/* There are a total of 13 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 41 entries in the constant variable array. */ /* * CONSTANTS[0] is t_ss in component Vstim_para (second). * CONSTANTS[1] is V_actHolding in component Vstim_para (mV). * CONSTANTS[2] is t_act in component Vstim_para (second). * CONSTANTS[3] is V_actTest in component Vstim_para (mV). * CONSTANTS[4] is t_intp in component Vstim_para (second). * CONSTANTS[5] is np in component Vstim_para (dimensionless). * CONSTANTS[6] is Nai in component control_para (mM). * CONSTANTS[7] is Cai_init in component control_para (mM). * CONSTANTS[8] is inhPump in component control_para (dimensionless). * VOI is time in component time_s (second). * ALGEBRAIC[1] is V in component mPulse_protocol_s (mV). * STATES[0] is Cai in component Cai (mM). * ALGEBRAIC[10] is J_VOCC in component J_VOCC (mM_per_s). * ALGEBRAIC[3] is J_CaPump in component J_CaPump (mM_per_s). * ALGEBRAIC[12] is J_NaCa in component J_NaCa (mM_per_s). * ALGEBRAIC[5] is stress in component CB4HM (dimensionless). * ALGEBRAIC[6] is phosphorylation in component CB4HM (dimensionless). * CONSTANTS[9] is R in component constants (J_per_K_mol). * CONSTANTS[10] is F in component constants (C_per_mmol). * CONSTANTS[11] is T in component model_para (kelvin). * CONSTANTS[12] is Nao in component model_para (mM). * CONSTANTS[13] is Cao in component model_para (mM). * CONSTANTS[14] is V_cell in component model_para (fm3). * CONSTANTS[15] is V_Cahalf in component model_para (mV). * CONSTANTS[16] is K_Cahalf in component model_para (mV). * CONSTANTS[17] is g_mCa in component model_para (nS). * CONSTANTS[18] is V_pmax in component model_para (mM_per_s). * CONSTANTS[19] is n in component model_para (dimensionless). * CONSTANTS[20] is K_ph in component model_para (mM). * CONSTANTS[21] is K_NaCa in component model_para (mM). * CONSTANTS[22] is G_NaCa in component model_para (mM_per_s_mV). * CONSTANTS[23] is n_M in component model_para (dimensionless). * CONSTANTS[24] is Ca_halfMLCK in component model_para (mM). * CONSTANTS[25] is M_init in component initials (dimensionless). * CONSTANTS[26] is Mp_init in component initials (dimensionless). * CONSTANTS[27] is AM_init in component initials (dimensionless). * CONSTANTS[28] is AMp_init in component initials (dimensionless). * CONSTANTS[29] is K_7 in component model_para (per_s). * CONSTANTS[30] is K_2 in component model_para (per_s). * CONSTANTS[31] is K_3 in component model_para (per_s). * CONSTANTS[32] is K_4 in component model_para (per_s). * CONSTANTS[33] is K_5 in component model_para (per_s). * ALGEBRAIC[2] is rho_vCa in component J_VOCC (dimensionless). * CONSTANTS[40] is stimPeriod in component mPulse_protocol_s (second). * ALGEBRAIC[0] is t in component mPulse_protocol_s (second). * CONSTANTS[34] is Nai in component model_para (mM). * CONSTANTS[35] is inhPump in component model_para (dimensionless). * CONSTANTS[36] is Cai_init in component initials (mM). * CONSTANTS[37] is z_Ca in component E_Ca (dimensionless). * ALGEBRAIC[8] is E in component Nernst_potential (mV). * CONSTANTS[38] is z_Na in component E_Na (dimensionless). * CONSTANTS[39] is E in component Nernst_potential (mV). * ALGEBRAIC[9] is I in component Ionic_currents (pA). * ALGEBRAIC[11] is V_mNaCa in component J_NaCa (mV). * ALGEBRAIC[7] is K_1 in component K_1 (per_s). * ALGEBRAIC[4] is norm in component CB4HM (dimensionless). * STATES[1] is M in component CB4HM (dimensionless). * STATES[2] is Mp in component CB4HM (dimensionless). * STATES[3] is AM in component CB4HM (dimensionless). * STATES[4] is AMp in component CB4HM (dimensionless). * RATES[0] is d/dt Cai in component Cai (mM). * RATES[1] is d/dt M in component CB4HM (dimensionless). * RATES[2] is d/dt Mp in component CB4HM (dimensionless). * RATES[3] is d/dt AM in component CB4HM (dimensionless). * RATES[4] is d/dt AMp in component CB4HM (dimensionless). * There are a total of 4 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 0; CONSTANTS[1] = -80; CONSTANTS[2] = 0.1; CONSTANTS[3] = 0; CONSTANTS[4] = 0.33; CONSTANTS[5] = 10; CONSTANTS[6] = 16.55; CONSTANTS[7] = 0.1e-3; CONSTANTS[8] = 1; CONSTANTS[9] = 8.314; CONSTANTS[10] = 96.48534; CONSTANTS[11] = 310; CONSTANTS[12] = 140; CONSTANTS[13] = 2; CONSTANTS[14] = 21; CONSTANTS[15] = -27; CONSTANTS[16] = 11; CONSTANTS[17] = 0.046842; CONSTANTS[18] = 5.1449e-4; CONSTANTS[19] = 1.9015; CONSTANTS[20] = 0.6e-3; CONSTANTS[21] = 7e-3; CONSTANTS[22] = 5.7297e-5; CONSTANTS[23] = 8.7613; CONSTANTS[24] = 256.98e-6; CONSTANTS[25] = 1; CONSTANTS[26] = 0; CONSTANTS[27] = 0; CONSTANTS[28] = 0; CONSTANTS[29] = 0.0378; CONSTANTS[30] = 1.2387; CONSTANTS[31] = 0.1419; CONSTANTS[32] = 0.035475; CONSTANTS[33] = 1.2387; CONSTANTS[34] = 2.9836; CONSTANTS[35] = 1; CONSTANTS[36] = 0.1e-6; CONSTANTS[37] = 2; CONSTANTS[38] = 1; CONSTANTS[39] = (( CONSTANTS[9]*CONSTANTS[11])/( CONSTANTS[38]*CONSTANTS[10]))*log(CONSTANTS[12]/CONSTANTS[6]); CONSTANTS[40] = CONSTANTS[2]+CONSTANTS[4]; STATES[0] = CONSTANTS[7]; STATES[1] = CONSTANTS[25]; STATES[2] = CONSTANTS[26]; STATES[3] = CONSTANTS[27]; STATES[4] = CONSTANTS[28]; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - ALGEBRAIC[10]+ CONSTANTS[8]*ALGEBRAIC[3]+ALGEBRAIC[12]; resid[1] = RATES[1] - ( - ALGEBRAIC[7]*STATES[1])/ALGEBRAIC[4]+( CONSTANTS[30]*STATES[2])/ALGEBRAIC[4]+( CONSTANTS[29]*STATES[3])/ALGEBRAIC[4]; resid[2] = RATES[2] - (( CONSTANTS[32]*STATES[4])/ALGEBRAIC[4]+( ALGEBRAIC[7]*STATES[1])/ALGEBRAIC[4]) - ( (CONSTANTS[30]+CONSTANTS[31])*STATES[2])/ALGEBRAIC[4]; resid[3] = RATES[3] - ( CONSTANTS[33]*STATES[4])/ALGEBRAIC[4] - ( (ALGEBRAIC[7]+CONSTANTS[29])*STATES[3])/ALGEBRAIC[4]; resid[4] = RATES[4] - (( CONSTANTS[31]*STATES[2])/ALGEBRAIC[4]+( ALGEBRAIC[7]*STATES[3])/ALGEBRAIC[4]) - ( (CONSTANTS[32]+CONSTANTS[33])*STATES[4])/ALGEBRAIC[4]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[5] = STATES[4]+STATES[3]; ALGEBRAIC[6] = STATES[4]+STATES[2]; } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = ( - CONSTANTS[18]*pow(STATES[0], CONSTANTS[19]))/(pow(CONSTANTS[20], CONSTANTS[19])+pow(STATES[0], CONSTANTS[19])); ALGEBRAIC[4] = STATES[1]+STATES[2]+STATES[3]+STATES[4]; ALGEBRAIC[7] = (pow(STATES[0], CONSTANTS[23])/(pow(CONSTANTS[24], CONSTANTS[23])+pow(STATES[0], CONSTANTS[23])))*1.00000; ALGEBRAIC[0] = (VOI - CONSTANTS[0]) - CONSTANTS[40]*floor((VOI - CONSTANTS[0])/CONSTANTS[40]); ALGEBRAIC[1] = (CONDVAR[0]<=0.00000 ? CONSTANTS[1] : CONDVAR[1]>0.00000&&CONDVAR[2]<=0.00000&&CONDVAR[3]<=0.00000 ? CONSTANTS[3] : CONSTANTS[1]); ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[15] - ALGEBRAIC[1])/CONSTANTS[16])); ALGEBRAIC[8] = (( CONSTANTS[9]*CONSTANTS[11])/( CONSTANTS[37]*CONSTANTS[10]))*log(CONSTANTS[13]/STATES[0]); ALGEBRAIC[9] = CONSTANTS[17]*ALGEBRAIC[2]*(ALGEBRAIC[1] - ALGEBRAIC[8]); ALGEBRAIC[10] = - ALGEBRAIC[9]/( 2.00000*CONSTANTS[14]*CONSTANTS[10]); ALGEBRAIC[11] = 3.00000*CONSTANTS[39] - 2.00000*ALGEBRAIC[8]; ALGEBRAIC[12] = (( CONSTANTS[22]*STATES[0])/(STATES[0]+CONSTANTS[21]))*(ALGEBRAIC[1] - ALGEBRAIC[11]); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - CONSTANTS[0]; CONDVAR[1] = VOI - CONSTANTS[0]; CONDVAR[2] = ALGEBRAIC[0] - CONSTANTS[2]; CONDVAR[3] = VOI - (CONSTANTS[0]+ CONSTANTS[40]*CONSTANTS[5]); }