Sensitivity analysis

In the Sensitivity analysis experiment, the Membrane potential component is configured and parameterised with an applied periodic stimulus current.

You can change the parameters of stimulation in the component Istim_parameters and the maximum conductances of ionic channels in the component g_parameters.

You can also bypass the parameters in the component model_parameters and initial_conditions and define your own parameters.

The simulation experiment can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation.

Sensitivity analysis result

Figure [1] shows sensitivity analysis by 50% increase or decrease in maximum channel conductance. This evaluates the contributions of key ionic currents towards hJSMC membrane voltage. (e) shows the free intracellular Ca2 +  concentrations corresponding to changes in (d).