parameters (mM)'); LEGEND_CONSTANTS(:,59) = strpad('Na_C1_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,60) = strpad('Na_C2_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,61) = strpad('Na_C3_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,62) = strpad('I1_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,63) = strpad('I2_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,64) = strpad('O_Na_init in component initial_conditions (dimensionless)'); LEGEND_CONSTANTS(:,65) = strpad('K_mCa in component model_parameters (mM)'); LEGEND_CONSTANTS(:,66) = strpad('K_mNai in component model_parameters (mM)'); LEGEND_CONSTANTS(:,67) = strpad('k_sat in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,68) = strpad('gamma in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,69) = strpad('P_NCX in component model_parameters (pA)'); LEGEND_CONSTANTS(:,70) = strpad('K_mK in component model_parameters (mM)'); LEGEND_CONSTANTS(:,71) = strpad('K_mNa in component model_parameters (mM)'); LEGEND_CONSTANTS(:,72) = strpad('P_NaK in component model_parameters (pA)'); LEGEND_CONSTANTS(:,73) = strpad('g_NsNa in component model_parameters (nS)'); LEGEND_CONSTANTS(:,74) = strpad('g_NsK in component model_parameters (nS)'); LEGEND_CONSTANTS(:,75) = strpad('T in component model_parameters (kelvin)'); LEGEND_CONSTANTS(:,76) = strpad('Cm in component model_parameters (pF)'); LEGEND_CONSTANTS(:,77) = strpad('V_cell in component model_parameters (litre)'); LEGEND_CONSTANTS(:,78) = strpad('Cao in component model_parameters (mM)'); LEGEND_CONSTANTS(:,79) = strpad('n_CRT in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,80) = strpad('n_CaM in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,81) = strpad('CRT_total in component model_parameters (mM)'); LEGEND_CONSTANTS(:,82) = strpad('CaM_total in component model_parameters (mM)'); LEGEND_CONSTANTS(:,83) = strpad('K_D_CRT in component model_parameters (mM)'); LEGEND_CONSTANTS(:,84) = strpad('K_D_CaM in component model_parameters (mM4)'); LEGEND_CONSTANTS(:,85) = strpad('V_init in component initial_conditions (mV)'); LEGEND_CONSTANTS(:,86) = strpad('Cai_total_init in component initial_conditions (mM)'); LEGEND_CONSTANTS(:,87) = strpad('Cai_init in component initial_conditions (mM)'); LEGEND_CONSTANTS(:,88) = strpad('Ki_init in component initial_conditions (mM)'); LEGEND_CONSTANTS(:,89) = strpad('Nai_init in component initial_conditions (mM)'); LEGEND_ALGEBRAIC(:,55) = strpad('norm in component IBK_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,56) = strpad('norm in component INa_channel_states (dimensionless)'); LEGEND_CONSTANTS(:,90) = strpad('PO in component INS_Na (dimensionless)'); LEGEND_CONSTANTS(:,91) = strpad('PO in component INS_K (dimensionless)'); LEGEND_CONSTANTS(:,128) = strpad('E in component Nernst_potential (mV)'); LEGEND_STATES(:,8) = strpad('C0 in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,9) = strpad('C1 in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,10) = strpad('C2 in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,11) = strpad('C3 in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,12) = strpad('C0Ca in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,13) = strpad('C1Ca in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,14) = strpad('C2Ca in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,15) = strpad('C3Ca in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,16) = strpad('ICa in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,17) = strpad('IVs in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,18) = strpad('IVf in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,19) = strpad('IVfCa in component ICaL_channel_states (dimensionless)'); LEGEND_STATES(:,20) = strpad('IVsCa in component ICaL_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,3) = strpad('alpha in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,11) = strpad('beta in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,16) = strpad('alpha_0 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,20) = strpad('alpha_1 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,24) = strpad('alpha_2 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,28) = strpad('alpha_3 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,33) = strpad('beta_0 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,38) = strpad('beta_1 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,42) = strpad('beta_2 in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,46) = strpad('beta_3 in component ICaL_channel_states (per_ms)'); LEGEND_CONSTANTS(:,129) = strpad('delta in component ICaL_channel_states (per_ms)'); LEGEND_CONSTANTS(:,130) = strpad('theta in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,54) = strpad('phi_s in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,50) = strpad('phi_f in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,62) = strpad('omega_s in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,61) = strpad('omega_f in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,64) = strpad('omega_fs in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,63) = strpad('omega_sf in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,60) = strpad('psi_s in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,59) = strpad('psi_f in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,58) = strpad('xi_s in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,57) = strpad('xi_f in component ICaL_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,65) = strpad('norm in component ICaL_channel_states (dimensionless)'); LEGEND_CONSTANTS(:,127) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_CONSTANTS(:,153) = strpad('E in component Nernst_potential (mV)'); LEGEND_ALGEBRAIC(:,4) = strpad('X_inf in component d_inf (dimensionless)'); LEGEND_CONSTANTS(:,131) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_ALGEBRAIC(:,5) = strpad('X_inf in component f_inf (dimensionless)'); LEGEND_ALGEBRAIC(:,12) = strpad('tau in component tau_f (ms)'); LEGEND_CONSTANTS(:,132) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_CONSTANTS(:,154) = strpad('E in component Nernst_potential (mV)'); LEGEND_ALGEBRAIC(:,6) = strpad('X_inf in component x_inf (dimensionless)'); LEGEND_CONSTANTS(:,133) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_ALGEBRAIC(:,7) = strpad('X_inf in component y_inf (dimensionless)'); LEGEND_CONSTANTS(:,134) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_CONSTANTS(:,135) = strpad('E in component Nernst_potential (mV)'); LEGEND_STATES(:,21) = strpad('C0 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,22) = strpad('C1 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,23) = strpad('C2 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,24) = strpad('C3 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,25) = strpad('C4 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,26) = strpad('O0 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,27) = strpad('O1 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,28) = strpad('O2 in component IBK_channel_states (dimensionless)'); LEGEND_STATES(:,29) = strpad('O3 in component IBK_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,8) = strpad('alpha in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,13) = strpad('beta in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,17) = strpad('k_C0O0 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,21) = strpad('k_C1O1 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,25) = strpad('k_C2O2 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,29) = strpad('k_C3O3 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,34) = strpad('k_C4O4 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,36) = strpad('k_O0C0 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,40) = strpad('k_O1C1 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,44) = strpad('k_O2C2 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,48) = strpad('k_O3C3 in component IBK_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,52) = strpad('k_O4C4 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,136) = strpad('k_C0C1 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,137) = strpad('k_C1C2 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,138) = strpad('k_C2C3 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,139) = strpad('k_C3C4 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,140) = strpad('k_C4C3 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,141) = strpad('k_C3C2 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,142) = strpad('k_C2C1 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,143) = strpad('k_C1C0 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,144) = strpad('k_O0O1 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,145) = strpad('k_O1O2 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,146) = strpad('k_O2O3 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,147) = strpad('k_O3O4 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,148) = strpad('k_O4O3 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,149) = strpad('k_O3O2 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,150) = strpad('k_O2O1 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,151) = strpad('k_O1O0 in component IBK_channel_states (per_ms)'); LEGEND_CONSTANTS(:,152) = strpad('E in component Nernst_potential (mV)'); LEGEND_STATES(:,30) = strpad('C1 in component INa_channel_states (dimensionless)'); LEGEND_STATES(:,31) = strpad('C2 in component INa_channel_states (dimensionless)'); LEGEND_STATES(:,32) = strpad('C3 in component INa_channel_states (dimensionless)'); LEGEND_STATES(:,33) = strpad('I1 in component INa_channel_states (dimensionless)'); LEGEND_STATES(:,34) = strpad('I2 in component INa_channel_states (dimensionless)'); LEGEND_ALGEBRAIC(:,9) = strpad('k_I2I1 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,14) = strpad('k_I1O in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,18) = strpad('k_OC1 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,22) = strpad('k_C1C2 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,26) = strpad('k_C2C3 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,30) = strpad('k_C3C2 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,32) = strpad('k_C2C1 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,37) = strpad('k_C1O in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,41) = strpad('k_OI1 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,45) = strpad('k_I1I2 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,49) = strpad('k_I1C1 in component INa_channel_states (per_ms)'); LEGEND_ALGEBRAIC(:,53) = strpad('k_C1I1 in component INa_channel_states (per_ms)'); LEGEND_CONSTANTS(:,155) = strpad('phi in component temperature_factor (dimensionless)'); LEGEND_CONSTANTS(:,156) = strpad('E in component Nernst_potential (mV)'); LEGEND_CONSTANTS(:,157) = strpad('E in component Nernst_potential (mV)'); LEGEND_CONSTANTS(:,92) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,93) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,94) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,95) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,96) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,97) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,98) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,99) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,100) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,101) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,102) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,103) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,104) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,105) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,106) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,107) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,108) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,109) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,110) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,111) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,112) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,113) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,114) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,115) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,116) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,117) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,118) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,119) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,120) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_CONSTANTS(:,121) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,122) = strpad('R in component constants (J_per_K_mol)'); LEGEND_CONSTANTS(:,123) = strpad('F in component constants (C_per_mmol)'); LEGEND_CONSTANTS(:,124) = strpad('z_K in component constants (dimensionless)'); LEGEND_CONSTANTS(:,125) = strpad('z_Na in component constants (dimensionless)'); LEGEND_CONSTANTS(:,126) = strpad('z_Ca in component constants (dimensionless)'); LEGEND_RATES(:,11) = strpad('d/dt C3 in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,10) = strpad('d/dt C2 in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,9) = strpad('d/dt C1 in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,8) = strpad('d/dt C0 in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,15) = strpad('d/dt C3Ca in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,14) = strpad('d/dt C2Ca in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,13) = strpad('d/dt C1Ca in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,12) = strpad('d/dt C0Ca in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,1) = strpad('d/dt O_CaL in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,16) = strpad('d/dt ICa in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,17) = strpad('d/dt IVs in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,18) = strpad('d/dt IVf in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,20) = strpad('d/dt IVsCa in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,19) = strpad('d/dt IVfCa in component ICaL_channel_states (dimensionless)'); LEGEND_RATES(:,4) = strpad('d/dt X in component gating_kinetics (dimensionless)'); LEGEND_RATES(:,5) = strpad('d/dt X in component gating_kinetics (dimensionless)'); LEGEND_RATES(:,6) = strpad('d/dt X in component gating_kinetics (dimensionless)'); LEGEND_RATES(:,7) = strpad('d/dt X in component gating_kinetics (dimensionless)'); LEGEND_RATES(:,25) = strpad('d/dt C4 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,24) = strpad('d/dt C3 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,23) = strpad('d/dt C2 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,22) = strpad('d/dt C1 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,21) = strpad('d/dt C0 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,2) = strpad('d/dt O4 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,29) = strpad('d/dt O3 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,28) = strpad('d/dt O2 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,27) = strpad('d/dt O1 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,26) = strpad('d/dt O0 in component IBK_channel_states (dimensionless)'); LEGEND_RATES(:,32) = strpad('d/dt C3 in component INa_channel_states (dimensionless)'); LEGEND_RATES(:,31) = strpad('d/dt C2 in component INa_channel_states (dimensionless)'); LEGEND_RATES(:,30) = strpad('d/dt C1 in component INa_channel_states (dimensionless)'); LEGEND_RATES(:,3) = strpad('d/dt O_Na in component INa_channel_states (dimensionless)'); LEGEND_RATES(:,34) = strpad('d/dt I2 in component INa_channel_states (dimensionless)'); LEGEND_RATES(:,33) = strpad('d/dt I1 in component INa_channel_states (dimensionless)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 1000; CONSTANTS(:,2) = -100; CONSTANTS(:,3) = -90; CONSTANTS(:,4) = 5.38843941249284e-5; CONSTANTS(:,5) = 2; CONSTANTS(:,6) = 153.604280337996; CONSTANTS(:,7) = 50; CONSTANTS(:,8) = 297; CONSTANTS(:,9) = 1.44; CONSTANTS(:,10) = 8.314; CONSTANTS(:,11) = 96.48534; CONSTANTS(:,12) = 310; CONSTANTS(:,13) = 297; CONSTANTS(:,14) = 2.1; CONSTANTS(:,15) = 0.815464741971086; CONSTANTS(:,16) = 0.152399266235657; CONSTANTS(:,17) = 0.0106805060777161; CONSTANTS(:,18) = 0.000332673548872087; CONSTANTS(:,19) = 0.0175888495282545; CONSTANTS(:,20) = 0.00328711668724504; CONSTANTS(:,21) = 0.000230369020877669; CONSTANTS(:,22) = 7.1754726923539e-6; CONSTANTS(:,23) = 8.38123983500905e-8; CONSTANTS(:,24) = 1.1193313274705e-6; CONSTANTS(:,25) = 4.0998751301597e-6; CONSTANTS(:,26) = 8.84306615061238e-8; CONSTANTS(:,27) = 2.41429816075123e-8; CONSTANTS(:,28) = 3.88576045134351e-6; CONSTANTS(:,29) = 0.0425; CONSTANTS(:,30) = 0.0791635737410974; CONSTANTS(:,31) = 0.377831534375835; CONSTANTS(:,32) = 1.9508; CONSTANTS(:,33) = 1.0217; CONSTANTS(:,34) = 297; CONSTANTS(:,35) = 3.1; CONSTANTS(:,36) = 5.4; CONSTANTS(:,37) = 0.14714161078933; CONSTANTS(:,38) = 0.99994773314105; CONSTANTS(:,39) = 4.7803; CONSTANTS(:,40) = 763.7564; CONSTANTS(:,41) = 80; CONSTANTS(:,42) = 0.48379087935899; CONSTANTS(:,43) = 0.385183559520031; CONSTANTS(:,44) = 0.115002824567753; CONSTANTS(:,45) = 0.0152602714149774; CONSTANTS(:,46) = 0.000759264410974374; CONSTANTS(:,47) = 6.94960798375172e-7; CONSTANTS(:,48) = 5.55636826398253e-8; CONSTANTS(:,49) = 2.85143702125325e-8; CONSTANTS(:,50) = 1.59832806123435e-6; CONSTANTS(:,51) = 1.82113764497095e-6; CONSTANTS(:,52) = 40633; CONSTANTS(:,53) = 11; CONSTANTS(:,54) = 1.1; CONSTANTS(:,55) = 25.1; CONSTANTS(:,56) = 297; CONSTANTS(:,57) = 2.45; CONSTANTS(:,58) = 140; CONSTANTS(:,59) = 0.0119443135223679; CONSTANTS(:,60) = 0.0109545368437155; CONSTANTS(:,61) = 0.973782548650071; CONSTANTS(:,62) = 0.000126882921013389; CONSTANTS(:,63) = 0.00318975045717667; CONSTANTS(:,64) = 1.96760342050475e-6; CONSTANTS(:,65) = 1.38; CONSTANTS(:,66) = 87.5; CONSTANTS(:,67) = 0.1; CONSTANTS(:,68) = 0.35; CONSTANTS(:,69) = 1992.1865; CONSTANTS(:,70) = 1; CONSTANTS(:,71) = 40; CONSTANTS(:,72) = 16.197; CONSTANTS(:,73) = 0.022488; CONSTANTS(:,74) = 0.017512; CONSTANTS(:,75) = 310; CONSTANTS(:,76) = 50; CONSTANTS(:,77) = 3.5e-12; CONSTANTS(:,78) = 2; CONSTANTS(:,79) = 1; CONSTANTS(:,80) = 4; CONSTANTS(:,81) = 0.034; CONSTANTS(:,82) = 0.012; CONSTANTS(:,83) = 0.0009; CONSTANTS(:,84) = 0.0001; CONSTANTS(:,85) = -73.5049651455872; CONSTANTS(:,86) = 0.004914; CONSTANTS(:,87) = 5.38843941249284e-5; CONSTANTS(:,88) = 153.604280337996; CONSTANTS(:,89) = 10.5731241425458; CONSTANTS(:,90) = 1; CONSTANTS(:,91) = 1; CONSTANTS(:,92) = 8.314; CONSTANTS(:,93) = 96.48534; CONSTANTS(:,94) = 2; CONSTANTS(:,95) = 1; CONSTANTS(:,96) = 1; CONSTANTS(:,97) = 8.314; CONSTANTS(:,98) = 96.48534; CONSTANTS(:,99) = 2; CONSTANTS(:,100) = 1; CONSTANTS(:,101) = 1; CONSTANTS(:,102) = 8.314; CONSTANTS(:,103) = 96.48534; CONSTANTS(:,104) = 1; CONSTANTS(:,105) = 1; CONSTANTS(:,106) = 2; CONSTANTS(:,107) = 8.314; CONSTANTS(:,108) = 96.48534; CONSTANTS(:,109) = 1; CONSTANTS(:,110) = 1; CONSTANTS(:,111) = 2; CONSTANTS(:,112) = 8.314; CONSTANTS(:,113) = 96.48534; CONSTANTS(:,114) = 1; CONSTANTS(:,115) = 2; CONSTANTS(:,116) = 1; CONSTANTS(:,117) = 8.314; CONSTANTS(:,118) = 96.48534; CONSTANTS(:,119) = 1; CONSTANTS(:,120) = 2; CONSTANTS(:,121) = 1; CONSTANTS(:,122) = 8.314; CONSTANTS(:,123) = 96.48534; CONSTANTS(:,124) = 1; CONSTANTS(:,125) = 1; CONSTANTS(:,126) = 2; CONSTANTS(:,127) = power(CONSTANTS(:,14), (CONSTANTS(:,8) - CONSTANTS(:,12))./10.0000); CONSTANTS(:,128) = (( CONSTANTS(:,92).*CONSTANTS(:,8))./( CONSTANTS(:,94).*CONSTANTS(:,93))).*log(CONSTANTS(:,5)./CONSTANTS(:,4)); CONSTANTS(:,129) = 0.00000; CONSTANTS(:,130) = 0.00000; CONSTANTS(:,131) = power(CONSTANTS(:,14), (CONSTANTS(:,8) - CONSTANTS(:,13))./10.0000); CONSTANTS(:,132) = power(CONSTANTS(:,14), (CONSTANTS(:,8) - CONSTANTS(:,13))./10.0000); CONSTANTS(:,133) = power(CONSTANTS(:,35), (CONSTANTS(:,8) - CONSTANTS(:,34))./10.0000); CONSTANTS(:,134) = power(CONSTANTS(:,35), (CONSTANTS(:,8) - CONSTANTS(:,34))./10.0000); CONSTANTS(:,135) = (( CONSTANTS(:,107).*CONSTANTS(:,8))./( CONSTANTS(:,109).*CONSTANTS(:,108))).*log(CONSTANTS(:,36)./CONSTANTS(:,6)); CONSTANTS(:,136) = 4.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,137) = 3.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,138) = 2.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,139) = 1.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,140) = 4.00000.*CONSTANTS(:,53); CONSTANTS(:,141) = 3.00000.*CONSTANTS(:,53); CONSTANTS(:,142) = 2.00000.*CONSTANTS(:,53); CONSTANTS(:,143) = 1.00000.*CONSTANTS(:,53); CONSTANTS(:,144) = 4.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,145) = 3.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,146) = 2.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,147) = 1.00000.*CONSTANTS(:,52).*CONSTANTS(:,4); CONSTANTS(:,148) = 4.00000.*CONSTANTS(:,54); CONSTANTS(:,149) = 3.00000.*CONSTANTS(:,54); CONSTANTS(:,150) = 2.00000.*CONSTANTS(:,54); CONSTANTS(:,151) = 1.00000.*CONSTANTS(:,54); CONSTANTS(:,152) = (( CONSTANTS(:,112).*CONSTANTS(:,8))./( CONSTANTS(:,114).*CONSTANTS(:,113))).*log(CONSTANTS(:,58)./CONSTANTS(:,7)); CONSTANTS(:,153) = (( CONSTANTS(:,97).*CONSTANTS(:,8))./( CONSTANTS(:,99).*CONSTANTS(:,98))).*log(CONSTANTS(:,5)./CONSTANTS(:,4)); CONSTANTS(:,154) = (( CONSTANTS(:,102).*CONSTANTS(:,8))./( CONSTANTS(:,104).*CONSTANTS(:,103))).*log(CONSTANTS(:,36)./CONSTANTS(:,6)); CONSTANTS(:,155) = power(CONSTANTS(:,57), (CONSTANTS(:,8) - CONSTANTS(:,56))./10.0000); CONSTANTS(:,156) = (( CONSTANTS(:,117).*CONSTANTS(:,8))./( CONSTANTS(:,119).*CONSTANTS(:,118))).*log(CONSTANTS(:,58)./CONSTANTS(:,7)); CONSTANTS(:,157) = (( CONSTANTS(:,122).*CONSTANTS(:,8))./( CONSTANTS(:,124).*CONSTANTS(:,123))).*log(CONSTANTS(:,36)./CONSTANTS(:,6)); STATES(:,1) = CONSTANTS(:,28); STATES(:,2) = CONSTANTS(:,51); STATES(:,3) = CONSTANTS(:,64); STATES(:,4) = CONSTANTS(:,30); STATES(:,5) = CONSTANTS(:,31); STATES(:,6) = CONSTANTS(:,37); STATES(:,7) = CONSTANTS(:,38); STATES(:,8) = CONSTANTS(:,15); STATES(:,9) = CONSTANTS(:,16); STATES(:,10) = CONSTANTS(:,17); STATES(:,11) = CONSTANTS(:,18); STATES(:,12) = CONSTANTS(:,19); STATES(:,13) = CONSTANTS(:,20); STATES(:,14) = CONSTANTS(:,21); STATES(:,15) = CONSTANTS(:,22); STATES(:,16) = CONSTANTS(:,23); STATES(:,17) = CONSTANTS(:,24); STATES(:,18) = CONSTANTS(:,25); STATES(:,19) = CONSTANTS(:,26); STATES(:,20) = CONSTANTS(:,26); STATES(:,21) = CONSTANTS(:,42); STATES(:,22) = CONSTANTS(:,43); STATES(:,23) = CONSTANTS(:,44); STATES(:,24) = CONSTANTS(:,45); STATES(:,25) = CONSTANTS(:,46); STATES(:,26) = CONSTANTS(:,47); STATES(:,27) = CONSTANTS(:,48); STATES(:,28) = CONSTANTS(:,49); STATES(:,29) = CONSTANTS(:,50); STATES(:,30) = CONSTANTS(:,59); STATES(:,31) = CONSTANTS(:,60); STATES(:,32) = CONSTANTS(:,61); STATES(:,33) = CONSTANTS(:,62); STATES(:,34) = CONSTANTS(:,63); if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = piecewise({VOI req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end