/* There are a total of 13 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 39 entries in the constant variable array. */ /* * CONSTANTS[0] is t_ss in component Vstim_para (second). * CONSTANTS[1] is V_actHolding in component Vstim_para (mV). * CONSTANTS[2] is t_act in component Vstim_para (second). * CONSTANTS[3] is V_actTest in component Vstim_para (mV). * CONSTANTS[4] is Nai in component control_para (mM). * CONSTANTS[5] is Cai_init in component control_para (mM). * CONSTANTS[6] is inhPump in component control_para (dimensionless). * CONSTANTS[7] is K_Cahalf in component control_para (mV). * VOI is time in component time_s (second). * ALGEBRAIC[0] is V in component sPulse_protocol_s (mV). * STATES[0] is Cai in component Cai (mM). * ALGEBRAIC[9] is J_VOCC in component J_VOCC (mM_per_s). * ALGEBRAIC[2] is J_CaPump in component J_CaPump (mM_per_s). * ALGEBRAIC[11] is J_NaCa in component J_NaCa (mM_per_s). * ALGEBRAIC[4] is stress in component CB4HM (dimensionless). * ALGEBRAIC[5] is phosphorylation in component CB4HM (dimensionless). * CONSTANTS[8] is R in component constants (J_per_K_mol). * CONSTANTS[9] is F in component constants (C_per_mmol). * CONSTANTS[10] is T in component model_para (kelvin). * CONSTANTS[11] is Nao in component model_para (mM). * CONSTANTS[12] is Cao in component model_para (mM). * CONSTANTS[13] is V_cell in component model_para (fm3). * CONSTANTS[14] is V_Cahalf in component model_para (mV). * CONSTANTS[15] is g_mCa in component model_para (nS). * CONSTANTS[16] is V_pmax in component model_para (mM_per_s). * CONSTANTS[17] is n in component model_para (dimensionless). * CONSTANTS[18] is K_ph in component model_para (mM). * CONSTANTS[19] is K_NaCa in component model_para (mM). * CONSTANTS[20] is G_NaCa in component model_para (mM_per_s_mV). * CONSTANTS[21] is n_M in component model_para (dimensionless). * CONSTANTS[22] is Ca_halfMLCK in component model_para (mM). * CONSTANTS[23] is M_init in component initials (dimensionless). * CONSTANTS[24] is Mp_init in component initials (dimensionless). * CONSTANTS[25] is AM_init in component initials (dimensionless). * CONSTANTS[26] is AMp_init in component initials (dimensionless). * CONSTANTS[27] is K_7 in component model_para (per_s). * CONSTANTS[28] is K_2 in component model_para (per_s). * CONSTANTS[29] is K_3 in component model_para (per_s). * ALGEBRAIC[1] is rho_vCa in component J_VOCC (dimensionless). * CONSTANTS[30] is Nai in component model_para (mM). * CONSTANTS[31] is K_Cahalf in component model_para (mV). * CONSTANTS[32] is inhPump in component model_para (dimensionless). * CONSTANTS[33] is Cai_init in component initials (mM). * CONSTANTS[34] is z_Ca in component E_Ca (dimensionless). * ALGEBRAIC[7] is E in component Nernst_potential (mV). * CONSTANTS[35] is z_Na in component E_Na (dimensionless). * CONSTANTS[36] is E in component Nernst_potential (mV). * ALGEBRAIC[8] is I in component Ionic_currents (pA). * ALGEBRAIC[10] is V_mNaCa in component J_NaCa (mV). * ALGEBRAIC[6] is K_1 in component K_1 (per_s). * CONSTANTS[37] is K_4 in component CB4HM (per_s). * CONSTANTS[38] is K_5 in component CB4HM (per_s). * ALGEBRAIC[12] is K_6 in component CB4HM (per_s). * ALGEBRAIC[3] is norm in component CB4HM (dimensionless). * STATES[1] is M in component CB4HM (dimensionless). * STATES[2] is Mp in component CB4HM (dimensionless). * STATES[3] is AM in component CB4HM (dimensionless). * STATES[4] is AMp in component CB4HM (dimensionless). * RATES[0] is d/dt Cai in component Cai (mM). * RATES[1] is d/dt M in component CB4HM (dimensionless). * RATES[2] is d/dt Mp in component CB4HM (dimensionless). * RATES[3] is d/dt AM in component CB4HM (dimensionless). * RATES[4] is d/dt AMp in component CB4HM (dimensionless). * There are a total of 3 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0; CONSTANTS[1] = -80; CONSTANTS[2] = 1; CONSTANTS[3] = 0; CONSTANTS[4] = 16.55; CONSTANTS[5] = 0.1e-3; CONSTANTS[6] = 1; CONSTANTS[7] = 11; CONSTANTS[8] = 8.314; CONSTANTS[9] = 96.48534; CONSTANTS[10] = 310; CONSTANTS[11] = 140; CONSTANTS[12] = 2; CONSTANTS[13] = 21; CONSTANTS[14] = -27; CONSTANTS[15] = 0.046842; CONSTANTS[16] = 5.1449e-4; CONSTANTS[17] = 1.9015; CONSTANTS[18] = 0.6e-3; CONSTANTS[19] = 7e-3; CONSTANTS[20] = 5.7297e-5; CONSTANTS[21] = 8.7613; CONSTANTS[22] = 256.98e-6; CONSTANTS[23] = 1; CONSTANTS[24] = 0; CONSTANTS[25] = 0; CONSTANTS[26] = 0; CONSTANTS[27] = 0.0378; CONSTANTS[28] = 1.2387; CONSTANTS[29] = 0.1419; CONSTANTS[30] = 2.9836; CONSTANTS[31] = 11; CONSTANTS[32] = 1; CONSTANTS[33] = 0.1e-6; CONSTANTS[34] = 2; CONSTANTS[35] = 1; CONSTANTS[36] = (( CONSTANTS[8]*CONSTANTS[10])/( CONSTANTS[35]*CONSTANTS[9]))*log(CONSTANTS[11]/CONSTANTS[4]); CONSTANTS[37] = CONSTANTS[29]/4.00000; CONSTANTS[38] = CONSTANTS[28]; STATES[0] = CONSTANTS[5]; STATES[1] = CONSTANTS[23]; STATES[2] = CONSTANTS[24]; STATES[3] = CONSTANTS[25]; STATES[4] = CONSTANTS[26]; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ALGEBRAIC[9]+ CONSTANTS[6]*ALGEBRAIC[2]+ALGEBRAIC[11]; resid[1] = RATES[1] - ( - ALGEBRAIC[6]*STATES[1])/ALGEBRAIC[3]+( CONSTANTS[28]*STATES[2])/ALGEBRAIC[3]+( CONSTANTS[27]*STATES[3])/ALGEBRAIC[3]; resid[2] = RATES[2] - (( CONSTANTS[37]*STATES[4])/ALGEBRAIC[3]+( ALGEBRAIC[6]*STATES[1])/ALGEBRAIC[3]) - ( (CONSTANTS[28]+CONSTANTS[29])*STATES[2])/ALGEBRAIC[3]; resid[3] = RATES[3] - ( CONSTANTS[38]*STATES[4])/ALGEBRAIC[3] - ( (ALGEBRAIC[12]+CONSTANTS[27])*STATES[3])/ALGEBRAIC[3]; resid[4] = RATES[4] - (( CONSTANTS[29]*STATES[2])/ALGEBRAIC[3]+( ALGEBRAIC[12]*STATES[3])/ALGEBRAIC[3]) - ( (CONSTANTS[37]+CONSTANTS[38])*STATES[4])/ALGEBRAIC[3]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[4] = STATES[4]+STATES[3]; ALGEBRAIC[5] = STATES[4]+STATES[2]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = ( - CONSTANTS[16]*pow(STATES[0], CONSTANTS[17]))/(pow(CONSTANTS[18], CONSTANTS[17])+pow(STATES[0], CONSTANTS[17])); ALGEBRAIC[3] = STATES[1]+STATES[2]+STATES[3]+STATES[4]; ALGEBRAIC[6] = (pow(STATES[0], CONSTANTS[21])/(pow(CONSTANTS[22], CONSTANTS[21])+pow(STATES[0], CONSTANTS[21])))*1.00000; ALGEBRAIC[0] = (CONDVAR[0]<0.00000 ? CONSTANTS[1] : CONDVAR[1]>=0.00000&&CONDVAR[2]<0.00000 ? CONSTANTS[3] : CONSTANTS[1]); ALGEBRAIC[1] = 1.00000/(1.00000+exp((CONSTANTS[14] - ALGEBRAIC[0])/CONSTANTS[7])); ALGEBRAIC[7] = (( CONSTANTS[8]*CONSTANTS[10])/( CONSTANTS[34]*CONSTANTS[9]))*log(CONSTANTS[12]/STATES[0]); ALGEBRAIC[8] = CONSTANTS[15]*ALGEBRAIC[1]*(ALGEBRAIC[0] - ALGEBRAIC[7]); ALGEBRAIC[9] = - ALGEBRAIC[8]/( 2.00000*CONSTANTS[13]*CONSTANTS[9]); ALGEBRAIC[10] = 3.00000*CONSTANTS[36] - 2.00000*ALGEBRAIC[7]; ALGEBRAIC[11] = (( CONSTANTS[20]*STATES[0])/(STATES[0]+CONSTANTS[19]))*(ALGEBRAIC[0] - ALGEBRAIC[10]); ALGEBRAIC[12] = ALGEBRAIC[6]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[0]; CONDVAR[1] = VOI - CONSTANTS[0]; CONDVAR[2] = VOI - (CONSTANTS[2]+CONSTANTS[0]); }